TY  - JOUR
AU  - Petrović, Daniela
AU  - Seke, Mariana
AU  - Labudović Borović, Milica
AU  - Jović, Danica
AU  - Borišev, Ivana
AU  - Srđenovic, Branislava
AU  - Rakočević, Zlatko
AU  - Pavlović, Vladimir B.
AU  - Đorđevic, Aleksandar
PY  - 2018
UR  - https://dais.sanu.ac.rs/123456789/3755
AB  - In our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats. © 2018
PB  - Elsevier
T2  - Experimental and Molecular Pathology
T1  - Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats
SP  - 199
EP  - 211
VL  - 104
IS  - 3
DO  - 10.1016/j.yexmp.2018.04.005
UR  - https://hdl.handle.net/21.15107/rcub_dais_3755
ER  - 

@article{
author = "Petrović, Daniela and Seke, Mariana and Labudović Borović, Milica and Jović, Danica and Borišev, Ivana and Srđenovic, Branislava and Rakočević, Zlatko and Pavlović, Vladimir B. and Đorđevic, Aleksandar",
year = "2018",
abstract = "In our recent studies we have designed fullerenol/doxorubicin nanocomposite (FNP/DOX) as the new drug nanocarrier. This research has demonstrated that this novel nanocomposite has had better implications on the liver tissue in vivo (Wistar rats treated intraperitoneally), than treatment based only on DOX. FNP/DOX has been characterised by DLS, TEM and AFM measurements which have shown that DOX loaded onto FNP did not influence fullerenol nanoparticle's size. FNP/DOX affected oxidative status in blood causing a significant decrease of catalase and SOD activity in comparison to DOX, implicating the reduction in oxidative stress. qRT-PCR results on the mRNA level of antioxidative enzymes (catalase and MnSOD) revealed that the effect of oxidative stress is significantly reduced by the treatment with FNP/DOX (p <.05). The ultrastructural analysis of the liver tissue has revealed that FNP/DOX nanocomposite generated considerably less damage in the liver tissue, than DOX applied at the same dose. Hence, our results have indicated that FNP, within FNP/DOX nanocomposite, exhibits protective effects to the liver tissue of the healthy rats. © 2018",
publisher = "Elsevier",
journal = "Experimental and Molecular Pathology",
title = "Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats",
pages = "199-211",
volume = "104",
number = "3",
doi = "10.1016/j.yexmp.2018.04.005",
url = "https://hdl.handle.net/21.15107/rcub_dais_3755"
}

Petrović, D., Seke, M., Labudović Borović, M., Jović, D., Borišev, I., Srđenovic, B., Rakočević, Z., Pavlović, V. B.,& Đorđevic, A.. (2018). Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats. in Experimental and Molecular Pathology
Elsevier., 104(3), 199-211.
https://doi.org/10.1016/j.yexmp.2018.04.005
https://hdl.handle.net/21.15107/rcub_dais_3755

Petrović D, Seke M, Labudović Borović M, Jović D, Borišev I, Srđenovic B, Rakočević Z, Pavlović VB, Đorđevic A. Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats. in Experimental and Molecular Pathology. 2018;104(3):199-211.
doi:10.1016/j.yexmp.2018.04.005
https://hdl.handle.net/21.15107/rcub_dais_3755 .

Petrović, Daniela, Seke, Mariana, Labudović Borović, Milica, Jović, Danica, Borišev, Ivana, Srđenovic, Branislava, Rakočević, Zlatko, Pavlović, Vladimir B., Đorđevic, Aleksandar, "Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats" in Experimental and Molecular Pathology, 104, no. 3 (2018):199-211,
https://doi.org/10.1016/j.yexmp.2018.04.005 .,
https://hdl.handle.net/21.15107/rcub_dais_3755 .

TY  - JOUR
AU  - Đorđević, Aleksandar
AU  - Ignjatović, Nenad
AU  - Seke, Mariana
AU  - Jović, Danica
AU  - Uskoković, Dragan
AU  - Rakočević, Zlatko
PY  - 2015
UR  - https://dais.sanu.ac.rs/123456789/575
AB  - Fullerenols are polyhydroxylated, water soluble derivatives of fullerene C60, with potential application in medicine as diagnostic agents, antioxidants or nano drug carriers. This paper describes synthesis and physical characterization of a new nanocomposite hydroxyapatite/fullerenol. Surface of the nanocomposite hydroxyapatite/fullerenol is inhomogeneous with the diameter of the particles in the range from 100 nm to 350 nm. The zeta potential of this nanocomposite is ten times lower when compared to hydroxyapatite. Surface phosphate groups of hydroxyapatite are prone to forming hydrogen bonds, when in close contact with hydroxyl groups, which could lead to formation of hydrogen bonds between hydroxyapatite and hydroxyl groups of fullerenol. The surface of hydroxyapatite
particles (−2.5 mV) was modified by fullerenol particles, as confirmed by the obtained zeta
potential value of the nanocomposite biomaterial hydroxyapatite/fullerenol (−25.0 mV).
T2  - Journal of Nanoscience and Nanotechnology
T1  - Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites
SP  - 1538
EP  - 1542
VL  - 15
IS  - 2
DO  - 10.1166/jnn.2015.8671
UR  - https://hdl.handle.net/21.15107/rcub_dais_575
ER  - 

@article{
author = "Đorđević, Aleksandar and Ignjatović, Nenad and Seke, Mariana and Jović, Danica and Uskoković, Dragan and Rakočević, Zlatko",
year = "2015",
abstract = "Fullerenols are polyhydroxylated, water soluble derivatives of fullerene C60, with potential application in medicine as diagnostic agents, antioxidants or nano drug carriers. This paper describes synthesis and physical characterization of a new nanocomposite hydroxyapatite/fullerenol. Surface of the nanocomposite hydroxyapatite/fullerenol is inhomogeneous with the diameter of the particles in the range from 100 nm to 350 nm. The zeta potential of this nanocomposite is ten times lower when compared to hydroxyapatite. Surface phosphate groups of hydroxyapatite are prone to forming hydrogen bonds, when in close contact with hydroxyl groups, which could lead to formation of hydrogen bonds between hydroxyapatite and hydroxyl groups of fullerenol. The surface of hydroxyapatite
particles (−2.5 mV) was modified by fullerenol particles, as confirmed by the obtained zeta
potential value of the nanocomposite biomaterial hydroxyapatite/fullerenol (−25.0 mV).",
journal = "Journal of Nanoscience and Nanotechnology",
title = "Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites",
pages = "1538-1542",
volume = "15",
number = "2",
doi = "10.1166/jnn.2015.8671",
url = "https://hdl.handle.net/21.15107/rcub_dais_575"
}

Đorđević, A., Ignjatović, N., Seke, M., Jović, D., Uskoković, D.,& Rakočević, Z.. (2015). Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites. in Journal of Nanoscience and Nanotechnology, 15(2), 1538-1542.
https://doi.org/10.1166/jnn.2015.8671
https://hdl.handle.net/21.15107/rcub_dais_575

Đorđević A, Ignjatović N, Seke M, Jović D, Uskoković D, Rakočević Z. Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites. in Journal of Nanoscience and Nanotechnology. 2015;15(2):1538-1542.
doi:10.1166/jnn.2015.8671
https://hdl.handle.net/21.15107/rcub_dais_575 .

Đorđević, Aleksandar, Ignjatović, Nenad, Seke, Mariana, Jović, Danica, Uskoković, Dragan, Rakočević, Zlatko, "Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites" in Journal of Nanoscience and Nanotechnology, 15, no. 2 (2015):1538-1542,
https://doi.org/10.1166/jnn.2015.8671 .,
https://hdl.handle.net/21.15107/rcub_dais_575 .