TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Ignjatović, Nenad
AU  - Gudić, Senka
AU  - Vrsalović, Ladislav
AU  - Božić, Katarina Đ.
AU  - Popović, Marko E.
AU  - Pavlović, Miroslav M.
PY  - 2024
UR  - https://dais.sanu.ac.rs/123456789/16571
UR  - https://dais.sanu.ac.rs/123456789/16572
AB  - Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants’ osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosan oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the nACP@ChOL-Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Physico-chemical characterization was used to analyze the surface of the coating (scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy). The distribution of Se within the coating was examined with energy-dispersive X-ray spectroscopy (EDS). Bioactivity was evaluated in simulated body fluid (SBF), and adhesion was tested using a scratch test method. In vitro testing determined the release mechanism of Se. SEM images illustrated the surface morphology, while AFM provided a detailed analysis of surface roughness. XRD analysis revealed structural and phase composition, and EDS confirmed Se distribution within the coating. The coating exhibited bioactivity in SBF and showed good adhesion according to the scratch test. In vitro testing uncovered the release mechanism of Se from the coating. This study successfully characterized the surface morphology, composition, bioactivity, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates, offering insights for developing immunomodulatory coatings for medical and dental applications.
T2  - Annals of Biomedical Engineering
T1  - Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application
DO  - 10.1007/s10439-024-03521-0
UR  - https://hdl.handle.net/21.15107/rcub_dais_16572
ER  - 

@article{
author = "Pantović Pavlović, Marijana and Ignjatović, Nenad and Gudić, Senka and Vrsalović, Ladislav and Božić, Katarina Đ. and Popović, Marko E. and Pavlović, Miroslav M.",
year = "2024",
abstract = "Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants’ osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosan oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the nACP@ChOL-Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Physico-chemical characterization was used to analyze the surface of the coating (scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy). The distribution of Se within the coating was examined with energy-dispersive X-ray spectroscopy (EDS). Bioactivity was evaluated in simulated body fluid (SBF), and adhesion was tested using a scratch test method. In vitro testing determined the release mechanism of Se. SEM images illustrated the surface morphology, while AFM provided a detailed analysis of surface roughness. XRD analysis revealed structural and phase composition, and EDS confirmed Se distribution within the coating. The coating exhibited bioactivity in SBF and showed good adhesion according to the scratch test. In vitro testing uncovered the release mechanism of Se from the coating. This study successfully characterized the surface morphology, composition, bioactivity, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates, offering insights for developing immunomodulatory coatings for medical and dental applications.",
journal = "Annals of Biomedical Engineering",
title = "Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application",
doi = "10.1007/s10439-024-03521-0",
url = "https://hdl.handle.net/21.15107/rcub_dais_16572"
}

Pantović Pavlović, M., Ignjatović, N., Gudić, S., Vrsalović, L., Božić, K. Đ., Popović, M. E.,& Pavlović, M. M.. (2024). Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application. in Annals of Biomedical Engineering.
https://doi.org/10.1007/s10439-024-03521-0
https://hdl.handle.net/21.15107/rcub_dais_16572

Pantović Pavlović M, Ignjatović N, Gudić S, Vrsalović L, Božić KĐ, Popović ME, Pavlović MM. Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application. in Annals of Biomedical Engineering. 2024;.
doi:10.1007/s10439-024-03521-0
https://hdl.handle.net/21.15107/rcub_dais_16572 .

Pantović Pavlović, Marijana, Ignjatović, Nenad, Gudić, Senka, Vrsalović, Ladislav, Božić, Katarina Đ., Popović, Marko E., Pavlović, Miroslav M., "Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application" in Annals of Biomedical Engineering (2024),
https://doi.org/10.1007/s10439-024-03521-0 .,
https://hdl.handle.net/21.15107/rcub_dais_16572 .

TY  - JOUR
AU  - Pantović Pavlović, Marijana
AU  - Ignjatović, Nenad
AU  - Gudić, Senka
AU  - Vrsalović, Ladislav
AU  - Božić, Katarina Đ.
AU  - Popović, Marko E.
AU  - Pavlović, Miroslav M.
PY  - 2024
UR  - https://dais.sanu.ac.rs/123456789/16571
AB  - Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants’ osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosan oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the nACP@ChOL-Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Physico-chemical characterization was used to analyze the surface of the coating (scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy). The distribution of Se within the coating was examined with energy-dispersive X-ray spectroscopy (EDS). Bioactivity was evaluated in simulated body fluid (SBF), and adhesion was tested using a scratch test method. In vitro testing determined the release mechanism of Se. SEM images illustrated the surface morphology, while AFM provided a detailed analysis of surface roughness. XRD analysis revealed structural and phase composition, and EDS confirmed Se distribution within the coating. The coating exhibited bioactivity in SBF and showed good adhesion according to the scratch test. In vitro testing uncovered the release mechanism of Se from the coating. This study successfully characterized the surface morphology, composition, bioactivity, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates, offering insights for developing immunomodulatory coatings for medical and dental applications.
T2  - Annals of Biomedical Engineering
T1  - Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application
DO  - 10.1007/s10439-024-03521-0
UR  - https://hdl.handle.net/21.15107/rcub_dais_16571
ER  - 

@article{
author = "Pantović Pavlović, Marijana and Ignjatović, Nenad and Gudić, Senka and Vrsalović, Ladislav and Božić, Katarina Đ. and Popović, Marko E. and Pavlović, Miroslav M.",
year = "2024",
abstract = "Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants’ osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosan oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the nACP@ChOL-Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Physico-chemical characterization was used to analyze the surface of the coating (scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy). The distribution of Se within the coating was examined with energy-dispersive X-ray spectroscopy (EDS). Bioactivity was evaluated in simulated body fluid (SBF), and adhesion was tested using a scratch test method. In vitro testing determined the release mechanism of Se. SEM images illustrated the surface morphology, while AFM provided a detailed analysis of surface roughness. XRD analysis revealed structural and phase composition, and EDS confirmed Se distribution within the coating. The coating exhibited bioactivity in SBF and showed good adhesion according to the scratch test. In vitro testing uncovered the release mechanism of Se from the coating. This study successfully characterized the surface morphology, composition, bioactivity, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates, offering insights for developing immunomodulatory coatings for medical and dental applications.",
journal = "Annals of Biomedical Engineering",
title = "Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application",
doi = "10.1007/s10439-024-03521-0",
url = "https://hdl.handle.net/21.15107/rcub_dais_16571"
}

Pantović Pavlović, M., Ignjatović, N., Gudić, S., Vrsalović, L., Božić, K. Đ., Popović, M. E.,& Pavlović, M. M.. (2024). Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application. in Annals of Biomedical Engineering.
https://doi.org/10.1007/s10439-024-03521-0
https://hdl.handle.net/21.15107/rcub_dais_16571

Pantović Pavlović M, Ignjatović N, Gudić S, Vrsalović L, Božić KĐ, Popović ME, Pavlović MM. Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application. in Annals of Biomedical Engineering. 2024;.
doi:10.1007/s10439-024-03521-0
https://hdl.handle.net/21.15107/rcub_dais_16571 .

Pantović Pavlović, Marijana, Ignjatović, Nenad, Gudić, Senka, Vrsalović, Ladislav, Božić, Katarina Đ., Popović, Marko E., Pavlović, Miroslav M., "Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application" in Annals of Biomedical Engineering (2024),
https://doi.org/10.1007/s10439-024-03521-0 .,
https://hdl.handle.net/21.15107/rcub_dais_16571 .