TY  - JOUR
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Poljanšek, Ida
AU  - Žagar, Ema
AU  - Kralj, Bogdan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/14363
AB  - The novel concept of a simultaneous, controlled release of a drug and a prodrug with different physico-chemical properties was applied in order to prolong the release period of antibiotics and estimate their high local concentrations, which are the necessary preconditions for the treatment of some chronic infection diseases. For this purpose poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) core–shell nanostructures were used as the carrier of clindamycin-base, as a drug, and clindamycin-2-phosphate, as a prodrug model. As a result, a two-step release was observed: the controlled release of the more soluble phosphate form and the sustained release of the less-soluble base form of clindamycin, resulting in a high overall concentration of the released drug during the period of 30 days in vitro. The HAp phase within the PLGA core–shells, applied as a drug carrier, delayed the process of the degradation of the polymer; however, the presence of the drug affected the process of degradation and this influence was the dominant factor in the control over the degradation of the polymer phase of PLGA/HAp and the consequent kinetics of the drug release.
PB  - Elsevier BV
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)
SP  - 414
EP  - 421
VL  - 82
IS  - 2
DO  - 10.1016/j.colsurfb.2010.09.012
UR  - https://hdl.handle.net/21.15107/rcub_dais_14363
ER  - 

@article{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Poljanšek, Ida and Žagar, Ema and Kralj, Bogdan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2011",
abstract = "The novel concept of a simultaneous, controlled release of a drug and a prodrug with different physico-chemical properties was applied in order to prolong the release period of antibiotics and estimate their high local concentrations, which are the necessary preconditions for the treatment of some chronic infection diseases. For this purpose poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) core–shell nanostructures were used as the carrier of clindamycin-base, as a drug, and clindamycin-2-phosphate, as a prodrug model. As a result, a two-step release was observed: the controlled release of the more soluble phosphate form and the sustained release of the less-soluble base form of clindamycin, resulting in a high overall concentration of the released drug during the period of 30 days in vitro. The HAp phase within the PLGA core–shells, applied as a drug carrier, delayed the process of the degradation of the polymer; however, the presence of the drug affected the process of degradation and this influence was the dominant factor in the control over the degradation of the polymer phase of PLGA/HAp and the consequent kinetics of the drug release.",
publisher = "Elsevier BV",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)",
pages = "414-421",
volume = "82",
number = "2",
doi = "10.1016/j.colsurfb.2010.09.012",
url = "https://hdl.handle.net/21.15107/rcub_dais_14363"
}

Vukomanović, M., Škapin, S. D., Poljanšek, I., Žagar, E., Kralj, B., Ignjatović, N.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate). in Colloids and Surfaces B: Biointerfaces
Elsevier BV., 82(2), 414-421.
https://doi.org/10.1016/j.colsurfb.2010.09.012
https://hdl.handle.net/21.15107/rcub_dais_14363

Vukomanović M, Škapin SD, Poljanšek I, Žagar E, Kralj B, Ignjatović N, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate). in Colloids and Surfaces B: Biointerfaces. 2011;82(2):414-421.
doi:10.1016/j.colsurfb.2010.09.012
https://hdl.handle.net/21.15107/rcub_dais_14363 .

Vukomanović, Marija, Škapin, Srečo Davor, Poljanšek, Ida, Žagar, Ema, Kralj, Bogdan, Ignjatović, Nenad, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)" in Colloids and Surfaces B: Biointerfaces, 82, no. 2 (2011):414-421,
https://doi.org/10.1016/j.colsurfb.2010.09.012 .,
https://hdl.handle.net/21.15107/rcub_dais_14363 .

TY  - JOUR
AU  - Vukomanović, Marija
AU  - Mitrić, Miodrag
AU  - Škapin, Srečo Davor
AU  - Žagar, Ema
AU  - Plavec, Janez
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/2747
AB  - In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Ultrasonics Sonochemistry
T1  - Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite
SP  - 902
EP  - 908
VL  - 17
IS  - 5
DO  - 10.1016/j.ultsonch.2010.01.007
UR  - https://hdl.handle.net/21.15107/rcub_dais_2747
ER  - 

@article{
author = "Vukomanović, Marija and Mitrić, Miodrag and Škapin, Srečo Davor and Žagar, Ema and Plavec, Janez and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
abstract = "In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Ultrasonics Sonochemistry",
title = "Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite",
pages = "902-908",
volume = "17",
number = "5",
doi = "10.1016/j.ultsonch.2010.01.007",
url = "https://hdl.handle.net/21.15107/rcub_dais_2747"
}

Vukomanović, M., Mitrić, M., Škapin, S. D., Žagar, E., Plavec, J., Ignjatović, N.,& Uskoković, D.. (2010). Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite. in Ultrasonics Sonochemistry, 17(5), 902-908.
https://doi.org/10.1016/j.ultsonch.2010.01.007
https://hdl.handle.net/21.15107/rcub_dais_2747

Vukomanović M, Mitrić M, Škapin SD, Žagar E, Plavec J, Ignjatović N, Uskoković D. Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite. in Ultrasonics Sonochemistry. 2010;17(5):902-908.
doi:10.1016/j.ultsonch.2010.01.007
https://hdl.handle.net/21.15107/rcub_dais_2747 .

Vukomanović, Marija, Mitrić, Miodrag, Škapin, Srečo Davor, Žagar, Ema, Plavec, Janez, Ignjatović, Nenad, Uskoković, Dragan, "Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite" in Ultrasonics Sonochemistry, 17, no. 5 (2010):902-908,
https://doi.org/10.1016/j.ultsonch.2010.01.007 .,
https://hdl.handle.net/21.15107/rcub_dais_2747 .

TY  - CONF
AU  - Jevtić, Marija
AU  - Škapin, Srečo Davor
AU  - Žagar, Ema
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2008
UR  - https://dais.sanu.ac.rs/123456789/296
AB  - Poster presented at the Women in Nano Winter School, Kranjska Gora, Slovenija, 7-9. februar 2008.
T1  - Composition, morphology and structure of DLPLG/HAp nanocomposite fabricated in the field of ultrasound
UR  - https://hdl.handle.net/21.15107/rcub_dais_296
ER  - 

@conference{
author = "Jevtić, Marija and Škapin, Srečo Davor and Žagar, Ema and Ignjatović, Nenad and Uskoković, Dragan",
year = "2008",
abstract = "Poster presented at the Women in Nano Winter School, Kranjska Gora, Slovenija, 7-9. februar 2008.",
title = "Composition, morphology and structure of DLPLG/HAp nanocomposite fabricated in the field of ultrasound",
url = "https://hdl.handle.net/21.15107/rcub_dais_296"
}

Jevtić, M., Škapin, S. D., Žagar, E., Ignjatović, N.,& Uskoković, D.. (2008). Composition, morphology and structure of DLPLG/HAp nanocomposite fabricated in the field of ultrasound. .
https://hdl.handle.net/21.15107/rcub_dais_296

Jevtić M, Škapin SD, Žagar E, Ignjatović N, Uskoković D. Composition, morphology and structure of DLPLG/HAp nanocomposite fabricated in the field of ultrasound. 2008;.
https://hdl.handle.net/21.15107/rcub_dais_296 .

Jevtić, Marija, Škapin, Srečo Davor, Žagar, Ema, Ignjatović, Nenad, Uskoković, Dragan, "Composition, morphology and structure of DLPLG/HAp nanocomposite fabricated in the field of ultrasound" (2008),
https://hdl.handle.net/21.15107/rcub_dais_296 .