TY  - JOUR
AU  - Radan, Milica
AU  - Ćujić Nikolić, Nada
AU  - Kuzmanović Nedeljković, Snežana
AU  - Mutavski, Zorana
AU  - Krgović, Nemanja
AU  - Stević, Tatjana
AU  - Marković, Smilja
AU  - Jovanović, Aleksandra
AU  - Živković, Jelena
AU  - Šavikin, Katarina
PY  - 2024
UR  - https://dais.sanu.ac.rs/123456789/16332
AB  - Recovering the bioactive components from pomegranate peel (PP) in the fruit-processing industry has attracted great attention in terms of minimizing the waste burden, as well as providing a new source of a multitude of functional compounds. The present study aimed to develop a feasible microencapsulation process of PP extract by using pectin and a pectin/2-hydroxypropyl-β-cyclodextrin (HP-β-CD) blend as coating materials. Microsized powders obtained by a spray drying technique were examined in terms of technological characteristics, exhibiting high powder yield and desirable moisture content, flowability, and cohesive properties. Assuming that the interactions with the used biopolymers occur on the surface hydrophobic domain, their presence significantly improved the thermal stability of the microencapsulated powders up to 200 °C. The health-promoting effects of PP have been associated with its high content in ellagitannins, particularly punicalagin. The obtained PP powders exhibited strong antioxidant and hypoglycemic potential, while an antimicrobial assay revealed their potent activity against Gram-positive bacteria. Additionally, an in vitro release study suggested that the used biopolymers can modify the release of target bioactive compounds, thus establishing a basis for developing an oral-controlled release system. Altogether, biowaste valorization from PP by the production of effective multifunctional microsized powders represents a sustainable way to obtain novel nutraceuticals and/or pharmaceuticals.
PB  - Basel : MDPI AG
T2  - Plants
T1  - Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals
SP  - 281
VL  - 13
IS  - 2
DO  - 10.3390/plants13020281
UR  - https://hdl.handle.net/21.15107/rcub_dais_16332
ER  - 

@article{
author = "Radan, Milica and Ćujić Nikolić, Nada and Kuzmanović Nedeljković, Snežana and Mutavski, Zorana and Krgović, Nemanja and Stević, Tatjana and Marković, Smilja and Jovanović, Aleksandra and Živković, Jelena and Šavikin, Katarina",
year = "2024",
abstract = "Recovering the bioactive components from pomegranate peel (PP) in the fruit-processing industry has attracted great attention in terms of minimizing the waste burden, as well as providing a new source of a multitude of functional compounds. The present study aimed to develop a feasible microencapsulation process of PP extract by using pectin and a pectin/2-hydroxypropyl-β-cyclodextrin (HP-β-CD) blend as coating materials. Microsized powders obtained by a spray drying technique were examined in terms of technological characteristics, exhibiting high powder yield and desirable moisture content, flowability, and cohesive properties. Assuming that the interactions with the used biopolymers occur on the surface hydrophobic domain, their presence significantly improved the thermal stability of the microencapsulated powders up to 200 °C. The health-promoting effects of PP have been associated with its high content in ellagitannins, particularly punicalagin. The obtained PP powders exhibited strong antioxidant and hypoglycemic potential, while an antimicrobial assay revealed their potent activity against Gram-positive bacteria. Additionally, an in vitro release study suggested that the used biopolymers can modify the release of target bioactive compounds, thus establishing a basis for developing an oral-controlled release system. Altogether, biowaste valorization from PP by the production of effective multifunctional microsized powders represents a sustainable way to obtain novel nutraceuticals and/or pharmaceuticals.",
publisher = "Basel : MDPI AG",
journal = "Plants",
title = "Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals",
pages = "281",
volume = "13",
number = "2",
doi = "10.3390/plants13020281",
url = "https://hdl.handle.net/21.15107/rcub_dais_16332"
}

Radan, M., Ćujić Nikolić, N., Kuzmanović Nedeljković, S., Mutavski, Z., Krgović, N., Stević, T., Marković, S., Jovanović, A., Živković, J.,& Šavikin, K.. (2024). Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals. in Plants
Basel : MDPI AG., 13(2), 281.
https://doi.org/10.3390/plants13020281
https://hdl.handle.net/21.15107/rcub_dais_16332

Radan M, Ćujić Nikolić N, Kuzmanović Nedeljković S, Mutavski Z, Krgović N, Stević T, Marković S, Jovanović A, Živković J, Šavikin K. Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals. in Plants. 2024;13(2):281.
doi:10.3390/plants13020281
https://hdl.handle.net/21.15107/rcub_dais_16332 .

Radan, Milica, Ćujić Nikolić, Nada, Kuzmanović Nedeljković, Snežana, Mutavski, Zorana, Krgović, Nemanja, Stević, Tatjana, Marković, Smilja, Jovanović, Aleksandra, Živković, Jelena, Šavikin, Katarina, "Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals" in Plants, 13, no. 2 (2024):281,
https://doi.org/10.3390/plants13020281 .,
https://hdl.handle.net/21.15107/rcub_dais_16332 .