Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation
Abstract
An ultrasound field was applied to obtain PLGA/HAp biocomposite nanospheres. Formulation of PLGA/HAp, composite revealed significant dependence of the morphology of the obtained composite on synthesis parameters, like the intensity of applied ultrasonic field, polymeric and ceramic parts wt.% ratio in the composite, temperature of the medium, type of surfactant, and the sequence of steps in the formation of PLGA/HAp. Optimal parameters for the formation of PLGA/HAp included a lower content of the ceramic phase (PLGA/HAp = 90: 10), higher power of ultrasonic field (P = 142.4 W), lower temperature of the medium during ultrasonic treatment (T = 8 degrees C), dilute solution of PVP as surfactant and dispersion of hydroxyapatite in polymer solution in order to achieve required homogeneity before the formulation of the composite. The morphology of PLGA/HAp particles synthesized under these conditions was highly regular: sphere-like, with particles of very small dimensions (150-320 nm), highl...y uniform particle size distribution and characteristic planar spatial self-organization. These characteristics indicate significant improvements in PLGA/HAp composite resulting from ultrasonic method. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Keywords:
Biocomposite / PLGA/hydroxyapatite / Nanospheres / Core-shell / Ultrasonic methodSource:
Acta Biomaterialia, 2009, 5, 1, 208-218Publisher:
- Elsevier
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
DOI: 10.1016/j.actbio.2008.07.026
ISSN: 1742-7061 (print); 1878-7568 (electronic)
PubMed: 18753023
WoS: 000261922400022
Scopus: 2-s2.0-56349094659
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Jevtić, Marija AU - Radulović, Aleksandra AU - Ignjatović, Nenad AU - Mitrić, Miodrag AU - Uskoković, Dragan PY - 2009 UR - https://dais.sanu.ac.rs/123456789/2742 AB - An ultrasound field was applied to obtain PLGA/HAp biocomposite nanospheres. Formulation of PLGA/HAp, composite revealed significant dependence of the morphology of the obtained composite on synthesis parameters, like the intensity of applied ultrasonic field, polymeric and ceramic parts wt.% ratio in the composite, temperature of the medium, type of surfactant, and the sequence of steps in the formation of PLGA/HAp. Optimal parameters for the formation of PLGA/HAp included a lower content of the ceramic phase (PLGA/HAp = 90: 10), higher power of ultrasonic field (P = 142.4 W), lower temperature of the medium during ultrasonic treatment (T = 8 degrees C), dilute solution of PVP as surfactant and dispersion of hydroxyapatite in polymer solution in order to achieve required homogeneity before the formulation of the composite. The morphology of PLGA/HAp particles synthesized under these conditions was highly regular: sphere-like, with particles of very small dimensions (150-320 nm), highly uniform particle size distribution and characteristic planar spatial self-organization. These characteristics indicate significant improvements in PLGA/HAp composite resulting from ultrasonic method. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. PB - Elsevier T2 - Acta Biomaterialia T1 - Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation SP - 208 EP - 218 VL - 5 IS - 1 DO - 10.1016/j.actbio.2008.07.026 UR - https://hdl.handle.net/21.15107/rcub_dais_2742 ER -
@article{ author = "Jevtić, Marija and Radulović, Aleksandra and Ignjatović, Nenad and Mitrić, Miodrag and Uskoković, Dragan", year = "2009", abstract = "An ultrasound field was applied to obtain PLGA/HAp biocomposite nanospheres. Formulation of PLGA/HAp, composite revealed significant dependence of the morphology of the obtained composite on synthesis parameters, like the intensity of applied ultrasonic field, polymeric and ceramic parts wt.% ratio in the composite, temperature of the medium, type of surfactant, and the sequence of steps in the formation of PLGA/HAp. Optimal parameters for the formation of PLGA/HAp included a lower content of the ceramic phase (PLGA/HAp = 90: 10), higher power of ultrasonic field (P = 142.4 W), lower temperature of the medium during ultrasonic treatment (T = 8 degrees C), dilute solution of PVP as surfactant and dispersion of hydroxyapatite in polymer solution in order to achieve required homogeneity before the formulation of the composite. The morphology of PLGA/HAp particles synthesized under these conditions was highly regular: sphere-like, with particles of very small dimensions (150-320 nm), highly uniform particle size distribution and characteristic planar spatial self-organization. These characteristics indicate significant improvements in PLGA/HAp composite resulting from ultrasonic method. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.", publisher = "Elsevier", journal = "Acta Biomaterialia", title = "Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation", pages = "208-218", volume = "5", number = "1", doi = "10.1016/j.actbio.2008.07.026", url = "https://hdl.handle.net/21.15107/rcub_dais_2742" }
Jevtić, M., Radulović, A., Ignjatović, N., Mitrić, M.,& Uskoković, D.. (2009). Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation. in Acta Biomaterialia Elsevier., 5(1), 208-218. https://doi.org/10.1016/j.actbio.2008.07.026 https://hdl.handle.net/21.15107/rcub_dais_2742
Jevtić M, Radulović A, Ignjatović N, Mitrić M, Uskoković D. Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation. in Acta Biomaterialia. 2009;5(1):208-218. doi:10.1016/j.actbio.2008.07.026 https://hdl.handle.net/21.15107/rcub_dais_2742 .
Jevtić, Marija, Radulović, Aleksandra, Ignjatović, Nenad, Mitrić, Miodrag, Uskoković, Dragan, "Controlled assembly of Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres under ultrasonic irradiation" in Acta Biomaterialia, 5, no. 1 (2009):208-218, https://doi.org/10.1016/j.actbio.2008.07.026 ., https://hdl.handle.net/21.15107/rcub_dais_2742 .