The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles

Stojanović, Zoran S.; Otoničar, Mojca; Lee, Jongwook; Stevanović, Magdalena; Hwang, Mintai P.; Lee, Hyi; Choi, Jonghoon; Uskoković, Dragan

doi:10.1016/j.colsurfb.2013.03.053

2013

ZS-Manuscript.pdf (714.0Kb)

Authors

Stojanović, Zoran S.

Otoničar, Mojca

Lee, Jongwook
Stevanović, Magdalena

Hwang, Mintai P.
Lee, Hyi
Choi, Jonghoon

Uskoković, Dragan

Article (Accepted Version)

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Abstract

We report a simple and green procedure for the preparation of magnetic iron oxide nanocrystals via solvothermal synthesis. The nanocrystal synthesis was carried out under mild conditions in the water–ethanol–oleic acid solvent system with the use of the oleate anion as a surface modifier of nanocrystals and glucose as a reducing agent. Specific conditions for homogenous precipitation achieved in such a reaction system lead to the formation of uniform high-quality nanocrystals down to 5 nm in diameter. The obtained hydrophobic nanocrystals can easily be converted to hydrophilic magnetic nanoparticles by being immobilized in a poly(l-lactide)–polyethyleneimine polymeric matrix. These hybrid nano-constructs may find various biomedical applications, such as magnetic separation, gene transfection and/or magnetic resonance imaging.

Keywords:

iron oxide / magnetic particles / nanocrystals / poly(l-lactide) / polyethyleneimine / solvothermal synthesis

Source:
Colloids and Surfaces B: Biointerfaces, 2013, 109, 236-243

Funding / projects:

Molecular designing of nanoparticles with controlled morphological and physicochemical characteristics and functional materials based on them (RS-45004)
National Research Foundation of Korea - R11-2008-0061852
Korean Institute of Science and Technology - Institute of Technical Science of SASA joint research project Advanced Materials for Biomedical Applications

Note:

This is the peer reviewed version of the following article: Stojanović, Zoran, Mojca Otoničar, Jongwook Lee, Magdalena M. Stevanović, Mintai P. Hwang, Kwan Hyi Lee, Jonghoon Choi, and Dragan Uskoković. 2013. “The Solvothermal Synthesis of Magnetic Iron Oxide Nanocrystals and the Preparation of Hybrid Poly(l-lactide)–polyethyleneimine Magnetic Particles.” Colloids and Surfaces B: Biointerfaces 109 (September 1): 236–243. http://dx.doi.org/ 10.1016/j.colsurfb.2013.03.053 .

DOI: 10.1016/j.colsurfb.2013.03.053

ISSN: 0927-7765

WoS: 000320413300034

Scopus: 2-s2.0-84877355396

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TY  - JOUR
AU  - Stojanović, Zoran S.
AU  - Otoničar, Mojca
AU  - Lee, Jongwook
AU  - Stevanović, Magdalena
AU  - Hwang, Mintai P.
AU  - Lee, Hyi
AU  - Choi, Jonghoon
AU  - Uskoković, Dragan
PY  - 2013
UR  - https://dais.sanu.ac.rs/123456789/163
AB  - We report a simple and green procedure for the preparation of magnetic iron oxide nanocrystals via solvothermal synthesis. The nanocrystal synthesis was carried out under mild conditions in the water–ethanol–oleic acid solvent system with the use of the oleate anion as a surface modifier of nanocrystals and glucose as a reducing agent. Specific conditions for homogenous precipitation achieved in such a reaction system lead to the formation of uniform high-quality nanocrystals down to 5 nm in diameter. The obtained hydrophobic nanocrystals can easily be converted to hydrophilic magnetic nanoparticles by being immobilized in a poly(l-lactide)–polyethyleneimine polymeric matrix. These hybrid nano-constructs may find various biomedical applications, such as magnetic separation, gene transfection and/or magnetic resonance imaging.
T2  - Colloids and Surfaces B: Biointerfaces
T1  - The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles
SP  - 236
EP  - 243
VL  - 109
DO  - 10.1016/j.colsurfb.2013.03.053
UR  - https://hdl.handle.net/21.15107/rcub_dais_163
ER  -

@article{
author = "Stojanović, Zoran S. and Otoničar, Mojca and Lee, Jongwook and Stevanović, Magdalena and Hwang, Mintai P. and Lee, Hyi and Choi, Jonghoon and Uskoković, Dragan",
year = "2013",
abstract = "We report a simple and green procedure for the preparation of magnetic iron oxide nanocrystals via solvothermal synthesis. The nanocrystal synthesis was carried out under mild conditions in the water–ethanol–oleic acid solvent system with the use of the oleate anion as a surface modifier of nanocrystals and glucose as a reducing agent. Specific conditions for homogenous precipitation achieved in such a reaction system lead to the formation of uniform high-quality nanocrystals down to 5 nm in diameter. The obtained hydrophobic nanocrystals can easily be converted to hydrophilic magnetic nanoparticles by being immobilized in a poly(l-lactide)–polyethyleneimine polymeric matrix. These hybrid nano-constructs may find various biomedical applications, such as magnetic separation, gene transfection and/or magnetic resonance imaging.",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles",
pages = "236-243",
volume = "109",
doi = "10.1016/j.colsurfb.2013.03.053",
url = "https://hdl.handle.net/21.15107/rcub_dais_163"
}

Stojanović, Z. S., Otoničar, M., Lee, J., Stevanović, M., Hwang, M. P., Lee, H., Choi, J.,& Uskoković, D.. (2013). The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles. in Colloids and Surfaces B: Biointerfaces, 109, 236-243.
https://doi.org/10.1016/j.colsurfb.2013.03.053
https://hdl.handle.net/21.15107/rcub_dais_163

Stojanović ZS, Otoničar M, Lee J, Stevanović M, Hwang MP, Lee H, Choi J, Uskoković D. The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles. in Colloids and Surfaces B: Biointerfaces. 2013;109:236-243.
doi:10.1016/j.colsurfb.2013.03.053
https://hdl.handle.net/21.15107/rcub_dais_163 .

Stojanović, Zoran S., Otoničar, Mojca, Lee, Jongwook, Stevanović, Magdalena, Hwang, Mintai P., Lee, Hyi, Choi, Jonghoon, Uskoković, Dragan, "The solvothermal synthesis of magnetic iron oxide nanocrystals and the preparation of hybrid poly(L-lactide)-polyethyleneimine magnetic particles" in Colloids and Surfaces B: Biointerfaces, 109 (2013):236-243,
https://doi.org/10.1016/j.colsurfb.2013.03.053 .,
https://hdl.handle.net/21.15107/rcub_dais_163 .