TY  - JOUR
AU  - Milićević, Dejan S.
AU  - Trifunović, Saša B.
AU  - Mudrinić, Tihana M.
AU  - Leskovac, Andreja
AU  - Ignjatović, Nenad
AU  - Dojčilović, Jablan R.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/2756
AB  - U ovom radu ispitivan je uticaj gama zračenja na molekulsku masu i staklasti prelaz poli-L-laktida (PLLA). S obzirom da je PLLA pri izlaganju visokoenergijskom zračenju sklon kidanju lanaca i velikoj degradaciji, promene u molekulskoj masi su određene primenom gel propusne hromatografije (GPC). Radijaciono-indukovane promene u staklastom prelazu su ispitane pomoću diferencijalno skenirajuće kalorimetrije (DSC). Prividna aktivaciona energija za staklasti prelaz, ΔH*, određena je na osnovu zavisnosti temperature staklastog prelaza, Tg, od brzine zagrevanja. Kidanje lanaca, uzrokovano zračenjem, glavni je razlog opadanja Tg i ΔH*sa apsorbovanom dozom. Izazvane promene u molekulskoj masi i temperaturi staklastog prelaza odigravaju se na predvidljiv i prilično precizan način. Stoga, gama zračenje može biti korišćeno ne samo za sterilizaciju nego i za dobijanje ovog biomaterijala poželjnih karakteristika.
AB  - The influence of gamma radiation on the structure and glass transition behaviour of poly-L-lactide (PLLA) has been studied. Since PLLA exposed to high-energy radiation in the presence of air is prone to chain scission reactions and large degradation, changes in molecular weight were obtained by the gel permeation chromatography (GPC). Alterations in the glass transition behaviour were investigated by differential scanning calorimetry (DSC). The apparent activation energy, Delta H*, for the glass transition was determined on the basis of the heating rate dependence of the glass transition temperature, T(g). Our findings support the fact that chain scission is the main reason for the decrease of Tg and Delta H* with the absorbed dose. At low doses, despite large changes in molecular weight, only small alterations are observed in the glass transition temperature and apparent activation energy. Further increase in the absorbed dose introduces not only significant changes in the molecular weight but also in the glass transition temperature and the activation energy. Such glass transition behaviour is a manifestation of a well-known effect of molecular weight on Tg, postulated by the Fox-Flory equation. However, all the observed alterations are small and tolerable at absorbed doses required for sterilization (up to 25 kGy in most circumstances). Furthermore, this study reveals that the radiation-induced changes in the molecular weight and the glass transition temperature occur in a predictable and fairly accurate manner. Therefore, gamma radiation can be used not only for sterilization but also for tailoring desirable end-use properties of PLLA based implants.
T2  - Hemijska industrija
T1  - Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA
SP  - 275
EP  - 281
VL  - 64
IS  - 4
DO  - 10.2298/HEMIND100329020M
UR  - https://hdl.handle.net/21.15107/rcub_dais_2756
ER  - 

@article{
author = "Milićević, Dejan S. and Trifunović, Saša B. and Mudrinić, Tihana M. and Leskovac, Andreja and Ignjatović, Nenad and Dojčilović, Jablan R. and Suljovrujić, Edin H.",
year = "2010",
abstract = "U ovom radu ispitivan je uticaj gama zračenja na molekulsku masu i staklasti prelaz poli-L-laktida (PLLA). S obzirom da je PLLA pri izlaganju visokoenergijskom zračenju sklon kidanju lanaca i velikoj degradaciji, promene u molekulskoj masi su određene primenom gel propusne hromatografije (GPC). Radijaciono-indukovane promene u staklastom prelazu su ispitane pomoću diferencijalno skenirajuće kalorimetrije (DSC). Prividna aktivaciona energija za staklasti prelaz, ΔH*, određena je na osnovu zavisnosti temperature staklastog prelaza, Tg, od brzine zagrevanja. Kidanje lanaca, uzrokovano zračenjem, glavni je razlog opadanja Tg i ΔH*sa apsorbovanom dozom. Izazvane promene u molekulskoj masi i temperaturi staklastog prelaza odigravaju se na predvidljiv i prilično precizan način. Stoga, gama zračenje može biti korišćeno ne samo za sterilizaciju nego i za dobijanje ovog biomaterijala poželjnih karakteristika., The influence of gamma radiation on the structure and glass transition behaviour of poly-L-lactide (PLLA) has been studied. Since PLLA exposed to high-energy radiation in the presence of air is prone to chain scission reactions and large degradation, changes in molecular weight were obtained by the gel permeation chromatography (GPC). Alterations in the glass transition behaviour were investigated by differential scanning calorimetry (DSC). The apparent activation energy, Delta H*, for the glass transition was determined on the basis of the heating rate dependence of the glass transition temperature, T(g). Our findings support the fact that chain scission is the main reason for the decrease of Tg and Delta H* with the absorbed dose. At low doses, despite large changes in molecular weight, only small alterations are observed in the glass transition temperature and apparent activation energy. Further increase in the absorbed dose introduces not only significant changes in the molecular weight but also in the glass transition temperature and the activation energy. Such glass transition behaviour is a manifestation of a well-known effect of molecular weight on Tg, postulated by the Fox-Flory equation. However, all the observed alterations are small and tolerable at absorbed doses required for sterilization (up to 25 kGy in most circumstances). Furthermore, this study reveals that the radiation-induced changes in the molecular weight and the glass transition temperature occur in a predictable and fairly accurate manner. Therefore, gamma radiation can be used not only for sterilization but also for tailoring desirable end-use properties of PLLA based implants.",
journal = "Hemijska industrija",
title = "Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA",
pages = "275-281",
volume = "64",
number = "4",
doi = "10.2298/HEMIND100329020M",
url = "https://hdl.handle.net/21.15107/rcub_dais_2756"
}

Milićević, D. S., Trifunović, S. B., Mudrinić, T. M., Leskovac, A., Ignjatović, N., Dojčilović, J. R.,& Suljovrujić, E. H.. (2010). Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA. in Hemijska industrija, 64(4), 275-281.
https://doi.org/10.2298/HEMIND100329020M
https://hdl.handle.net/21.15107/rcub_dais_2756

Milićević DS, Trifunović SB, Mudrinić TM, Leskovac A, Ignjatović N, Dojčilović JR, Suljovrujić EH. Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA. in Hemijska industrija. 2010;64(4):275-281.
doi:10.2298/HEMIND100329020M
https://hdl.handle.net/21.15107/rcub_dais_2756 .

Milićević, Dejan S., Trifunović, Saša B., Mudrinić, Tihana M., Leskovac, Andreja, Ignjatović, Nenad, Dojčilović, Jablan R., Suljovrujić, Edin H., "Uticaj gama zračenja na molekulsku masu i staklasti prelaz PLLA" in Hemijska industrija, 64, no. 4 (2010):275-281,
https://doi.org/10.2298/HEMIND100329020M .,
https://hdl.handle.net/21.15107/rcub_dais_2756 .

TY  - JOUR
AU  - Milićević, Dejan S.
AU  - Trifunović, S.
AU  - Dojčilović, Jablan R.
AU  - Ignjatović, Nenad
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/2755
AB  - The influence of gamma radiation on the molecular weight and glass transition behaviour of poly-L-lactide (PLLA) and hydroxyapatite/poly-L-lactide (HAp/PLLA) nanocomposite has been studied Since PLLA exposed to high-energy radiation in the presence of air is prone to chain scission reactions and large degradation, changes in molecular weight were obtained by gel permeation chromatography (GPC). Alterations in the glass transition behaviour were investigated by differential scanning calorimetry (DSC) The apparent activation energy (Delta H*) for glass transition was determined on the basis of the heating rate dependence of the glass transition temperature (T-g). Our findings support the fact that chain scission is the main reason for the decrease of T-g and Delta H* with the absorbed dose Furthermore, more intensive chain scission degradation of PLLA was observed in HAp/PLLA and can only be ascribed to the presence of HAp nanoparticles. Consequently, initial differences in the glass transition temperature and/or apparent activation energy of PLLA and HAp/PLLA became more pronounced with absorbed dose. This study reveals that radiation-induced changes in molecular weight and glass transition temperature occur in a predictable and fairly accurate manner Therefore, gamma radiation can be used not only for sterilization but also for tailoring desirable end-use properties of these biomaterials (C) 2010 Elsevier B V. All rights reserved
T2  - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
T1  - The influence of gamma radiation on the molecular weight and glass transition of PLLA and HAp/PLLA nanocomposite
SP  - 2744
EP  - 2749
VL  - 268
IS  - 17-18
DO  - 10.1016/j.nimb.2010.06.036
UR  - https://hdl.handle.net/21.15107/rcub_dais_2755
ER  - 

@article{
author = "Milićević, Dejan S. and Trifunović, S. and Dojčilović, Jablan R. and Ignjatović, Nenad and Suljovrujić, Edin H.",
year = "2010",
abstract = "The influence of gamma radiation on the molecular weight and glass transition behaviour of poly-L-lactide (PLLA) and hydroxyapatite/poly-L-lactide (HAp/PLLA) nanocomposite has been studied Since PLLA exposed to high-energy radiation in the presence of air is prone to chain scission reactions and large degradation, changes in molecular weight were obtained by gel permeation chromatography (GPC). Alterations in the glass transition behaviour were investigated by differential scanning calorimetry (DSC) The apparent activation energy (Delta H*) for glass transition was determined on the basis of the heating rate dependence of the glass transition temperature (T-g). Our findings support the fact that chain scission is the main reason for the decrease of T-g and Delta H* with the absorbed dose Furthermore, more intensive chain scission degradation of PLLA was observed in HAp/PLLA and can only be ascribed to the presence of HAp nanoparticles. Consequently, initial differences in the glass transition temperature and/or apparent activation energy of PLLA and HAp/PLLA became more pronounced with absorbed dose. This study reveals that radiation-induced changes in molecular weight and glass transition temperature occur in a predictable and fairly accurate manner Therefore, gamma radiation can be used not only for sterilization but also for tailoring desirable end-use properties of these biomaterials (C) 2010 Elsevier B V. All rights reserved",
journal = "Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms",
title = "The influence of gamma radiation on the molecular weight and glass transition of PLLA and HAp/PLLA nanocomposite",
pages = "2744-2749",
volume = "268",
number = "17-18",
doi = "10.1016/j.nimb.2010.06.036",
url = "https://hdl.handle.net/21.15107/rcub_dais_2755"
}

Milićević, D. S., Trifunović, S., Dojčilović, J. R., Ignjatović, N.,& Suljovrujić, E. H.. (2010). The influence of gamma radiation on the molecular weight and glass transition of PLLA and HAp/PLLA nanocomposite. in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 268(17-18), 2744-2749.
https://doi.org/10.1016/j.nimb.2010.06.036
https://hdl.handle.net/21.15107/rcub_dais_2755

Milićević DS, Trifunović S, Dojčilović JR, Ignjatović N, Suljovrujić EH. The influence of gamma radiation on the molecular weight and glass transition of PLLA and HAp/PLLA nanocomposite. in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. 2010;268(17-18):2744-2749.
doi:10.1016/j.nimb.2010.06.036
https://hdl.handle.net/21.15107/rcub_dais_2755 .

Milićević, Dejan S., Trifunović, S., Dojčilović, Jablan R., Ignjatović, Nenad, Suljovrujić, Edin H., "The influence of gamma radiation on the molecular weight and glass transition of PLLA and HAp/PLLA nanocomposite" in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 268, no. 17-18 (2010):2744-2749,
https://doi.org/10.1016/j.nimb.2010.06.036 .,
https://hdl.handle.net/21.15107/rcub_dais_2755 .

TY  - CONF
AU  - Milićević, Dejan S.
AU  - Trifunović, S.
AU  - Ignjatović, Nenad
AU  - Suljovrujić, Edin H.
PY  - 2007
UR  - https://dais.sanu.ac.rs/123456789/2754
AB  - Hydroxyapatite/poly L-lactide (HAp/PLLA) is a composite biomaterial which has been widely utilized for substitution and reparation of the hard bone tissue. It is well known that gamma irradiation has been successfully employed in the modification/sterilization of such porous composites and that it has advantages over other procedures. In this study, differential scanning calorimetry (DSC) measurements were made to investigate the influence of the radiation on glass transition behavior and structural relaxation, as well as to estimate the activation energy for this process. The apparent activation energy Delta H* for structural relaxation in the glass transition region was determined on the basis of the heating rate dependence of the glass transition temperature T-g. Furthermore, the results were correlated with those obtained by gel permeation chromatography (GPC). Our findings support the fact that the radiation-induced chain scission in the PLLA phase is the main reason for the decrease of the glass transition temperature and/or activation energy with the absorbed dose.
PB  - Trans Tech Publications, Ltd.
C3  - Research Trends in Contemporary Materials Science
T1  - The influence of gamma radiation on the glass transition of hydroxyapatite/poly L-lactide composite
SP  - 497
EP  - 502
VL  - 555
DO  - 10.4028/www.scientific.net/MSF.555.497
UR  - https://hdl.handle.net/21.15107/rcub_dais_2754
ER  - 

@conference{
author = "Milićević, Dejan S. and Trifunović, S. and Ignjatović, Nenad and Suljovrujić, Edin H.",
year = "2007",
abstract = "Hydroxyapatite/poly L-lactide (HAp/PLLA) is a composite biomaterial which has been widely utilized for substitution and reparation of the hard bone tissue. It is well known that gamma irradiation has been successfully employed in the modification/sterilization of such porous composites and that it has advantages over other procedures. In this study, differential scanning calorimetry (DSC) measurements were made to investigate the influence of the radiation on glass transition behavior and structural relaxation, as well as to estimate the activation energy for this process. The apparent activation energy Delta H* for structural relaxation in the glass transition region was determined on the basis of the heating rate dependence of the glass transition temperature T-g. Furthermore, the results were correlated with those obtained by gel permeation chromatography (GPC). Our findings support the fact that the radiation-induced chain scission in the PLLA phase is the main reason for the decrease of the glass transition temperature and/or activation energy with the absorbed dose.",
publisher = "Trans Tech Publications, Ltd.",
journal = "Research Trends in Contemporary Materials Science",
title = "The influence of gamma radiation on the glass transition of hydroxyapatite/poly L-lactide composite",
pages = "497-502",
volume = "555",
doi = "10.4028/www.scientific.net/MSF.555.497",
url = "https://hdl.handle.net/21.15107/rcub_dais_2754"
}

Milićević, D. S., Trifunović, S., Ignjatović, N.,& Suljovrujić, E. H.. (2007). The influence of gamma radiation on the glass transition of hydroxyapatite/poly L-lactide composite. in Research Trends in Contemporary Materials Science
Trans Tech Publications, Ltd.., 555, 497-502.
https://doi.org/10.4028/www.scientific.net/MSF.555.497
https://hdl.handle.net/21.15107/rcub_dais_2754

Milićević DS, Trifunović S, Ignjatović N, Suljovrujić EH. The influence of gamma radiation on the glass transition of hydroxyapatite/poly L-lactide composite. in Research Trends in Contemporary Materials Science. 2007;555:497-502.
doi:10.4028/www.scientific.net/MSF.555.497
https://hdl.handle.net/21.15107/rcub_dais_2754 .

Milićević, Dejan S., Trifunović, S., Ignjatović, Nenad, Suljovrujić, Edin H., "The influence of gamma radiation on the glass transition of hydroxyapatite/poly L-lactide composite" in Research Trends in Contemporary Materials Science, 555 (2007):497-502,
https://doi.org/10.4028/www.scientific.net/MSF.555.497 .,
https://hdl.handle.net/21.15107/rcub_dais_2754 .

TY  - JOUR
AU  - Suljovrujić, Edin H.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
AU  - Mitrić, Miodrag
AU  - Mitrovic, M.
AU  - Tomić, Simonida
PY  - 2007
UR  - https://dais.sanu.ac.rs/123456789/2752
AB  - The effects of gamma irradiation on the structure and properties of hydroxyapatite/poly L-lactide (HAp/PLLA) biomaterial have been investigated. Effects of radiation on microstructure, degradation of polymer part and thermal stability of composite were determined by scanning electronic microscopy (SEM), gel permeation chromatography (GPC) and thermogravimetric analysis (TGA), respectively. Mechanical properties were obtained through mechanical strength and elasticity modulus. Presented results show that properties of HAp/PLLA decay with irradiation dose, but for doses required for sterilization, changes and damaging effects are acceptable. (C) 2006 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial
SP  - 722
EP  - 728
VL  - 76
IS  - 4
DO  - 10.1016/j.radphyschem.2006.02.013
UR  - https://hdl.handle.net/21.15107/rcub_dais_2752
ER  - 

@article{
author = "Suljovrujić, Edin H. and Ignjatović, Nenad and Uskoković, Dragan and Mitrić, Miodrag and Mitrovic, M. and Tomić, Simonida",
year = "2007",
abstract = "The effects of gamma irradiation on the structure and properties of hydroxyapatite/poly L-lactide (HAp/PLLA) biomaterial have been investigated. Effects of radiation on microstructure, degradation of polymer part and thermal stability of composite were determined by scanning electronic microscopy (SEM), gel permeation chromatography (GPC) and thermogravimetric analysis (TGA), respectively. Mechanical properties were obtained through mechanical strength and elasticity modulus. Presented results show that properties of HAp/PLLA decay with irradiation dose, but for doses required for sterilization, changes and damaging effects are acceptable. (C) 2006 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial",
pages = "722-728",
volume = "76",
number = "4",
doi = "10.1016/j.radphyschem.2006.02.013",
url = "https://hdl.handle.net/21.15107/rcub_dais_2752"
}

Suljovrujić, E. H., Ignjatović, N., Uskoković, D., Mitrić, M., Mitrovic, M.,& Tomić, S.. (2007). Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial. in Radiation Physics and Chemistry, 76(4), 722-728.
https://doi.org/10.1016/j.radphyschem.2006.02.013
https://hdl.handle.net/21.15107/rcub_dais_2752

Suljovrujić EH, Ignjatović N, Uskoković D, Mitrić M, Mitrovic M, Tomić S. Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial. in Radiation Physics and Chemistry. 2007;76(4):722-728.
doi:10.1016/j.radphyschem.2006.02.013
https://hdl.handle.net/21.15107/rcub_dais_2752 .

Suljovrujić, Edin H., Ignjatović, Nenad, Uskoković, Dragan, Mitrić, Miodrag, Mitrovic, M., Tomić, Simonida, "Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial" in Radiation Physics and Chemistry, 76, no. 4 (2007):722-728,
https://doi.org/10.1016/j.radphyschem.2006.02.013 .,
https://hdl.handle.net/21.15107/rcub_dais_2752 .

TY  - JOUR
AU  - Nikčević, Irena
AU  - Maravić, Dubravka
AU  - Ignjatović, Nenad
AU  - Mitrić, Miodrag
AU  - Suljovrujić, Edin
AU  - Makovec, Darko
AU  - Cvjetićanin, Nikola
AU  - Uskoković, Dragan
PY  - 2004
UR  - https://dais.sanu.ac.rs/123456789/14743
AB  - Promena strukture i osobina biokompozitnog materijala HAp/PLLA tokom mehano­hemijskog tretmana predmet su analize u ovom radu. Smeša HAp/PLLA uparena je u vakuumu i zatim podvrgnuta suvom mlevenju u planetarnom mlinu do 480 minuta. Korišćene su rendgenostrukturna analiza (XRD), diferencijalna skanirajuća kalorimetrija (DSC), skenirajuća elektronska mikroskopija (SEM) transmisiona elektronska mikroskopija (TEM) i infracrvena spektroskopija (IR) za karakterizaciju dobijenog materijala. Na osnovu prime­njenih analiza utvđen je uticaj mehanohemijskog tretmana na promene kompozitnog biomaterijala. U najvećoj meri dolazi do smanjenja kristaliničnosti poli-L-laktida(PLLA) i smanjenja veličine kristalita hidroksiapatita (HAp). Sa povećanjem vremena mehano­hemijskog tretmana dobija se homogena raspodela faza.
AB  - Mechanochemically treated hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial undergoes significant changes in structure and properties. These were the subject of the analysis presented in this paper. HAp/PLLA mixture was evaporated in vacuum and then subjected to dry milling in a planetary ball mill for 480 minutes. Characterization of the material obtained was carried out using X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electronic microscopy (SEM), transmission electronic microscopy (TEM) and infrared spectroscopy (IR). These techniques confirmed that mechanochemical treatment induces changes in the composite biomaterial. The most significant changes are reduction of PLLA crystallinity and size of HAp crystalites. Homogeneous phase arrangenment is obtained by extending the duration of mechanochemical treatment.
T2  - Tehnika - Novi materijali
T1  - Uticaj mehanohemijskog tretmana na strukturne promene u kompozitu hidroksiapatit/poli-l-laktid
SP  - 5
EP  - 12
VL  - 13
IS  - 2
UR  - https://hdl.handle.net/21.15107/rcub_dais_14743
ER  - 

@article{
author = "Nikčević, Irena and Maravić, Dubravka and Ignjatović, Nenad and Mitrić, Miodrag and Suljovrujić, Edin and Makovec, Darko and Cvjetićanin, Nikola and Uskoković, Dragan",
year = "2004",
abstract = "Promena strukture i osobina biokompozitnog materijala HAp/PLLA tokom mehano­hemijskog tretmana predmet su analize u ovom radu. Smeša HAp/PLLA uparena je u vakuumu i zatim podvrgnuta suvom mlevenju u planetarnom mlinu do 480 minuta. Korišćene su rendgenostrukturna analiza (XRD), diferencijalna skanirajuća kalorimetrija (DSC), skenirajuća elektronska mikroskopija (SEM) transmisiona elektronska mikroskopija (TEM) i infracrvena spektroskopija (IR) za karakterizaciju dobijenog materijala. Na osnovu prime­njenih analiza utvđen je uticaj mehanohemijskog tretmana na promene kompozitnog biomaterijala. U najvećoj meri dolazi do smanjenja kristaliničnosti poli-L-laktida(PLLA) i smanjenja veličine kristalita hidroksiapatita (HAp). Sa povećanjem vremena mehano­hemijskog tretmana dobija se homogena raspodela faza., Mechanochemically treated hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial undergoes significant changes in structure and properties. These were the subject of the analysis presented in this paper. HAp/PLLA mixture was evaporated in vacuum and then subjected to dry milling in a planetary ball mill for 480 minutes. Characterization of the material obtained was carried out using X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electronic microscopy (SEM), transmission electronic microscopy (TEM) and infrared spectroscopy (IR). These techniques confirmed that mechanochemical treatment induces changes in the composite biomaterial. The most significant changes are reduction of PLLA crystallinity and size of HAp crystalites. Homogeneous phase arrangenment is obtained by extending the duration of mechanochemical treatment.",
journal = "Tehnika - Novi materijali",
title = "Uticaj mehanohemijskog tretmana na strukturne promene u kompozitu hidroksiapatit/poli-l-laktid",
pages = "5-12",
volume = "13",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_dais_14743"
}

Nikčević, I., Maravić, D., Ignjatović, N., Mitrić, M., Suljovrujić, E., Makovec, D., Cvjetićanin, N.,& Uskoković, D.. (2004). Uticaj mehanohemijskog tretmana na strukturne promene u kompozitu hidroksiapatit/poli-l-laktid. in Tehnika - Novi materijali, 13(2), 5-12.
https://hdl.handle.net/21.15107/rcub_dais_14743

Nikčević I, Maravić D, Ignjatović N, Mitrić M, Suljovrujić E, Makovec D, Cvjetićanin N, Uskoković D. Uticaj mehanohemijskog tretmana na strukturne promene u kompozitu hidroksiapatit/poli-l-laktid. in Tehnika - Novi materijali. 2004;13(2):5-12.
https://hdl.handle.net/21.15107/rcub_dais_14743 .

Nikčević, Irena, Maravić, Dubravka, Ignjatović, Nenad, Mitrić, Miodrag, Suljovrujić, Edin, Makovec, Darko, Cvjetićanin, Nikola, Uskoković, Dragan, "Uticaj mehanohemijskog tretmana na strukturne promene u kompozitu hidroksiapatit/poli-l-laktid" in Tehnika - Novi materijali, 13, no. 2 (2004):5-12,
https://hdl.handle.net/21.15107/rcub_dais_14743 .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Suljovrujić, Edin H.
AU  - Budinski-Simendić, Jaroslava K.
AU  - Krakovsky, Ivan
AU  - Uskoković, Dragan
PY  - 2004
UR  - https://dais.sanu.ac.rs/123456789/2744
AB  - Hydroxyapatite/poly-L-lactide (HAp/PLLA) is a ceramic/polymer composite, whose application as a resorbable biomaterial for the substitution and repair of hard bone tissue is widely promising in orthopedic, oral, maxillofacial, and reconstructive surgery. Hot processing is a necessary step for obtaining HAp/PLLA composite blocks with mechanical properties similar to those of bones. In this article, the changes in structure and physicochemical properties of HAp/PLLA composite, hot pressed for different pressing times (5, 15, 30, 45, and 60 min), were studied. Because the morphology of HAp/PLLA composite biomaterial is very sensitive to this procedure, its surface microstructure was analyzed by scanning electron microscopy (SEM) coupled with an energy-dispersive X-ray (EDX) detector system. Structural changes occurring in the material, mostly changes in crystallinity of PLLA, were studied by wide-angle X-ray structural analyses (WAXS) and infrared (FTIR) spectroscopy. Using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and gel permeation chromatography (GPC), the influence of hot pressing on the properties, crystallization kinetics, and decomposition of HAp/PLLA composite biomaterial was analyzed. (C) 2004 Wiley Periodicals, Inc.
T2  - Journal of Biomedical Materials Research. Part B: Applied Biomaterials
T1  - Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics
SP  - 284
EP  - 294
VL  - 71B
IS  - 2
DO  - 10.1002/jbm.b.30093
UR  - https://hdl.handle.net/21.15107/rcub_dais_2744
ER  - 

@article{
author = "Ignjatović, Nenad and Suljovrujić, Edin H. and Budinski-Simendić, Jaroslava K. and Krakovsky, Ivan and Uskoković, Dragan",
year = "2004",
abstract = "Hydroxyapatite/poly-L-lactide (HAp/PLLA) is a ceramic/polymer composite, whose application as a resorbable biomaterial for the substitution and repair of hard bone tissue is widely promising in orthopedic, oral, maxillofacial, and reconstructive surgery. Hot processing is a necessary step for obtaining HAp/PLLA composite blocks with mechanical properties similar to those of bones. In this article, the changes in structure and physicochemical properties of HAp/PLLA composite, hot pressed for different pressing times (5, 15, 30, 45, and 60 min), were studied. Because the morphology of HAp/PLLA composite biomaterial is very sensitive to this procedure, its surface microstructure was analyzed by scanning electron microscopy (SEM) coupled with an energy-dispersive X-ray (EDX) detector system. Structural changes occurring in the material, mostly changes in crystallinity of PLLA, were studied by wide-angle X-ray structural analyses (WAXS) and infrared (FTIR) spectroscopy. Using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and gel permeation chromatography (GPC), the influence of hot pressing on the properties, crystallization kinetics, and decomposition of HAp/PLLA composite biomaterial was analyzed. (C) 2004 Wiley Periodicals, Inc.",
journal = "Journal of Biomedical Materials Research. Part B: Applied Biomaterials",
title = "Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics",
pages = "284-294",
volume = "71B",
number = "2",
doi = "10.1002/jbm.b.30093",
url = "https://hdl.handle.net/21.15107/rcub_dais_2744"
}

Ignjatović, N., Suljovrujić, E. H., Budinski-Simendić, J. K., Krakovsky, I.,& Uskoković, D.. (2004). Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics. in Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 71B(2), 284-294.
https://doi.org/10.1002/jbm.b.30093
https://hdl.handle.net/21.15107/rcub_dais_2744

Ignjatović N, Suljovrujić EH, Budinski-Simendić JK, Krakovsky I, Uskoković D. Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics. in Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 2004;71B(2):284-294.
doi:10.1002/jbm.b.30093
https://hdl.handle.net/21.15107/rcub_dais_2744 .

Ignjatović, Nenad, Suljovrujić, Edin H., Budinski-Simendić, Jaroslava K., Krakovsky, Ivan, Uskoković, Dragan, "Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics" in Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 71B, no. 2 (2004):284-294,
https://doi.org/10.1002/jbm.b.30093 .,
https://hdl.handle.net/21.15107/rcub_dais_2744 .

TY  - CONF
AU  - Jovanović, Jelena
AU  - Adnađević, Borivoj
AU  - Suljovrujić, Edin H.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2003
UR  - https://dais.sanu.ac.rs/123456789/2746
AB  - Injectable and gas-permeable composite cements, polydimethylsiloxane/hydroxyapatite (PDMS/HAp), were synthesized using bi-component polysiloxane precursors (RTV-A and RTV-B), which react by hydrosilylation, and different mass fractions of hydroxyapatite (HAp) having particle size of about 100 nm. The effect of HAp mass fraction (0-60%) on the thermodynamic and kinetic parameters of polysiloxanes cross-linking, i.e., PDMS/HAp composite preparation, was investigated by means of differential scanning calorimetry (DSC). It was determined that small mass fractions of HAp (up to about 10%) cause a decrease in temperature (T-max), and activation energy (E-a) of the investigated cross-linking process, while the total heat of the process (H-tot) increases. For the HAp mass fraction greater than 20%, an opposite effect was observed. The temperature and the time interval of cross-linking increase rapidly for smaller, but slowly, almost insignificantly, for larger HAp mass fractions. The determined order (n) of the reaction shows a trend similar to H-tot, but due to small variations found, this does not merit discussion.
C3  - Contemporary Studies in Advanced Materials and Processes, 4th Yugoslav-Materials-Research-Society Conference, Sep 10-14, 2001, Herceg Novi, Yugoslavia
T1  - Influence of the HAp ratio on the thermodynamic and kinetic parameters of PDMS/HAp composites cross-linking
SP  - 263
EP  - 268
DO  - 10.4028/www.scientific.net/MSF.413.263
UR  - https://hdl.handle.net/21.15107/rcub_dais_2746
ER  - 

@conference{
author = "Jovanović, Jelena and Adnađević, Borivoj and Suljovrujić, Edin H. and Ignjatović, Nenad and Uskoković, Dragan",
year = "2003",
abstract = "Injectable and gas-permeable composite cements, polydimethylsiloxane/hydroxyapatite (PDMS/HAp), were synthesized using bi-component polysiloxane precursors (RTV-A and RTV-B), which react by hydrosilylation, and different mass fractions of hydroxyapatite (HAp) having particle size of about 100 nm. The effect of HAp mass fraction (0-60%) on the thermodynamic and kinetic parameters of polysiloxanes cross-linking, i.e., PDMS/HAp composite preparation, was investigated by means of differential scanning calorimetry (DSC). It was determined that small mass fractions of HAp (up to about 10%) cause a decrease in temperature (T-max), and activation energy (E-a) of the investigated cross-linking process, while the total heat of the process (H-tot) increases. For the HAp mass fraction greater than 20%, an opposite effect was observed. The temperature and the time interval of cross-linking increase rapidly for smaller, but slowly, almost insignificantly, for larger HAp mass fractions. The determined order (n) of the reaction shows a trend similar to H-tot, but due to small variations found, this does not merit discussion.",
journal = "Contemporary Studies in Advanced Materials and Processes, 4th Yugoslav-Materials-Research-Society Conference, Sep 10-14, 2001, Herceg Novi, Yugoslavia",
title = "Influence of the HAp ratio on the thermodynamic and kinetic parameters of PDMS/HAp composites cross-linking",
pages = "263-268",
doi = "10.4028/www.scientific.net/MSF.413.263",
url = "https://hdl.handle.net/21.15107/rcub_dais_2746"
}

Jovanović, J., Adnađević, B., Suljovrujić, E. H., Ignjatović, N.,& Uskoković, D.. (2003). Influence of the HAp ratio on the thermodynamic and kinetic parameters of PDMS/HAp composites cross-linking. in Contemporary Studies in Advanced Materials and Processes, 4th Yugoslav-Materials-Research-Society Conference, Sep 10-14, 2001, Herceg Novi, Yugoslavia, 263-268.
https://doi.org/10.4028/www.scientific.net/MSF.413.263
https://hdl.handle.net/21.15107/rcub_dais_2746

Jovanović J, Adnađević B, Suljovrujić EH, Ignjatović N, Uskoković D. Influence of the HAp ratio on the thermodynamic and kinetic parameters of PDMS/HAp composites cross-linking. in Contemporary Studies in Advanced Materials and Processes, 4th Yugoslav-Materials-Research-Society Conference, Sep 10-14, 2001, Herceg Novi, Yugoslavia. 2003;:263-268.
doi:10.4028/www.scientific.net/MSF.413.263
https://hdl.handle.net/21.15107/rcub_dais_2746 .

Jovanović, Jelena, Adnađević, Borivoj, Suljovrujić, Edin H., Ignjatović, Nenad, Uskoković, Dragan, "Influence of the HAp ratio on the thermodynamic and kinetic parameters of PDMS/HAp composites cross-linking" in Contemporary Studies in Advanced Materials and Processes, 4th Yugoslav-Materials-Research-Society Conference, Sep 10-14, 2001, Herceg Novi, Yugoslavia (2003):263-268,
https://doi.org/10.4028/www.scientific.net/MSF.413.263 .,
https://hdl.handle.net/21.15107/rcub_dais_2746 .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Jovanovic, Jelena
AU  - Suljovrujić, Edin H.
AU  - Uskoković, Dragan
PY  - 2003
UR  - https://dais.sanu.ac.rs/123456789/2748
AB  - An injectable polydimethylsiloxane/hydroxyapatite (PDMS/HAp) composite cement was synthesised using linear PDMS and HAp (particles of about 100 nm in size) of different mass fractions. The effect of HAp mass fraction (5-60 mass%) on the hardness of PDMS/HAp composite cement was investigated. The hardness achieved is 25-49degreesShA. Differential scanning calorimetry (DSC) was used to study the cross-linking process and the influence of HAp on the temperature and duration of PDMS/HAp cross-linking. The microstructure of composite cement surfaces after 10 days in vivo tests was observed by scanning electron microscopy (SEM). The presence of well-adhered macrophages, fibroblasts and monocytes was found on the implant surface upon its extraction from the organism.
T2  - Bio-Medical Materials and Engineering
T1  - Injectable polydimethylsiloxane-hydroxyapatite composite cement
SP  - 401
EP  - 410
VL  - 13
IS  - 4
UR  - https://hdl.handle.net/21.15107/rcub_dais_2748
ER  - 

@article{
author = "Ignjatović, Nenad and Jovanovic, Jelena and Suljovrujić, Edin H. and Uskoković, Dragan",
year = "2003",
abstract = "An injectable polydimethylsiloxane/hydroxyapatite (PDMS/HAp) composite cement was synthesised using linear PDMS and HAp (particles of about 100 nm in size) of different mass fractions. The effect of HAp mass fraction (5-60 mass%) on the hardness of PDMS/HAp composite cement was investigated. The hardness achieved is 25-49degreesShA. Differential scanning calorimetry (DSC) was used to study the cross-linking process and the influence of HAp on the temperature and duration of PDMS/HAp cross-linking. The microstructure of composite cement surfaces after 10 days in vivo tests was observed by scanning electron microscopy (SEM). The presence of well-adhered macrophages, fibroblasts and monocytes was found on the implant surface upon its extraction from the organism.",
journal = "Bio-Medical Materials and Engineering",
title = "Injectable polydimethylsiloxane-hydroxyapatite composite cement",
pages = "401-410",
volume = "13",
number = "4",
url = "https://hdl.handle.net/21.15107/rcub_dais_2748"
}

Ignjatović, N., Jovanovic, J., Suljovrujić, E. H.,& Uskoković, D.. (2003). Injectable polydimethylsiloxane-hydroxyapatite composite cement. in Bio-Medical Materials and Engineering, 13(4), 401-410.
https://hdl.handle.net/21.15107/rcub_dais_2748

Ignjatović N, Jovanovic J, Suljovrujić EH, Uskoković D. Injectable polydimethylsiloxane-hydroxyapatite composite cement. in Bio-Medical Materials and Engineering. 2003;13(4):401-410.
https://hdl.handle.net/21.15107/rcub_dais_2748 .

Ignjatović, Nenad, Jovanovic, Jelena, Suljovrujić, Edin H., Uskoković, Dragan, "Injectable polydimethylsiloxane-hydroxyapatite composite cement" in Bio-Medical Materials and Engineering, 13, no. 4 (2003):401-410,
https://hdl.handle.net/21.15107/rcub_dais_2748 .

TY  - JOUR
AU  - Suljovrujić, Edin H.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2003
UR  - https://dais.sanu.ac.rs/123456789/2745
AB  - Effects of gamma irradiation on structure and physicochemical properties of the hydroxyapatite/poly-L-lactide (HAp/PLLA) composite were studied in this paper. Since the morphology of HAp/PLLA is very sensitive to gamma irradiation, surface microstructure was analyzed by scanning electron microscopy. Structural changes occurring in the material, mostly changes in PLLA which is more sensitive to irradiation than HAp, were studied by wide angle X-ray structural analyses and infrared spectroscopy. Differential scanning calorimetry measurements were used to study the changes in thermal behavior and crystallinity. Conclusions derived according to different methods were compared. (C) 2003 Elsevier Science Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Gamma irradiation processing of hydroxyapatite/poly-L-lactide composite biomaterial
SP  - 375
EP  - 379
VL  - 67
IS  - 3-4
DO  - 10.1016/S0969-806X(03)00070-7
UR  - https://hdl.handle.net/21.15107/rcub_dais_2745
ER  - 

@article{
author = "Suljovrujić, Edin H. and Ignjatović, Nenad and Uskoković, Dragan",
year = "2003",
abstract = "Effects of gamma irradiation on structure and physicochemical properties of the hydroxyapatite/poly-L-lactide (HAp/PLLA) composite were studied in this paper. Since the morphology of HAp/PLLA is very sensitive to gamma irradiation, surface microstructure was analyzed by scanning electron microscopy. Structural changes occurring in the material, mostly changes in PLLA which is more sensitive to irradiation than HAp, were studied by wide angle X-ray structural analyses and infrared spectroscopy. Differential scanning calorimetry measurements were used to study the changes in thermal behavior and crystallinity. Conclusions derived according to different methods were compared. (C) 2003 Elsevier Science Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Gamma irradiation processing of hydroxyapatite/poly-L-lactide composite biomaterial",
pages = "375-379",
volume = "67",
number = "3-4",
doi = "10.1016/S0969-806X(03)00070-7",
url = "https://hdl.handle.net/21.15107/rcub_dais_2745"
}

Suljovrujić, E. H., Ignjatović, N.,& Uskoković, D.. (2003). Gamma irradiation processing of hydroxyapatite/poly-L-lactide composite biomaterial. in Radiation Physics and Chemistry, 67(3-4), 375-379.
https://doi.org/10.1016/S0969-806X(03)00070-7
https://hdl.handle.net/21.15107/rcub_dais_2745

Suljovrujić EH, Ignjatović N, Uskoković D. Gamma irradiation processing of hydroxyapatite/poly-L-lactide composite biomaterial. in Radiation Physics and Chemistry. 2003;67(3-4):375-379.
doi:10.1016/S0969-806X(03)00070-7
https://hdl.handle.net/21.15107/rcub_dais_2745 .

Suljovrujić, Edin H., Ignjatović, Nenad, Uskoković, Dragan, "Gamma irradiation processing of hydroxyapatite/poly-L-lactide composite biomaterial" in Radiation Physics and Chemistry, 67, no. 3-4 (2003):375-379,
https://doi.org/10.1016/S0969-806X(03)00070-7 .,
https://hdl.handle.net/21.15107/rcub_dais_2745 .

TY  - JOUR
AU  - Ignjatović, Nenad
AU  - Suljovrujić, Edin H.
AU  - Stojanović, Z.
AU  - Uskoković, Dragan
PY  - 2002
UR  - https://dais.sanu.ac.rs/123456789/234
AB  - Hydroxyapatite/poly-L-lactide (HAp/PLL) composite biomaterial can be obtained by different processing methods. Three-dimensional blocks of HAp/PLLA composite biomaterial with mechanical characteristics close to the natural bone tissue can be obtained by hot pressing procedure. Effects of synthesis and compacting on the structure and characteristics of the HAp/PLLA composite biomaterial were studied in this work. Using wade angle X-ray structural analyses (WAXS), differentially scanning calorimetry (DSC), thermogravimetric analysis (TGA) and infrared (IR) spectroscopy, the changes occurring in the material during synthesis and hot pressing were monitored. Surface microstructure was analyzed by scanning electronic microscopy (SEM) coupled with electron-dispersion analysis (EDX). The results obtained indicate a possible decrease in the degree of crystallinity with hot pressing time increase. A block of HAp/PLLA composite biomaterial with 1.6 times lower crystallinity of the polymer phase was obtained by hot pressing in a given time interval with a maximum of 60 minutes. Results of TG analysis show that PLLA stability decreases with increasing hot pressing time, and vice versa. IR study proved that neither destructive changes in constituents nor formation of new phases occurred during hot pressing.
PB  - Belgrade : International Institute for the Science of Sintering
T2  - Science of Sintering
T1  - Structure and characteristics of the hot pressed hydroxyapatite/poly-L-lactide composite
SP  - 79
EP  - 93
VL  - 34
IS  - 1
DO  - 10.2298/SOS0201079I
UR  - https://hdl.handle.net/21.15107/rcub_dais_234
ER  - 

@article{
author = "Ignjatović, Nenad and Suljovrujić, Edin H. and Stojanović, Z. and Uskoković, Dragan",
year = "2002",
abstract = "Hydroxyapatite/poly-L-lactide (HAp/PLL) composite biomaterial can be obtained by different processing methods. Three-dimensional blocks of HAp/PLLA composite biomaterial with mechanical characteristics close to the natural bone tissue can be obtained by hot pressing procedure. Effects of synthesis and compacting on the structure and characteristics of the HAp/PLLA composite biomaterial were studied in this work. Using wade angle X-ray structural analyses (WAXS), differentially scanning calorimetry (DSC), thermogravimetric analysis (TGA) and infrared (IR) spectroscopy, the changes occurring in the material during synthesis and hot pressing were monitored. Surface microstructure was analyzed by scanning electronic microscopy (SEM) coupled with electron-dispersion analysis (EDX). The results obtained indicate a possible decrease in the degree of crystallinity with hot pressing time increase. A block of HAp/PLLA composite biomaterial with 1.6 times lower crystallinity of the polymer phase was obtained by hot pressing in a given time interval with a maximum of 60 minutes. Results of TG analysis show that PLLA stability decreases with increasing hot pressing time, and vice versa. IR study proved that neither destructive changes in constituents nor formation of new phases occurred during hot pressing.",
publisher = "Belgrade : International Institute for the Science of Sintering",
journal = "Science of Sintering",
title = "Structure and characteristics of the hot pressed hydroxyapatite/poly-L-lactide composite",
pages = "79-93",
volume = "34",
number = "1",
doi = "10.2298/SOS0201079I",
url = "https://hdl.handle.net/21.15107/rcub_dais_234"
}

Ignjatović, N., Suljovrujić, E. H., Stojanović, Z.,& Uskoković, D.. (2002). Structure and characteristics of the hot pressed hydroxyapatite/poly-L-lactide composite. in Science of Sintering
Belgrade : International Institute for the Science of Sintering., 34(1), 79-93.
https://doi.org/10.2298/SOS0201079I
https://hdl.handle.net/21.15107/rcub_dais_234

Ignjatović N, Suljovrujić EH, Stojanović Z, Uskoković D. Structure and characteristics of the hot pressed hydroxyapatite/poly-L-lactide composite. in Science of Sintering. 2002;34(1):79-93.
doi:10.2298/SOS0201079I
https://hdl.handle.net/21.15107/rcub_dais_234 .

Ignjatović, Nenad, Suljovrujić, Edin H., Stojanović, Z., Uskoković, Dragan, "Structure and characteristics of the hot pressed hydroxyapatite/poly-L-lactide composite" in Science of Sintering, 34, no. 1 (2002):79-93,
https://doi.org/10.2298/SOS0201079I .,
https://hdl.handle.net/21.15107/rcub_dais_234 .