Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments
Abstract
We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the developme...nt of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum. © 2015 Published by Elsevier B.V.
Keywords:
adsorption-desorption noise / fluctuations / mass transfer / microfluidic biosensor / multianalyte detectionSource:
Microelectronic Engineering, 2015, 144, 32-36Publisher:
- Elsevier
Funding / projects:
- Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
- Serbian Academy of Sciences and Arts, Project F-150
DOI: 10.1016/j.mee.2015.02.032
ISSN: 0167-9317
WoS: 000357908500008
Scopus: 2-s2.0-84924049788
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Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Jokić, Ivana AU - Frantlović, Miloš AU - Đurić, Zoran G. AU - Radulović, Katarina AU - Jokić, Zorana PY - 2015 UR - https://dais.sanu.ac.rs/123456789/3519 AB - We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the development of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum. © 2015 Published by Elsevier B.V. PB - Elsevier T2 - Microelectronic Engineering T1 - Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments SP - 32 EP - 36 VL - 144 DO - 10.1016/j.mee.2015.02.032 UR - https://hdl.handle.net/21.15107/rcub_dais_3519 ER -
@article{ author = "Jokić, Ivana and Frantlović, Miloš and Đurić, Zoran G. and Radulović, Katarina and Jokić, Zorana", year = "2015", abstract = "We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the development of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum. © 2015 Published by Elsevier B.V.", publisher = "Elsevier", journal = "Microelectronic Engineering", title = "Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments", pages = "32-36", volume = "144", doi = "10.1016/j.mee.2015.02.032", url = "https://hdl.handle.net/21.15107/rcub_dais_3519" }
Jokić, I., Frantlović, M., Đurić, Z. G., Radulović, K.,& Jokić, Z.. (2015). Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments. in Microelectronic Engineering Elsevier., 144, 32-36. https://doi.org/10.1016/j.mee.2015.02.032 https://hdl.handle.net/21.15107/rcub_dais_3519
Jokić I, Frantlović M, Đurić ZG, Radulović K, Jokić Z. Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments. in Microelectronic Engineering. 2015;144:32-36. doi:10.1016/j.mee.2015.02.032 https://hdl.handle.net/21.15107/rcub_dais_3519 .
Jokić, Ivana, Frantlović, Miloš, Đurić, Zoran G., Radulović, Katarina, Jokić, Zorana, "Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments" in Microelectronic Engineering, 144 (2015):32-36, https://doi.org/10.1016/j.mee.2015.02.032 ., https://hdl.handle.net/21.15107/rcub_dais_3519 .