TY  - JOUR
AU  - Vučen, Sonja
AU  - Vuleta, Gordana
AU  - Crean, Abina
AU  - Moore, Anne C.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2013
UR  - https://dais.sanu.ac.rs/123456789/383
AB  - Abstract

Objectives
The aim of our study was to evaluate the effect of designing ketoprofen-loaded nanosized spheres and combining them with solid silicon microneedles for enhanced and sustained percutaneous drug delivery.

Methods
Ketoprofen-loaded nanoparticles (KET-NP) were designed by modified solvent displacement method, using poly (D, L-lactic acid) (PDLLA). All prepared nanoparticles were characterised with regard to their particle size distribution, morphology, surface properties, thermal behaviour, drug content, drug release and stability. In-vitro skin permeation studies were conducted on Franz-type diffusion cells using porcine skin treated with ImmuPatch silicon microneedles (Tyndall Nation Institute, Cork, Ireland).

Key findings
The study showed that uniform nanospheres were prepared with high encapsulation efficiency and retained stable for 2 months. After an initial burst release, the PDLLA nanoparticles were capable of sustaining and controlling ketoprofen release that followed Korsmeyer–Peppas kinetics. An enhanced flux of ketoprofen was observed in the skin treated with silicon microneedles over a prolonged period of time.

Conclusions
Following application of silicon microneedle arrays, KET-NP were able to enhance ketoprofen flux and supply the porcine skin with drug over a prolonged (24 h) period of time. Our findings indicate that the delivery strategy described here could be used for the further development of effective and painless administration systems for sustained percutaneous delivery of ketoprofen.
PB  - Hoboken, NJ : John Wiley & Sons
T2  - Journal of Pharmacy and Pharmacology
T1  - Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles
SP  - 1451
EP  - 1462
VL  - 65
IS  - 10
DO  - 10.1111/jphp.12118
UR  - https://hdl.handle.net/21.15107/rcub_dais_383
ER  - 

@article{
author = "Vučen, Sonja and Vuleta, Gordana and Crean, Abina and Moore, Anne C. and Ignjatović, Nenad and Uskoković, Dragan",
year = "2013",
abstract = "Abstract

Objectives
The aim of our study was to evaluate the effect of designing ketoprofen-loaded nanosized spheres and combining them with solid silicon microneedles for enhanced and sustained percutaneous drug delivery.

Methods
Ketoprofen-loaded nanoparticles (KET-NP) were designed by modified solvent displacement method, using poly (D, L-lactic acid) (PDLLA). All prepared nanoparticles were characterised with regard to their particle size distribution, morphology, surface properties, thermal behaviour, drug content, drug release and stability. In-vitro skin permeation studies were conducted on Franz-type diffusion cells using porcine skin treated with ImmuPatch silicon microneedles (Tyndall Nation Institute, Cork, Ireland).

Key findings
The study showed that uniform nanospheres were prepared with high encapsulation efficiency and retained stable for 2 months. After an initial burst release, the PDLLA nanoparticles were capable of sustaining and controlling ketoprofen release that followed Korsmeyer–Peppas kinetics. An enhanced flux of ketoprofen was observed in the skin treated with silicon microneedles over a prolonged period of time.

Conclusions
Following application of silicon microneedle arrays, KET-NP were able to enhance ketoprofen flux and supply the porcine skin with drug over a prolonged (24 h) period of time. Our findings indicate that the delivery strategy described here could be used for the further development of effective and painless administration systems for sustained percutaneous delivery of ketoprofen.",
publisher = "Hoboken, NJ : John Wiley & Sons",
journal = "Journal of Pharmacy and Pharmacology",
title = "Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles",
pages = "1451-1462",
volume = "65",
number = "10",
doi = "10.1111/jphp.12118",
url = "https://hdl.handle.net/21.15107/rcub_dais_383"
}

Vučen, S., Vuleta, G., Crean, A., Moore, A. C., Ignjatović, N.,& Uskoković, D.. (2013). Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles. in Journal of Pharmacy and Pharmacology
Hoboken, NJ : John Wiley & Sons., 65(10), 1451-1462.
https://doi.org/10.1111/jphp.12118
https://hdl.handle.net/21.15107/rcub_dais_383

Vučen S, Vuleta G, Crean A, Moore AC, Ignjatović N, Uskoković D. Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles. in Journal of Pharmacy and Pharmacology. 2013;65(10):1451-1462.
doi:10.1111/jphp.12118
https://hdl.handle.net/21.15107/rcub_dais_383 .

Vučen, Sonja, Vuleta, Gordana, Crean, Abina, Moore, Anne C., Ignjatović, Nenad, Uskoković, Dragan, "Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles" in Journal of Pharmacy and Pharmacology, 65, no. 10 (2013):1451-1462,
https://doi.org/10.1111/jphp.12118 .,
https://hdl.handle.net/21.15107/rcub_dais_383 .