Gubitak koštanog tkiva, usled resorpcije viličnih kostiju, ima značajno mesto u stomatologiji. U cilju rešavanja problema deficita koštanog tkiva nastalih resorpcijom alveolarne kosti pristupilo se primeni sintetičkih materijala na bazi CP/PLGA (kalcijum-fosfat/polilaktid-co-glikolid) kompozita. Istraživanja su radena na pacovima kod kojih je arteficijelno izazivana resorpcija viličnih kostiju. Rezultati su pokazali da se najbolji efekat regeneracije alveolarne kosti postižu implantacijom nanokompozita. Efekat nanokompozita praćenje određivanjem sadržaja kalcijuma i fosfata, kao osnova kristalne rešetke hidroksiapatita. Dobijeni rezultati pokazuju da sintetički CP/PLGA nanokompozit olakšava rehabilitaciju oslabljene alveolarne kosti, pa zahvaljujući svom osteokonduktivnom efektu može u budućnosti biti materijal izbora u zameni koštanog tkiva.
The alveolar bone tissue resorption defect has a significant role in dentistry. Because of the bone tissue deficit developed by alveolar resorption, the use of synthetic material CP/PLGA (calcium-phosphate/polylactide-co-gliycolide) composite was introduced. Investigations were performed on rats with artificially produced resorption of the mandibular bone. The results show that the best effect on alveolar bone were attained by using nano-composite implants. The effect of the nanocomposite was ascertained by determining the calcium and phosphate content, as a basis of the hydroxyapatite structure. The results show that synthetic CP/PLGA nanocomposite alleviate the rehabilitation of weakened alveolar bone. Due to its osteoconductive effect, CP/PLGA can be the material of choice for bone substitution in the future.
Keywords:
CP/PLGA / alveolar bone / calcium phosphate / lead / cadmium
Source:
Hemijska industrija, 2007, 61, 2, 96-100
Publisher:
Belgrade : Association of the Chemical Engineers of Serbia
TY - JOUR
AU - Kaličanin, Biljana
AU - Ajduković, Zorica
AU - Kostić, Milena
AU - Najman, Stevo
AU - Savić, Vojin
AU - Ignjatović, Nenad
PY - 2007
UR - https://dais.sanu.ac.rs/123456789/13687
AB - Gubitak koštanog tkiva, usled resorpcije viličnih kostiju, ima značajno mesto u stomatologiji. U cilju rešavanja problema deficita koštanog tkiva nastalih resorpcijom alveolarne kosti pristupilo se primeni sintetičkih materijala na bazi CP/PLGA (kalcijum-fosfat/polilaktid-co-glikolid) kompozita. Istraživanja su radena na pacovima kod kojih je arteficijelno izazivana resorpcija viličnih kostiju. Rezultati su pokazali da se najbolji efekat regeneracije alveolarne kosti postižu implantacijom nanokompozita. Efekat nanokompozita praćenje određivanjem sadržaja kalcijuma i fosfata, kao osnova kristalne rešetke hidroksiapatita. Dobijeni rezultati pokazuju da sintetički CP/PLGA nanokompozit olakšava rehabilitaciju oslabljene alveolarne kosti, pa zahvaljujući svom osteokonduktivnom efektu može u budućnosti biti materijal izbora u zameni koštanog tkiva.
AB - The alveolar bone tissue resorption defect has a significant role in dentistry. Because of the bone tissue deficit developed by alveolar resorption, the use of synthetic material CP/PLGA (calcium-phosphate/polylactide-co-gliycolide) composite was introduced. Investigations were performed on rats with artificially produced resorption of the mandibular bone. The results show that the best effect on alveolar bone were attained by using nano-composite implants. The effect of the nanocomposite was ascertained by determining the calcium and phosphate content, as a basis of the hydroxyapatite structure. The results show that synthetic CP/PLGA nanocomposite alleviate the rehabilitation of weakened alveolar bone. Due to its osteoconductive effect, CP/PLGA can be the material of choice for bone substitution in the future.
PB - Belgrade : Association of the Chemical Engineers of Serbia
T2 - Hemijska industrija
T1 - Uloga sintetičkih biomaterijala u procesu regeneracije resorbovane alveolarne kosti
T1 - The role of synthetic biomaterials in resorptive alveolar bone regeneration
SP - 96
EP - 100
VL - 61
IS - 2
DO - 10.2298/HEMIND0702096K
UR - https://hdl.handle.net/21.15107/rcub_dais_13687
ER -
@article{
author = "Kaličanin, Biljana and Ajduković, Zorica and Kostić, Milena and Najman, Stevo and Savić, Vojin and Ignjatović, Nenad",
year = "2007",
abstract = "Gubitak koštanog tkiva, usled resorpcije viličnih kostiju, ima značajno mesto u stomatologiji. U cilju rešavanja problema deficita koštanog tkiva nastalih resorpcijom alveolarne kosti pristupilo se primeni sintetičkih materijala na bazi CP/PLGA (kalcijum-fosfat/polilaktid-co-glikolid) kompozita. Istraživanja su radena na pacovima kod kojih je arteficijelno izazivana resorpcija viličnih kostiju. Rezultati su pokazali da se najbolji efekat regeneracije alveolarne kosti postižu implantacijom nanokompozita. Efekat nanokompozita praćenje određivanjem sadržaja kalcijuma i fosfata, kao osnova kristalne rešetke hidroksiapatita. Dobijeni rezultati pokazuju da sintetički CP/PLGA nanokompozit olakšava rehabilitaciju oslabljene alveolarne kosti, pa zahvaljujući svom osteokonduktivnom efektu može u budućnosti biti materijal izbora u zameni koštanog tkiva., The alveolar bone tissue resorption defect has a significant role in dentistry. Because of the bone tissue deficit developed by alveolar resorption, the use of synthetic material CP/PLGA (calcium-phosphate/polylactide-co-gliycolide) composite was introduced. Investigations were performed on rats with artificially produced resorption of the mandibular bone. The results show that the best effect on alveolar bone were attained by using nano-composite implants. The effect of the nanocomposite was ascertained by determining the calcium and phosphate content, as a basis of the hydroxyapatite structure. The results show that synthetic CP/PLGA nanocomposite alleviate the rehabilitation of weakened alveolar bone. Due to its osteoconductive effect, CP/PLGA can be the material of choice for bone substitution in the future.",
publisher = "Belgrade : Association of the Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Uloga sintetičkih biomaterijala u procesu regeneracije resorbovane alveolarne kosti, The role of synthetic biomaterials in resorptive alveolar bone regeneration",
pages = "96-100",
volume = "61",
number = "2",
doi = "10.2298/HEMIND0702096K",
url = "https://hdl.handle.net/21.15107/rcub_dais_13687"
}
Kaličanin, B., Ajduković, Z., Kostić, M., Najman, S., Savić, V.,& Ignjatović, N.. (2007). Uloga sintetičkih biomaterijala u procesu regeneracije resorbovane alveolarne kosti. in Hemijska industrija
Belgrade : Association of the Chemical Engineers of Serbia., 61(2), 96-100.
https://doi.org/10.2298/HEMIND0702096K
https://hdl.handle.net/21.15107/rcub_dais_13687
Kaličanin B, Ajduković Z, Kostić M, Najman S, Savić V, Ignjatović N. Uloga sintetičkih biomaterijala u procesu regeneracije resorbovane alveolarne kosti. in Hemijska industrija. 2007;61(2):96-100.
doi:10.2298/HEMIND0702096K
https://hdl.handle.net/21.15107/rcub_dais_13687 .
