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Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations

Authorized Users Only
2018
Authors
Janićijević, Željko
Radovanović, Filip
Article (Published version)
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Abstract
We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes performed by combining photoirradiation with a traditional liquid phase inversion process. Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and 75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker were investigated in vitro using methylene blue as a model drug. Passive release kinetics was diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a l...ot of promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.

Keywords:
Composite hydrogel membrane Crosslinker Ion exchange Diffusion Iontophoresis Drug release
Source:
Polymer, 2018, 147, 56-66
Publisher:
  • Elsevier
Funding / projects:
  • Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
Note:
  • Supplementary information: https://hdl.handle.net/21.15107/rcub_dais_3392
  • Peer-reviewed manuscript: https://hdl.handle.net/21.15107/rcub_dais_4526
Related info:
  • Version of
    https://hdl.handle.net/21.15107/rcub_dais_4526
  • Referenced by
    https://hdl.handle.net/21.15107/rcub_dais_3392

DOI: 10.1016/j.polymer.2018.05.065

ISSN: 0032-3861

WoS: 000436484100007

Scopus: 2-s2.0-85048491046
[ Google Scholar ]
6
4
Handle
https://hdl.handle.net/21.15107/rcub_dais_3391
URI
https://dais.sanu.ac.rs/123456789/3391
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - JOUR
AU  - Janićijević, Željko
AU  - Radovanović, Filip
PY  - 2018
UR  - https://dais.sanu.ac.rs/123456789/3391
AB  - We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes
performed by combining photoirradiation with a traditional liquid phase inversion process.
Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and
75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their
microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was
crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive
and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker
were investigated in vitro using methylene blue as a model drug. Passive release kinetics was
diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was
demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot of
promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.
PB  - Elsevier
T2  - Polymer
T1  - Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations
SP  - 56
EP  - 66
VL  - 147
DO  - 10.1016/j.polymer.2018.05.065
UR  - https://hdl.handle.net/21.15107/rcub_dais_3391
ER  - 
@article{
author = "Janićijević, Željko and Radovanović, Filip",
year = "2018",
abstract = "We present the innovative synthesis of polyethersulfone/poly(acrylic acid) composite hydrogel membranes
performed by combining photoirradiation with a traditional liquid phase inversion process.
Fabricated membranes exhibited ion exchange capacity and water content as high as 5.2 mmol/g and
75%, respectively. The chemical composition of the membranes was determined using FTIR-ATR and their
microstructure was examined with SEM. Our findings suggest that the use of hydrophilic crosslinker was
crucial for the synthesis of symmetric and mechanically stable composite hydrogel membranes. Passive
and iontophoretic release kinetics from membrane reservoirs synthesized with the hydrophilic crosslinker
were investigated in vitro using methylene blue as a model drug. Passive release kinetics was
diffusion-controlled with pH-sensitive and loading-dependent behavior. Linear release kinetics was
demonstrated during the iontophoretic release. Synthesized composite hydrogel membranes hold a lot of
promise as compact stand-alone reservoirs for passive and iontophoretic delivery of cationic drugs.",
publisher = "Elsevier",
journal = "Polymer",
title = "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations",
pages = "56-66",
volume = "147",
doi = "10.1016/j.polymer.2018.05.065",
url = "https://hdl.handle.net/21.15107/rcub_dais_3391"
}
Janićijević, Ž.,& Radovanović, F.. (2018). Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. in Polymer
Elsevier., 147, 56-66.
https://doi.org/10.1016/j.polymer.2018.05.065
https://hdl.handle.net/21.15107/rcub_dais_3391
Janićijević Ž, Radovanović F. Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations. in Polymer. 2018;147:56-66.
doi:10.1016/j.polymer.2018.05.065
https://hdl.handle.net/21.15107/rcub_dais_3391 .
Janićijević, Željko, Radovanović, Filip, "Polyethersulfone/poly(acrylic acid) composite hydrogel membrane reservoirs for controlled delivery of cationic drug formulations" in Polymer, 147 (2018):56-66,
https://doi.org/10.1016/j.polymer.2018.05.065 .,
https://hdl.handle.net/21.15107/rcub_dais_3391 .

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