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Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation

Authorized Users Only
2009
Authors
Jevtić, Marija
Radulović, Aleksandra
Ignjatović, Nenad
Mitrić, Miodrag
Uskoković, Dragan
Article (Published version)
Metadata
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Abstract
An ultrasound field was applied to obtain PLGA/HAp biocomposite nanospheres. Formulation of PLGA/HAp, composite revealed significant dependence of the morphology of the obtained composite on synthesis parameters, like the intensity of applied ultrasonic field, polymeric and ceramic parts wt.% ratio in the composite, temperature of the medium, type of surfactant, and the sequence of steps in the formation of PLGA/HAp. Optimal parameters for the formation of PLGA/HAp included a lower content of the ceramic phase (PLGA/HAp = 90: 10), higher power of ultrasonic field (P = 142.4 W), lower temperature of the medium during ultrasonic treatment (T = 8 degrees C), dilute solution of PVP as surfactant and dispersion of hydroxyapatite in polymer solution in order to achieve required homogeneity before the formulation of the composite. The morphology of PLGA/HAp particles synthesized under these conditions was highly regular: sphere-like, with particles of very small dimensions (150-320 nm), highl...y uniform particle size distribution and characteristic planar spatial self-organization. These characteristics indicate significant improvements in PLGA/HAp composite resulting from ultrasonic method. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Keywords:
Biocomposite / PLGA/hydroxyapatite / Nanospheres / Core-shell / Ultrasonic method
Source:
Acta Biomaterialia, 2009, 5, 1, 208-218
Publisher:
  • Elsevier
Funding / projects:
  • Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)

DOI: 10.1016/j.actbio.2008.07.026

ISSN: 1742-7061 (print); 1878-7568 (electronic)

PubMed: 18753023

WoS: 000261922400022

Scopus: 2-s2.0-56349094659
[ Google Scholar ]
48
41
Handle
https://hdl.handle.net/21.15107/rcub_dais_2742
URI
https://dais.sanu.ac.rs/123456789/2742
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - JOUR
AU  - Jevtić, Marija
AU  - Radulović, Aleksandra
AU  - Ignjatović, Nenad
AU  - Mitrić, Miodrag
AU  - Uskoković, Dragan
PY  - 2009
UR  - https://dais.sanu.ac.rs/123456789/2742
AB  - An ultrasound field was applied to obtain PLGA/HAp biocomposite nanospheres. Formulation of PLGA/HAp, composite revealed significant dependence of the morphology of the obtained composite on synthesis parameters, like the intensity of applied ultrasonic field, polymeric and ceramic parts wt.% ratio in the composite, temperature of the medium, type of surfactant, and the sequence of steps in the formation of PLGA/HAp. Optimal parameters for the formation of PLGA/HAp included a lower content of the ceramic phase (PLGA/HAp = 90: 10), higher power of ultrasonic field (P = 142.4 W), lower temperature of the medium during ultrasonic treatment (T = 8 degrees C), dilute solution of PVP as surfactant and dispersion of hydroxyapatite in polymer solution in order to achieve required homogeneity before the formulation of the composite. The morphology of PLGA/HAp particles synthesized under these conditions was highly regular: sphere-like, with particles of very small dimensions (150-320 nm), highly uniform particle size distribution and characteristic planar spatial self-organization. These characteristics indicate significant improvements in PLGA/HAp composite resulting from ultrasonic method. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Acta Biomaterialia
T1  - Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation
SP  - 208
EP  - 218
VL  - 5
IS  - 1
DO  - 10.1016/j.actbio.2008.07.026
UR  - https://hdl.handle.net/21.15107/rcub_dais_2742
ER  - 
@article{
author = "Jevtić, Marija and Radulović, Aleksandra and Ignjatović, Nenad and Mitrić, Miodrag and Uskoković, Dragan",
year = "2009",
abstract = "An ultrasound field was applied to obtain PLGA/HAp biocomposite nanospheres. Formulation of PLGA/HAp, composite revealed significant dependence of the morphology of the obtained composite on synthesis parameters, like the intensity of applied ultrasonic field, polymeric and ceramic parts wt.% ratio in the composite, temperature of the medium, type of surfactant, and the sequence of steps in the formation of PLGA/HAp. Optimal parameters for the formation of PLGA/HAp included a lower content of the ceramic phase (PLGA/HAp = 90: 10), higher power of ultrasonic field (P = 142.4 W), lower temperature of the medium during ultrasonic treatment (T = 8 degrees C), dilute solution of PVP as surfactant and dispersion of hydroxyapatite in polymer solution in order to achieve required homogeneity before the formulation of the composite. The morphology of PLGA/HAp particles synthesized under these conditions was highly regular: sphere-like, with particles of very small dimensions (150-320 nm), highly uniform particle size distribution and characteristic planar spatial self-organization. These characteristics indicate significant improvements in PLGA/HAp composite resulting from ultrasonic method. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Acta Biomaterialia",
title = "Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation",
pages = "208-218",
volume = "5",
number = "1",
doi = "10.1016/j.actbio.2008.07.026",
url = "https://hdl.handle.net/21.15107/rcub_dais_2742"
}
Jevtić, M., Radulović, A., Ignjatović, N., Mitrić, M.,& Uskoković, D.. (2009). Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation. in Acta Biomaterialia
Elsevier., 5(1), 208-218.
https://doi.org/10.1016/j.actbio.2008.07.026
https://hdl.handle.net/21.15107/rcub_dais_2742
Jevtić M, Radulović A, Ignjatović N, Mitrić M, Uskoković D. Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation. in Acta Biomaterialia. 2009;5(1):208-218.
doi:10.1016/j.actbio.2008.07.026
https://hdl.handle.net/21.15107/rcub_dais_2742 .
Jevtić, Marija, Radulović, Aleksandra, Ignjatović, Nenad, Mitrić, Miodrag, Uskoković, Dragan, "Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation" in Acta Biomaterialia, 5, no. 1 (2009):208-218,
https://doi.org/10.1016/j.actbio.2008.07.026 .,
https://hdl.handle.net/21.15107/rcub_dais_2742 .

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