TY  - DATA
AU  - Janićijević, Željko
AU  - Vujčić, Ivica
AU  - Veljović, Đorđe
AU  - Vujisić, Miloš
AU  - Radovanović, Filip
PY  - 2020
UR  - https://dais.sanu.ac.rs/123456789/6944
AB  - Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.
T2  - Radiation Physics and Chemistry
T1  - Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466
VL  - 166
UR  - https://hdl.handle.net/21.15107/rcub_dais_6944
ER  - 

@misc{
author = "Janićijević, Željko and Vujčić, Ivica and Veljović, Đorđe and Vujisić, Miloš and Radovanović, Filip",
year = "2020",
abstract = "Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.",
journal = "Radiation Physics and Chemistry",
title = "Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466",
volume = "166",
url = "https://hdl.handle.net/21.15107/rcub_dais_6944"
}

Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M.,& Radovanović, F.. (2020). Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466. in Radiation Physics and Chemistry, 166.
https://hdl.handle.net/21.15107/rcub_dais_6944

Janićijević Ž, Vujčić I, Veljović Đ, Vujisić M, Radovanović F. Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466. in Radiation Physics and Chemistry. 2020;166.
https://hdl.handle.net/21.15107/rcub_dais_6944 .

Janićijević, Željko, Vujčić, Ivica, Veljović, Đorđe, Vujisić, Miloš, Radovanović, Filip, "Supplementary data for the article: Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M., Radovanović, F., 2020. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. Radiation Physics and Chemistry 166, 108466. https://doi.org/10.1016/j.radphyschem.2019.108466" in Radiation Physics and Chemistry, 166 (2020),
https://hdl.handle.net/21.15107/rcub_dais_6944 .

TY  - JOUR
AU  - Janićijević, Željko
AU  - Vujčić, Ivica
AU  - Veljović, Đorđe
AU  - Vujisić, Miloš
AU  - Radovanović, Filip
PY  - 2020
UR  - http://www.sciencedirect.com/science/article/pii/S0969806X19301380
UR  - https://dais.sanu.ac.rs/123456789/6943
AB  - Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.
PB  - Elsevier
T2  - Radiation Physics and Chemistry
T1  - Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties
SP  - 108466
VL  - 166
DO  - 10.1016/j.radphyschem.2019.108466
UR  - https://hdl.handle.net/21.15107/rcub_dais_6943
ER  - 

@article{
author = "Janićijević, Željko and Vujčić, Ivica and Veljović, Đorđe and Vujisić, Miloš and Radovanović, Filip",
year = "2020",
abstract = "Composite hydrogels capable of controlled drug delivery via ion exchange are an interesting group of materials for the construction of implantable drug reservoirs for electrically charged drugs. In this study, we synthesized composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) (PLGA-PAA) hydrogels by sequential application of UV or gamma irradiation and traditional phase inversion. Physicochemical properties of the composite PLGA-PAA hydrogels were investigated using Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). We examined the ion exchange capacity (IEC) and swelling behavior of these materials to determine their potential as drug reservoirs. Composite PLGA-PAA hydrogel synthesized using UV irradiation (UV-PLGA-PAA) exhibited a porous microstructure with submicron-sized hydrogel-rich aggregates and homogeneous chemical composition. Swelling behavior and IEC of this material were highly reproducible. Composite PLGA-PAA hydrogels synthesized using gamma irradiation (G-PLGA-PAAs) had a less uniform microstructure with larger pores and micron-sized hydrogel-rich aggregates while exhibiting rather inhomogeneous chemical composition. These materials showed superior swelling properties, but a more variable IEC, compared to the material fabricated using UV irradiation. Results of DSC analysis showed a dose-dependent decrease in glass transition temperature for G-PLGA-PAAs indicating the effects of PLGA chain scission. Our findings indicate that gamma irradiation is a possible alternative to UV irradiation in the synthesis of composite PLGA-PAA hydrogels which can modify or control important material properties. However, the synthesis protocol using gamma irradiation should be further optimized to improve the IEC reproducibility. In our future research, we will investigate the in vitro release of charged drugs from synthesized composite PLGA-PAA hydrogels under physiological conditions.",
publisher = "Elsevier",
journal = "Radiation Physics and Chemistry",
title = "Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties",
pages = "108466",
volume = "166",
doi = "10.1016/j.radphyschem.2019.108466",
url = "https://hdl.handle.net/21.15107/rcub_dais_6943"
}

Janićijević, Ž., Vujčić, I., Veljović, Đ., Vujisić, M.,& Radovanović, F.. (2020). Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. in Radiation Physics and Chemistry
Elsevier., 166, 108466.
https://doi.org/10.1016/j.radphyschem.2019.108466
https://hdl.handle.net/21.15107/rcub_dais_6943

Janićijević Ž, Vujčić I, Veljović Đ, Vujisić M, Radovanović F. Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties. in Radiation Physics and Chemistry. 2020;166:108466.
doi:10.1016/j.radphyschem.2019.108466
https://hdl.handle.net/21.15107/rcub_dais_6943 .

Janićijević, Željko, Vujčić, Ivica, Veljović, Đorđe, Vujisić, Miloš, Radovanović, Filip, "Composite poly(DL-lactide-co-glycolide)/poly(acrylic acid) hydrogels synthesized using UV and gamma irradiation: comparison of material properties" in Radiation Physics and Chemistry, 166 (2020):108466,
https://doi.org/10.1016/j.radphyschem.2019.108466 .,
https://hdl.handle.net/21.15107/rcub_dais_6943 .

TY  - CONF
AU  - Janićijević, Željko
AU  - Vujčić, Ivica T.
AU  - Vujisić, Miloš Lj.
AU  - Radovanović, Filip
PY  - 2018
UR  - https://dais.sanu.ac.rs/123456789/4720
AB  - Composite implants comprising a biodegradable hydrophobic polymer matrix and crosslinked hydrogel with fixed ion exchange groups are promising materials for the construction of controlled drug delivery systems. Poly(lactic-co-glycolic acid)/poly(acrylic acid) (PLGA/PAA) composite implants in our study were synthesized using the sequential application of irradiation and immersion precipitation. Precursor solutions with all functional components were dispensed into a disc-shaped non-stick mold and cured either by ultraviolet (UV) or gamma irradiation. Cured disks were subsequently immersed in the phosphate buffer saline bath to finalize phase separation and solidification of the implants. The synthesized implants were characterized by FTIR-ATR and DSC, and their basic properties such as ion exchange capacity, swelling degree, and swelling kinetics were examined. Synthesis using gamma irradiation resulted in implants with similar ion exchange capacity, but the greater swelling degree and faster swelling kinetics compared to the implants prepared with UV irradiation. Gamma irradiation also resulted in altered and less homogeneous chemical composition compared to the implants synthesized with UV irradiation. Further investigations are required to determine the differences in drug release kinetics and degradation behavior of the synthesized implants.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia
T1  - Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation
SP  - 28
EP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_dais_4720
ER  - 

@conference{
author = "Janićijević, Željko and Vujčić, Ivica T. and Vujisić, Miloš Lj. and Radovanović, Filip",
year = "2018",
abstract = "Composite implants comprising a biodegradable hydrophobic polymer matrix and crosslinked hydrogel with fixed ion exchange groups are promising materials for the construction of controlled drug delivery systems. Poly(lactic-co-glycolic acid)/poly(acrylic acid) (PLGA/PAA) composite implants in our study were synthesized using the sequential application of irradiation and immersion precipitation. Precursor solutions with all functional components were dispensed into a disc-shaped non-stick mold and cured either by ultraviolet (UV) or gamma irradiation. Cured disks were subsequently immersed in the phosphate buffer saline bath to finalize phase separation and solidification of the implants. The synthesized implants were characterized by FTIR-ATR and DSC, and their basic properties such as ion exchange capacity, swelling degree, and swelling kinetics were examined. Synthesis using gamma irradiation resulted in implants with similar ion exchange capacity, but the greater swelling degree and faster swelling kinetics compared to the implants prepared with UV irradiation. Gamma irradiation also resulted in altered and less homogeneous chemical composition compared to the implants synthesized with UV irradiation. Further investigations are required to determine the differences in drug release kinetics and degradation behavior of the synthesized implants.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia",
title = "Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation",
pages = "28-28",
url = "https://hdl.handle.net/21.15107/rcub_dais_4720"
}

Janićijević, Ž., Vujčić, I. T., Vujisić, M. Lj.,& Radovanović, F.. (2018). Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation. in Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 28-28.
https://hdl.handle.net/21.15107/rcub_dais_4720

Janićijević Ž, Vujčić IT, Vujisić ML, Radovanović F. Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation. in Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia. 2018;:28-28.
https://hdl.handle.net/21.15107/rcub_dais_4720 .

Janićijević, Željko, Vujčić, Ivica T., Vujisić, Miloš Lj., Radovanović, Filip, "Comparative properties of composite poly(lactic-co-glycolic acid)/poly(acrylic acid) implants synthesized using ultraviolet and gamma irradiation" in Program and the Book of Abstracts / Seventeenth Young Researchers' Conference Materials Sciences and Engineering, December 5-7, 2018, Belgrade, Serbia (2018):28-28,
https://hdl.handle.net/21.15107/rcub_dais_4720 .