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dc.creatorIgnjatović, Nenad
dc.creatorUskoković, Vuk
dc.creatorAjduković, Zorica
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2013
dc.identifier.issn0928-4931
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/354
dc.description.abstractCholecalciferol, vitamin D3, plays an important role in bone metabolism by regulating extracellular levels of calcium. Presented here is a study on the effects of the local delivery of cholecalciferol (D3) using nanoparticulate carriers composed of hydroxyapatite (HAp) and poly(d,l-lactide-co-glycolide) (PLGA). Multifunctional nanoparticulate HAp-based powders were prepared for the purpose of: (a) either fast or sustained, local delivery of cholecalciferol, and (b) the secondary, osteoconductive and defect-filling effect of the carrier itself. Two types of HAp-based powders with particles of narrowly dispersed sizes in the nano range were prepared and tested in this study: HAp nanoparticles as direct cholecalciferol delivery agents and HAp nanoparticles coated with cholecalciferol-loaded poly(d,l)-lactide-co-glycolide (HAp/D3/PLGA). Satisfying biocompatibility of particulate systems, when incubated in contact with MC3T3-E1 osteoblastic cells in vitro, was observed for HAp/D3/PLGA and pure HAp. In contrast, an extensively fast release of cholecalciferol from the system comprising HAp nanoparticles coated with cholecalciferol (HAp/D3) triggered necrosis of the osteoblastic cells in vitro. Artificial defects induced in the osteoporotic bone of the rat mandible were successfully reconstructed following implantation of cholecalciferol-coated HAp nanoparticles as well as those comprising HAp nanoparticles coated with cholecalciferol-loaded PLGA (HAp/D3/PLGA). The greatest levels of enhanced angiogenesis, vascularization, osteogenesis and bone structure differentiation were achieved upon the implementation of HAp/D3/PLGA systems.en
dc.format33 2 (2013) 943-950
dc.languageen
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45004/RS//
dc.relationUnited States National Institutes of Health (NIH) / National Institute of Dental and Craniofacial Research (NIDCR), Grant K99-DE021416
dc.rightsrestrictedAccess
dc.sourceMaterials Science and Engineering: Cen
dc.subjectmultifunctional nanomaterials
dc.subjectcholecalciferol
dc.subjecthydroxyapatite
dc.subjectpoly(D,L-lactide-co-glycolide)en
dc.subjectvitamin D3
dc.titleMultifunctional hydroxyapatite and poly(D,L-lactide-co-glycolide) nanoparticles for the local delivery of cholecalciferolen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractУскоковић, Вук; Игњатовић, Ненад; Ускоковић, Драган; Aјдуковић, Зорица;
dc.citation.spage943
dc.citation.epage950
dc.citation.volume33
dc.citation.issue2
dc.identifier.wos000315761700053
dc.identifier.doi10.1016/j.msec.2012.11.026
dc.identifier.scopus2-s2.0-84871364442
dc.description.otherPeer-reviewed manuscript: [http://dais.sanu.ac.rs/123456789/15982]
dc.type.versionpublishedVersion


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