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dc.creatorVukomanović, Marija
dc.creatorMitrić, Miodrag
dc.creatorŠkapin, Srečo Davor
dc.creatorŽagar, Ema
dc.creatorPlavec, Janez
dc.creatorIgnjatović, Nenad
dc.creatorUskoković, Dragan
dc.date.accessioned2018-03-01T21:08:36Z
dc.date.accessioned2018-05-08T08:43:42Z
dc.date.available2018-03-01T21:08:36Z
dc.date.available2018-05-08T08:43:42Z
dc.date.issued2010
dc.identifier.issn1350-4177 (print)
dc.identifier.issn1873-2828 (electronic)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/2747
dc.description.abstractIn this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//
dc.rightsrestrictedAccessen
dc.sourceUltrasonics Sonochemistryen
dc.subjectpoly(D,L-lactide-co-glycolide)en
dc.subjectpoly(D,L-lactide-co-glycolide)en
dc.subjectMolar mass averagesen
dc.subjectCompositionen
dc.subjectGlass-transition temperatureen
dc.subjectUltrasonic processingen
dc.subjecthydroxyapatiteen
dc.titleInfluence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatiteen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractМитрић, Миодраг; Вукомановић, Марија; Игњатовић, Ненад; Ускоковић, Драган; Шкапин, Сречо Давор; Жагар, Ема; Плавец, Јанез;
dc.citation.spage902
dc.citation.epage908
dc.citation.volume17
dc.citation.issue5
dc.identifier.wos000278297400027
dc.identifier.doi10.1016/j.ultsonch.2010.01.007
dc.identifier.pmid20163978
dc.identifier.scopus2-s2.0-77953650673
dc.type.versionpublishedVersion


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