Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200003 (Institute for Medicinal Plant Research 'Dr. Josif Pančić ', Belgrade)

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200003 (Institute for Medicinal Plant Research 'Dr. Josif Pančić ', Belgrade) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200003 (Institut za proučavanje lekovitog bilja 'Dr Josif Pančić', Beograd) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200003 (Институт за проучавање лековитог биља 'Др Јосиф Панчић', Београд) (sr)
Authors

Publications

Dissolving and water absorption ability of spray-dried willow gentian extract

Jovanović, Miloš; Ćujić Nikolić, Nada; Drinić, Zorica; Janković, Teodora; Marković, Smilja; Šavikin, Katarina

(Belgrade : Institute of Technical Sciences of SASA, 2021)

TY  - CONF
AU  - Jovanović, Miloš
AU  - Ćujić Nikolić, Nada
AU  - Drinić, Zorica
AU  - Janković, Teodora
AU  - Marković, Smilja
AU  - Šavikin, Katarina
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/12289
AB  - Roots of the willow gentian (Gentiana asclepiadea L., Gentianaceae) are used in folk medicine to treat gastrointestinal diseases.Spray drying is the most commonly used technique for microencapsulation of plant extracts in the pharmaceutical, cosmetic and food industries. The choosing of suitable carriers is one of the critical points in the development of microencapsulated powder with the desired physicochemical properties.The extract of the willow gentian roots was spray-dried using different carriers (maltodextrin (MD) and whey protein (WP)at concentrations of 20, 40, and 60%; pectin (P), starch (S), and gelatin (G) at concentrations of 2.5, 5, and 7.5%).The aim of this study was to examine the ability of the obtained powdersto dissolveand absorb water.For this purpose, the values of water solubility (WSI) and water absorption index (WAI) were determined.WSI is a measure of the powder degradation and dissolving in water, while WAI represents an indicator of water absorption ability. It is desirable that instant tea powders show high WSI and low WAI values.WSI values ranged from 71.15% (7.5% P) to 91.94% (7.5% G) indicating good powder disintegration properties. Concentration-dependent decrease in WSI values was observed for WP, P and S, while the opposite trend was observed in the case of MD.The carrier-free powdershowed relatively low WAI value (13.32%). Powders with 20% MD and 5% S showed slightly lower WAI values (12.77 and 12.72%, respectively). On the other hand, powders with 5 and 7.5% P showed remarkably high WAI values of 91.59 and 91.49%, respectively. A concentration-dependent increase in WAI was observed in powders encapsulated withMD and WP.All encapsulated powders showed acceptable disintegration properties (high WSI), while in terms of water absorption (low WAI) powders with 20% MD and 5% S were the most suitable.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia
T1  - Dissolving and water absorption ability of spray-dried willow gentian extract
SP  - 16
EP  - 16
UR  - https://hdl.handle.net/21.15107/rcub_dais_12289
ER  - 
@conference{
author = "Jovanović, Miloš and Ćujić Nikolić, Nada and Drinić, Zorica and Janković, Teodora and Marković, Smilja and Šavikin, Katarina",
year = "2021",
abstract = "Roots of the willow gentian (Gentiana asclepiadea L., Gentianaceae) are used in folk medicine to treat gastrointestinal diseases.Spray drying is the most commonly used technique for microencapsulation of plant extracts in the pharmaceutical, cosmetic and food industries. The choosing of suitable carriers is one of the critical points in the development of microencapsulated powder with the desired physicochemical properties.The extract of the willow gentian roots was spray-dried using different carriers (maltodextrin (MD) and whey protein (WP)at concentrations of 20, 40, and 60%; pectin (P), starch (S), and gelatin (G) at concentrations of 2.5, 5, and 7.5%).The aim of this study was to examine the ability of the obtained powdersto dissolveand absorb water.For this purpose, the values of water solubility (WSI) and water absorption index (WAI) were determined.WSI is a measure of the powder degradation and dissolving in water, while WAI represents an indicator of water absorption ability. It is desirable that instant tea powders show high WSI and low WAI values.WSI values ranged from 71.15% (7.5% P) to 91.94% (7.5% G) indicating good powder disintegration properties. Concentration-dependent decrease in WSI values was observed for WP, P and S, while the opposite trend was observed in the case of MD.The carrier-free powdershowed relatively low WAI value (13.32%). Powders with 20% MD and 5% S showed slightly lower WAI values (12.77 and 12.72%, respectively). On the other hand, powders with 5 and 7.5% P showed remarkably high WAI values of 91.59 and 91.49%, respectively. A concentration-dependent increase in WAI was observed in powders encapsulated withMD and WP.All encapsulated powders showed acceptable disintegration properties (high WSI), while in terms of water absorption (low WAI) powders with 20% MD and 5% S were the most suitable.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia",
title = "Dissolving and water absorption ability of spray-dried willow gentian extract",
pages = "16-16",
url = "https://hdl.handle.net/21.15107/rcub_dais_12289"
}
Jovanović, M., Ćujić Nikolić, N., Drinić, Z., Janković, T., Marković, S.,& Šavikin, K.. (2021). Dissolving and water absorption ability of spray-dried willow gentian extract. in Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 16-16.
https://hdl.handle.net/21.15107/rcub_dais_12289
Jovanović M, Ćujić Nikolić N, Drinić Z, Janković T, Marković S, Šavikin K. Dissolving and water absorption ability of spray-dried willow gentian extract. in Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia. 2021;:16-16.
https://hdl.handle.net/21.15107/rcub_dais_12289 .
Jovanović, Miloš, Ćujić Nikolić, Nada, Drinić, Zorica, Janković, Teodora, Marković, Smilja, Šavikin, Katarina, "Dissolving and water absorption ability of spray-dried willow gentian extract" in Program and the Book of abstracts / Nineteenth Young Researchers' Conference Materials Science and Engineering, December 1-3, 2021, Belgrade, Serbia (2021):16-16,
https://hdl.handle.net/21.15107/rcub_dais_12289 .

Freeze vs. Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material

Jovanović, Aleksandra A.; Lević, Steva M.; Pavlović, Vladimir B.; Marković, Smilja B.; Pjanović, Rada V.; Đorđević, Verica B.; Nedović, Viktor; Bugarski, Branko M.

(Basel : MDPI AG, 2021)

TY  - JOUR
AU  - Jovanović, Aleksandra A.
AU  - Lević, Steva M.
AU  - Pavlović, Vladimir B.
AU  - Marković, Smilja B.
AU  - Pjanović, Rada V.
AU  - Đorđević, Verica B.
AU  - Nedović, Viktor
AU  - Bugarski, Branko M.
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/11798
AB  - Freeze drying was compared with spray drying regarding feasibility to process wild thyme drugs in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration and heat-, ultrasound-, and microwave-assisted extractions. Higher total powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher total powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53–75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation was distinguished from the others by a higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process mainly affected the position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray-dried formulations compared to freeze-dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and a higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151–223 µm) compared to small microspheres (~8 µm) in spray-dried powder.
PB  - Basel : MDPI AG
T2  - Molecules
T1  - Freeze vs. Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material
SP  - 3933
VL  - 26
IS  - 13
DO  - 10.3390/molecules26133933
UR  - https://hdl.handle.net/21.15107/rcub_dais_11798
ER  - 
@article{
author = "Jovanović, Aleksandra A. and Lević, Steva M. and Pavlović, Vladimir B. and Marković, Smilja B. and Pjanović, Rada V. and Đorđević, Verica B. and Nedović, Viktor and Bugarski, Branko M.",
year = "2021",
abstract = "Freeze drying was compared with spray drying regarding feasibility to process wild thyme drugs in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration and heat-, ultrasound-, and microwave-assisted extractions. Higher total powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher total powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53–75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation was distinguished from the others by a higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process mainly affected the position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray-dried formulations compared to freeze-dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and a higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151–223 µm) compared to small microspheres (~8 µm) in spray-dried powder.",
publisher = "Basel : MDPI AG",
journal = "Molecules",
title = "Freeze vs. Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material",
pages = "3933",
volume = "26",
number = "13",
doi = "10.3390/molecules26133933",
url = "https://hdl.handle.net/21.15107/rcub_dais_11798"
}
Jovanović, A. A., Lević, S. M., Pavlović, V. B., Marković, S. B., Pjanović, R. V., Đorđević, V. B., Nedović, V.,& Bugarski, B. M.. (2021). Freeze vs. Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material. in Molecules
Basel : MDPI AG., 26(13), 3933.
https://doi.org/10.3390/molecules26133933
https://hdl.handle.net/21.15107/rcub_dais_11798
Jovanović AA, Lević SM, Pavlović VB, Marković SB, Pjanović RV, Đorđević VB, Nedović V, Bugarski BM. Freeze vs. Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material. in Molecules. 2021;26(13):3933.
doi:10.3390/molecules26133933
https://hdl.handle.net/21.15107/rcub_dais_11798 .
Jovanović, Aleksandra A., Lević, Steva M., Pavlović, Vladimir B., Marković, Smilja B., Pjanović, Rada V., Đorđević, Verica B., Nedović, Viktor, Bugarski, Branko M., "Freeze vs. Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material" in Molecules, 26, no. 13 (2021):3933,
https://doi.org/10.3390/molecules26133933 .,
https://hdl.handle.net/21.15107/rcub_dais_11798 .
2
1
2

Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material

Jovanović, Aleksandra A.; Lević, Steva; Pavlović, Vladimir B.; Marković, Smilja; Pjanović, Rada; Đorđević, Verica B.; Nedović, Viktor; Bugarski, Branko

(2021)

TY  - GEN
AU  - Jovanović, Aleksandra A.
AU  - Lević, Steva
AU  - Pavlović, Vladimir B.
AU  - Marković, Smilja
AU  - Pjanović, Rada
AU  - Đorđević, Verica B.
AU  - Nedović, Viktor
AU  - Bugarski, Branko
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/11637
AB  - Freeze drying was compared with spray drying regarding feasibility to process wild thyme drug in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration, heat-, ultrasound-, and microwave-assisted extractions. Higher powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation distinguished from others by higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process affected mainly position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray dried formulations compared to freeze dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 µm) compared to small microspheres (~8 µm) in spray-dried powder.
T2  - Preprints
T1  - Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material
DO  - 10.20944/preprints202105.0358.v1
UR  - https://hdl.handle.net/21.15107/rcub_dais_11637
ER  - 
@misc{
author = "Jovanović, Aleksandra A. and Lević, Steva and Pavlović, Vladimir B. and Marković, Smilja and Pjanović, Rada and Đorđević, Verica B. and Nedović, Viktor and Bugarski, Branko",
year = "2021",
abstract = "Freeze drying was compared with spray drying regarding feasibility to process wild thyme drug in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration, heat-, ultrasound-, and microwave-assisted extractions. Higher powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation distinguished from others by higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process affected mainly position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray dried formulations compared to freeze dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 µm) compared to small microspheres (~8 µm) in spray-dried powder.",
journal = "Preprints",
title = "Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material",
doi = "10.20944/preprints202105.0358.v1",
url = "https://hdl.handle.net/21.15107/rcub_dais_11637"
}
Jovanović, A. A., Lević, S., Pavlović, V. B., Marković, S., Pjanović, R., Đorđević, V. B., Nedović, V.,& Bugarski, B.. (2021). Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material. in Preprints.
https://doi.org/10.20944/preprints202105.0358.v1
https://hdl.handle.net/21.15107/rcub_dais_11637
Jovanović AA, Lević S, Pavlović VB, Marković S, Pjanović R, Đorđević VB, Nedović V, Bugarski B. Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material. in Preprints. 2021;.
doi:10.20944/preprints202105.0358.v1
https://hdl.handle.net/21.15107/rcub_dais_11637 .
Jovanović, Aleksandra A., Lević, Steva, Pavlović, Vladimir B., Marković, Smilja, Pjanović, Rada, Đorđević, Verica B., Nedović, Viktor, Bugarski, Branko, "Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material" in Preprints (2021),
https://doi.org/10.20944/preprints202105.0358.v1 .,
https://hdl.handle.net/21.15107/rcub_dais_11637 .
1