TY  - CONF
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Šarčev, Ivan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/252
AB  - Poster presented at the Third International “NanoBio – Zurich 2010” Conference, August 2010, Zurich, Switzerland
T1  - Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics
UR  - https://hdl.handle.net/21.15107/rcub_dais_252
ER  - 

@conference{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Šarčev, Ivan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
abstract = "Poster presented at the Third International “NanoBio – Zurich 2010” Conference, August 2010, Zurich, Switzerland",
title = "Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics",
url = "https://hdl.handle.net/21.15107/rcub_dais_252"
}

Vukomanović, M., Škapin, S. D., Šarčev, I., Ignjatović, N.,& Uskoković, D.. (2010). Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. .
https://hdl.handle.net/21.15107/rcub_dais_252

Vukomanović M, Škapin SD, Šarčev I, Ignjatović N, Uskoković D. Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. 2010;.
https://hdl.handle.net/21.15107/rcub_dais_252 .

Vukomanović, Marija, Škapin, Srečo Davor, Šarčev, Ivan, Ignjatović, Nenad, Uskoković, Dragan, "Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics" (2010),
https://hdl.handle.net/21.15107/rcub_dais_252 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Šarčev, Ivan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/3436
AB  - Local drug delivery for the treatment of infectious bone tissue diseases is a high importance topic in the field of biomedicine for a last two decades. [1] In general, some of the main problems related to controlled drug delivery of antibiotics are: (i) high initial burst effect with toxic outcome and (ii) low concentration of released drug during extended period of time with possibility for development of resistant spaces.[2] There are some examples suggesting that core-shell particles applied as carriers of drug are able to provide high control over the process of drug release and to prevent burst effect.[3,4] Therefore, the main goal of our work is to design material which will be able to provide these characteristics.
PB  - Davos: AO Research Institute Davos
C3  - European Cells and Materials
C3  - European Cells and Materials
T1  - Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics
SP  - 266
EP  - 266
VL  - 20
IS  - SUPPL. 3
UR  - https://hdl.handle.net/21.15107/rcub_dais_3436
ER  - 

@conference{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Šarčev, Ivan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
abstract = "Local drug delivery for the treatment of infectious bone tissue diseases is a high importance topic in the field of biomedicine for a last two decades. [1] In general, some of the main problems related to controlled drug delivery of antibiotics are: (i) high initial burst effect with toxic outcome and (ii) low concentration of released drug during extended period of time with possibility for development of resistant spaces.[2] There are some examples suggesting that core-shell particles applied as carriers of drug are able to provide high control over the process of drug release and to prevent burst effect.[3,4] Therefore, the main goal of our work is to design material which will be able to provide these characteristics.",
publisher = "Davos: AO Research Institute Davos",
journal = "European Cells and Materials, European Cells and Materials",
title = "Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics",
pages = "266-266",
volume = "20",
number = "SUPPL. 3",
url = "https://hdl.handle.net/21.15107/rcub_dais_3436"
}

Vukomanović, M., Škapin, S. D., Šarčev, I., Ignjatović, N.,& Uskoković, D.. (2010). Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. in European Cells and Materials
Davos: AO Research Institute Davos., 20(SUPPL. 3), 266-266.
https://hdl.handle.net/21.15107/rcub_dais_3436

Vukomanović M, Škapin SD, Šarčev I, Ignjatović N, Uskoković D. Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. in European Cells and Materials. 2010;20(SUPPL. 3):266-266.
https://hdl.handle.net/21.15107/rcub_dais_3436 .

Vukomanović, Marija, Škapin, Srečo Davor, Šarčev, Ivan, Ignjatović, Nenad, Uskoković, Dragan, "Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics" in European Cells and Materials, 20, no. SUPPL. 3 (2010):266-266,
https://hdl.handle.net/21.15107/rcub_dais_3436 .

TY  - CONF
AU  - Vuković, Gorica
AU  - Lazić, Sanja
AU  - Šunjka, Dragana
AU  - Bursić, Vojislava
AU  - Šarčev, Ivan
AU  - Vukomanović, Marija
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/3453
AB  - Clindamycin was determined in pig plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The multiple reaction monitoring (MRM) mode of precursor-product ion transitions for clindamycin (m/z=421.1/126.1) and the internal standard, caffeine (m/z=192/125) was used. The samples were prepared by two methods: 0.1% formic acid in methanol and 1.5% trichloacetic acid. The recovery for the two preparation methods at 0.05mg/ml (n=6) was found to be for the first 104.3% and for the second method 106.5%, with repeatability RSD 1.1% and RSD 4.34%, respectively. The results of the comparison of the two different preparation methods of samples demonstrated that both methods were satisfactory.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia
T1  - Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry
SP  - 19
EP  - 19
UR  - https://hdl.handle.net/21.15107/rcub_dais_3453
ER  - 

@conference{
author = "Vuković, Gorica and Lazić, Sanja and Šunjka, Dragana and Bursić, Vojislava and Šarčev, Ivan and Vukomanović, Marija and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
abstract = "Clindamycin was determined in pig plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The multiple reaction monitoring (MRM) mode of precursor-product ion transitions for clindamycin (m/z=421.1/126.1) and the internal standard, caffeine (m/z=192/125) was used. The samples were prepared by two methods: 0.1% formic acid in methanol and 1.5% trichloacetic acid. The recovery for the two preparation methods at 0.05mg/ml (n=6) was found to be for the first 104.3% and for the second method 106.5%, with repeatability RSD 1.1% and RSD 4.34%, respectively. The results of the comparison of the two different preparation methods of samples demonstrated that both methods were satisfactory.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia",
title = "Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry",
pages = "19-19",
url = "https://hdl.handle.net/21.15107/rcub_dais_3453"
}

Vuković, G., Lazić, S., Šunjka, D., Bursić, V., Šarčev, I., Vukomanović, M., Ignjatović, N.,& Uskoković, D.. (2010). Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry. in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 19-19.
https://hdl.handle.net/21.15107/rcub_dais_3453

Vuković G, Lazić S, Šunjka D, Bursić V, Šarčev I, Vukomanović M, Ignjatović N, Uskoković D. Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry. in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia. 2010;:19-19.
https://hdl.handle.net/21.15107/rcub_dais_3453 .

Vuković, Gorica, Lazić, Sanja, Šunjka, Dragana, Bursić, Vojislava, Šarčev, Ivan, Vukomanović, Marija, Ignjatović, Nenad, Uskoković, Dragan, "Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry" in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia (2010):19-19,
https://hdl.handle.net/21.15107/rcub_dais_3453 .

TY  - CONF
AU  - Šarčev, Ivan
AU  - Petronijević, Branislava
AU  - Jevtić, Marija
AU  - Ignjatović, Nenad
PY  - 2009
UR  - https://dais.sanu.ac.rs/123456789/14851
AB  - Nano sfere kompozitnog biomaterijala poli(d,l-laktid-ko-glikolid)/hidroksiapatit u kojima je imobilisan/inkapsuliran antibiotik mogu imati širok aplikativan značaj kao sistemi sa kontrolisanom i ciljanom dostavom lekova u rekonstrukcijama humanih tvrdih tkiva. Ispitivanje citotoksičnosti je prvi korak u ocenjivanju biokompatibilnosti ovog biomaterijala. Cilj ovog istraživanja bio je da se ispita citotoksičnost nanokompozitnog biomaterijala poli(d,l-laktid-ko-glikolid)/hidroksiapatit sa sadržajem antibiotika klindamicina od 0%, 1%, 5% i 10%. Citotoksičnost ispitvanog materijala je određena testom odbacivanja boje (DET-Dye exclusion test) i kolorimetrijskim testom sa tetrazolijum solima (MTT-test). Ispitivanje je rađeno na fibroblastima kontinuiranih ćelijskih linija L929 i MRC5. Rezultati istraživanja su pokazali visoku biokompatibilnost ispitivanog biomaterijala bez obzira na udeo antibiotika klindamicina i nizak nivo citotoksičnosti kod svih sadržaja antibiotika.
PB  - Beograd : Institut tehničkih nauka SANU
C3  - Program i knjiga apstrakata / Osma konferencija mladih istraživača Nauka i inženjerstvo novih materijala, Beograd, 21–23. decembar 2009.
T1  - Ispitivanje biokompatibilnosti nanokompozitnog biomaterijala za kontrolisanu dostavu klindamicina - test citotoksičnosti
SP  - 21
EP  - 21
UR  - https://hdl.handle.net/21.15107/rcub_dais_14851
ER  - 

@conference{
author = "Šarčev, Ivan and Petronijević, Branislava and Jevtić, Marija and Ignjatović, Nenad",
year = "2009",
abstract = "Nano sfere kompozitnog biomaterijala poli(d,l-laktid-ko-glikolid)/hidroksiapatit u kojima je imobilisan/inkapsuliran antibiotik mogu imati širok aplikativan značaj kao sistemi sa kontrolisanom i ciljanom dostavom lekova u rekonstrukcijama humanih tvrdih tkiva. Ispitivanje citotoksičnosti je prvi korak u ocenjivanju biokompatibilnosti ovog biomaterijala. Cilj ovog istraživanja bio je da se ispita citotoksičnost nanokompozitnog biomaterijala poli(d,l-laktid-ko-glikolid)/hidroksiapatit sa sadržajem antibiotika klindamicina od 0%, 1%, 5% i 10%. Citotoksičnost ispitvanog materijala je određena testom odbacivanja boje (DET-Dye exclusion test) i kolorimetrijskim testom sa tetrazolijum solima (MTT-test). Ispitivanje je rađeno na fibroblastima kontinuiranih ćelijskih linija L929 i MRC5. Rezultati istraživanja su pokazali visoku biokompatibilnost ispitivanog biomaterijala bez obzira na udeo antibiotika klindamicina i nizak nivo citotoksičnosti kod svih sadržaja antibiotika.",
publisher = "Beograd : Institut tehničkih nauka SANU",
journal = "Program i knjiga apstrakata / Osma konferencija mladih istraživača Nauka i inženjerstvo novih materijala, Beograd, 21–23. decembar 2009.",
title = "Ispitivanje biokompatibilnosti nanokompozitnog biomaterijala za kontrolisanu dostavu klindamicina - test citotoksičnosti",
pages = "21-21",
url = "https://hdl.handle.net/21.15107/rcub_dais_14851"
}

Šarčev, I., Petronijević, B., Jevtić, M.,& Ignjatović, N.. (2009). Ispitivanje biokompatibilnosti nanokompozitnog biomaterijala za kontrolisanu dostavu klindamicina - test citotoksičnosti. in Program i knjiga apstrakata / Osma konferencija mladih istraživača Nauka i inženjerstvo novih materijala, Beograd, 21–23. decembar 2009.
Beograd : Institut tehničkih nauka SANU., 21-21.
https://hdl.handle.net/21.15107/rcub_dais_14851

Šarčev I, Petronijević B, Jevtić M, Ignjatović N. Ispitivanje biokompatibilnosti nanokompozitnog biomaterijala za kontrolisanu dostavu klindamicina - test citotoksičnosti. in Program i knjiga apstrakata / Osma konferencija mladih istraživača Nauka i inženjerstvo novih materijala, Beograd, 21–23. decembar 2009.. 2009;:21-21.
https://hdl.handle.net/21.15107/rcub_dais_14851 .

Šarčev, Ivan, Petronijević, Branislava, Jevtić, Marija, Ignjatović, Nenad, "Ispitivanje biokompatibilnosti nanokompozitnog biomaterijala za kontrolisanu dostavu klindamicina - test citotoksičnosti" in Program i knjiga apstrakata / Osma konferencija mladih istraživača Nauka i inženjerstvo novih materijala, Beograd, 21–23. decembar 2009. (2009):21-21,
https://hdl.handle.net/21.15107/rcub_dais_14851 .