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dc.creatorIgnjatović, Nenad
dc.creatorNinkov, Petar
dc.creatorSabetrasekh, Roya
dc.creatorUskoković, Dragan
dc.date.accessioned2017-06-10T15:45:07Z
dc.date.issued2010
dc.identifier.issn0957-4530 (print)
dc.identifier.issn1573-4838 (online)
dc.identifier.urihttp://dais.sanu.ac.rs/123456789/179
dc.description.abstractThe purpose of the study presented in this paper has been to examine the possibility of the synthesis of a new nanoparticulate system for controlled and systemic drug delivery with double effect. In the first step, a drug is released from bioresorbable polymer; in the second stage, after resorption of the polymer, non-bioresorbable calcium phosphate remains the chief part of the particle and takes the role of a filler, filling a bone defect. The obtained tigecycline-loaded calcium-phosphate(CP)/poly(dl-lactide-co-glycolide)(PLGA) nanoparticles contain calcium phosphate coated with bioresorbable polymer. The composite was analyzed by FT-IR, XRD and AFM methods. The average particle size of the nanocomposite ranges between 65 and 95 nm. Release profiles of tigecycline were obtained by UV–VIS spectroscopy in physiological solution at 37°C. Experimental results were analyzed using Peppas and Weibull mathematical models. Based on kinetic parameters, tigecycline release was defined as non-Fickian transport. The cytotoxicity of the nanocomposite was examined on standard cell lines of MC3T3-E1, in vitro. The obtained low values of lactate dehydrogenase (LDH) activity (under 37%) indicate low cytotoxicity level. The behaviour of the composite under real-life conditions was analyzed through implantation of the nanocomposite into living organisms, in vivo. The system with the lowest tigecycline content proved to be an adequate system for local and controlled release. Having in mind the registered antibiotics concentration in other tissues, delivery systems with a higher tigecycline content show both local and systemic effects.en
dc.languageen
dc.publisherSpringer US
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142006/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Materials Science: Materials in Medicineen
dc.subjectpoly-dl-lactide-co-glycolide
dc.subjecttigecycline
dc.subjectnanoparticles
dc.subjectcalcium phosphate
dc.subjectdrug delivery
dc.subjectPLGA
dc.subjectHAp
dc.titleA novel nano drug delivery system based on tigecycline-loaded calciumphosphate coated with poly-dl-lactide-co-glycolideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИгњатовић, Ненад; Сабетрасекх, Роyа; Ускоковић, Драган; Нинков, Петар;
dc.citation.spage231
dc.citation.epage239
dc.citation.volume21
dc.citation.issue1
dc.identifier.wos000273592200026
dc.identifier.doi10.1007/s10856-009-3854-6
dc.identifier.scopus2-s2.0-75049085742
dc.type.versionpublishedVersion


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