DAIS - Digital Archive of the Serbian Academy of Sciences and Arts
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences of SASA
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
  • View Item
  •   DAIS
  • Институт техничких наука САНУ / Institute of Technical Sciences of SASA
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments

Authorized Users Only
2015
Authors
Jokić, Ivana
Frantlović, Miloš
Đurić, Zoran G.
Radulović, Katarina
Jokić, Zorana
Article (Published version)
Metadata
Show full item record
Abstract
We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the developme...nt of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum. © 2015 Published by Elsevier B.V.

Keywords:
adsorption-desorption noise / fluctuations / mass transfer / microfluidic biosensor / multianalyte detection
Source:
Microelectronic Engineering, 2015, 144, 32-36
Publisher:
  • Elsevier
Funding / projects:
  • Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
  • Serbian Academy of Sciences and Arts, Project F-150

DOI: 10.1016/j.mee.2015.02.032

ISSN: 0167-9317

WoS: 000357908500008

Scopus: 2-s2.0-84924049788
[ Google Scholar ]
10
9
Handle
https://hdl.handle.net/21.15107/rcub_dais_3519
URI
https://dais.sanu.ac.rs/123456789/3519
Collections
  • Општа колекција САНУ / General collection of SASA
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - JOUR
AU  - Jokić, Ivana
AU  - Frantlović, Miloš
AU  - Đurić, Zoran G.
AU  - Radulović, Katarina
AU  - Jokić, Zorana
PY  - 2015
UR  - https://dais.sanu.ac.rs/123456789/3519
AB  - We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the development of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum. © 2015 Published by Elsevier B.V.
PB  - Elsevier
T2  - Microelectronic Engineering
T1  - Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments
SP  - 32
EP  - 36
VL  - 144
DO  - 10.1016/j.mee.2015.02.032
UR  - https://hdl.handle.net/21.15107/rcub_dais_3519
ER  - 
@article{
author = "Jokić, Ivana and Frantlović, Miloš and Đurić, Zoran G. and Radulović, Katarina and Jokić, Zorana",
year = "2015",
abstract = "We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the development of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum. © 2015 Published by Elsevier B.V.",
publisher = "Elsevier",
journal = "Microelectronic Engineering",
title = "Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments",
pages = "32-36",
volume = "144",
doi = "10.1016/j.mee.2015.02.032",
url = "https://hdl.handle.net/21.15107/rcub_dais_3519"
}
Jokić, I., Frantlović, M., Đurić, Z. G., Radulović, K.,& Jokić, Z.. (2015). Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments. in Microelectronic Engineering
Elsevier., 144, 32-36.
https://doi.org/10.1016/j.mee.2015.02.032
https://hdl.handle.net/21.15107/rcub_dais_3519
Jokić I, Frantlović M, Đurić ZG, Radulović K, Jokić Z. Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments. in Microelectronic Engineering. 2015;144:32-36.
doi:10.1016/j.mee.2015.02.032
https://hdl.handle.net/21.15107/rcub_dais_3519 .
Jokić, Ivana, Frantlović, Miloš, Đurić, Zoran G., Radulović, Katarina, Jokić, Zorana, "Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments" in Microelectronic Engineering, 144 (2015):32-36,
https://doi.org/10.1016/j.mee.2015.02.032 .,
https://hdl.handle.net/21.15107/rcub_dais_3519 .

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

CoreTrustSealre3dataOpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About DAIS - Digital Archive of the Serbian Academy of Sciences and Arts | Send Feedback

CoreTrustSealre3dataOpenAIRERCUB