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TY - JOUR
AU - Jovanović, Ivana
AU - Jordović, Branka
AU - Petković, Marijana
AU - Ignjatović, Nenad
AU - Uskoković, Dragan
PY - 2008
UR - http://dais.sanu.ac.rs/123456789/177
AB - Biodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modified precipitation method. For this purpose, the following parameters were varied: co-solvent (methanol or ethanol), the concentration of stabilizer polyvinyl alcohol (PVA), chloroform-to-water ratio and the speed and time of homogenization. Scanning electron microscopy (SEM) and stereological analysis were used to characterize the particles. The average size and morphology of the microspheres varied substantially with preparation conditions from 8.44–1.25 μm. Results showed that the smallest particles were obtained with methanol, 1% PVA and with 10 min of homogenization at 21,000 rpm. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc.
PB - Hoboken, NJ : John Wiley & Sons
T2 - Microscopy Research and Technique
T1 - Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters
SP - 86
EP - 92
VL - 72
IS - 2
DO - 10.1002/jemt.20529
ER -
@article{
author = "Jovanović, Ivana and Jordović, Branka and Petković, Marijana and Ignjatović, Nenad and Uskoković, Dragan",
year = "2008",
url = "http://dais.sanu.ac.rs/123456789/177",
abstract = "Biodegradable microspheres such as those made of poly-D,L-lactide (PDLLA) are widely investigated delivery systems for drugs or antigens. The aim of this study was to examine experimental conditions in order to produce PDLLA microspheres with the best properties for controlled and sustained drug delivery by the modified precipitation method. For this purpose, the following parameters were varied: co-solvent (methanol or ethanol), the concentration of stabilizer polyvinyl alcohol (PVA), chloroform-to-water ratio and the speed and time of homogenization. Scanning electron microscopy (SEM) and stereological analysis were used to characterize the particles. The average size and morphology of the microspheres varied substantially with preparation conditions from 8.44–1.25 μm. Results showed that the smallest particles were obtained with methanol, 1% PVA and with 10 min of homogenization at 21,000 rpm. Microsc. Res. Tech., 2008. © 2007 Wiley-Liss, Inc.",
publisher = "Hoboken, NJ : John Wiley & Sons",
journal = "Microscopy Research and Technique",
title = "Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters",
pages = "86-92",
volume = "72",
number = "2",
doi = "10.1002/jemt.20529"
}
Jovanović I, Jordović B, Petković M, Ignjatović N, Uskoković D. Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters. Microscopy Research and Technique. 2008;72(2):86-92
Jovanović, I., Jordović, B., Petković, M., Ignjatović, N.,& Uskoković, D. (2008). Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters.
Microscopy Research and TechniqueHoboken, NJ : John Wiley & Sons., 72(2), 86-92.
https://doi.org/10.1002/jemt.20529
Jovanović Ivana, Jordović Branka, Petković Marijana, Ignjatović Nenad, Uskoković Dragan, "Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: Influence of the process parameters" 72, no. 2 (2008):86-92,
https://doi.org/10.1002/jemt.20529 .
