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dc.creatorIgnjatović, Nenad
dc.creatorVučen, Sonja
dc.creatorVuleta, Gordana
dc.creatorUskoković, Dragan
dc.date.accessioned2018-07-27T11:44:26Z
dc.date.available2018-07-27T11:44:26Z
dc.date.issued2010
dc.identifier.isbn9788680321189
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/3554
dc.description.abstractThe transdermal delivery system provides a highly efficient, safe, and easy to use method for delivering active ingredients and other compounds to the body through intact skin, thereby offering many other advantages over the traditional dosage forms. Ketoprofen is a poorly watersoluble non-steroidal antiinflammatory drug and widely used for the acute and long-term treatment of rheumatoid arthritis and associated diseases. The purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new nanoparticulate system for drug delivery of ketoprofene suitable for transdermal applications. Multi-scale design of a transdermal drug delivery system, from the molecular or nano scale through the macroscopic scale, was analyzed. The obtained nano particles contain ketoprofene-loaded spheres of poly(D,L-lactide acid) (PDLLA). Characterization was performed with wide-angle X-ray structural analysis (XRD), infrared spectroscopy (FT-IR), field-emission scanning electron microscopy (FESEM), high performance liquid chromatography (HPLC) and particle sized distribution (PSD) methods. XRD and FT-IR analyses confirmed that the ketoprofene is immobilized into PDLLA. The encapsulation of ketoprofen into the PDLLA nanoparticles was highly accomplished and the drug loading efficiency was 75%. The observed average particle dimension (d50) of ketoprofene-loaded nano particles was 63 nm.en
dc.language.isoensr
dc.publisherBelgrade : Institute of Technical Sciences of SASAsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//sr
dc.rightsopenAccesssr
dc.sourceProgramme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010sr
dc.subjecttransdermal drug deliverysr
dc.subjectketoprofensr
dc.subjectPDLLAsr
dc.titleNano-bioresorbable polymer spheres as carriers for transdermal delivery of ketoprofeneen
dc.typeconferenceObjectsr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractУскоковић, Драган; Вулета, Гордана; Игњатовић, Ненад; Вучен, Соња;
dc.citation.spage61
dc.citation.epage61
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://dais.sanu.ac.rs/bitstream/id/11382/Ignjatovic_YUCOMAT2010_61.pdf


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