TY  - JOUR
AU  - Ajduković, Zorica
AU  - Najman, Stevo
AU  - Ðorđević, Lj.
AU  - Savić, Vojin
AU  - Mihailović, D.
AU  - Petrović, D.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2005
UR  - https://dais.sanu.ac.rs/123456789/14299
AB  - The aim of this study is to examine the reparatory ability of the synthetic biomaterial hydroxyapatite-poly-L-lactide (HAp-PLLA), the replacement of alveolar ridge, and rehabilitation of bone defects caused by osteoporosis, in an experimental group of animals. The experiments are performed on syngeneic Sprague Dawley rats. Osteoporosis is induced by glucocorticoids in rats during a 12-week period. After this, the experimental group of animals is divided into five subgroups. An artificial defect is made in the alveolar bone on the left side of the mandible. In one group of animals, the defect is left to heal by itself, while in other groups, pure HAp-PLLA or one mixed with plasma is implanted. The best results are achieved by the implantation of the HAp-PLLA composite biomaterial mixed with autologous plasma. Formation of a new mandibular bone is seen, growing intensely, leading to rapid osteogenesis.
PB  - SAGE Publications
T2  - Journal of Biomaterials Applications
T1  - Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) with and Without Blood Plasma
SP  - 179
EP  - 190
VL  - 20
IS  - 2
DO  - 10.1177/0885328205050519
UR  - https://hdl.handle.net/21.15107/rcub_dais_14299
ER  - 

@article{
author = "Ajduković, Zorica and Najman, Stevo and Ðorđević, Lj. and Savić, Vojin and Mihailović, D. and Petrović, D. and Ignjatović, Nenad and Uskoković, Dragan",
year = "2005",
abstract = "The aim of this study is to examine the reparatory ability of the synthetic biomaterial hydroxyapatite-poly-L-lactide (HAp-PLLA), the replacement of alveolar ridge, and rehabilitation of bone defects caused by osteoporosis, in an experimental group of animals. The experiments are performed on syngeneic Sprague Dawley rats. Osteoporosis is induced by glucocorticoids in rats during a 12-week period. After this, the experimental group of animals is divided into five subgroups. An artificial defect is made in the alveolar bone on the left side of the mandible. In one group of animals, the defect is left to heal by itself, while in other groups, pure HAp-PLLA or one mixed with plasma is implanted. The best results are achieved by the implantation of the HAp-PLLA composite biomaterial mixed with autologous plasma. Formation of a new mandibular bone is seen, growing intensely, leading to rapid osteogenesis.",
publisher = "SAGE Publications",
journal = "Journal of Biomaterials Applications",
title = "Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) with and Without Blood Plasma",
pages = "179-190",
volume = "20",
number = "2",
doi = "10.1177/0885328205050519",
url = "https://hdl.handle.net/21.15107/rcub_dais_14299"
}

Ajduković, Z., Najman, S., Ðorđević, Lj., Savić, V., Mihailović, D., Petrović, D., Ignjatović, N.,& Uskoković, D.. (2005). Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) with and Without Blood Plasma. in Journal of Biomaterials Applications
SAGE Publications., 20(2), 179-190.
https://doi.org/10.1177/0885328205050519
https://hdl.handle.net/21.15107/rcub_dais_14299

Ajduković Z, Najman S, Ðorđević L, Savić V, Mihailović D, Petrović D, Ignjatović N, Uskoković D. Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) with and Without Blood Plasma. in Journal of Biomaterials Applications. 2005;20(2):179-190.
doi:10.1177/0885328205050519
https://hdl.handle.net/21.15107/rcub_dais_14299 .

Ajduković, Zorica, Najman, Stevo, Ðorđević, Lj., Savić, Vojin, Mihailović, D., Petrović, D., Ignjatović, Nenad, Uskoković, Dragan, "Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) with and Without Blood Plasma" in Journal of Biomaterials Applications, 20, no. 2 (2005):179-190,
https://doi.org/10.1177/0885328205050519 .,
https://hdl.handle.net/21.15107/rcub_dais_14299 .

TY  - CONF
AU  - Tang, Chak Yin
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
AU  - Uskoković, Petar S.
AU  - Chan, K.C.
AU  - Lo, S.C.L.
AU  - Lee, Tai Chiu
PY  - 2004
UR  - https://dais.sanu.ac.rs/123456789/14300
AB  - This study descripts processing of biphasic calcium-phosphate (BCP) and poly-L-lactide (PLLA) biocomposite implant material. The composite was obtained by mixing completely dissolved PLLA with granules of high crystalline BCP and was compacted by hot pressing using cylindrical dies at 450 K temperature and 98.1 MPa pressure, for 30 and 60 minutes. Wide-angle Xray structural (WAXS) analyses of BCP, PLLA and BCP/PLLA composite blocks were made followed by calorimetric (DSC) tests in the 320-520 K temperature range. Compression tests revealed that Young’s modulus and compressive strength of the composite increased with extended hot pressing time and were found to be within the bounds of the cortical bone values.
PB  - Trans Tech Publications, Ltd.
C3  - Advances in Materials Manufacturing Science and Technology
T1  - Processing and Mechanical Properties of Biphasic Calcium-Phosphate/Poly-L-Lactide Composite Biomaterials
SP  - 273
EP  - 277
DO  - 10.4028/www.scientific.net/MSF.471-472.273
UR  - https://hdl.handle.net/21.15107/rcub_dais_14300
ER  - 

@conference{
author = "Tang, Chak Yin and Ignjatović, Nenad and Uskoković, Dragan and Uskoković, Petar S. and Chan, K.C. and Lo, S.C.L. and Lee, Tai Chiu",
year = "2004",
abstract = "This study descripts processing of biphasic calcium-phosphate (BCP) and poly-L-lactide (PLLA) biocomposite implant material. The composite was obtained by mixing completely dissolved PLLA with granules of high crystalline BCP and was compacted by hot pressing using cylindrical dies at 450 K temperature and 98.1 MPa pressure, for 30 and 60 minutes. Wide-angle Xray structural (WAXS) analyses of BCP, PLLA and BCP/PLLA composite blocks were made followed by calorimetric (DSC) tests in the 320-520 K temperature range. Compression tests revealed that Young’s modulus and compressive strength of the composite increased with extended hot pressing time and were found to be within the bounds of the cortical bone values.",
publisher = "Trans Tech Publications, Ltd.",
journal = "Advances in Materials Manufacturing Science and Technology",
title = "Processing and Mechanical Properties of Biphasic Calcium-Phosphate/Poly-L-Lactide Composite Biomaterials",
pages = "273-277",
doi = "10.4028/www.scientific.net/MSF.471-472.273",
url = "https://hdl.handle.net/21.15107/rcub_dais_14300"
}

Tang, C. Y., Ignjatović, N., Uskoković, D., Uskoković, P. S., Chan, K.C., Lo, S.C.L.,& Lee, T. C.. (2004). Processing and Mechanical Properties of Biphasic Calcium-Phosphate/Poly-L-Lactide Composite Biomaterials. in Advances in Materials Manufacturing Science and Technology
Trans Tech Publications, Ltd.., 273-277.
https://doi.org/10.4028/www.scientific.net/MSF.471-472.273
https://hdl.handle.net/21.15107/rcub_dais_14300

Tang CY, Ignjatović N, Uskoković D, Uskoković PS, Chan K, Lo S, Lee TC. Processing and Mechanical Properties of Biphasic Calcium-Phosphate/Poly-L-Lactide Composite Biomaterials. in Advances in Materials Manufacturing Science and Technology. 2004;:273-277.
doi:10.4028/www.scientific.net/MSF.471-472.273
https://hdl.handle.net/21.15107/rcub_dais_14300 .

Tang, Chak Yin, Ignjatović, Nenad, Uskoković, Dragan, Uskoković, Petar S., Chan, K.C., Lo, S.C.L., Lee, Tai Chiu, "Processing and Mechanical Properties of Biphasic Calcium-Phosphate/Poly-L-Lactide Composite Biomaterials" in Advances in Materials Manufacturing Science and Technology (2004):273-277,
https://doi.org/10.4028/www.scientific.net/MSF.471-472.273 .,
https://hdl.handle.net/21.15107/rcub_dais_14300 .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Suljovrujić, Edin H.
AU  - Budinski-Simendić, Jaroslava K.
AU  - Krakovsky, Ivan
AU  - Uskoković, Dragan
PY  - 2004
UR  - https://dais.sanu.ac.rs/123456789/2744
AB  - Hydroxyapatite/poly-L-lactide (HAp/PLLA) is a ceramic/polymer composite, whose application as a resorbable biomaterial for the substitution and repair of hard bone tissue is widely promising in orthopedic, oral, maxillofacial, and reconstructive surgery. Hot processing is a necessary step for obtaining HAp/PLLA composite blocks with mechanical properties similar to those of bones. In this article, the changes in structure and physicochemical properties of HAp/PLLA composite, hot pressed for different pressing times (5, 15, 30, 45, and 60 min), were studied. Because the morphology of HAp/PLLA composite biomaterial is very sensitive to this procedure, its surface microstructure was analyzed by scanning electron microscopy (SEM) coupled with an energy-dispersive X-ray (EDX) detector system. Structural changes occurring in the material, mostly changes in crystallinity of PLLA, were studied by wide-angle X-ray structural analyses (WAXS) and infrared (FTIR) spectroscopy. Using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and gel permeation chromatography (GPC), the influence of hot pressing on the properties, crystallization kinetics, and decomposition of HAp/PLLA composite biomaterial was analyzed. (C) 2004 Wiley Periodicals, Inc.
T2  - Journal of Biomedical Materials Research. Part B: Applied Biomaterials
T1  - Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics
SP  - 284
EP  - 294
VL  - 71B
IS  - 2
DO  - 10.1002/jbm.b.30093
UR  - https://hdl.handle.net/21.15107/rcub_dais_2744
ER  - 

@article{
author = "Ignjatović, Nenad and Suljovrujić, Edin H. and Budinski-Simendić, Jaroslava K. and Krakovsky, Ivan and Uskoković, Dragan",
year = "2004",
abstract = "Hydroxyapatite/poly-L-lactide (HAp/PLLA) is a ceramic/polymer composite, whose application as a resorbable biomaterial for the substitution and repair of hard bone tissue is widely promising in orthopedic, oral, maxillofacial, and reconstructive surgery. Hot processing is a necessary step for obtaining HAp/PLLA composite blocks with mechanical properties similar to those of bones. In this article, the changes in structure and physicochemical properties of HAp/PLLA composite, hot pressed for different pressing times (5, 15, 30, 45, and 60 min), were studied. Because the morphology of HAp/PLLA composite biomaterial is very sensitive to this procedure, its surface microstructure was analyzed by scanning electron microscopy (SEM) coupled with an energy-dispersive X-ray (EDX) detector system. Structural changes occurring in the material, mostly changes in crystallinity of PLLA, were studied by wide-angle X-ray structural analyses (WAXS) and infrared (FTIR) spectroscopy. Using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and gel permeation chromatography (GPC), the influence of hot pressing on the properties, crystallization kinetics, and decomposition of HAp/PLLA composite biomaterial was analyzed. (C) 2004 Wiley Periodicals, Inc.",
journal = "Journal of Biomedical Materials Research. Part B: Applied Biomaterials",
title = "Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics",
pages = "284-294",
volume = "71B",
number = "2",
doi = "10.1002/jbm.b.30093",
url = "https://hdl.handle.net/21.15107/rcub_dais_2744"
}

Ignjatović, N., Suljovrujić, E. H., Budinski-Simendić, J. K., Krakovsky, I.,& Uskoković, D.. (2004). Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics. in Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 71B(2), 284-294.
https://doi.org/10.1002/jbm.b.30093
https://hdl.handle.net/21.15107/rcub_dais_2744

Ignjatović N, Suljovrujić EH, Budinski-Simendić JK, Krakovsky I, Uskoković D. Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics. in Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 2004;71B(2):284-294.
doi:10.1002/jbm.b.30093
https://hdl.handle.net/21.15107/rcub_dais_2744 .

Ignjatović, Nenad, Suljovrujić, Edin H., Budinski-Simendić, Jaroslava K., Krakovsky, Ivan, Uskoković, Dragan, "Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics" in Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 71B, no. 2 (2004):284-294,
https://doi.org/10.1002/jbm.b.30093 .,
https://hdl.handle.net/21.15107/rcub_dais_2744 .