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Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry
Clindamycin was determined in pig plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The multiple reaction monitoring (MRM) mode of precursor-product ion transitions for clindamycin (m/z=421.1/126.1) and the internal standard, caffeine (m/z=192/125) was used. The samples were prepared by two methods: 0.1% formic acid in methanol and 1.5% trichloacetic acid. The recovery for the two preparation methods at 0.05mg/ml (n=6) was found to be for the first 104.3% and for the second method 106.5%, with repeatability RSD 1.1% and RSD 4.34%, respectively. The results of the comparison of the two different preparation methods of samples demonstrated that both methods were satisfactory.
Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia, 2010, 19-19
Publisher:
Belgrade : Institute of Technical Sciences of SASA
TY - CONF
AU - Vuković, Gorica
AU - Lazić, Sanja
AU - Šunjka, Dragana
AU - Bursić, Vojislava
AU - Šarčev, Ivan
AU - Vukomanović, Marija
AU - Ignjatović, Nenad
AU - Uskoković, Dragan
PY - 2010
UR - http://dais.sanu.ac.rs/123456789/3453
AB - Clindamycin was determined in pig plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The multiple reaction monitoring (MRM) mode of precursor-product ion transitions for clindamycin (m/z=421.1/126.1) and the internal standard, caffeine (m/z=192/125) was used. The samples were prepared by two methods: 0.1% formic acid in methanol and 1.5% trichloacetic acid. The recovery for the two preparation methods at 0.05mg/ml (n=6) was found to be for the first 104.3% and for the second method 106.5%, with repeatability RSD 1.1% and RSD 4.34%, respectively. The results of the comparison of the two different preparation methods of samples demonstrated that both methods were satisfactory.
PB - Belgrade : Institute of Technical Sciences of SASA
C3 - Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia
T1 - Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry
SP - 19
EP - 19
ER -
@conference{
author = "Vuković, Gorica and Lazić, Sanja and Šunjka, Dragana and Bursić, Vojislava and Šarčev, Ivan and Vukomanović, Marija and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
url = "http://dais.sanu.ac.rs/123456789/3453",
abstract = "Clindamycin was determined in pig plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The multiple reaction monitoring (MRM) mode of precursor-product ion transitions for clindamycin (m/z=421.1/126.1) and the internal standard, caffeine (m/z=192/125) was used. The samples were prepared by two methods: 0.1% formic acid in methanol and 1.5% trichloacetic acid. The recovery for the two preparation methods at 0.05mg/ml (n=6) was found to be for the first 104.3% and for the second method 106.5%, with repeatability RSD 1.1% and RSD 4.34%, respectively. The results of the comparison of the two different preparation methods of samples demonstrated that both methods were satisfactory.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia",
title = "Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry",
pages = "19-19"
}
Vuković G, Lazić S, Šunjka D, Bursić V, Šarčev I, Vukomanović M, Ignjatović N, Uskoković D. Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry. Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia. 2010;:19-19
Vuković, G., Lazić, S., Šunjka, D., Bursić, V., Šarčev, I., Vukomanović, M., Ignjatović, N.,& Uskoković, D. (2010). Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry.
Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, SerbiaBelgrade : Institute of Technical Sciences of SASA., null, 19-19.
Vuković Gorica, Lazić Sanja, Šunjka Dragana, Bursić Vojislava, Šarčev Ivan, Vukomanović Marija, Ignjatović Nenad, Uskoković Dragan, "Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry" null (2010):19-19
