Efficacy of nanocrystalline bone substitute biphasic calcium phosphate/poly-DL-lactide-co-glycolide for periodontal intrabony defects filling
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Background/Aim. Different bone substitutes have been used for filling and reparation of intrabony defects. The aim of this study was to compare nanocrystalline material, biphasic calcium phosphate poly-DL-lactidecoglycolide (BCP/PLGA) with deproteinised bovine bone (DPBB) and β-tricalcium phosphate (β-TCP) in the treatment of periodontal intrabony defects. Methods. The study included 24 patients with bilateral, intrabony defects in the region of the upper first and second premolar, and the upper first molar. On one side of the mouth, DPBB (BioOss®) was used to fill defects in upper premolars while β-TCP (RTR®) was used for the upper first molar. BCP/PLGA was applied into periodontal defects of the upper premolars and upper first molar of the opposite side. Results. The comparison of the BCP/PLGA and the β-TCP group, 6 months following filling of defects, showed a statistically significant reduction of periodontal pocket depth (PPD) and the position of the cement-enamel junction (CEJ) i...n the group with BCP/PLGA, when compared to the β-TCP group. The reduction of PPD and CEJ was similar in the groups treated with BCP/PLGA and DPBB. Conclusion. Significant reductions of PPD and CEJ were registered in the group with BCP/PLGA when compared to the β-TCP group. © 2015, Institut za Vojnomedicinske Naucne Informacije/Documentaciju. All rights reserved.
Keywords:
biocompatible materials / bone resorption / bone substitutes / nanoparticles / oral surgical procedures / treatment outcomeSource:
Vojnosanitetski Pregled, 2015, 72, 8, 689-695Publisher:
- Belgrade : Military Medical Academy
Funding / projects:
- Pain Control and Molecular Mechanisms as Factors for Tissue Regeneration in Dentistry in Healthy and Diabetic Patients (RS-175021)
- Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
DOI: 10.2298/VSP140528049S
ISSN: 0042-8450 (Print); 2406-0720
WoS: 000361082500005
Scopus: 2-s2.0-84938304406
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Stevanović, Momir AU - Biočanin, Vladimir AU - Nedić, Milica AU - Ignjatović, Nenad PY - 2015 UR - https://dais.sanu.ac.rs/123456789/3520 AB - Background/Aim. Different bone substitutes have been used for filling and reparation of intrabony defects. The aim of this study was to compare nanocrystalline material, biphasic calcium phosphate poly-DL-lactidecoglycolide (BCP/PLGA) with deproteinised bovine bone (DPBB) and β-tricalcium phosphate (β-TCP) in the treatment of periodontal intrabony defects. Methods. The study included 24 patients with bilateral, intrabony defects in the region of the upper first and second premolar, and the upper first molar. On one side of the mouth, DPBB (BioOss®) was used to fill defects in upper premolars while β-TCP (RTR®) was used for the upper first molar. BCP/PLGA was applied into periodontal defects of the upper premolars and upper first molar of the opposite side. Results. The comparison of the BCP/PLGA and the β-TCP group, 6 months following filling of defects, showed a statistically significant reduction of periodontal pocket depth (PPD) and the position of the cement-enamel junction (CEJ) in the group with BCP/PLGA, when compared to the β-TCP group. The reduction of PPD and CEJ was similar in the groups treated with BCP/PLGA and DPBB. Conclusion. Significant reductions of PPD and CEJ were registered in the group with BCP/PLGA when compared to the β-TCP group. © 2015, Institut za Vojnomedicinske Naucne Informacije/Documentaciju. All rights reserved. PB - Belgrade : Military Medical Academy T2 - Vojnosanitetski Pregled T1 - Efficacy of nanocrystalline bone substitute biphasic calcium phosphate/poly-DL-lactide-co-glycolide for periodontal intrabony defects filling SP - 689 EP - 695 VL - 72 IS - 8 DO - 10.2298/VSP140528049S UR - https://hdl.handle.net/21.15107/rcub_dais_3520 ER -
@article{ author = "Stevanović, Momir and Biočanin, Vladimir and Nedić, Milica and Ignjatović, Nenad", year = "2015", abstract = "Background/Aim. Different bone substitutes have been used for filling and reparation of intrabony defects. The aim of this study was to compare nanocrystalline material, biphasic calcium phosphate poly-DL-lactidecoglycolide (BCP/PLGA) with deproteinised bovine bone (DPBB) and β-tricalcium phosphate (β-TCP) in the treatment of periodontal intrabony defects. Methods. The study included 24 patients with bilateral, intrabony defects in the region of the upper first and second premolar, and the upper first molar. On one side of the mouth, DPBB (BioOss®) was used to fill defects in upper premolars while β-TCP (RTR®) was used for the upper first molar. BCP/PLGA was applied into periodontal defects of the upper premolars and upper first molar of the opposite side. Results. The comparison of the BCP/PLGA and the β-TCP group, 6 months following filling of defects, showed a statistically significant reduction of periodontal pocket depth (PPD) and the position of the cement-enamel junction (CEJ) in the group with BCP/PLGA, when compared to the β-TCP group. The reduction of PPD and CEJ was similar in the groups treated with BCP/PLGA and DPBB. Conclusion. Significant reductions of PPD and CEJ were registered in the group with BCP/PLGA when compared to the β-TCP group. © 2015, Institut za Vojnomedicinske Naucne Informacije/Documentaciju. All rights reserved.", publisher = "Belgrade : Military Medical Academy", journal = "Vojnosanitetski Pregled", title = "Efficacy of nanocrystalline bone substitute biphasic calcium phosphate/poly-DL-lactide-co-glycolide for periodontal intrabony defects filling", pages = "689-695", volume = "72", number = "8", doi = "10.2298/VSP140528049S", url = "https://hdl.handle.net/21.15107/rcub_dais_3520" }
Stevanović, M., Biočanin, V., Nedić, M.,& Ignjatović, N.. (2015). Efficacy of nanocrystalline bone substitute biphasic calcium phosphate/poly-DL-lactide-co-glycolide for periodontal intrabony defects filling. in Vojnosanitetski Pregled Belgrade : Military Medical Academy., 72(8), 689-695. https://doi.org/10.2298/VSP140528049S https://hdl.handle.net/21.15107/rcub_dais_3520
Stevanović M, Biočanin V, Nedić M, Ignjatović N. Efficacy of nanocrystalline bone substitute biphasic calcium phosphate/poly-DL-lactide-co-glycolide for periodontal intrabony defects filling. in Vojnosanitetski Pregled. 2015;72(8):689-695. doi:10.2298/VSP140528049S https://hdl.handle.net/21.15107/rcub_dais_3520 .
Stevanović, Momir, Biočanin, Vladimir, Nedić, Milica, Ignjatović, Nenad, "Efficacy of nanocrystalline bone substitute biphasic calcium phosphate/poly-DL-lactide-co-glycolide for periodontal intrabony defects filling" in Vojnosanitetski Pregled, 72, no. 8 (2015):689-695, https://doi.org/10.2298/VSP140528049S ., https://hdl.handle.net/21.15107/rcub_dais_3520 .