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Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model

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2008
0367-598X0803205J.pdf (723.2Kb)
Authors
Janićijević, Jelena M.
Najman, Stevo
Ignjatović, Nenad
Savić, Vojin P.
Kocić, Jelena S.
Vasiljević, Perica
Vukelić, Marija Đ.
Uskoković, Dragan
Article (Published version)
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Abstract
The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal of this investigation was to examine weather N-CP/DLPLG has ability to sustain growth of bone marrow cells after subcutaneous implantation in Balb/c mice. For that purpose N-CP/DLPLG implants with and without bone marrow cells (control) were made. Implants were extracted after eight days and eight weeks. In implants loaded with bone marrow cells after eight days and eight weeks we observed fields rich in cells, angiogenesis and collagen genesis. These results showed that N-CP/DLPLG has property of tissue scaffold which sustain bone marrow cells growth and collagen production. This represents a good way for further examination of N-CP/DLPLG as potentional tissue scaffold in osteoreparation.
Source:
Hemijska industrija, 2008, 62, 3, 205-210
Publisher:
  • Belgrade : Association of the Chemical Engineers of Serbia
Funding / projects:
  • Regeneracija skeletnih tkiva pomognuta biomaterijalima kao tkivnim matricama - in vivo i in vitro studija (RS-145072)

DOI: 10.2298/HEMIND0803205J

ISSN: 0367-598X

WoS: 000257697700019

Scopus: 2-s2.0-77952907590
[ Google Scholar ]
3
2
Handle
https://hdl.handle.net/21.15107/rcub_dais_3363
URI
http://www.ncbi.nlm.nih.gov/pubmed/0367-598X0803205J
https://dais.sanu.ac.rs/123456789/3363
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - JOUR
AU  - Janićijević, Jelena M.
AU  - Najman, Stevo
AU  - Ignjatović, Nenad
AU  - Savić, Vojin P.
AU  - Kocić, Jelena S.
AU  - Vasiljević, Perica
AU  - Vukelić, Marija Đ.
AU  - Uskoković, Dragan
PY  - 2008
UR  - http://www.ncbi.nlm.nih.gov/pubmed/0367-598X0803205J
UR  - https://dais.sanu.ac.rs/123456789/3363
AB  - The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal of this investigation was to examine weather N-CP/DLPLG has ability to sustain growth of bone marrow cells after subcutaneous implantation in Balb/c mice. For that purpose N-CP/DLPLG implants with and without bone marrow cells (control) were made. Implants were extracted after eight days and eight weeks. In implants loaded with bone marrow cells after eight days and eight weeks we observed fields rich in cells, angiogenesis and collagen genesis. These results showed that N-CP/DLPLG has property of tissue scaffold which sustain bone marrow cells growth and collagen production. This represents a good way for further examination of N-CP/DLPLG as potentional tissue scaffold in osteoreparation.
PB  - Belgrade : Association of the Chemical Engineers of Serbia
T2  - Hemijska industrija
T2  - Hemijska industrija
T1  - Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model
SP  - 205
EP  - 210
VL  - 62
IS  - 3
DO  - 10.2298/HEMIND0803205J
UR  - https://hdl.handle.net/21.15107/rcub_dais_3363
ER  - 
@article{
author = "Janićijević, Jelena M. and Najman, Stevo and Ignjatović, Nenad and Savić, Vojin P. and Kocić, Jelena S. and Vasiljević, Perica and Vukelić, Marija Đ. and Uskoković, Dragan",
year = "2008",
abstract = "The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal of this investigation was to examine weather N-CP/DLPLG has ability to sustain growth of bone marrow cells after subcutaneous implantation in Balb/c mice. For that purpose N-CP/DLPLG implants with and without bone marrow cells (control) were made. Implants were extracted after eight days and eight weeks. In implants loaded with bone marrow cells after eight days and eight weeks we observed fields rich in cells, angiogenesis and collagen genesis. These results showed that N-CP/DLPLG has property of tissue scaffold which sustain bone marrow cells growth and collagen production. This represents a good way for further examination of N-CP/DLPLG as potentional tissue scaffold in osteoreparation.",
publisher = "Belgrade : Association of the Chemical Engineers of Serbia",
journal = "Hemijska industrija, Hemijska industrija",
title = "Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model",
pages = "205-210",
volume = "62",
number = "3",
doi = "10.2298/HEMIND0803205J",
url = "https://hdl.handle.net/21.15107/rcub_dais_3363"
}
Janićijević, J. M., Najman, S., Ignjatović, N., Savić, V. P., Kocić, J. S., Vasiljević, P., Vukelić, M. Đ.,& Uskoković, D.. (2008). Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model. in Hemijska industrija
Belgrade : Association of the Chemical Engineers of Serbia., 62(3), 205-210.
https://doi.org/10.2298/HEMIND0803205J
https://hdl.handle.net/21.15107/rcub_dais_3363
Janićijević JM, Najman S, Ignjatović N, Savić VP, Kocić JS, Vasiljević P, Vukelić MĐ, Uskoković D. Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model. in Hemijska industrija. 2008;62(3):205-210.
doi:10.2298/HEMIND0803205J
https://hdl.handle.net/21.15107/rcub_dais_3363 .
Janićijević, Jelena M., Najman, Stevo, Ignjatović, Nenad, Savić, Vojin P., Kocić, Jelena S., Vasiljević, Perica, Vukelić, Marija Đ., Uskoković, Dragan, "Nanomaterial N-CP/DLPLG as potentional tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model" in Hemijska industrija, 62, no. 3 (2008):205-210,
https://doi.org/10.2298/HEMIND0803205J .,
https://hdl.handle.net/21.15107/rcub_dais_3363 .

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