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dc.creatorStevanović, Magdalena
dc.creatorUskoković, Dragan
dc.date.accessioned2018-07-06T17:36:49Z
dc.date.available2018-07-06T17:36:49Z
dc.date.issued2009
dc.identifier.issn1875-6786
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/3478
dc.description.abstractControlled drug delivery systems and polymeric carriers have undergone significant development in recent years. Polymers like polylactides (PLA), polyglycolides (PGA), poly(lactide-co-glycolides) (PLGA), are approved by the World Health Organization (WHO) and Food and Drug Administration (FDA) as materials that can be used in medicine and pharmacy. Owing to their biodegradable nature, polymer materials, such as copolymer poly(DL-lactide-co-glycolide), are widely used in various medical applications; controlled release of delivering drugs, carriers in the tissue engineering, fixation of bone fractures, chirurgical strings, etc. Polymeric particles are used for the controlled delivery of several types of medicaments, including anticancer agents, antihypertensive agents, immunomodulatory drugs, hormones, vitamins and macromolecules, such as nucleic acid, proteins, peptides, antibodies, etc. Preparation of poly(lactideco-glycolide) submicron spheres poses serious challenges. The present review attempts to address some important issues related to micro-nanoparticle-based delivery systems comprising poly(lactide-co-glycolide), with a special reference to PLGA for the controlled delivery of vitamins. A range of topics is discussed, including formulation aspects of micro- and nanoparticles, the effects of particle size and size distribution, most commonly used incorporation techniques, surface modification with stabilizers, surface functionalization, and factors affecting degradation and drug release rate. © 2009 Bentham Science Publishers Ltd.en
dc.publisherBentham Science Publishers
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Nanoscience
dc.subjectdrug delivery
dc.subjectdrug release
dc.subjectmicro- and nanoparticles
dc.subjectpoly(lactide-co-glycolide)
dc.subjectvitamins delivery
dc.titlePoly(lactide-co-glycolide)-based micro and nanoparticles for the controlled drug delivery of vitaminsen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractСтевановић, Магдалена; Ускоковић, Драган;
dc.citation.spage1
dc.citation.epage14
dc.citation.volume5
dc.citation.issue1
dc.identifier.wos000263961400001
dc.identifier.doi10.2174/157341309787314566
dc.identifier.scopus2-s2.0-65949099508
dc.description.otherPeer-reviewed version available: [https://dais.sanu.ac.rs/handle/123456789/76]
dc.type.versionpublishedVersion


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