Evaluation compensation of an osteoporotic rat bone with Ca/Co-HAp nanoparticles

Abstract

This study examined the role of Ca / Co-HAp nanoparticles on time distance in regeneration of osteoporotic alveolar bone in rats by biochemical blood markers analysis (ALP, Ca, Mg, P) and through histochemical analysis. The research was carried out on female Westar rats, aged 6-8 weeks. The obtained results for the biochemical blood markers showed statistically significant rise. Histological analysis revealed high level reparatory skills of the biocomposite implanted in the bone defect as early as in the mineralized tissues. It can be concluded that Ca/Co-HAp stimulates the regeneration of osteoporotic alveolar bone in tested animals as confirmed by the increased levels of biochemical blood markers and through histochemical analysis. Therefore, it can be concluded that Ca/Co-HAp nanocomposite should be choise material in the osteoconstructive processes in the future.