Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid
Abstract
Ascorbic acid (vitamin Q is essential for preserving optimal health and is used by the body for many purposes. The problem is that ascorbic acid easily decomposes into biologically inactive compounds making its use very limited in the field of pharmaceuticals, dermatological and cosmetics. By encapsulating the ascorbic acid into a polymer matrix it is assumed that its chemical instability can be overcome as well as higher, more efficient and equally distributed concentration throughout extended period of time can be achieved. This paper is describing the process of obtaining poly(DL-lactide-co-glycolide) (DLPLG) nanospheres (110-170 nm) using chemical method with solvent/non-solvent systems where obtained solutions have been centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenisation of water and organic phases. Nanoparticles of the copolymer DLPLG with the different contents of the ascorbic acid have different morphological characteristics,... i.e. variable degree of uniformity, agglomeration, sizes and spherical shaping. The degradation of the nanospheres of DLPLG, DLPLG/ascorbic acid nanoparticles and release rate of the ascorbic acid were studied for 8 weeks in a physiological solution (0.9% sodium chloride in water). The samples have been characterised by infrared spectroscopy (IR), scanning electron microscopy (SEM), stereological analysis and ultraviolet (UV) spectroscopy. (C) 2007 Elsevier B.V. All rights reserved.
Keywords:
nanospheres / poly (DL-lactide-co-glycolide)/ascorbic acid nanoparticles / degradation / drug delivery / drug releaseSource:
Colloids and Surfaces B: Biointerfaces, 2007, 59, 2, 215-223Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
DOI: 10.1016/j.colsurfb.2007.05.011
ISSN: 0927-7765 (print); 1873-4367 (electronic)
PubMed: 17596919
WoS: 000249420500014
Scopus: 2-s2.0-34547702105
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Stevanović, Magdalena AU - Savić, Jasmina AU - Jordović, Branka AU - Uskoković, Dragan PY - 2007 UR - https://dais.sanu.ac.rs/123456789/2741 AB - Ascorbic acid (vitamin Q is essential for preserving optimal health and is used by the body for many purposes. The problem is that ascorbic acid easily decomposes into biologically inactive compounds making its use very limited in the field of pharmaceuticals, dermatological and cosmetics. By encapsulating the ascorbic acid into a polymer matrix it is assumed that its chemical instability can be overcome as well as higher, more efficient and equally distributed concentration throughout extended period of time can be achieved. This paper is describing the process of obtaining poly(DL-lactide-co-glycolide) (DLPLG) nanospheres (110-170 nm) using chemical method with solvent/non-solvent systems where obtained solutions have been centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenisation of water and organic phases. Nanoparticles of the copolymer DLPLG with the different contents of the ascorbic acid have different morphological characteristics, i.e. variable degree of uniformity, agglomeration, sizes and spherical shaping. The degradation of the nanospheres of DLPLG, DLPLG/ascorbic acid nanoparticles and release rate of the ascorbic acid were studied for 8 weeks in a physiological solution (0.9% sodium chloride in water). The samples have been characterised by infrared spectroscopy (IR), scanning electron microscopy (SEM), stereological analysis and ultraviolet (UV) spectroscopy. (C) 2007 Elsevier B.V. All rights reserved. T2 - Colloids and Surfaces B: Biointerfaces T1 - Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid SP - 215 EP - 223 VL - 59 IS - 2 DO - 10.1016/j.colsurfb.2007.05.011 UR - https://hdl.handle.net/21.15107/rcub_dais_2741 ER -
@article{ author = "Stevanović, Magdalena and Savić, Jasmina and Jordović, Branka and Uskoković, Dragan", year = "2007", abstract = "Ascorbic acid (vitamin Q is essential for preserving optimal health and is used by the body for many purposes. The problem is that ascorbic acid easily decomposes into biologically inactive compounds making its use very limited in the field of pharmaceuticals, dermatological and cosmetics. By encapsulating the ascorbic acid into a polymer matrix it is assumed that its chemical instability can be overcome as well as higher, more efficient and equally distributed concentration throughout extended period of time can be achieved. This paper is describing the process of obtaining poly(DL-lactide-co-glycolide) (DLPLG) nanospheres (110-170 nm) using chemical method with solvent/non-solvent systems where obtained solutions have been centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenisation of water and organic phases. Nanoparticles of the copolymer DLPLG with the different contents of the ascorbic acid have different morphological characteristics, i.e. variable degree of uniformity, agglomeration, sizes and spherical shaping. The degradation of the nanospheres of DLPLG, DLPLG/ascorbic acid nanoparticles and release rate of the ascorbic acid were studied for 8 weeks in a physiological solution (0.9% sodium chloride in water). The samples have been characterised by infrared spectroscopy (IR), scanning electron microscopy (SEM), stereological analysis and ultraviolet (UV) spectroscopy. (C) 2007 Elsevier B.V. All rights reserved.", journal = "Colloids and Surfaces B: Biointerfaces", title = "Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid", pages = "215-223", volume = "59", number = "2", doi = "10.1016/j.colsurfb.2007.05.011", url = "https://hdl.handle.net/21.15107/rcub_dais_2741" }
Stevanović, M., Savić, J., Jordović, B.,& Uskoković, D.. (2007). Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid. in Colloids and Surfaces B: Biointerfaces, 59(2), 215-223. https://doi.org/10.1016/j.colsurfb.2007.05.011 https://hdl.handle.net/21.15107/rcub_dais_2741
Stevanović M, Savić J, Jordović B, Uskoković D. Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid. in Colloids and Surfaces B: Biointerfaces. 2007;59(2):215-223. doi:10.1016/j.colsurfb.2007.05.011 https://hdl.handle.net/21.15107/rcub_dais_2741 .
Stevanović, Magdalena, Savić, Jasmina, Jordović, Branka, Uskoković, Dragan, "Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid" in Colloids and Surfaces B: Biointerfaces, 59, no. 2 (2007):215-223, https://doi.org/10.1016/j.colsurfb.2007.05.011 ., https://hdl.handle.net/21.15107/rcub_dais_2741 .