Additive-free resveratrol micro- and nanoparticles and assessment of their toxicity
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Resveratrol, polyphenol from stilbene family, has demonstrated beneficial effects on human health in numerous studies. Among these effects are cardioprotective, anti-cancer, neuroprotective, antimicrobial and other. In vivo, application of this phytochemical often lacks significant results. This is mainly because of its poor bioavailability, caused by low water solubility, sensitivity to light, oxygen and pH change, and high reactivity. Micro- and nanoformulations of resveratrol have been described to highly improve bioavailabiliy. However, there are limitations to this approach, such as demanding synthesis process, necessity of expensive or toxic chemicals, or poor loading capacity. We have used a simple physicochemical solvent-non solvent method to synthetise additive-free, stabile and uniform elongated resveratrol micro- and nanoparticles (RES-particles). The drying conditions were varied to examine their influence on the morphological characteristics of resveratrol particles. Diffe...rential effects of drying at ambient, low, and elevated temperature as well as effects of centrifugation and stability of RES-particle suspension during the time were documented. RES-particles were characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), ultraviolet-visible (UV-Vis) spectrophotometry, Fourier transform infrared spectroscopy (FTIR) and optical microscopy. Biocompatibility of RESparticles was preliminary assessed through MTT toxicity assay.
Keywords:
resveratrol / solvent-non solvent method / XRD / DSC / UV-Vis / FTIR / MTT toxicity assaySource:
Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia, 2021, 4-4Publisher:
- Belgrade : Institute of Technical Sciences of SASA
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200175 (Institute of Technical Sciences of SASA, Belgrade) (RS-MESTD-inst-2020-200175)
Institution/Community
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Tomić, Nina AU - Kuzmanović, Maja AU - Mitić Ćulafić, Dragana AU - Stevanović, Magdalena PY - 2021 UR - https://dais.sanu.ac.rs/123456789/12283 AB - Resveratrol, polyphenol from stilbene family, has demonstrated beneficial effects on human health in numerous studies. Among these effects are cardioprotective, anti-cancer, neuroprotective, antimicrobial and other. In vivo, application of this phytochemical often lacks significant results. This is mainly because of its poor bioavailability, caused by low water solubility, sensitivity to light, oxygen and pH change, and high reactivity. Micro- and nanoformulations of resveratrol have been described to highly improve bioavailabiliy. However, there are limitations to this approach, such as demanding synthesis process, necessity of expensive or toxic chemicals, or poor loading capacity. We have used a simple physicochemical solvent-non solvent method to synthetise additive-free, stabile and uniform elongated resveratrol micro- and nanoparticles (RES-particles). The drying conditions were varied to examine their influence on the morphological characteristics of resveratrol particles. Differential effects of drying at ambient, low, and elevated temperature as well as effects of centrifugation and stability of RES-particle suspension during the time were documented. RES-particles were characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), ultraviolet-visible (UV-Vis) spectrophotometry, Fourier transform infrared spectroscopy (FTIR) and optical microscopy. Biocompatibility of RESparticles was preliminary assessed through MTT toxicity assay. PB - Belgrade : Institute of Technical Sciences of SASA C3 - Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia T1 - Additive-free resveratrol micro- and nanoparticles and assessment of their toxicity SP - 4 EP - 4 UR - https://hdl.handle.net/21.15107/rcub_dais_12283 ER -
@conference{ author = "Tomić, Nina and Kuzmanović, Maja and Mitić Ćulafić, Dragana and Stevanović, Magdalena", year = "2021", abstract = "Resveratrol, polyphenol from stilbene family, has demonstrated beneficial effects on human health in numerous studies. Among these effects are cardioprotective, anti-cancer, neuroprotective, antimicrobial and other. In vivo, application of this phytochemical often lacks significant results. This is mainly because of its poor bioavailability, caused by low water solubility, sensitivity to light, oxygen and pH change, and high reactivity. Micro- and nanoformulations of resveratrol have been described to highly improve bioavailabiliy. However, there are limitations to this approach, such as demanding synthesis process, necessity of expensive or toxic chemicals, or poor loading capacity. We have used a simple physicochemical solvent-non solvent method to synthetise additive-free, stabile and uniform elongated resveratrol micro- and nanoparticles (RES-particles). The drying conditions were varied to examine their influence on the morphological characteristics of resveratrol particles. Differential effects of drying at ambient, low, and elevated temperature as well as effects of centrifugation and stability of RES-particle suspension during the time were documented. RES-particles were characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), ultraviolet-visible (UV-Vis) spectrophotometry, Fourier transform infrared spectroscopy (FTIR) and optical microscopy. Biocompatibility of RESparticles was preliminary assessed through MTT toxicity assay.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia", title = "Additive-free resveratrol micro- and nanoparticles and assessment of their toxicity", pages = "4-4", url = "https://hdl.handle.net/21.15107/rcub_dais_12283" }
Tomić, N., Kuzmanović, M., Mitić Ćulafić, D.,& Stevanović, M.. (2021). Additive-free resveratrol micro- and nanoparticles and assessment of their toxicity. in Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia Belgrade : Institute of Technical Sciences of SASA., 4-4. https://hdl.handle.net/21.15107/rcub_dais_12283
Tomić N, Kuzmanović M, Mitić Ćulafić D, Stevanović M. Additive-free resveratrol micro- and nanoparticles and assessment of their toxicity. in Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia. 2021;:4-4. https://hdl.handle.net/21.15107/rcub_dais_12283 .
Tomić, Nina, Kuzmanović, Maja, Mitić Ćulafić, Dragana, Stevanović, Magdalena, "Additive-free resveratrol micro- and nanoparticles and assessment of their toxicity" in Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia (2021):4-4, https://hdl.handle.net/21.15107/rcub_dais_12283 .