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Size effect of calcium phosphate coated with poly-DL-lactideco-glycolide on healing processes in bone reconstruction

Authorized Users Only
2010
Authors
Ignjatović, Nenad
Ajduković, Zorica
Savić, Vojin. P.
Uskoković, Dragan
Article (Published version)
Metadata
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Abstract
In this article, synthesis and application of calcium phosphate/poly-DL- lactide-co-glycolide (CP/PLGA) composite biomaterial in particulate form, in which each CP granule/particle is coated with PLGA, are described. Two types of the particulate material having different particle sizes were synthesized: one with an average particle diameter between 150 and 250 μm (micron-sized particles, MPs) and the other with an average particle diameter smaller than 50 nm (nanoparticles, NPs). A comparative in vivo analysis was done by reconstructing defects in osteoporotic alveolar bones using both composites. The material, CP granules/particles covered with polymer, was characterized using X-ray structural analysis, scanning electron microscopy, and atomic force microscopy. Changes in reparatory functions of tissues affected by osteoporosis were examined in mice in vivo, using these two kinds of composite materials, with and without autologous plasma. Having defined the target segment, histomorpho...metric parameters - bone area fraction, area, and mean density - were determined. The best results in the regeneration and recuperation of alveolar bone damaged by osteoporosis were achieved with the implantation of a mixture of nanoparticulate CP/PLGA composite and autologous plasma. After the implantation of microparticulate CP/PLGA, in the form of granules, mixed with autologous plasma, into an artificial defect in alveolar bone, new bone formation was also observed, although its formation rate was slower. © 2010 Wiley Periodicals, Inc.

Keywords:
nanoparticles / microparticles / alveolar bone / autologous plasma / Calcium phosphate/poly-DL-lactide-co-glycolide (CP/PLGA)
Source:
Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2010, 94, 1, 108-117
Publisher:
  • Hoboken, NJ : John Wiley & Sons
Funding / projects:
  • Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
  • Biokompatibilnost i mogućnosti primene biomaterijala na bazi hidroksiapatita i biopolimera u tkivnoj reparaciji - eksperimentalna i klinička studija (RS-145068)

DOI: 10.1002/jbm.b.31630

ISSN: 1552-4973

WoS: 000278697400012

Scopus: 2-s2.0-77954136401
[ Google Scholar ]
31
24
Handle
https://hdl.handle.net/21.15107/rcub_dais_3419
URI
https://dais.sanu.ac.rs/123456789/3419
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Ajduković, Zorica
AU  - Savić, Vojin. P.
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/3419
AB  - In this article, synthesis and application of calcium phosphate/poly-DL- lactide-co-glycolide (CP/PLGA) composite biomaterial in particulate form, in which each CP granule/particle is coated with PLGA, are described. Two types of the particulate material having different particle sizes were synthesized: one with an average particle diameter between 150 and 250 μm (micron-sized particles, MPs) and the other with an average particle diameter smaller than 50 nm (nanoparticles, NPs). A comparative in vivo analysis was done by reconstructing defects in osteoporotic alveolar bones using both composites. The material, CP granules/particles covered with polymer, was characterized using X-ray structural analysis, scanning electron microscopy, and atomic force microscopy. Changes in reparatory functions of tissues affected by osteoporosis were examined in mice in vivo, using these two kinds of composite materials, with and without autologous plasma. Having defined the target segment, histomorphometric parameters - bone area fraction, area, and mean density - were determined. The best results in the regeneration and recuperation of alveolar bone damaged by osteoporosis were achieved with the implantation of a mixture of nanoparticulate CP/PLGA composite and autologous plasma. After the implantation of microparticulate CP/PLGA, in the form of granules, mixed with autologous plasma, into an artificial defect in alveolar bone, new bone formation was also observed, although its formation rate was slower. © 2010 Wiley Periodicals, Inc.
PB  - Hoboken, NJ : John Wiley & Sons
T2  - Journal of Biomedical Materials Research - Part B Applied Biomaterials
T1  - Size effect of calcium phosphate coated with poly-DL-lactideco-glycolide on healing processes in bone reconstruction
SP  - 108
EP  - 117
VL  - 94
IS  - 1
DO  - 10.1002/jbm.b.31630
UR  - https://hdl.handle.net/21.15107/rcub_dais_3419
ER  - 
@article{
author = "Ignjatović, Nenad and Ajduković, Zorica and Savić, Vojin. P. and Uskoković, Dragan",
year = "2010",
abstract = "In this article, synthesis and application of calcium phosphate/poly-DL- lactide-co-glycolide (CP/PLGA) composite biomaterial in particulate form, in which each CP granule/particle is coated with PLGA, are described. Two types of the particulate material having different particle sizes were synthesized: one with an average particle diameter between 150 and 250 μm (micron-sized particles, MPs) and the other with an average particle diameter smaller than 50 nm (nanoparticles, NPs). A comparative in vivo analysis was done by reconstructing defects in osteoporotic alveolar bones using both composites. The material, CP granules/particles covered with polymer, was characterized using X-ray structural analysis, scanning electron microscopy, and atomic force microscopy. Changes in reparatory functions of tissues affected by osteoporosis were examined in mice in vivo, using these two kinds of composite materials, with and without autologous plasma. Having defined the target segment, histomorphometric parameters - bone area fraction, area, and mean density - were determined. The best results in the regeneration and recuperation of alveolar bone damaged by osteoporosis were achieved with the implantation of a mixture of nanoparticulate CP/PLGA composite and autologous plasma. After the implantation of microparticulate CP/PLGA, in the form of granules, mixed with autologous plasma, into an artificial defect in alveolar bone, new bone formation was also observed, although its formation rate was slower. © 2010 Wiley Periodicals, Inc.",
publisher = "Hoboken, NJ : John Wiley & Sons",
journal = "Journal of Biomedical Materials Research - Part B Applied Biomaterials",
title = "Size effect of calcium phosphate coated with poly-DL-lactideco-glycolide on healing processes in bone reconstruction",
pages = "108-117",
volume = "94",
number = "1",
doi = "10.1002/jbm.b.31630",
url = "https://hdl.handle.net/21.15107/rcub_dais_3419"
}
Ignjatović, N., Ajduković, Z., Savić, Vojin. P.,& Uskoković, D.. (2010). Size effect of calcium phosphate coated with poly-DL-lactideco-glycolide on healing processes in bone reconstruction. in Journal of Biomedical Materials Research - Part B Applied Biomaterials
Hoboken, NJ : John Wiley & Sons., 94(1), 108-117.
https://doi.org/10.1002/jbm.b.31630
https://hdl.handle.net/21.15107/rcub_dais_3419
Ignjatović N, Ajduković Z, Savić VP, Uskoković D. Size effect of calcium phosphate coated with poly-DL-lactideco-glycolide on healing processes in bone reconstruction. in Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2010;94(1):108-117.
doi:10.1002/jbm.b.31630
https://hdl.handle.net/21.15107/rcub_dais_3419 .
Ignjatović, Nenad, Ajduković, Zorica, Savić, Vojin. P., Uskoković, Dragan, "Size effect of calcium phosphate coated with poly-DL-lactideco-glycolide on healing processes in bone reconstruction" in Journal of Biomedical Materials Research - Part B Applied Biomaterials, 94, no. 1 (2010):108-117,
https://doi.org/10.1002/jbm.b.31630 .,
https://hdl.handle.net/21.15107/rcub_dais_3419 .

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