Rastvorljivost lekova predstavlja veoma važno svojstvo koje direktno utiče na njihovu primenu. S obzirom na činjenicu da rastvorljivost može delovati kao ograničavajući faktor u procesu apsorpcije leka, takođe može uticati i na njegovu bioraspoloživost. Više od 40% potencijalnih lekova su slabo rastvorni u vodi što ima za posledicu da važni farmaceutski proizvodi ne ostvare komercijalnu primenu ili ne postižu svoj potpuni potencijal. U ovom radu ispitivana je mogućnost poboljšanja rastvorljivosti verapamil hidrohlorida (VHCl) primenom mehanohemijskog tretmana. Uticaj mehanohemijskog procesiranja na fizičkohemijska svojstva VHCl-a ispitan je primenom metoda XRPD, FTIR i Ramanske spektroskopije, kao i FESEM analize. Osim toga, određena je i raspodela veličina čestica. Rastvorljivost VHCl prahova nakon mehanohemijskog procesiranja određena je UV-Vis spektrofotometrijom. Konačno, rastvorljivost VHCl je korelisana sa srednjom veličinom čestica, strukturnim i morfološkim karakteristikama.
Dissolution of drugs is a very important factor that directly affects their potential application. Due to the fact that solubility may act as a limiting factor in the process of absorption of the drug, it can also affect its bio-availableness. More than 40 percent of potential drugs have a property of a poor solubility in the water, resulting in potentially important pharmaceutical products not reaching patients or reaching their full potential. This work examined the possibility of improving the solubility of verapamil hydrochloride (VHCl) by applying mechanochemical treatment. The impact of mechanochemical treatment on physiochemical properties was comprehended by applying XRPD, FTIR and Raman spectroscopy, as well as FESEM analysis. Besides, particle size distribution was determined. Solubility of verapamil hydrochloride was determined by using UV-VIS spectroscopy. Finally, the solubility of verapamil hydrochloride was correlated with particle size distribution, structural and morph...ological characteristics.
TY - JOUR
AU - Stanković, Ana
AU - Jovanović, Sonja
PY - 2021
UR - https://dais.sanu.ac.rs/123456789/12384
AB - Rastvorljivost lekova predstavlja veoma važno svojstvo koje direktno utiče na njihovu primenu. S obzirom na činjenicu da rastvorljivost može delovati kao ograničavajući faktor u procesu apsorpcije leka, takođe može uticati i na njegovu bioraspoloživost. Više od 40% potencijalnih lekova su slabo rastvorni u vodi što ima za posledicu da važni farmaceutski proizvodi ne ostvare komercijalnu primenu ili ne postižu svoj potpuni potencijal. U ovom radu ispitivana je mogućnost poboljšanja rastvorljivosti verapamil hidrohlorida (VHCl) primenom mehanohemijskog tretmana. Uticaj mehanohemijskog procesiranja na fizičkohemijska svojstva VHCl-a ispitan je primenom metoda XRPD, FTIR i Ramanske spektroskopije, kao i FESEM analize. Osim toga, određena je i raspodela veličina čestica. Rastvorljivost VHCl prahova nakon mehanohemijskog procesiranja određena je UV-Vis spektrofotometrijom. Konačno, rastvorljivost VHCl je korelisana sa srednjom veličinom čestica, strukturnim i morfološkim karakteristikama.
AB - Dissolution of drugs is a very important factor that directly affects their potential application. Due to the fact that solubility may act as a limiting factor in the process of absorption of the drug, it can also affect its bio-availableness. More than 40 percent of potential drugs have a property of a poor solubility in the water, resulting in potentially important pharmaceutical products not reaching patients or reaching their full potential. This work examined the possibility of improving the solubility of verapamil hydrochloride (VHCl) by applying mechanochemical treatment. The impact of mechanochemical treatment on physiochemical properties was comprehended by applying XRPD, FTIR and Raman spectroscopy, as well as FESEM analysis. Besides, particle size distribution was determined. Solubility of verapamil hydrochloride was determined by using UV-VIS spectroscopy. Finally, the solubility of verapamil hydrochloride was correlated with particle size distribution, structural and morphological characteristics.
PB - Centre for Evaluation in Education and Science (CEON/CEES)
T2 - Tehnika
T1 - Ispitivanje uticaja mehanohemijskog procesiranja na rastvorljivost verapamil hidrohlorida
SP - 9
EP - 14
VL - 76
IS - 1
DO - 10.5937/tehnika2101009S
UR - https://hdl.handle.net/21.15107/rcub_dais_12384
ER -
@article{
author = "Stanković, Ana and Jovanović, Sonja",
year = "2021",
abstract = "Rastvorljivost lekova predstavlja veoma važno svojstvo koje direktno utiče na njihovu primenu. S obzirom na činjenicu da rastvorljivost može delovati kao ograničavajući faktor u procesu apsorpcije leka, takođe može uticati i na njegovu bioraspoloživost. Više od 40% potencijalnih lekova su slabo rastvorni u vodi što ima za posledicu da važni farmaceutski proizvodi ne ostvare komercijalnu primenu ili ne postižu svoj potpuni potencijal. U ovom radu ispitivana je mogućnost poboljšanja rastvorljivosti verapamil hidrohlorida (VHCl) primenom mehanohemijskog tretmana. Uticaj mehanohemijskog procesiranja na fizičkohemijska svojstva VHCl-a ispitan je primenom metoda XRPD, FTIR i Ramanske spektroskopije, kao i FESEM analize. Osim toga, određena je i raspodela veličina čestica. Rastvorljivost VHCl prahova nakon mehanohemijskog procesiranja određena je UV-Vis spektrofotometrijom. Konačno, rastvorljivost VHCl je korelisana sa srednjom veličinom čestica, strukturnim i morfološkim karakteristikama., Dissolution of drugs is a very important factor that directly affects their potential application. Due to the fact that solubility may act as a limiting factor in the process of absorption of the drug, it can also affect its bio-availableness. More than 40 percent of potential drugs have a property of a poor solubility in the water, resulting in potentially important pharmaceutical products not reaching patients or reaching their full potential. This work examined the possibility of improving the solubility of verapamil hydrochloride (VHCl) by applying mechanochemical treatment. The impact of mechanochemical treatment on physiochemical properties was comprehended by applying XRPD, FTIR and Raman spectroscopy, as well as FESEM analysis. Besides, particle size distribution was determined. Solubility of verapamil hydrochloride was determined by using UV-VIS spectroscopy. Finally, the solubility of verapamil hydrochloride was correlated with particle size distribution, structural and morphological characteristics.",
publisher = "Centre for Evaluation in Education and Science (CEON/CEES)",
journal = "Tehnika",
title = "Ispitivanje uticaja mehanohemijskog procesiranja na rastvorljivost verapamil hidrohlorida",
pages = "9-14",
volume = "76",
number = "1",
doi = "10.5937/tehnika2101009S",
url = "https://hdl.handle.net/21.15107/rcub_dais_12384"
}
Stanković, A.,& Jovanović, S.. (2021). Ispitivanje uticaja mehanohemijskog procesiranja na rastvorljivost verapamil hidrohlorida. in Tehnika
Centre for Evaluation in Education and Science (CEON/CEES)., 76(1), 9-14.
https://doi.org/10.5937/tehnika2101009S
https://hdl.handle.net/21.15107/rcub_dais_12384
Stanković A, Jovanović S. Ispitivanje uticaja mehanohemijskog procesiranja na rastvorljivost verapamil hidrohlorida. in Tehnika. 2021;76(1):9-14.
doi:10.5937/tehnika2101009S
https://hdl.handle.net/21.15107/rcub_dais_12384 .
Stanković, Ana, Jovanović, Sonja, "Ispitivanje uticaja mehanohemijskog procesiranja na rastvorljivost verapamil hidrohlorida" in Tehnika, 76, no. 1 (2021):9-14,
https://doi.org/10.5937/tehnika2101009S .,
https://hdl.handle.net/21.15107/rcub_dais_12384 .
