TY  - JOUR
AU  - Jokić, Ivana
AU  - Frantlović, Miloš
AU  - Đurić, Zoran G.
AU  - Radulović, Katarina
AU  - Jokić, Zorana
PY  - 2015
UR  - https://dais.sanu.ac.rs/123456789/3519
AB  - We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the development of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum. © 2015 Published by Elsevier B.V.
PB  - Elsevier
T2  - Microelectronic Engineering
T1  - Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments
SP  - 32
EP  - 36
VL  - 144
DO  - 10.1016/j.mee.2015.02.032
UR  - https://hdl.handle.net/21.15107/rcub_dais_3519
ER  - 

@article{
author = "Jokić, Ivana and Frantlović, Miloš and Đurić, Zoran G. and Radulović, Katarina and Jokić, Zorana",
year = "2015",
abstract = "We present a theoretical model of adsorption-desorption (AD) noise in microfluidic biosensors operating in multianalyte environments. This noise is caused by the stochastic nature of the processes that generate the sensor response: reversible adsorption of n analytes coupled with mass transfer (convection and diffusion) of analyte particles through the microfluidic channel to and from the surface binding sites. The parameters of the obtained analytical expression for the AD noise power spectral density, determining the shape of the noise spectrum, contain information on the concentrations of all the adsorbing species, their association and dissociation rate constants, mass transfer coefficients and molecular masses. The AD noise spectrum, therefore, offers additional data about multiple analytes, apart from those obtained by the commonly used time domain analysis of sensor response. Therefore the derived model of AD noise contributes to the theoretical basis necessary for the development of new methods for determination of target analyte parameters in complex samples or even for simultaneous detection of multiple analytes using a single sensor, based on the measured noise spectrum. © 2015 Published by Elsevier B.V.",
publisher = "Elsevier",
journal = "Microelectronic Engineering",
title = "Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments",
pages = "32-36",
volume = "144",
doi = "10.1016/j.mee.2015.02.032",
url = "https://hdl.handle.net/21.15107/rcub_dais_3519"
}

Jokić, I., Frantlović, M., Đurić, Z. G., Radulović, K.,& Jokić, Z.. (2015). Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments. in Microelectronic Engineering
Elsevier., 144, 32-36.
https://doi.org/10.1016/j.mee.2015.02.032
https://hdl.handle.net/21.15107/rcub_dais_3519

Jokić I, Frantlović M, Đurić ZG, Radulović K, Jokić Z. Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments. in Microelectronic Engineering. 2015;144:32-36.
doi:10.1016/j.mee.2015.02.032
https://hdl.handle.net/21.15107/rcub_dais_3519 .

Jokić, Ivana, Frantlović, Miloš, Đurić, Zoran G., Radulović, Katarina, Jokić, Zorana, "Adsorption-desorption noise in microfluidic biosensors operating in multianalyte environments" in Microelectronic Engineering, 144 (2015):32-36,
https://doi.org/10.1016/j.mee.2015.02.032 .,
https://hdl.handle.net/21.15107/rcub_dais_3519 .

TY  - JOUR
AU  - Jokić, Ivana
AU  - Đurić, Zoran G.
AU  - Frantlović, Miloš
AU  - Radulović, Katarina
AU  - Krstajić, Predrag
AU  - Jokić, Zorana
PY  - 2012
UR  - https://dais.sanu.ac.rs/123456789/470
AB  - We derived a simple theory of fluctuations of the equilibrium number of adsorbed molecules in biosensors, caused by the stochastic nature of adsorption–desorption (AD) processes coupled with mass transfer. The two-compartment model is used for approximation of the spatial dependence of analyte concentration in the reaction chamber, which is justified when a thin layer depleted of the analyte exists close to the surface on which the binding reaction occurs. By using the obtained analytical expression for the power spectral density of fluctuations we perform for the first time the quantitative analysis of the influence of the mass transfer on the fluctuations spectrum. For realistic parameter values, the influence of mass transfer proved to be significant, causing the increase in the fluctuations level of up to two orders of magnitude compared to the rapid mixing case. The dependences of the mass transfer influenced fluctuations spectrum on various parameters of the analyte–receptor binding process are also systematically investigated. The presented theoretical model of fluctuations enables good estimation of the AD noise, which affects the total noise and the minimal detectable signal of biosensors. It provides the guidelines for improvement of the limits of detection, and for optimization of detection methods. The theory is also proposed as a basis for development of highly sensitive methods for analyte detection and characterization of biomolecular binding processes, based on the measured fluctuations spectrum. It is applicable for various types of sensors whose operation principle relies on the adsorption process of analyte molecules.
PB  - Elsevier
T2  - Sensors and Actuators B: Chemical
T1  - Fluctuations of the number of adsorbed molecules in biosensors due to stochastic adsorption–desorption processes coupled with mass transfer
SP  - 535
EP  - 543
DO  - 10.1016/j.snb.2012.03.004
UR  - https://hdl.handle.net/21.15107/rcub_dais_470
ER  - 

@article{
author = "Jokić, Ivana and Đurić, Zoran G. and Frantlović, Miloš and Radulović, Katarina and Krstajić, Predrag and Jokić, Zorana",
year = "2012",
abstract = "We derived a simple theory of fluctuations of the equilibrium number of adsorbed molecules in biosensors, caused by the stochastic nature of adsorption–desorption (AD) processes coupled with mass transfer. The two-compartment model is used for approximation of the spatial dependence of analyte concentration in the reaction chamber, which is justified when a thin layer depleted of the analyte exists close to the surface on which the binding reaction occurs. By using the obtained analytical expression for the power spectral density of fluctuations we perform for the first time the quantitative analysis of the influence of the mass transfer on the fluctuations spectrum. For realistic parameter values, the influence of mass transfer proved to be significant, causing the increase in the fluctuations level of up to two orders of magnitude compared to the rapid mixing case. The dependences of the mass transfer influenced fluctuations spectrum on various parameters of the analyte–receptor binding process are also systematically investigated. The presented theoretical model of fluctuations enables good estimation of the AD noise, which affects the total noise and the minimal detectable signal of biosensors. It provides the guidelines for improvement of the limits of detection, and for optimization of detection methods. The theory is also proposed as a basis for development of highly sensitive methods for analyte detection and characterization of biomolecular binding processes, based on the measured fluctuations spectrum. It is applicable for various types of sensors whose operation principle relies on the adsorption process of analyte molecules.",
publisher = "Elsevier",
journal = "Sensors and Actuators B: Chemical",
title = "Fluctuations of the number of adsorbed molecules in biosensors due to stochastic adsorption–desorption processes coupled with mass transfer",
pages = "535-543",
doi = "10.1016/j.snb.2012.03.004",
url = "https://hdl.handle.net/21.15107/rcub_dais_470"
}

Jokić, I., Đurić, Z. G., Frantlović, M., Radulović, K., Krstajić, P.,& Jokić, Z.. (2012). Fluctuations of the number of adsorbed molecules in biosensors due to stochastic adsorption–desorption processes coupled with mass transfer. in Sensors and Actuators B: Chemical
Elsevier., 535-543.
https://doi.org/10.1016/j.snb.2012.03.004
https://hdl.handle.net/21.15107/rcub_dais_470

Jokić I, Đurić ZG, Frantlović M, Radulović K, Krstajić P, Jokić Z. Fluctuations of the number of adsorbed molecules in biosensors due to stochastic adsorption–desorption processes coupled with mass transfer. in Sensors and Actuators B: Chemical. 2012;:535-543.
doi:10.1016/j.snb.2012.03.004
https://hdl.handle.net/21.15107/rcub_dais_470 .

Jokić, Ivana, Đurić, Zoran G., Frantlović, Miloš, Radulović, Katarina, Krstajić, Predrag, Jokić, Zorana, "Fluctuations of the number of adsorbed molecules in biosensors due to stochastic adsorption–desorption processes coupled with mass transfer" in Sensors and Actuators B: Chemical (2012):535-543,
https://doi.org/10.1016/j.snb.2012.03.004 .,
https://hdl.handle.net/21.15107/rcub_dais_470 .