TY  - CONF
AU  - Najman, Stevo
AU  - Petrović, Dragan
AU  - Vučković, I.
AU  - Živković, Jelena M.
AU  - Stojanović, S.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2013
UR  - https://dais.sanu.ac.rs/123456789/400
AB  - The aim of this study was to investigate the osteogenic potential of freshly isolated adipose tissue-derived mesenchymal stromal/stem cells (ASCs) in bone regeneration of rabbit calvaria defects. ASCs were applied together with calcium phosphate-poly-DL-lactide-co-glycolide (CPPLGA) nanoparticles that are mixed in an appropriately prepared blood clot (BC). Parallelly were analysed defects filled with fragmented adipose tissue (FAT) instead of ASCs, with CP-PLGA in BC, and only with nanoparticles. Bone density in defects was measured after I, III and VI weeks, and histological examination was done after IV and VIII weeks after filling defects. Approach to assisted osteoregeneration which is based on the use of fresh non-induced ASCs has proven to be promising due to the favorable effect on bone regeneration and simplicity of their application.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
T1  - Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles
SP  - 45
EP  - 45
UR  - https://hdl.handle.net/21.15107/rcub_dais_400
ER  - 

@conference{
author = "Najman, Stevo and Petrović, Dragan and Vučković, I. and Živković, Jelena M. and Stojanović, S. and Ignjatović, Nenad and Uskoković, Dragan",
year = "2013",
abstract = "The aim of this study was to investigate the osteogenic potential of freshly isolated adipose tissue-derived mesenchymal stromal/stem cells (ASCs) in bone regeneration of rabbit calvaria defects. ASCs were applied together with calcium phosphate-poly-DL-lactide-co-glycolide (CPPLGA) nanoparticles that are mixed in an appropriately prepared blood clot (BC). Parallelly were analysed defects filled with fragmented adipose tissue (FAT) instead of ASCs, with CP-PLGA in BC, and only with nanoparticles. Bone density in defects was measured after I, III and VI weeks, and histological examination was done after IV and VIII weeks after filling defects. Approach to assisted osteoregeneration which is based on the use of fresh non-induced ASCs has proven to be promising due to the favorable effect on bone regeneration and simplicity of their application.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts",
title = "Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles",
pages = "45-45",
url = "https://hdl.handle.net/21.15107/rcub_dais_400"
}

Najman, S., Petrović, D., Vučković, I., Živković, J. M., Stojanović, S., Ignjatović, N.,& Uskoković, D.. (2013). Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 45-45.
https://hdl.handle.net/21.15107/rcub_dais_400

Najman S, Petrović D, Vučković I, Živković JM, Stojanović S, Ignjatović N, Uskoković D. Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles. in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts. 2013;:45-45.
https://hdl.handle.net/21.15107/rcub_dais_400 .

Najman, Stevo, Petrović, Dragan, Vučković, I., Živković, Jelena M., Stojanović, S., Ignjatović, Nenad, Uskoković, Dragan, "Osteogenic potential of freshly isolated cells of adiposederived mesenchymal fraction applied with nanoparticles" in The Fifteenth Annual Conference YUCOMAT 2013: Programme and the Book of Abstracts (2013):45-45,
https://hdl.handle.net/21.15107/rcub_dais_400 .

TY  - JOUR
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad
AU  - Petrović, Dragan
AU  - Uskoković, Dragan
PY  - 2007
UR  - https://dais.sanu.ac.rs/123456789/14366
AB  - Lost bone tissue due to osteoporosis makes dentistry very difficult. The aim of thisstudy is to reconstruct the bone tissue with composite biomaterials and to estimate the optical density and alveolar ridge height of the mandible. Research is conducted on 30 postmenopausal women aged from 46 to 62 years, with diagnosed osteoporosis and defects in alveolar bones caused by extraction of paradontopathic teeth, enucleation of cysts and periapical changes, extraction of impacted teeth,or by trauma.Biphasic calcium phosphate/poly-DL-lactide-co-glycolide (BCP/PLGA) composite is implanted into the defects of alveolar bones. Six weeks after implantation of BCP/PLGA, the alveolar bone density in the region of premolars on the experimental side of the jaw is found to be lower than that on the untreated, control, side of the jaw. On thecontrary, 24 weeks after implantation, it is significantly higher compared with the density of the control side. A significant increase in optical density of alveolar bones in the region of premolars on the experimental side compared with the control one is noticed. These results indicate a high level of osteoregeneration and osteoblast activity. Synthetic BCP/PLGA composite belongs to the group of biomaterials, which facilitate formation of new bones and rehabilitation of alveolar bones weakened by osteoporosis. Because of its osteoconductive characteristics, BCP/PLGA composite is supposed to be the material of choice for replacement of bone tissue in the future.
PB  - SAGE Publications
T2  - Journal of Biomaterials Applications
T1  - Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium                 Phosphate/Poly-DL-lactide-co-glycolide Biomaterials
SP  - 317
EP  - 328
VL  - 21
IS  - 3
DO  - 10.1177/0885328207073760
UR  - https://hdl.handle.net/21.15107/rcub_dais_14366
ER  - 

@article{
author = "Ajduković, Zorica and Ignjatović, Nenad and Petrović, Dragan and Uskoković, Dragan",
year = "2007",
abstract = "Lost bone tissue due to osteoporosis makes dentistry very difficult. The aim of thisstudy is to reconstruct the bone tissue with composite biomaterials and to estimate the optical density and alveolar ridge height of the mandible. Research is conducted on 30 postmenopausal women aged from 46 to 62 years, with diagnosed osteoporosis and defects in alveolar bones caused by extraction of paradontopathic teeth, enucleation of cysts and periapical changes, extraction of impacted teeth,or by trauma.Biphasic calcium phosphate/poly-DL-lactide-co-glycolide (BCP/PLGA) composite is implanted into the defects of alveolar bones. Six weeks after implantation of BCP/PLGA, the alveolar bone density in the region of premolars on the experimental side of the jaw is found to be lower than that on the untreated, control, side of the jaw. On thecontrary, 24 weeks after implantation, it is significantly higher compared with the density of the control side. A significant increase in optical density of alveolar bones in the region of premolars on the experimental side compared with the control one is noticed. These results indicate a high level of osteoregeneration and osteoblast activity. Synthetic BCP/PLGA composite belongs to the group of biomaterials, which facilitate formation of new bones and rehabilitation of alveolar bones weakened by osteoporosis. Because of its osteoconductive characteristics, BCP/PLGA composite is supposed to be the material of choice for replacement of bone tissue in the future.",
publisher = "SAGE Publications",
journal = "Journal of Biomaterials Applications",
title = "Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium                 Phosphate/Poly-DL-lactide-co-glycolide Biomaterials",
pages = "317-328",
volume = "21",
number = "3",
doi = "10.1177/0885328207073760",
url = "https://hdl.handle.net/21.15107/rcub_dais_14366"
}

Ajduković, Z., Ignjatović, N., Petrović, D.,& Uskoković, D.. (2007). Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium                 Phosphate/Poly-DL-lactide-co-glycolide Biomaterials. in Journal of Biomaterials Applications
SAGE Publications., 21(3), 317-328.
https://doi.org/10.1177/0885328207073760
https://hdl.handle.net/21.15107/rcub_dais_14366

Ajduković Z, Ignjatović N, Petrović D, Uskoković D. Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium                 Phosphate/Poly-DL-lactide-co-glycolide Biomaterials. in Journal of Biomaterials Applications. 2007;21(3):317-328.
doi:10.1177/0885328207073760
https://hdl.handle.net/21.15107/rcub_dais_14366 .

Ajduković, Zorica, Ignjatović, Nenad, Petrović, Dragan, Uskoković, Dragan, "Substitution of Osteoporotic Alveolar Bone by Biphasic Calcium                 Phosphate/Poly-DL-lactide-co-glycolide Biomaterials" in Journal of Biomaterials Applications, 21, no. 3 (2007):317-328,
https://doi.org/10.1177/0885328207073760 .,
https://hdl.handle.net/21.15107/rcub_dais_14366 .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad
AU  - Petrović, Dragan
AU  - Savić, Vesna
AU  - Kaličanin, Biljana
AU  - Anđelković, Maja
AU  - Nikolov, S.
PY  - 2007
UR  - https://dais.sanu.ac.rs/123456789/6295
AB  - Application of synthetic polymer biomaterials is very often used in biomedicine and
dentistry. That’s why the need for creating the new polymer biomaterials is more and more
obvious. Hydroxy-apatite, as a natural constituent of bone, has been already used for many years
in all segments of dentistry. In order to develop better properties, hydroxy-apatite is combined
with polymers. In this research, application of micro and nano composite biomaterials in
reconstruction of osteoporosis damaged alveolar bone of rats is analyzed. Evaluation of
regeneration of restored osteoporosis damaged alveolar bone of rats was done by
histopathological analyses. The optimal results were after 24 weeks after implantation of
calcium-phosphate/poly-D, L-lactide-co-glycolide (CP/DLPLG) composite biomaterials nano
particles in comparison to micro particles. Regeneration and reparation of damaged alveolar
bone with creation of new bone tissue which is very similar to mature bone, are much better on
the place of nano CP/DLPLG implantation. Because of its very good osteoconductive effect,
applied nano CP/DLPLG composite can totally renew lost bone tissue, so it can be the material
of choice for the alveolar bone defect rehabilitation.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007
T1  - Application analysis of micro and nano composites in restoring of bone tissue of the jaw
SP  - 178
EP  - 178
UR  - https://hdl.handle.net/21.15107/rcub_dais_6295
ER  - 

@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad and Petrović, Dragan and Savić, Vesna and Kaličanin, Biljana and Anđelković, Maja and Nikolov, S.",
year = "2007",
abstract = "Application of synthetic polymer biomaterials is very often used in biomedicine and
dentistry. That’s why the need for creating the new polymer biomaterials is more and more
obvious. Hydroxy-apatite, as a natural constituent of bone, has been already used for many years
in all segments of dentistry. In order to develop better properties, hydroxy-apatite is combined
with polymers. In this research, application of micro and nano composite biomaterials in
reconstruction of osteoporosis damaged alveolar bone of rats is analyzed. Evaluation of
regeneration of restored osteoporosis damaged alveolar bone of rats was done by
histopathological analyses. The optimal results were after 24 weeks after implantation of
calcium-phosphate/poly-D, L-lactide-co-glycolide (CP/DLPLG) composite biomaterials nano
particles in comparison to micro particles. Regeneration and reparation of damaged alveolar
bone with creation of new bone tissue which is very similar to mature bone, are much better on
the place of nano CP/DLPLG implantation. Because of its very good osteoconductive effect,
applied nano CP/DLPLG composite can totally renew lost bone tissue, so it can be the material
of choice for the alveolar bone defect rehabilitation.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007",
title = "Application analysis of micro and nano composites in restoring of bone tissue of the jaw",
pages = "178-178",
url = "https://hdl.handle.net/21.15107/rcub_dais_6295"
}

Ajduković, Z., Ignjatović, N., Petrović, D., Savić, V., Kaličanin, B., Anđelković, M.,& Nikolov, S.. (2007). Application analysis of micro and nano composites in restoring of bone tissue of the jaw. in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007
Belgrade : Institute of Technical Sciences of SASA., 178-178.
https://hdl.handle.net/21.15107/rcub_dais_6295

Ajduković Z, Ignjatović N, Petrović D, Savić V, Kaličanin B, Anđelković M, Nikolov S. Application analysis of micro and nano composites in restoring of bone tissue of the jaw. in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007. 2007;:178-178.
https://hdl.handle.net/21.15107/rcub_dais_6295 .

Ajduković, Zorica, Ignjatović, Nenad, Petrović, Dragan, Savić, Vesna, Kaličanin, Biljana, Anđelković, Maja, Nikolov, S., "Application analysis of micro and nano composites in restoring of bone tissue of the jaw" in Programme and The Book of Abstracts / Ninth Annual Conference YUCOMAT 2007, Herceg Novi, September 10-14, 2007 (2007):178-178,
https://hdl.handle.net/21.15107/rcub_dais_6295 .