Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material
Аутори
Jovanović, Aleksandra A.Lević, Steva
Pavlović, Vladimir B.
Marković, Smilja
Pjanović, Rada
Đorđević, Verica B.
Nedović, Viktor
Bugarski, Branko
Препринт (Нерецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
Freeze drying was compared with spray drying regarding feasibility to process wild thyme drug in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration, heat-, ultrasound-, and microwave-assisted extractions. Higher powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation distinguished from others by higher content of polyphenols, proteins and suga...rs, higher bulk density and lower solubility. The type of the drying process affected mainly position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray dried formulations compared to freeze dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 µm) compared to small microspheres (~8 µm) in spray-dried powder.
Кључне речи:
encapsulation / freeze drying / gelatin / polyphenols / spray dryingИзвор:
Preprints, 2021Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-200135)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200003 (Институт за проучавање лековитог биља 'Др Јосиф Панчић', Београд) (RS-200003)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-200287)
Напомена:
- Preprint: 10.20944/preprints202105.0358.v1
Повезане информације:
- Друга верзија
http://dx.doi.org/10.20944/preprints202105.0358.v1
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - GEN AU - Jovanović, Aleksandra A. AU - Lević, Steva AU - Pavlović, Vladimir B. AU - Marković, Smilja AU - Pjanović, Rada AU - Đorđević, Verica B. AU - Nedović, Viktor AU - Bugarski, Branko PY - 2021 UR - https://dais.sanu.ac.rs/123456789/11637 AB - Freeze drying was compared with spray drying regarding feasibility to process wild thyme drug in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration, heat-, ultrasound-, and microwave-assisted extractions. Higher powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation distinguished from others by higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process affected mainly position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray dried formulations compared to freeze dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 µm) compared to small microspheres (~8 µm) in spray-dried powder. T2 - Preprints T1 - Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material DO - 10.20944/preprints202105.0358.v1 UR - https://hdl.handle.net/21.15107/rcub_dais_11637 ER -
@misc{ author = "Jovanović, Aleksandra A. and Lević, Steva and Pavlović, Vladimir B. and Marković, Smilja and Pjanović, Rada and Đorđević, Verica B. and Nedović, Viktor and Bugarski, Branko", year = "2021", abstract = "Freeze drying was compared with spray drying regarding feasibility to process wild thyme drug in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration, heat-, ultrasound-, and microwave-assisted extractions. Higher powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation distinguished from others by higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process affected mainly position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray dried formulations compared to freeze dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 µm) compared to small microspheres (~8 µm) in spray-dried powder.", journal = "Preprints", title = "Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material", doi = "10.20944/preprints202105.0358.v1", url = "https://hdl.handle.net/21.15107/rcub_dais_11637" }
Jovanović, A. A., Lević, S., Pavlović, V. B., Marković, S., Pjanović, R., Đorđević, V. B., Nedović, V.,& Bugarski, B.. (2021). Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material. in Preprints. https://doi.org/10.20944/preprints202105.0358.v1 https://hdl.handle.net/21.15107/rcub_dais_11637
Jovanović AA, Lević S, Pavlović VB, Marković S, Pjanović R, Đorđević VB, Nedović V, Bugarski B. Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material. in Preprints. 2021;. doi:10.20944/preprints202105.0358.v1 https://hdl.handle.net/21.15107/rcub_dais_11637 .
Jovanović, Aleksandra A., Lević, Steva, Pavlović, Vladimir B., Marković, Smilja, Pjanović, Rada, Đorđević, Verica B., Nedović, Viktor, Bugarski, Branko, "Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material" in Preprints (2021), https://doi.org/10.20944/preprints202105.0358.v1 ., https://hdl.handle.net/21.15107/rcub_dais_11637 .