Ascorbic acid (vitamin Q is essential for preserving optimal health and is used by the body for many purposes. The problem is that ascorbic acid easily decomposes into biologically inactive compounds making its use very limited in the field of pharmaceuticals, dermatological and cosmetics. By encapsulating the ascorbic acid into a polymer matrix it is assumed that its chemical instability can be overcome as well as higher, more efficient and equally distributed concentration throughout extended period of time can be achieved. This paper is describing the process of obtaining poly(DL-lactide-co-glycolide) (DLPLG) nanospheres (110-170 nm) using chemical method with solvent/non-solvent systems where obtained solutions have been centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenisation of water and organic phases. Nanoparticles of the copolymer DLPLG with the different contents of the ascorbic acid have different morphological characteristics,... i.e. variable degree of uniformity, agglomeration, sizes and spherical shaping. The degradation of the nanospheres of DLPLG, DLPLG/ascorbic acid nanoparticles and release rate of the ascorbic acid were studied for 8 weeks in a physiological solution (0.9% sodium chloride in water). The samples have been characterised by infrared spectroscopy (IR), scanning electron microscopy (SEM), stereological analysis and ultraviolet (UV) spectroscopy. (C) 2007 Elsevier B.V. All rights reserved.
Keywords:
nanospheres / poly (DL-lactide-co-glycolide)/ascorbic acid nanoparticles / degradation / drug delivery / drug release
Source:
Colloids and Surfaces B: Biointerfaces, 2007, 59, 2, 215-223
TY - JOUR
AU - Stevanović, Magdalena
AU - Savić, Jasmina
AU - Jordović, Branka
AU - Uskoković, Dragan
PY - 2007
AB - Ascorbic acid (vitamin Q is essential for preserving optimal health and is used by the body for many purposes. The problem is that ascorbic acid easily decomposes into biologically inactive compounds making its use very limited in the field of pharmaceuticals, dermatological and cosmetics. By encapsulating the ascorbic acid into a polymer matrix it is assumed that its chemical instability can be overcome as well as higher, more efficient and equally distributed concentration throughout extended period of time can be achieved. This paper is describing the process of obtaining poly(DL-lactide-co-glycolide) (DLPLG) nanospheres (110-170 nm) using chemical method with solvent/non-solvent systems where obtained solutions have been centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenisation of water and organic phases. Nanoparticles of the copolymer DLPLG with the different contents of the ascorbic acid have different morphological characteristics, i.e. variable degree of uniformity, agglomeration, sizes and spherical shaping. The degradation of the nanospheres of DLPLG, DLPLG/ascorbic acid nanoparticles and release rate of the ascorbic acid were studied for 8 weeks in a physiological solution (0.9% sodium chloride in water). The samples have been characterised by infrared spectroscopy (IR), scanning electron microscopy (SEM), stereological analysis and ultraviolet (UV) spectroscopy. (C) 2007 Elsevier B.V. All rights reserved.
T2 - Colloids and Surfaces B: Biointerfaces
T1 - Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid
SP - 215
EP - 223
VL - 59
IS - 2
DO - 10.1016/j.colsurfb.2007.05.011
UR - https://hdl.handle.net/21.15107/rcub_dais_2741
ER -
@article{
author = "Stevanović, Magdalena and Savić, Jasmina and Jordović, Branka and Uskoković, Dragan",
year = "2007",
abstract = "Ascorbic acid (vitamin Q is essential for preserving optimal health and is used by the body for many purposes. The problem is that ascorbic acid easily decomposes into biologically inactive compounds making its use very limited in the field of pharmaceuticals, dermatological and cosmetics. By encapsulating the ascorbic acid into a polymer matrix it is assumed that its chemical instability can be overcome as well as higher, more efficient and equally distributed concentration throughout extended period of time can be achieved. This paper is describing the process of obtaining poly(DL-lactide-co-glycolide) (DLPLG) nanospheres (110-170 nm) using chemical method with solvent/non-solvent systems where obtained solutions have been centrifuged. The encapsulation of the ascorbic acid in the polymer matrix is performed by homogenisation of water and organic phases. Nanoparticles of the copolymer DLPLG with the different contents of the ascorbic acid have different morphological characteristics, i.e. variable degree of uniformity, agglomeration, sizes and spherical shaping. The degradation of the nanospheres of DLPLG, DLPLG/ascorbic acid nanoparticles and release rate of the ascorbic acid were studied for 8 weeks in a physiological solution (0.9% sodium chloride in water). The samples have been characterised by infrared spectroscopy (IR), scanning electron microscopy (SEM), stereological analysis and ultraviolet (UV) spectroscopy. (C) 2007 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid",
pages = "215-223",
volume = "59",
number = "2",
doi = "10.1016/j.colsurfb.2007.05.011",
url = "https://hdl.handle.net/21.15107/rcub_dais_2741"
}
Stevanović, M., Savić, J., Jordović, B.,& Uskoković, D. (2007). Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid.
Colloids and Surfaces B: Biointerfaces, 59(2), 215-223.
https://doi.org/10.1016/j.colsurfb.2007.05.011
Stevanović M, Savić J, Jordović B, Uskoković D. Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid. Colloids and Surfaces B: Biointerfaces. 2007;59(2):215-223.
doi:10.1016/j.colsurfb.2007.05.011.
Stevanović Magdalena, Savić Jasmina, Jordović Branka, Uskoković Dragan, "Fabrication, in vitro degradation and the release behaviours of poly(DL-lactide-co-glycolide) nanospheres containing ascorbic acid" Colloids and Surfaces B: Biointerfaces, 59, no. 2 (2007):215-223,
https://doi.org/10.1016/j.colsurfb.2007.05.011 .
