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Chapter 11 – Polymeric micro- and nanoparticles for controlled and targeted drug delivery

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2017
Accepted manuscript (764.3Kb)
Authors
Stevanović, Magdalena
Book part (Accepted Version)
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Abstract
Nanotechnology has great potential in the field of medicine and pharmacy because nano objects have comparable dimensions to biological entities. Polymer-based particles play an integral role as vehicles in the controlled delivery of different forms and types of active substances, such as anticancer drugs, antihypertensive and immunomodulatory agents, medical imaging contrast media, hormones, vitamins, and different macromolecules, such as nucleic acids (deoxyribonucleic acid, ribonucleic acid), proteins, antibodies, etc. The release of the active agent may be constant over a long period, it may be cyclic over a long period, or it may be triggered by the environment or other external events. The purpose behind controlling the drug delivery is to achieve more effective therapies while eliminating the potential for both under and overdosing. Other benefits of using controlled-delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrat...ions, making optimal use of the drug in question, and increased patient compliance. This review article reports on obtaining polymeric micro- and nanoparticles with a special emphasis on obtaining polyester particles, the incorporation of different active substances within a polymer matrix, the degradation and release process of active substances from the polymeric particles, the physiochemical and biological properties of such obtained systems, as well as their application as drug-delivery systems.

Keywords:
nanotechnology / drug delivery / polymers / encapsulation / carriers
Source:
Nanostructures for Drug Delivery, 2017, 355-378
Publisher:
  • Elsevier
Funding / projects:
  • Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
Note:
  • This is the accepted manuscript of the book chapter: Wu, T.-J., Chiu, H.-Y., Yu, J., Cautela, M.P., Sarmento, B., das Neves, J., Catala, C., Pazos-Perez, N., Guerrini, L., Alvarez-Puebla, R.A., Vranješ-Đurić, S., Ignjatović, N.L., 2018. Nanotechnologies for early diagnosis, in situ disease monitoring, and prevention, in: Nanotechnologies in Preventive and Regenerative Medicine. Elsevier, pp. 1–92. https://doi.org/10.1016/B978-0-323-48063-5.00001-0

DOI: 10.1016/B978-0-323-46143-6.00011-7

ISBN: 978-0-323-46143-6

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_dais_2334
URI
https://dais.sanu.ac.rs/123456789/2334
Collections
  • ИТН САНУ - Општа колекција / ITS SASA - General collection
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASA
TY  - CHAP
AU  - Stevanović, Magdalena
PY  - 2017
UR  - https://dais.sanu.ac.rs/123456789/2334
AB  - Nanotechnology has great potential in the field of medicine and pharmacy because nano objects have comparable dimensions to biological entities. Polymer-based particles play an integral role as vehicles in the controlled delivery of different forms and types of active substances, such as anticancer drugs, antihypertensive and immunomodulatory agents, medical imaging contrast media, hormones, vitamins, and different macromolecules, such as nucleic acids (deoxyribonucleic acid, ribonucleic acid), proteins, antibodies, etc. The release of the active agent may be constant over a long period, it may be cyclic over a long period, or it may be triggered by the environment or other external events. The purpose behind controlling the drug delivery is to achieve more effective therapies while eliminating the potential for both under and overdosing. Other benefits of using controlled-delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrations, making optimal use of the drug in question, and increased patient compliance. This review article reports on obtaining polymeric micro- and nanoparticles with a special emphasis on obtaining polyester particles, the incorporation of different active substances within a polymer matrix, the degradation and release process of active substances from the polymeric particles, the physiochemical and biological properties of such obtained systems, as well as their application as drug-delivery systems.
PB  - Elsevier
T2  - Nanostructures for Drug Delivery
T1  - Chapter 11 – Polymeric micro- and nanoparticles for controlled and targeted drug delivery
SP  - 355
EP  - 378
DO  - 10.1016/B978-0-323-46143-6.00011-7
UR  - https://hdl.handle.net/21.15107/rcub_dais_2334
ER  - 
@inbook{
author = "Stevanović, Magdalena",
year = "2017",
abstract = "Nanotechnology has great potential in the field of medicine and pharmacy because nano objects have comparable dimensions to biological entities. Polymer-based particles play an integral role as vehicles in the controlled delivery of different forms and types of active substances, such as anticancer drugs, antihypertensive and immunomodulatory agents, medical imaging contrast media, hormones, vitamins, and different macromolecules, such as nucleic acids (deoxyribonucleic acid, ribonucleic acid), proteins, antibodies, etc. The release of the active agent may be constant over a long period, it may be cyclic over a long period, or it may be triggered by the environment or other external events. The purpose behind controlling the drug delivery is to achieve more effective therapies while eliminating the potential for both under and overdosing. Other benefits of using controlled-delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrations, making optimal use of the drug in question, and increased patient compliance. This review article reports on obtaining polymeric micro- and nanoparticles with a special emphasis on obtaining polyester particles, the incorporation of different active substances within a polymer matrix, the degradation and release process of active substances from the polymeric particles, the physiochemical and biological properties of such obtained systems, as well as their application as drug-delivery systems.",
publisher = "Elsevier",
journal = "Nanostructures for Drug Delivery",
booktitle = "Chapter 11 – Polymeric micro- and nanoparticles for controlled and targeted drug delivery",
pages = "355-378",
doi = "10.1016/B978-0-323-46143-6.00011-7",
url = "https://hdl.handle.net/21.15107/rcub_dais_2334"
}
Stevanović, M.. (2017). Chapter 11 – Polymeric micro- and nanoparticles for controlled and targeted drug delivery. in Nanostructures for Drug Delivery
Elsevier., 355-378.
https://doi.org/10.1016/B978-0-323-46143-6.00011-7
https://hdl.handle.net/21.15107/rcub_dais_2334
Stevanović M. Chapter 11 – Polymeric micro- and nanoparticles for controlled and targeted drug delivery. in Nanostructures for Drug Delivery. 2017;:355-378.
doi:10.1016/B978-0-323-46143-6.00011-7
https://hdl.handle.net/21.15107/rcub_dais_2334 .
Stevanović, Magdalena, "Chapter 11 – Polymeric micro- and nanoparticles for controlled and targeted drug delivery" in Nanostructures for Drug Delivery (2017):355-378,
https://doi.org/10.1016/B978-0-323-46143-6.00011-7 .,
https://hdl.handle.net/21.15107/rcub_dais_2334 .

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