TY  - JOUR
AU  - Vukomanović, Marija
AU  - Zavašnik-Bergant, Tina
AU  - Bračko, Ines
AU  - Škapin, Srečo Davor
AU  - Ignjatović, Nenad
AU  - Radmilović, Velimir
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/14364
AB  - A step-by-step analysis of the formation and the drug loading of the poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite was carried out in a perspective of the following parameters: the structure, the morphology and the adsorption/desorption properties of the composite's bioceramic part. The authors demonstrated the importance of the material's capacity to form a fine dispersion of solid HAp particles, as an initial step, for the further loading of the drug and for the formation of the core–shell structures. The nanometer-sized rods of HAp have the capacity of ensuring a rapid adsorption and a controlled desorption of the drug from their surface, and they can act as a nucleating site for the formation of polymeric cores. Each component of this material was labeled with fluorescence dye, which enabled an insight into the distribution of the components in the core–shells that were obtained as the final outcome. Such an analysis showed a high level of uniformity among the cores enclosed within polymeric shells. From a practical perspective, the labeling of each component of the composite can be regarded as an additional functionality of the material: labeling can enable us to monitor its action during the healing process. This ability to be easily detected is expected to enhance the procedure for the controlled delivery of antibiotics after their local implantation of carriers loaded with the antibiotic and to provide more careful control over this process.
PB  - Elsevier BV
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite
SP  - 226
EP  - 235
VL  - 87
IS  - 2
DO  - 10.1016/j.colsurfb.2011.05.023
UR  - https://hdl.handle.net/21.15107/rcub_dais_14364
ER  - 

@article{
author = "Vukomanović, Marija and Zavašnik-Bergant, Tina and Bračko, Ines and Škapin, Srečo Davor and Ignjatović, Nenad and Radmilović, Velimir and Uskoković, Dragan",
year = "2011",
abstract = "A step-by-step analysis of the formation and the drug loading of the poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite was carried out in a perspective of the following parameters: the structure, the morphology and the adsorption/desorption properties of the composite's bioceramic part. The authors demonstrated the importance of the material's capacity to form a fine dispersion of solid HAp particles, as an initial step, for the further loading of the drug and for the formation of the core–shell structures. The nanometer-sized rods of HAp have the capacity of ensuring a rapid adsorption and a controlled desorption of the drug from their surface, and they can act as a nucleating site for the formation of polymeric cores. Each component of this material was labeled with fluorescence dye, which enabled an insight into the distribution of the components in the core–shells that were obtained as the final outcome. Such an analysis showed a high level of uniformity among the cores enclosed within polymeric shells. From a practical perspective, the labeling of each component of the composite can be regarded as an additional functionality of the material: labeling can enable us to monitor its action during the healing process. This ability to be easily detected is expected to enhance the procedure for the controlled delivery of antibiotics after their local implantation of carriers loaded with the antibiotic and to provide more careful control over this process.",
publisher = "Elsevier BV",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite",
pages = "226-235",
volume = "87",
number = "2",
doi = "10.1016/j.colsurfb.2011.05.023",
url = "https://hdl.handle.net/21.15107/rcub_dais_14364"
}

Vukomanović, M., Zavašnik-Bergant, T., Bračko, I., Škapin, S. D., Ignjatović, N., Radmilović, V.,& Uskoković, D.. (2011). Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite. in Colloids and Surfaces B: Biointerfaces
Elsevier BV., 87(2), 226-235.
https://doi.org/10.1016/j.colsurfb.2011.05.023
https://hdl.handle.net/21.15107/rcub_dais_14364

Vukomanović M, Zavašnik-Bergant T, Bračko I, Škapin SD, Ignjatović N, Radmilović V, Uskoković D. Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite. in Colloids and Surfaces B: Biointerfaces. 2011;87(2):226-235.
doi:10.1016/j.colsurfb.2011.05.023
https://hdl.handle.net/21.15107/rcub_dais_14364 .

Vukomanović, Marija, Zavašnik-Bergant, Tina, Bračko, Ines, Škapin, Srečo Davor, Ignjatović, Nenad, Radmilović, Velimir, Uskoković, Dragan, "Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite" in Colloids and Surfaces B: Biointerfaces, 87, no. 2 (2011):226-235,
https://doi.org/10.1016/j.colsurfb.2011.05.023 .,
https://hdl.handle.net/21.15107/rcub_dais_14364 .