TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Ajduković, Zorica
AU  - Rajković, Jelena
AU  - Najman, Stevo
AU  - Mihailović, Dragan
AU  - Uskoković, Dragan
PY  - 2015
UR  - https://dais.sanu.ac.rs/123456789/3547
AB  - Hydroxyapatite (HAp) is an extensively studied material with known biocompatible and osteoconductive properties in bone tissue reconstruction. The improvement of the osteogenetic potential of HAp has been tested through modification of its structure, by replacing Ca2+ ions with Co2+ ions. In our study, we comparatively analyze the osteogenetic potential of the synthesized HAp and Co2+-substituted HAp (HAp/Co) designed on the nano-scale with the aim of specifically stimulating osteogenesis in vivo. We present a quantitative study of the microscopic organization and structure of the newly formed tissue in a bone defect after 12 weeks and 24 weeks. A quantitative analysis of the calcium, magnesium and phosphorus content in the defect and its close environment was used to determine the deposition of minerals after bone reconstruction. The defect reconstructed with HAp/Co nanoparticles (Co2+ content 12 wt%) was filled with a new tissue matrix composed of dense collagen fibers containing centers of mineralization after 24 weeks. The mineral deposition rate was also higher when the defect was reconstructed with HAp/Co than when it was filled with pure HAp. A histological analysis confirmed that the alveolar bone, in which osteoporosis-induced defects were repaired using HAp/Co nanoparticles, was recuperated. © 2015 Jilin University.
PB  - Elsevier
T2  - Journal of Bionic Engineering
T1  - Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite
SP  - 604
EP  - 612
VL  - 12
IS  - 4
DO  - 10.1016/S1672-6529(14)60150-5
UR  - https://hdl.handle.net/21.15107/rcub_dais_3547
ER  - 

@article{
author = "Ignjatović, Nenad and Ajduković, Zorica and Rajković, Jelena and Najman, Stevo and Mihailović, Dragan and Uskoković, Dragan",
year = "2015",
abstract = "Hydroxyapatite (HAp) is an extensively studied material with known biocompatible and osteoconductive properties in bone tissue reconstruction. The improvement of the osteogenetic potential of HAp has been tested through modification of its structure, by replacing Ca2+ ions with Co2+ ions. In our study, we comparatively analyze the osteogenetic potential of the synthesized HAp and Co2+-substituted HAp (HAp/Co) designed on the nano-scale with the aim of specifically stimulating osteogenesis in vivo. We present a quantitative study of the microscopic organization and structure of the newly formed tissue in a bone defect after 12 weeks and 24 weeks. A quantitative analysis of the calcium, magnesium and phosphorus content in the defect and its close environment was used to determine the deposition of minerals after bone reconstruction. The defect reconstructed with HAp/Co nanoparticles (Co2+ content 12 wt%) was filled with a new tissue matrix composed of dense collagen fibers containing centers of mineralization after 24 weeks. The mineral deposition rate was also higher when the defect was reconstructed with HAp/Co than when it was filled with pure HAp. A histological analysis confirmed that the alveolar bone, in which osteoporosis-induced defects were repaired using HAp/Co nanoparticles, was recuperated. © 2015 Jilin University.",
publisher = "Elsevier",
journal = "Journal of Bionic Engineering",
title = "Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite",
pages = "604-612",
volume = "12",
number = "4",
doi = "10.1016/S1672-6529(14)60150-5",
url = "https://hdl.handle.net/21.15107/rcub_dais_3547"
}

Ignjatović, N., Ajduković, Z., Rajković, J., Najman, S., Mihailović, D.,& Uskoković, D.. (2015). Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite. in Journal of Bionic Engineering
Elsevier., 12(4), 604-612.
https://doi.org/10.1016/S1672-6529(14)60150-5
https://hdl.handle.net/21.15107/rcub_dais_3547

Ignjatović N, Ajduković Z, Rajković J, Najman S, Mihailović D, Uskoković D. Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite. in Journal of Bionic Engineering. 2015;12(4):604-612.
doi:10.1016/S1672-6529(14)60150-5
https://hdl.handle.net/21.15107/rcub_dais_3547 .

Ignjatović, Nenad, Ajduković, Zorica, Rajković, Jelena, Najman, Stevo, Mihailović, Dragan, Uskoković, Dragan, "Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite" in Journal of Bionic Engineering, 12, no. 4 (2015):604-612,
https://doi.org/10.1016/S1672-6529(14)60150-5 .,
https://hdl.handle.net/21.15107/rcub_dais_3547 .