TY  - JOUR
AU  - Najman, Stevo
AU  - Savić, Vojin
AU  - Đorđević, Lj.
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2004
UR  - https://dais.sanu.ac.rs/123456789/14301
AB  - Histopathologic analysis of the tissue with HAp/PLLA implants was made and the leukocyte formula and chemiluminescence response of peritoneal phagocytes 2, 7 and 12 weeks after intraperitoneal implantation studied. Implants were made of HAp/PLLA biocomposites with PLLA molecular weights of 50,000 (HAp/PLLA(50)) and 430,000 g/mol (HAp/PLLA(430)) and of crushed devitalized femur bone of a young Wistar rat. Leukocyte formula and chemiluminescence of peritoneal phagocytes showed no systemic inflammatory response. The studied implants caused locally weak inflammatory reaction. The resorption of implants ranges in intensity (polymer resorption, i.e. disappearance rate), from the highest with the bone implants, low with HAp/PLLA(50), to the lowest with the HAp/PLLA(430) implants. Good resorption of the biocomposites and its mutual ingrowth with connective tissue prove their good biocompatibility.
PB  - IOS Press
T2  - Bio-Medical Materials and Engineering
T1  - Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice
SP  - 61
EP  - 70
VL  - 14
IS  - 1
UR  - https://hdl.handle.net/21.15107/rcub_dais_14301
ER  - 

@article{
author = "Najman, Stevo and Savić, Vojin and Đorđević, Lj. and Ignjatović, Nenad and Uskoković, Dragan",
year = "2004",
abstract = "Histopathologic analysis of the tissue with HAp/PLLA implants was made and the leukocyte formula and chemiluminescence response of peritoneal phagocytes 2, 7 and 12 weeks after intraperitoneal implantation studied. Implants were made of HAp/PLLA biocomposites with PLLA molecular weights of 50,000 (HAp/PLLA(50)) and 430,000 g/mol (HAp/PLLA(430)) and of crushed devitalized femur bone of a young Wistar rat. Leukocyte formula and chemiluminescence of peritoneal phagocytes showed no systemic inflammatory response. The studied implants caused locally weak inflammatory reaction. The resorption of implants ranges in intensity (polymer resorption, i.e. disappearance rate), from the highest with the bone implants, low with HAp/PLLA(50), to the lowest with the HAp/PLLA(430) implants. Good resorption of the biocomposites and its mutual ingrowth with connective tissue prove their good biocompatibility.",
publisher = "IOS Press",
journal = "Bio-Medical Materials and Engineering",
title = "Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice",
pages = "61-70",
volume = "14",
number = "1",
url = "https://hdl.handle.net/21.15107/rcub_dais_14301"
}

Najman, S., Savić, V., Đorđević, Lj., Ignjatović, N.,& Uskoković, D.. (2004). Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice. in Bio-Medical Materials and Engineering
IOS Press., 14(1), 61-70.
https://hdl.handle.net/21.15107/rcub_dais_14301

Najman S, Savić V, Đorđević L, Ignjatović N, Uskoković D. Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice. in Bio-Medical Materials and Engineering. 2004;14(1):61-70.
https://hdl.handle.net/21.15107/rcub_dais_14301 .

Najman, Stevo, Savić, Vojin, Đorđević, Lj., Ignjatović, Nenad, Uskoković, Dragan, "Biological evaluation of hydroxyapatite/poly‐L‐lactide (HAp/PLLA) composite biomaterials with poly‐L‐lactide of different molecular weights intraperitoneally implanted into mice" in Bio-Medical Materials and Engineering, 14, no. 1 (2004):61-70,
https://hdl.handle.net/21.15107/rcub_dais_14301 .

TY  - JOUR
AU  - Najman, Stevo
AU  - Đorđević, Lj.
AU  - Savić, Vojin
AU  - Ignjatović, Nenad
AU  - Plavšić, Milenko
AU  - Uskoković, Dragan
PY  - 2003
UR  - http://www.ncbi.nlm.nih.gov/pubmed/0354-21170303131N
UR  - https://dais.sanu.ac.rs/123456789/3361
AB  - Experimental and clinical studies have shown that HAp granules and powder may be successfully applied in reconstruction of bone defects. Composite HAp/PLLA biomaterial embodies good characteristics of each of these biomaterials. Differences in porosity, microstructure, compressive consistency as well as in bioresorbility of HAp/PLLA are achieved by using PLLA of different mole masses. The aim of this study was to analyse light microscopy of the tissue reaction and changes of implants made of combination of syngeneic bone fragments and HAp/PLLA biocomposites with PLLA molecule mass of 430 000 (HP2) and 50 000 (HP3). The mice were divided into 4 experimental studies, 8 animals each. Two groups underwent implantation one group of mice was falsely operated, and one group was used for general control. Pathohistological analysis of implants was performed three months after subcutaneous implantation. Phagocytosis of HAp/ PLLA and bone was noticed on both implants’ preparations. Blood vessels were also noticed confirming the process of angiogenesis around the implants’ particles. The holes around particles of biocomposites and bone fragments represented the signs of their resorption. The presence of multinuclear cells between implants’ particles was observed and it was more prominent in HP3 implants. Osteogenesis is more intense in HP3 and ectopic hematopoesis is present. Our results show that designed HAp/PLLA biocomposites have good biocompatibility, their combination with bone fragments of a vital bone enables osteogenesis and hematopoesis and these processes are more prominent if PLLA biocomposite with lower molecular mass was used.
PB  - Niš : University of Niš
T2  - Facta universitatis - series: Medicine and Biology
T1  - Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation
SP  - 131
EP  - 134
VL  - 10
IS  - 3
UR  - https://hdl.handle.net/21.15107/rcub_dais_3361
ER  - 

@article{
author = "Najman, Stevo and Đorđević, Lj. and Savić, Vojin and Ignjatović, Nenad and Plavšić, Milenko and Uskoković, Dragan",
year = "2003",
abstract = "Experimental and clinical studies have shown that HAp granules and powder may be successfully applied in reconstruction of bone defects. Composite HAp/PLLA biomaterial embodies good characteristics of each of these biomaterials. Differences in porosity, microstructure, compressive consistency as well as in bioresorbility of HAp/PLLA are achieved by using PLLA of different mole masses. The aim of this study was to analyse light microscopy of the tissue reaction and changes of implants made of combination of syngeneic bone fragments and HAp/PLLA biocomposites with PLLA molecule mass of 430 000 (HP2) and 50 000 (HP3). The mice were divided into 4 experimental studies, 8 animals each. Two groups underwent implantation one group of mice was falsely operated, and one group was used for general control. Pathohistological analysis of implants was performed three months after subcutaneous implantation. Phagocytosis of HAp/ PLLA and bone was noticed on both implants’ preparations. Blood vessels were also noticed confirming the process of angiogenesis around the implants’ particles. The holes around particles of biocomposites and bone fragments represented the signs of their resorption. The presence of multinuclear cells between implants’ particles was observed and it was more prominent in HP3 implants. Osteogenesis is more intense in HP3 and ectopic hematopoesis is present. Our results show that designed HAp/PLLA biocomposites have good biocompatibility, their combination with bone fragments of a vital bone enables osteogenesis and hematopoesis and these processes are more prominent if PLLA biocomposite with lower molecular mass was used.",
publisher = "Niš : University of Niš",
journal = "Facta universitatis - series: Medicine and Biology",
title = "Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation",
pages = "131-134",
volume = "10",
number = "3",
url = "https://hdl.handle.net/21.15107/rcub_dais_3361"
}

Najman, S., Đorđević, Lj., Savić, V., Ignjatović, N., Plavšić, M.,& Uskoković, D.. (2003). Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation. in Facta universitatis - series: Medicine and Biology
Niš : University of Niš., 10(3), 131-134.
https://hdl.handle.net/21.15107/rcub_dais_3361

Najman S, Đorđević L, Savić V, Ignjatović N, Plavšić M, Uskoković D. Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation. in Facta universitatis - series: Medicine and Biology. 2003;10(3):131-134.
https://hdl.handle.net/21.15107/rcub_dais_3361 .

Najman, Stevo, Đorđević, Lj., Savić, Vojin, Ignjatović, Nenad, Plavšić, Milenko, Uskoković, Dragan, "Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation" in Facta universitatis - series: Medicine and Biology, 10, no. 3 (2003):131-134,
https://hdl.handle.net/21.15107/rcub_dais_3361 .