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TY - JOUR
AU - Kostić, Ivana T.
AU - Ilić, Vesna Lj.
AU - Bukara, Katarina M.
AU - Mojsilović, Slavko B.
AU - Đurić, Zorka Ž.
AU - Draškovič, Petra
AU - Bugarski, Branko
PY - 2015
AB - Despite the fact that the methods based on the osmotic properties of the cells are the most widely used for loading of drugs in human and animal erythrocytes, data related to the osmotic properties of erythrocytes derived from animal blood are scarce. This work was performed with an aim to investigate the possibility of use the flow cytometry as a tool for determination the osmotic behaviour of porcine and bovine erythrocytes, and thus facilitates the engineering of erythrocytes from animal blood to be drug carriers. The method of flow cytometry successfully provided the information about bovine and porcine erythrocyte osmotic fragility, and made the initial steps in assessment of erythrocyte shape in a large number of erythrocytes. Although this method is not able to confirm the swelling of porcine erythrocytes, it indicated the differences in porcine erythrocytes that had basic hematological parameters inside and outside the reference values. In order to apply/use the porcine and bovine erythrocytes as drug carriers, the method of flow cytometry, confirming the presence of osmotically different fractions of red blood cells, indicated that various amounts of the encapsulated drug in porcine and bovine erythrocytes can be expected. © 2015, Association of Chemists and Chemical Engineers of Serbia. All rights reserved.
PB - Belgrade: Association of the Chemical Engineers of Serbia
T2 - Hemijska industrija
T1 - Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery
SP - 67
EP - 76
VL - 69
IS - 1
DO - 10.2298/HEMIND140124021K
UR - https://hdl.handle.net/21.15107/rcub_dais_3533
ER -
@article{
author = "Kostić, Ivana T. and Ilić, Vesna Lj. and Bukara, Katarina M. and Mojsilović, Slavko B. and Đurić, Zorka Ž. and Draškovič, Petra and Bugarski, Branko",
year = "2015",
abstract = "Despite the fact that the methods based on the osmotic properties of the cells are the most widely used for loading of drugs in human and animal erythrocytes, data related to the osmotic properties of erythrocytes derived from animal blood are scarce. This work was performed with an aim to investigate the possibility of use the flow cytometry as a tool for determination the osmotic behaviour of porcine and bovine erythrocytes, and thus facilitates the engineering of erythrocytes from animal blood to be drug carriers. The method of flow cytometry successfully provided the information about bovine and porcine erythrocyte osmotic fragility, and made the initial steps in assessment of erythrocyte shape in a large number of erythrocytes. Although this method is not able to confirm the swelling of porcine erythrocytes, it indicated the differences in porcine erythrocytes that had basic hematological parameters inside and outside the reference values. In order to apply/use the porcine and bovine erythrocytes as drug carriers, the method of flow cytometry, confirming the presence of osmotically different fractions of red blood cells, indicated that various amounts of the encapsulated drug in porcine and bovine erythrocytes can be expected. © 2015, Association of Chemists and Chemical Engineers of Serbia. All rights reserved.",
publisher = "Belgrade: Association of the Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery",
pages = "67-76",
volume = "69",
number = "1",
doi = "10.2298/HEMIND140124021K",
url = "https://hdl.handle.net/21.15107/rcub_dais_3533"
}
Kostić, I. T., Ilić, V. Lj., Bukara, K. M., Mojsilović, S. B., Đurić, Z. Ž., Draškovič, P.,& Bugarski, B. (2015). Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery.
Hemijska industrija
Belgrade: Association of the Chemical Engineers of Serbia., 69(1), 67-76.
https://doi.org/10.2298/HEMIND140124021K
Kostić IT, Ilić VL, Bukara KM, Mojsilović SB, Đurić ZŽ, Draškovič P, Bugarski B. Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery. Hemijska industrija. 2015;69(1):67-76.
doi:10.2298/HEMIND140124021K.
Kostić Ivana T., Ilić Vesna Lj., Bukara Katarina M., Mojsilović Slavko B., Đurić Zorka Ž., Draškovič Petra, Bugarski Branko, "Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery" Hemijska industrija, 69, no. 1 (2015):67-76,
https://doi.org/10.2298/HEMIND140124021K .
