Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics
Conference object (Published version)
Metadata
Show full item recordAbstract
Local drug delivery for the treatment of infectious bone tissue diseases is a high importance topic in the field of biomedicine for a last two decades. [1] In general, some of the main problems related to controlled drug delivery of antibiotics are: (i) high initial burst effect with toxic outcome and (ii) low concentration of released drug during extended period of time with possibility for development of resistant spaces.[2] There are some examples suggesting that core-shell particles applied as carriers of drug are able to provide high control over the process of drug release and to prevent burst effect.[3,4] Therefore, the main goal of our work is to design material which will be able to provide these characteristics.
Source:
European Cells and Materials, 2010, 20, SUPPL. 3, 266-266Publisher:
- Davos: AO Research Institute Davos
Projects:
- Bilateral cooperation program between the Republic of Serbia and the Republic of Slovenia
Note:
- 3rd International NanoBio Conference 2010, ETH Zurich, Switzerland, August 24-27 2010
TY - CONF AU - Vukomanović, Marija AU - Škapin, Srečo Davor AU - Šarčev, Ivan AU - Ignjatović, Nenad AU - Uskoković, Dragan PY - 2010 UR - http://dais.sanu.ac.rs/123456789/3436 AB - Local drug delivery for the treatment of infectious bone tissue diseases is a high importance topic in the field of biomedicine for a last two decades. [1] In general, some of the main problems related to controlled drug delivery of antibiotics are: (i) high initial burst effect with toxic outcome and (ii) low concentration of released drug during extended period of time with possibility for development of resistant spaces.[2] There are some examples suggesting that core-shell particles applied as carriers of drug are able to provide high control over the process of drug release and to prevent burst effect.[3,4] Therefore, the main goal of our work is to design material which will be able to provide these characteristics. PB - Davos: AO Research Institute Davos C3 - European Cells and Materials C3 - European Cells and Materials T1 - Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics SP - 266 EP - 266 VL - 20 IS - SUPPL. 3 ER -
@conference{ author = "Vukomanović, Marija and Škapin, Srečo Davor and Šarčev, Ivan and Ignjatović, Nenad and Uskoković, Dragan", year = "2010", url = "http://dais.sanu.ac.rs/123456789/3436", abstract = "Local drug delivery for the treatment of infectious bone tissue diseases is a high importance topic in the field of biomedicine for a last two decades. [1] In general, some of the main problems related to controlled drug delivery of antibiotics are: (i) high initial burst effect with toxic outcome and (ii) low concentration of released drug during extended period of time with possibility for development of resistant spaces.[2] There are some examples suggesting that core-shell particles applied as carriers of drug are able to provide high control over the process of drug release and to prevent burst effect.[3,4] Therefore, the main goal of our work is to design material which will be able to provide these characteristics.", publisher = "Davos: AO Research Institute Davos", journal = "European Cells and Materials, European Cells and Materials", title = "Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics", pages = "266-266", volume = "20", number = "SUPPL. 3" }
Vukomanović M, Škapin SD, Šarčev I, Ignjatović N, Uskoković D. Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. European Cells and Materials. 2010;20(SUPPL. 3):266-266
Vukomanović, M., Škapin, S. D., Šarčev, I., Ignjatović, N.,& Uskoković, D. (2010). Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. European Cells and MaterialsDavos: AO Research Institute Davos., 20(SUPPL. 3), 266-266.
Vukomanović Marija, Škapin Srečo Davor, Šarčev Ivan, Ignjatović Nenad, Uskoković Dragan, "Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics" 20, no. SUPPL. 3 (2010):266-266