In vitro evaluation of antimicrobial activity of nano composite biomaterials based on hydroxyapatite
Authors
Ajduković, Zorica
Milićević, Jelena

Petrović, Milica B.

Đorđević, Nadica

Mladenović Antić, Snežana
Kocić, Branislava
Ignjatović, Nenad

Uskoković, Dragan

Savić, Vojin P.
Conference object (Published version)
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Antimicrobial materials based on hydroxyapatite are potentially attractive in a wide variety of medical and stomatological applications. The objective of this paper is to examine antimicrobic activity of cobalt-substituted calcium hydroxyapatite nanopowders and biphased calciumphosphate/ poli-lactide-co-glicolide. The antimicrobial effects of these substances (powders) against two pathogen bacterial strains- Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) were tested by disc diffusion method and quantitative antimicrobial test in liquid medium. It was noted that the inhibition zone of the bacterial cells S. aureus around the sample of the Ca/Co- HAp, was a lot bigger compared to the inhibition zone of bacterial cells E. coli around the sample of the mentioned biomaterial, which means that this material has bigger antimicrobic activity on S. aureus, in relation to E. coli. Quantitative antimicrobial test in liquid medium demonstrate that cobalt-substituted calcium h...ydroxyapatite samples show viable cells reduction of both tested microorganisms. It may be concluded that nanoparticles of cobalt-substituted calcium hydoxyapatite nano-powders has a satisfactory antimicrobic activity according to the tested bacteria strain.
Keywords:
antimicrobial materials / hydroxyapatite / poli-lactide-co-glicolide / cobalt / nannopowdersSource:
Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia, 2010, 18-18Publisher:
- Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
- Biokompatibilnost i mogućnosti primene biomaterijala na bazi hidroksiapatita i biopolimera u tkivnoj reparaciji - eksperimentalna i klinička studija (RS-145068)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Ajduković, Zorica AU - Milićević, Jelena AU - Petrović, Milica B. AU - Đorđević, Nadica AU - Mladenović Antić, Snežana AU - Kocić, Branislava AU - Ignjatović, Nenad AU - Uskoković, Dragan AU - Savić, Vojin P. PY - 2010 UR - https://dais.sanu.ac.rs/123456789/3444 AB - Antimicrobial materials based on hydroxyapatite are potentially attractive in a wide variety of medical and stomatological applications. The objective of this paper is to examine antimicrobic activity of cobalt-substituted calcium hydroxyapatite nanopowders and biphased calciumphosphate/ poli-lactide-co-glicolide. The antimicrobial effects of these substances (powders) against two pathogen bacterial strains- Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) were tested by disc diffusion method and quantitative antimicrobial test in liquid medium. It was noted that the inhibition zone of the bacterial cells S. aureus around the sample of the Ca/Co- HAp, was a lot bigger compared to the inhibition zone of bacterial cells E. coli around the sample of the mentioned biomaterial, which means that this material has bigger antimicrobic activity on S. aureus, in relation to E. coli. Quantitative antimicrobial test in liquid medium demonstrate that cobalt-substituted calcium hydroxyapatite samples show viable cells reduction of both tested microorganisms. It may be concluded that nanoparticles of cobalt-substituted calcium hydoxyapatite nano-powders has a satisfactory antimicrobic activity according to the tested bacteria strain. PB - Belgrade : Institute of Technical Sciences of SASA C3 - Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia T1 - In vitro evaluation of antimicrobial activity of nano composite biomaterials based on hydroxyapatite SP - 18 EP - 18 UR - https://hdl.handle.net/21.15107/rcub_dais_3444 ER -
@conference{ author = "Ajduković, Zorica and Milićević, Jelena and Petrović, Milica B. and Đorđević, Nadica and Mladenović Antić, Snežana and Kocić, Branislava and Ignjatović, Nenad and Uskoković, Dragan and Savić, Vojin P.", year = "2010", abstract = "Antimicrobial materials based on hydroxyapatite are potentially attractive in a wide variety of medical and stomatological applications. The objective of this paper is to examine antimicrobic activity of cobalt-substituted calcium hydroxyapatite nanopowders and biphased calciumphosphate/ poli-lactide-co-glicolide. The antimicrobial effects of these substances (powders) against two pathogen bacterial strains- Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) were tested by disc diffusion method and quantitative antimicrobial test in liquid medium. It was noted that the inhibition zone of the bacterial cells S. aureus around the sample of the Ca/Co- HAp, was a lot bigger compared to the inhibition zone of bacterial cells E. coli around the sample of the mentioned biomaterial, which means that this material has bigger antimicrobic activity on S. aureus, in relation to E. coli. Quantitative antimicrobial test in liquid medium demonstrate that cobalt-substituted calcium hydroxyapatite samples show viable cells reduction of both tested microorganisms. It may be concluded that nanoparticles of cobalt-substituted calcium hydoxyapatite nano-powders has a satisfactory antimicrobic activity according to the tested bacteria strain.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia", title = "In vitro evaluation of antimicrobial activity of nano composite biomaterials based on hydroxyapatite", pages = "18-18", url = "https://hdl.handle.net/21.15107/rcub_dais_3444" }
Ajduković, Z., Milićević, J., Petrović, M. B., Đorđević, N., Mladenović Antić, S., Kocić, B., Ignjatović, N., Uskoković, D.,& Savić, V. P.. (2010). In vitro evaluation of antimicrobial activity of nano composite biomaterials based on hydroxyapatite. in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia Belgrade : Institute of Technical Sciences of SASA., 18-18. https://hdl.handle.net/21.15107/rcub_dais_3444
Ajduković Z, Milićević J, Petrović MB, Đorđević N, Mladenović Antić S, Kocić B, Ignjatović N, Uskoković D, Savić VP. In vitro evaluation of antimicrobial activity of nano composite biomaterials based on hydroxyapatite. in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia. 2010;:18-18. https://hdl.handle.net/21.15107/rcub_dais_3444 .
Ajduković, Zorica, Milićević, Jelena, Petrović, Milica B., Đorđević, Nadica, Mladenović Antić, Snežana, Kocić, Branislava, Ignjatović, Nenad, Uskoković, Dragan, Savić, Vojin P., "In vitro evaluation of antimicrobial activity of nano composite biomaterials based on hydroxyapatite" in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia (2010):18-18, https://hdl.handle.net/21.15107/rcub_dais_3444 .