Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters

Jovanović, Ivana; Jordović, Branka; Petković, Marijana; Ignjatović, Nenad; Uskoković, Dragan

doi:10.1002/jemt.20529

Authorized Users Only

2008

Authors

Jovanović, Ivana
Jordović, Branka
Petković, Marijana

Ignjatović, Nenad

Uskoković, Dragan

Article (Published version)

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Abstract

Biodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modified precipitation method. For this purpose, the following parameters were varied: co-solvent (methanol or ethanol), the concentration of stabilizer polyvinyl alcohol (PVA), chloroform-to-water ratio and the speed and time of homogenization. Scanning electron microscopy (SEM) and stereological analysis were used to characterize the particles. The average size and morphology of the microspheres varied substantially with preparation conditions from 8.44–1.25 μm. Results showed that the smallest particles were obtained with methanol, 1% PVA and with 10 min of homogenization at 21,000 rpm. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc.

Keywords:

microspheres / poly(D,L-lactide) / modified precipitation method / scanning electron microscopy / stereological analysis / PDLLA

Source:
Microscopy Research and Technique, 2008, 72, 2, 86-92

Publisher:

Hoboken, NJ : John Wiley & Sons

Funding / projects:

Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)

DOI: 10.1002/jemt.20529

ISSN: 1097-0029 (online); 1059-910X

WoS: 000253361200002

Scopus: 2-s2.0-39449102972

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	12
	9

TY  - JOUR
AU  - Jovanović, Ivana
AU  - Jordović, Branka
AU  - Petković, Marijana
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2008
UR  - https://dais.sanu.ac.rs/123456789/177
AB  - Biodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modified precipitation method. For this purpose, the following parameters were varied: co-solvent (methanol or ethanol), the concentration of stabilizer polyvinyl alcohol (PVA), chloroform-to-water ratio and the speed and time of homogenization. Scanning electron microscopy (SEM) and stereological analysis were used to characterize the particles. The average size and morphology of the microspheres varied substantially with preparation conditions from 8.44–1.25 μm. Results showed that the smallest particles were obtained with methanol, 1% PVA and with 10 min of homogenization at 21,000 rpm. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc.
PB  - Hoboken, NJ : John Wiley & Sons
T2  - Microscopy Research and Technique
T1  - Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters
SP  - 86
EP  - 92
VL  - 72
IS  - 2
DO  - 10.1002/jemt.20529
UR  - https://hdl.handle.net/21.15107/rcub_dais_177
ER  -

@article{
author = "Jovanović, Ivana and Jordović, Branka and Petković, Marijana and Ignjatović, Nenad and Uskoković, Dragan",
year = "2008",
abstract = "Biodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modified precipitation method. For this purpose, the following parameters were varied: co-solvent (methanol or ethanol), the concentration of stabilizer polyvinyl alcohol (PVA), chloroform-to-water ratio and the speed and time of homogenization. Scanning electron microscopy (SEM) and stereological analysis were used to characterize the particles. The average size and morphology of the microspheres varied substantially with preparation conditions from 8.44–1.25 μm. Results showed that the smallest particles were obtained with methanol, 1% PVA and with 10 min of homogenization at 21,000 rpm. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc.",
publisher = "Hoboken, NJ : John Wiley & Sons",
journal = "Microscopy Research and Technique",
title = "Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters",
pages = "86-92",
volume = "72",
number = "2",
doi = "10.1002/jemt.20529",
url = "https://hdl.handle.net/21.15107/rcub_dais_177"
}

Jovanović, I., Jordović, B., Petković, M., Ignjatović, N.,& Uskoković, D.. (2008). Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters. in Microscopy Research and Technique
Hoboken, NJ : John Wiley & Sons., 72(2), 86-92.
https://doi.org/10.1002/jemt.20529
https://hdl.handle.net/21.15107/rcub_dais_177

Jovanović I, Jordović B, Petković M, Ignjatović N, Uskoković D. Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters. in Microscopy Research and Technique. 2008;72(2):86-92.
doi:10.1002/jemt.20529
https://hdl.handle.net/21.15107/rcub_dais_177 .

Jovanović, Ivana, Jordović, Branka, Petković, Marijana, Ignjatović, Nenad, Uskoković, Dragan, "Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters" in Microscopy Research and Technique, 72, no. 2 (2008):86-92,
https://doi.org/10.1002/jemt.20529 .,
https://hdl.handle.net/21.15107/rcub_dais_177 .