Histochemical observation and the analysis of biochemical bone regeneration markers in treatment of an osteoporotic rat bone with Ca/Co-HAp nanoparticles
Authors
Ajduković, Zorica
Petrović, Milica B.

Milićević, Jelena

Đorđević, N.
Ignjatović, Nenad

Uskoković, Dragan

Savić, Vojin
Conference object (Published version)
Metadata
Show full item recordAbstract
One of the prerequisites for a good prosthetic rehabilitation is well preserved bone tissue. However, osteoporosis as a modern age disease often compromises a good dental treatment. Oral implantology offers a solution through the use of various biomaterials. Most researchers focus on the synthesis of the nanomaterials with magnetic and paramagnetic properties. The aim of this study is to examine the role of Ca / Co-HAp nanoparticles in the regeneration of the osteoporotic alveolar bone in experimental animals by analyzing the biochemical blood markers (ALP, Ca, Mg, and P) and through histochemical analysis. The research was carried out on female Westar rats, aged 6-8 weeks. The obtained results for the biochemical blood markers showed statistically significant rise. Histological analysis revealed high level reparatory skills of the biocomposite implanted in the bone defect as early as in the 6th week of the experiment as well as an increased alkaline phosphatase activity in the mineral...ized tissues. The implantation of the biomaterials facilitates osteogenesis, justifying their use in the accelerated regeneration treatment of the osteoporotic alveolar bone.
Keywords:
osteoporosis / magnetic nanomaterials / biocomposites / hydroxyapatiteSource:
Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010, 2010, 167-167Publisher:
- Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
- Biokompatibilnost i mogućnosti primene biomaterijala na bazi hidroksiapatita i biopolimera u tkivnoj reparaciji - eksperimentalna i klinička studija (RS-145068)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Ajduković, Zorica AU - Petrović, Milica B. AU - Milićević, Jelena AU - Đorđević, N. AU - Ignjatović, Nenad AU - Uskoković, Dragan AU - Savić, Vojin PY - 2010 UR - https://dais.sanu.ac.rs/123456789/3552 AB - One of the prerequisites for a good prosthetic rehabilitation is well preserved bone tissue. However, osteoporosis as a modern age disease often compromises a good dental treatment. Oral implantology offers a solution through the use of various biomaterials. Most researchers focus on the synthesis of the nanomaterials with magnetic and paramagnetic properties. The aim of this study is to examine the role of Ca / Co-HAp nanoparticles in the regeneration of the osteoporotic alveolar bone in experimental animals by analyzing the biochemical blood markers (ALP, Ca, Mg, and P) and through histochemical analysis. The research was carried out on female Westar rats, aged 6-8 weeks. The obtained results for the biochemical blood markers showed statistically significant rise. Histological analysis revealed high level reparatory skills of the biocomposite implanted in the bone defect as early as in the 6th week of the experiment as well as an increased alkaline phosphatase activity in the mineralized tissues. The implantation of the biomaterials facilitates osteogenesis, justifying their use in the accelerated regeneration treatment of the osteoporotic alveolar bone. PB - Belgrade : Institute of Technical Sciences of SASA C3 - Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 T1 - Histochemical observation and the analysis of biochemical bone regeneration markers in treatment of an osteoporotic rat bone with Ca/Co-HAp nanoparticles SP - 167 EP - 167 UR - https://hdl.handle.net/21.15107/rcub_dais_3552 ER -
@conference{ author = "Ajduković, Zorica and Petrović, Milica B. and Milićević, Jelena and Đorđević, N. and Ignjatović, Nenad and Uskoković, Dragan and Savić, Vojin", year = "2010", abstract = "One of the prerequisites for a good prosthetic rehabilitation is well preserved bone tissue. However, osteoporosis as a modern age disease often compromises a good dental treatment. Oral implantology offers a solution through the use of various biomaterials. Most researchers focus on the synthesis of the nanomaterials with magnetic and paramagnetic properties. The aim of this study is to examine the role of Ca / Co-HAp nanoparticles in the regeneration of the osteoporotic alveolar bone in experimental animals by analyzing the biochemical blood markers (ALP, Ca, Mg, and P) and through histochemical analysis. The research was carried out on female Westar rats, aged 6-8 weeks. The obtained results for the biochemical blood markers showed statistically significant rise. Histological analysis revealed high level reparatory skills of the biocomposite implanted in the bone defect as early as in the 6th week of the experiment as well as an increased alkaline phosphatase activity in the mineralized tissues. The implantation of the biomaterials facilitates osteogenesis, justifying their use in the accelerated regeneration treatment of the osteoporotic alveolar bone.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010", title = "Histochemical observation and the analysis of biochemical bone regeneration markers in treatment of an osteoporotic rat bone with Ca/Co-HAp nanoparticles", pages = "167-167", url = "https://hdl.handle.net/21.15107/rcub_dais_3552" }
Ajduković, Z., Petrović, M. B., Milićević, J., Đorđević, N., Ignjatović, N., Uskoković, D.,& Savić, V.. (2010). Histochemical observation and the analysis of biochemical bone regeneration markers in treatment of an osteoporotic rat bone with Ca/Co-HAp nanoparticles. in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 Belgrade : Institute of Technical Sciences of SASA., 167-167. https://hdl.handle.net/21.15107/rcub_dais_3552
Ajduković Z, Petrović MB, Milićević J, Đorđević N, Ignjatović N, Uskoković D, Savić V. Histochemical observation and the analysis of biochemical bone regeneration markers in treatment of an osteoporotic rat bone with Ca/Co-HAp nanoparticles. in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010. 2010;:167-167. https://hdl.handle.net/21.15107/rcub_dais_3552 .
Ajduković, Zorica, Petrović, Milica B., Milićević, Jelena, Đorđević, N., Ignjatović, Nenad, Uskoković, Dragan, Savić, Vojin, "Histochemical observation and the analysis of biochemical bone regeneration markers in treatment of an osteoporotic rat bone with Ca/Co-HAp nanoparticles" in Programme and The Book of Abstracts / Twelfth Annual Conference YUCOMAT 2010, Herceg Novi, September 6–10, 2010 (2010):167-167, https://hdl.handle.net/21.15107/rcub_dais_3552 .