Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals
Аутори
Radan, MilicaĆujić Nikolić, Nada
Kuzmanović Nedeljković, Snežana
Mutavski, Zorana
Krgović, Nemanja
Stević, Tatjana
Marković, Smilja
Jovanović, Aleksandra
Živković, Jelena
Šavikin, Katarina
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Recovering the bioactive components from pomegranate peel (PP) in the fruit-processing industry has attracted great attention in terms of minimizing the waste burden, as well as providing a new source of a multitude of functional compounds. The present study aimed to develop a feasible microencapsulation process of PP extract by using pectin and a pectin/2-hydroxypropyl-β-cyclodextrin (HP-β-CD) blend as coating materials. Microsized powders obtained by a spray drying technique were examined in terms of technological characteristics, exhibiting high powder yield and desirable moisture content, flowability, and cohesive properties. Assuming that the interactions with the used biopolymers occur on the surface hydrophobic domain, their presence significantly improved the thermal stability of the microencapsulated powders up to 200 °C. The health-promoting effects of PP have been associated with its high content in ellagitannins, particularly punicalagin. The obtained PP powders exhibited s...trong antioxidant and hypoglycemic potential, while an antimicrobial assay revealed their potent activity against Gram-positive bacteria. Additionally, an in vitro release study suggested that the used biopolymers can modify the release of target bioactive compounds, thus establishing a basis for developing an oral-controlled release system. Altogether, biowaste valorization from PP by the production of effective multifunctional microsized powders represents a sustainable way to obtain novel nutraceuticals and/or pharmaceuticals.
Кључне речи:
pomegranate peel / microencapsulation / spray drying / antioxidant / antimicrobial activity / molecular docking / in vitro releaseИзвор:
Plants, 2024, 13, 2, 281-Издавач:
- Basel : MDPI AG
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200003 (Институт за проучавање лековитог биља 'Др Јосиф Панчић', Београд) (RS-MESTD-inst-2020-200003)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200019 (Универзитет у Београду, Институт за примену нуклеарне енергије - ИНЕП) (RS-MESTD-inst-2020-200019)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200175 (Институт техничких наука САНУ, Београд) (RS-MESTD-inst-2020-200175)
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - JOUR AU - Radan, Milica AU - Ćujić Nikolić, Nada AU - Kuzmanović Nedeljković, Snežana AU - Mutavski, Zorana AU - Krgović, Nemanja AU - Stević, Tatjana AU - Marković, Smilja AU - Jovanović, Aleksandra AU - Živković, Jelena AU - Šavikin, Katarina PY - 2024 UR - https://dais.sanu.ac.rs/123456789/16332 AB - Recovering the bioactive components from pomegranate peel (PP) in the fruit-processing industry has attracted great attention in terms of minimizing the waste burden, as well as providing a new source of a multitude of functional compounds. The present study aimed to develop a feasible microencapsulation process of PP extract by using pectin and a pectin/2-hydroxypropyl-β-cyclodextrin (HP-β-CD) blend as coating materials. Microsized powders obtained by a spray drying technique were examined in terms of technological characteristics, exhibiting high powder yield and desirable moisture content, flowability, and cohesive properties. Assuming that the interactions with the used biopolymers occur on the surface hydrophobic domain, their presence significantly improved the thermal stability of the microencapsulated powders up to 200 °C. The health-promoting effects of PP have been associated with its high content in ellagitannins, particularly punicalagin. The obtained PP powders exhibited strong antioxidant and hypoglycemic potential, while an antimicrobial assay revealed their potent activity against Gram-positive bacteria. Additionally, an in vitro release study suggested that the used biopolymers can modify the release of target bioactive compounds, thus establishing a basis for developing an oral-controlled release system. Altogether, biowaste valorization from PP by the production of effective multifunctional microsized powders represents a sustainable way to obtain novel nutraceuticals and/or pharmaceuticals. PB - Basel : MDPI AG T2 - Plants T1 - Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals SP - 281 VL - 13 IS - 2 DO - 10.3390/plants13020281 UR - https://hdl.handle.net/21.15107/rcub_dais_16332 ER -
@article{ author = "Radan, Milica and Ćujić Nikolić, Nada and Kuzmanović Nedeljković, Snežana and Mutavski, Zorana and Krgović, Nemanja and Stević, Tatjana and Marković, Smilja and Jovanović, Aleksandra and Živković, Jelena and Šavikin, Katarina", year = "2024", abstract = "Recovering the bioactive components from pomegranate peel (PP) in the fruit-processing industry has attracted great attention in terms of minimizing the waste burden, as well as providing a new source of a multitude of functional compounds. The present study aimed to develop a feasible microencapsulation process of PP extract by using pectin and a pectin/2-hydroxypropyl-β-cyclodextrin (HP-β-CD) blend as coating materials. Microsized powders obtained by a spray drying technique were examined in terms of technological characteristics, exhibiting high powder yield and desirable moisture content, flowability, and cohesive properties. Assuming that the interactions with the used biopolymers occur on the surface hydrophobic domain, their presence significantly improved the thermal stability of the microencapsulated powders up to 200 °C. The health-promoting effects of PP have been associated with its high content in ellagitannins, particularly punicalagin. The obtained PP powders exhibited strong antioxidant and hypoglycemic potential, while an antimicrobial assay revealed their potent activity against Gram-positive bacteria. Additionally, an in vitro release study suggested that the used biopolymers can modify the release of target bioactive compounds, thus establishing a basis for developing an oral-controlled release system. Altogether, biowaste valorization from PP by the production of effective multifunctional microsized powders represents a sustainable way to obtain novel nutraceuticals and/or pharmaceuticals.", publisher = "Basel : MDPI AG", journal = "Plants", title = "Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals", pages = "281", volume = "13", number = "2", doi = "10.3390/plants13020281", url = "https://hdl.handle.net/21.15107/rcub_dais_16332" }
Radan, M., Ćujić Nikolić, N., Kuzmanović Nedeljković, S., Mutavski, Z., Krgović, N., Stević, T., Marković, S., Jovanović, A., Živković, J.,& Šavikin, K.. (2024). Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals. in Plants Basel : MDPI AG., 13(2), 281. https://doi.org/10.3390/plants13020281 https://hdl.handle.net/21.15107/rcub_dais_16332
Radan M, Ćujić Nikolić N, Kuzmanović Nedeljković S, Mutavski Z, Krgović N, Stević T, Marković S, Jovanović A, Živković J, Šavikin K. Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals. in Plants. 2024;13(2):281. doi:10.3390/plants13020281 https://hdl.handle.net/21.15107/rcub_dais_16332 .
Radan, Milica, Ćujić Nikolić, Nada, Kuzmanović Nedeljković, Snežana, Mutavski, Zorana, Krgović, Nemanja, Stević, Tatjana, Marković, Smilja, Jovanović, Aleksandra, Živković, Jelena, Šavikin, Katarina, "Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals" in Plants, 13, no. 2 (2024):281, https://doi.org/10.3390/plants13020281 ., https://hdl.handle.net/21.15107/rcub_dais_16332 .