TY  - JOUR
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Poljanšek, Ida
AU  - Žagar, Ema
AU  - Kralj, Bogdan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/14363
AB  - The novel concept of a simultaneous, controlled release of a drug and a prodrug with different physico-chemical properties was applied in order to prolong the release period of antibiotics and estimate their high local concentrations, which are the necessary preconditions for the treatment of some chronic infection diseases. For this purpose poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) core–shell nanostructures were used as the carrier of clindamycin-base, as a drug, and clindamycin-2-phosphate, as a prodrug model. As a result, a two-step release was observed: the controlled release of the more soluble phosphate form and the sustained release of the less-soluble base form of clindamycin, resulting in a high overall concentration of the released drug during the period of 30 days in vitro. The HAp phase within the PLGA core–shells, applied as a drug carrier, delayed the process of the degradation of the polymer; however, the presence of the drug affected the process of degradation and this influence was the dominant factor in the control over the degradation of the polymer phase of PLGA/HAp and the consequent kinetics of the drug release.
PB  - Elsevier BV
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)
SP  - 414
EP  - 421
VL  - 82
IS  - 2
DO  - 10.1016/j.colsurfb.2010.09.012
UR  - https://hdl.handle.net/21.15107/rcub_dais_14363
ER  - 

@article{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Poljanšek, Ida and Žagar, Ema and Kralj, Bogdan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2011",
abstract = "The novel concept of a simultaneous, controlled release of a drug and a prodrug with different physico-chemical properties was applied in order to prolong the release period of antibiotics and estimate their high local concentrations, which are the necessary preconditions for the treatment of some chronic infection diseases. For this purpose poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) core–shell nanostructures were used as the carrier of clindamycin-base, as a drug, and clindamycin-2-phosphate, as a prodrug model. As a result, a two-step release was observed: the controlled release of the more soluble phosphate form and the sustained release of the less-soluble base form of clindamycin, resulting in a high overall concentration of the released drug during the period of 30 days in vitro. The HAp phase within the PLGA core–shells, applied as a drug carrier, delayed the process of the degradation of the polymer; however, the presence of the drug affected the process of degradation and this influence was the dominant factor in the control over the degradation of the polymer phase of PLGA/HAp and the consequent kinetics of the drug release.",
publisher = "Elsevier BV",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)",
pages = "414-421",
volume = "82",
number = "2",
doi = "10.1016/j.colsurfb.2010.09.012",
url = "https://hdl.handle.net/21.15107/rcub_dais_14363"
}

Vukomanović, M., Škapin, S. D., Poljanšek, I., Žagar, E., Kralj, B., Ignjatović, N.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate). in Colloids and Surfaces B: Biointerfaces
Elsevier BV., 82(2), 414-421.
https://doi.org/10.1016/j.colsurfb.2010.09.012
https://hdl.handle.net/21.15107/rcub_dais_14363

Vukomanović M, Škapin SD, Poljanšek I, Žagar E, Kralj B, Ignjatović N, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate). in Colloids and Surfaces B: Biointerfaces. 2011;82(2):414-421.
doi:10.1016/j.colsurfb.2010.09.012
https://hdl.handle.net/21.15107/rcub_dais_14363 .

Vukomanović, Marija, Škapin, Srečo Davor, Poljanšek, Ida, Žagar, Ema, Kralj, Bogdan, Ignjatović, Nenad, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)" in Colloids and Surfaces B: Biointerfaces, 82, no. 2 (2011):414-421,
https://doi.org/10.1016/j.colsurfb.2010.09.012 .,
https://hdl.handle.net/21.15107/rcub_dais_14363 .