TY  - JOUR
AU  - Stevanović, Magdalena
AU  - Vukomanović, Marija
AU  - Milenković, M.
AU  - Boccaccini, Aldo R.
PY  - 2022
UR  - https://dais.sanu.ac.rs/123456789/13512
AB  - Antimicrobial resistance (AMR) and infections caused by multidrug-resistant microbial pathogens represent one of the major clinical challenges responsible for high-level morbidity and mortality. They are a significant problem to the public health and the economic stability of societies all over the world. In November 2021 WHO has declared AMR as one of the top 10 global public health threats (Antimicrobial resistance (who.int)). According to CDC’s 2019 AMR Report, although declining since 2013, with 2.8 million new cases and more than 35,000 deaths each year, the number of people facing the AMR problem in United States is still too high (Antibiotic Resistance Threats in the United States, 2019 (cdc.gov)). AMR also remains the major health concern of EU with more than 670,000 new cases of infections caused by antibiotic-resistant bacterial strains and more than 33,000 deaths per year (Antimicrobial resistance surveillance in Europe 2022 - 2020 data (europa.eu)). In 2019 China recorded 39-% drop of antibiotic use in hospitalised patients compare to 2011 (Antimicrobial resistance - China (who.int)). Still, with 73,000 estimated new cases only for multi-drug resistant tuberculosis, the region remained at second position of the global highest incident rates (Antimicrobial resistance - China (who.int)). Each year a large number of people receive different kinds of implants, for example, hip or knee. However recent discoveries reveal that, either during the operative protocol or due to secondary infections, the implant’s surface could be colonized by bacteria, fungi, or both which can have serious consequences on a patient’s health. According to Annual Epidemiological Report of ECDC in 2016, post-surgical infections were identified as most common healthcare-associated infections (Surgical site infections - Annual Epidemiological Report 2016 [2014 data] (europa.eu)). In recent years it has been also recognized that microbial biofilms are ubiquitous, which has resulted in a number of studies from a biofilm perspective. Currently, great efforts are focused on the development of innovative therapeutic strategies regarding both novel drug candidates and drug delivery systems for treating microbial infections associated with implants. However, despite all these efforts as well as the urgent need, an effective and long-lasting solution to this problem is still not found. In the last decades, great attention is paid to nanostructured polymeric materials and nanocomposites because of their unique properties, which make them appropriate candidates for various applications in different medical and pharmaceutical fields. This Research Topic draws attention to the up-to-date findings regarding these issues and advanced therapeutic strategies and approaches as possible solutions.
T2  - Frontiers in Bioengineering and Biotechnology
T1  - Editorial: Antimicrobial nanostructured polymeric materials and nanocomposites, volume II
VL  - 10
DO  - 10.3389/fbioe.2022.1015485
UR  - https://hdl.handle.net/21.15107/rcub_dais_13512
ER  - 

@article{
author = "Stevanović, Magdalena and Vukomanović, Marija and Milenković, M. and Boccaccini, Aldo R.",
year = "2022",
abstract = "Antimicrobial resistance (AMR) and infections caused by multidrug-resistant microbial pathogens represent one of the major clinical challenges responsible for high-level morbidity and mortality. They are a significant problem to the public health and the economic stability of societies all over the world. In November 2021 WHO has declared AMR as one of the top 10 global public health threats (Antimicrobial resistance (who.int)). According to CDC’s 2019 AMR Report, although declining since 2013, with 2.8 million new cases and more than 35,000 deaths each year, the number of people facing the AMR problem in United States is still too high (Antibiotic Resistance Threats in the United States, 2019 (cdc.gov)). AMR also remains the major health concern of EU with more than 670,000 new cases of infections caused by antibiotic-resistant bacterial strains and more than 33,000 deaths per year (Antimicrobial resistance surveillance in Europe 2022 - 2020 data (europa.eu)). In 2019 China recorded 39-% drop of antibiotic use in hospitalised patients compare to 2011 (Antimicrobial resistance - China (who.int)). Still, with 73,000 estimated new cases only for multi-drug resistant tuberculosis, the region remained at second position of the global highest incident rates (Antimicrobial resistance - China (who.int)). Each year a large number of people receive different kinds of implants, for example, hip or knee. However recent discoveries reveal that, either during the operative protocol or due to secondary infections, the implant’s surface could be colonized by bacteria, fungi, or both which can have serious consequences on a patient’s health. According to Annual Epidemiological Report of ECDC in 2016, post-surgical infections were identified as most common healthcare-associated infections (Surgical site infections - Annual Epidemiological Report 2016 [2014 data] (europa.eu)). In recent years it has been also recognized that microbial biofilms are ubiquitous, which has resulted in a number of studies from a biofilm perspective. Currently, great efforts are focused on the development of innovative therapeutic strategies regarding both novel drug candidates and drug delivery systems for treating microbial infections associated with implants. However, despite all these efforts as well as the urgent need, an effective and long-lasting solution to this problem is still not found. In the last decades, great attention is paid to nanostructured polymeric materials and nanocomposites because of their unique properties, which make them appropriate candidates for various applications in different medical and pharmaceutical fields. This Research Topic draws attention to the up-to-date findings regarding these issues and advanced therapeutic strategies and approaches as possible solutions.",
journal = "Frontiers in Bioengineering and Biotechnology",
title = "Editorial: Antimicrobial nanostructured polymeric materials and nanocomposites, volume II",
volume = "10",
doi = "10.3389/fbioe.2022.1015485",
url = "https://hdl.handle.net/21.15107/rcub_dais_13512"
}

Stevanović, M., Vukomanović, M., Milenković, M.,& Boccaccini, A. R.. (2022). Editorial: Antimicrobial nanostructured polymeric materials and nanocomposites, volume II. in Frontiers in Bioengineering and Biotechnology, 10.
https://doi.org/10.3389/fbioe.2022.1015485
https://hdl.handle.net/21.15107/rcub_dais_13512

Stevanović M, Vukomanović M, Milenković M, Boccaccini AR. Editorial: Antimicrobial nanostructured polymeric materials and nanocomposites, volume II. in Frontiers in Bioengineering and Biotechnology. 2022;10.
doi:10.3389/fbioe.2022.1015485
https://hdl.handle.net/21.15107/rcub_dais_13512 .

Stevanović, Magdalena, Vukomanović, Marija, Milenković, M., Boccaccini, Aldo R., "Editorial: Antimicrobial nanostructured polymeric materials and nanocomposites, volume II" in Frontiers in Bioengineering and Biotechnology, 10 (2022),
https://doi.org/10.3389/fbioe.2022.1015485 .,
https://hdl.handle.net/21.15107/rcub_dais_13512 .

TY  - JOUR
AU  - Stevanović, Magdalena
AU  - Vukomanović, Marija
AU  - Milenković, Marina
AU  - Boccaccini, Aldo R.
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3948
UR  - https://dais.sanu.ac.rs/123456789/11877
AB  - Infectious diseases are a significant burden on the public health and the economic stability of societies all over the world. Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs. The considerable concern regarding bacterial resistance to antimicrobial agents, bacterial adhesion, and proliferation has generated intense research in this field. Although urgently needed, an effective and long-lasting solution to this problem, i.e. microbial and especially bacterial colonization, has not yet been found. In the last decades, nanomaterials have attracted much attention because of their unique physical, chemical, and mechanical properties, due to their high surface area and size at the nanoscale. Owing to these extraordinary characteristics, nanomaterials are appropriate candidates for various applications in different fields such as medicine, pharmacy, food industry, etc. New strategies based on the use of nanomaterials such as nanoparticles, nanocapsules, nanogels, nanofibers, nanocomposites, or nanocoatings for controlling microbial virulence factors are very promising. In addition special focus recently is paid on nanostructured polymeric materials and nanocomposites with antimicrobial properties. The increasing attention within the scientific community regarding this topic can be easily assessed by searching the suitable keywords in some recognized literature databases. According to Scopus, in the last 10 years, more than 1,300 peer-reviewed documents have been published jointly containing keywords such as “nanocomposites” and “antimicrobial”. Interestingly, in the more specified search which refers to the utilization of nanostructured polymeric materials, it could be observed a similar profile i.e. growing tendency.
PB  - Frontiers Media S.A.
T2  - Frontiers in Materials
T1  - Editorial: Antimicrobial Nanostructured Polymeric Materials and Nanocomposites
VL  - 8
DO  - 10.3389/fmats.2021.748813
UR  - https://hdl.handle.net/21.15107/rcub_dais_11877
ER  - 

@article{
author = "Stevanović, Magdalena and Vukomanović, Marija and Milenković, Marina and Boccaccini, Aldo R.",
year = "2021",
abstract = "Infectious diseases are a significant burden on the public health and the economic stability of societies all over the world. Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs. The considerable concern regarding bacterial resistance to antimicrobial agents, bacterial adhesion, and proliferation has generated intense research in this field. Although urgently needed, an effective and long-lasting solution to this problem, i.e. microbial and especially bacterial colonization, has not yet been found. In the last decades, nanomaterials have attracted much attention because of their unique physical, chemical, and mechanical properties, due to their high surface area and size at the nanoscale. Owing to these extraordinary characteristics, nanomaterials are appropriate candidates for various applications in different fields such as medicine, pharmacy, food industry, etc. New strategies based on the use of nanomaterials such as nanoparticles, nanocapsules, nanogels, nanofibers, nanocomposites, or nanocoatings for controlling microbial virulence factors are very promising. In addition special focus recently is paid on nanostructured polymeric materials and nanocomposites with antimicrobial properties. The increasing attention within the scientific community regarding this topic can be easily assessed by searching the suitable keywords in some recognized literature databases. According to Scopus, in the last 10 years, more than 1,300 peer-reviewed documents have been published jointly containing keywords such as “nanocomposites” and “antimicrobial”. Interestingly, in the more specified search which refers to the utilization of nanostructured polymeric materials, it could be observed a similar profile i.e. growing tendency.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Materials",
title = "Editorial: Antimicrobial Nanostructured Polymeric Materials and Nanocomposites",
volume = "8",
doi = "10.3389/fmats.2021.748813",
url = "https://hdl.handle.net/21.15107/rcub_dais_11877"
}

Stevanović, M., Vukomanović, M., Milenković, M.,& Boccaccini, A. R.. (2021). Editorial: Antimicrobial Nanostructured Polymeric Materials and Nanocomposites. in Frontiers in Materials
Frontiers Media S.A.., 8.
https://doi.org/10.3389/fmats.2021.748813
https://hdl.handle.net/21.15107/rcub_dais_11877

Stevanović M, Vukomanović M, Milenković M, Boccaccini AR. Editorial: Antimicrobial Nanostructured Polymeric Materials and Nanocomposites. in Frontiers in Materials. 2021;8.
doi:10.3389/fmats.2021.748813
https://hdl.handle.net/21.15107/rcub_dais_11877 .

Stevanović, Magdalena, Vukomanović, Marija, Milenković, Marina, Boccaccini, Aldo R., "Editorial: Antimicrobial Nanostructured Polymeric Materials and Nanocomposites" in Frontiers in Materials, 8 (2021),
https://doi.org/10.3389/fmats.2021.748813 .,
https://hdl.handle.net/21.15107/rcub_dais_11877 .

TY  - JOUR
AU  - Veselinović, Ljiljana
AU  - Mitrić, Miodrag
AU  - Mančić, Lidija
AU  - Vukomanović, Marija
AU  - Hadžić, Branka
AU  - Marković, Smilja
AU  - Uskoković, Dragan
PY  - 2014
UR  - https://dais.sanu.ac.rs/123456789/668
AB  - The effect of Sn for Ti substitution on the crystal structure of a perovskite, barium titanate stannate (BTS), BaTi1−xSnxO3 for x = 0, 0.025, 0.05, 0.07, 0.10, 0.12, 0.15 and 0.20, was investigated. The powders were prepared by the conventional solid-state reaction technique. The structural investigations of the BTS powders were done at room temperature by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), high-resolution TEM (HRTEM), selected-area electron diffraction (SAED) and Raman spectroscopy analyses. Rietveld refinement of XRD data indicates that gradual replacement of titanium by tin in BaTiO3 provokes a phase transition from tetragonal for 0 ≤x≤ 0.07 to cubic for x = 0.12, 0.15 and 0.20. The coexistence of tetragonal (P4mm) and cubic (Pminline imagem) crystal phases was established in powder with nominal composition BaTi0.9Sn0.1O3. The crystal phases determined by Rietveld refinement were confirmed by HRTEM and SAED analyses. The crystal structures of the BTS powders at short-range scale were studied by Raman spectroscopy, which shows tetragonal (P4mm) and a small fraction of orthorhombic (Pmm2) crystal phases for all the examined BTS powders, implying a lower local ordering when compared to the average symmetry.
PB  - Hoboken, NJ : John Wiley & Sons
T2  - Journal of Applied Crystallography
T1  - The effect of Sn for Ti substitution on the average and local crystal structure of BaTi1−xSnxO3 (0 ≤x≤ 0.20)
SP  - 999
EP  - 1007
VL  - 47
IS  - 3
DO  - 10.1107/S1600576714007584
UR  - https://hdl.handle.net/21.15107/rcub_dais_668
ER  - 

@article{
author = "Veselinović, Ljiljana and Mitrić, Miodrag and Mančić, Lidija and Vukomanović, Marija and Hadžić, Branka and Marković, Smilja and Uskoković, Dragan",
year = "2014",
abstract = "The effect of Sn for Ti substitution on the crystal structure of a perovskite, barium titanate stannate (BTS), BaTi1−xSnxO3 for x = 0, 0.025, 0.05, 0.07, 0.10, 0.12, 0.15 and 0.20, was investigated. The powders were prepared by the conventional solid-state reaction technique. The structural investigations of the BTS powders were done at room temperature by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), high-resolution TEM (HRTEM), selected-area electron diffraction (SAED) and Raman spectroscopy analyses. Rietveld refinement of XRD data indicates that gradual replacement of titanium by tin in BaTiO3 provokes a phase transition from tetragonal for 0 ≤x≤ 0.07 to cubic for x = 0.12, 0.15 and 0.20. The coexistence of tetragonal (P4mm) and cubic (Pminline imagem) crystal phases was established in powder with nominal composition BaTi0.9Sn0.1O3. The crystal phases determined by Rietveld refinement were confirmed by HRTEM and SAED analyses. The crystal structures of the BTS powders at short-range scale were studied by Raman spectroscopy, which shows tetragonal (P4mm) and a small fraction of orthorhombic (Pmm2) crystal phases for all the examined BTS powders, implying a lower local ordering when compared to the average symmetry.",
publisher = "Hoboken, NJ : John Wiley & Sons",
journal = "Journal of Applied Crystallography",
title = "The effect of Sn for Ti substitution on the average and local crystal structure of BaTi1−xSnxO3 (0 ≤x≤ 0.20)",
pages = "999-1007",
volume = "47",
number = "3",
doi = "10.1107/S1600576714007584",
url = "https://hdl.handle.net/21.15107/rcub_dais_668"
}

Veselinović, L., Mitrić, M., Mančić, L., Vukomanović, M., Hadžić, B., Marković, S.,& Uskoković, D.. (2014). The effect of Sn for Ti substitution on the average and local crystal structure of BaTi1−xSnxO3 (0 ≤x≤ 0.20). in Journal of Applied Crystallography
Hoboken, NJ : John Wiley & Sons., 47(3), 999-1007.
https://doi.org/10.1107/S1600576714007584
https://hdl.handle.net/21.15107/rcub_dais_668

Veselinović L, Mitrić M, Mančić L, Vukomanović M, Hadžić B, Marković S, Uskoković D. The effect of Sn for Ti substitution on the average and local crystal structure of BaTi1−xSnxO3 (0 ≤x≤ 0.20). in Journal of Applied Crystallography. 2014;47(3):999-1007.
doi:10.1107/S1600576714007584
https://hdl.handle.net/21.15107/rcub_dais_668 .

Veselinović, Ljiljana, Mitrić, Miodrag, Mančić, Lidija, Vukomanović, Marija, Hadžić, Branka, Marković, Smilja, Uskoković, Dragan, "The effect of Sn for Ti substitution on the average and local crystal structure of BaTi1−xSnxO3 (0 ≤x≤ 0.20)" in Journal of Applied Crystallography, 47, no. 3 (2014):999-1007,
https://doi.org/10.1107/S1600576714007584 .,
https://hdl.handle.net/21.15107/rcub_dais_668 .

TY  - JOUR
AU  - Jugović, Dragana
AU  - Mitrić, Miodrag
AU  - Milović, Miloš
AU  - Jokić, Bojan
AU  - Vukomanović, Marija
AU  - Suvorov, Danilo
AU  - Uskoković, Dragan
PY  - 2013
UR  - https://dais.sanu.ac.rs/123456789/753
AB  - In this study, nanocrystalline LiFePO4/C composite powder has been synthesized via a cellulose matrix-assisted method. In an experiment conducted under extreme conditions involving rapid heating, short high-temperature delay, and subsequent quenching, well-ordered 35-nm crystallites have been obtained within 5 min. A quantitative filter paper has served both as a template and carbon source. It degrades pyrolytically through fragmentation reactions and formation of volatiles when exposed to rapid heating, which further has an impact on powder morphology, as revealed by electron microscopy studies. The electrochemical measurements in terms of galvanostatic cycling have shown that the approach presented in this study may enable to reach good rate capability and excellent cycling stability.
T2  - Powder Technology
T1  - Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method
SP  - 539
EP  - 544
VL  - 246
DO  - 10.1016/j.powtec.2013.06.021
UR  - https://hdl.handle.net/21.15107/rcub_dais_753
ER  - 

@article{
author = "Jugović, Dragana and Mitrić, Miodrag and Milović, Miloš and Jokić, Bojan and Vukomanović, Marija and Suvorov, Danilo and Uskoković, Dragan",
year = "2013",
abstract = "In this study, nanocrystalline LiFePO4/C composite powder has been synthesized via a cellulose matrix-assisted method. In an experiment conducted under extreme conditions involving rapid heating, short high-temperature delay, and subsequent quenching, well-ordered 35-nm crystallites have been obtained within 5 min. A quantitative filter paper has served both as a template and carbon source. It degrades pyrolytically through fragmentation reactions and formation of volatiles when exposed to rapid heating, which further has an impact on powder morphology, as revealed by electron microscopy studies. The electrochemical measurements in terms of galvanostatic cycling have shown that the approach presented in this study may enable to reach good rate capability and excellent cycling stability.",
journal = "Powder Technology",
title = "Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method",
pages = "539-544",
volume = "246",
doi = "10.1016/j.powtec.2013.06.021",
url = "https://hdl.handle.net/21.15107/rcub_dais_753"
}

Jugović, D., Mitrić, M., Milović, M., Jokić, B., Vukomanović, M., Suvorov, D.,& Uskoković, D.. (2013). Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method. in Powder Technology, 246, 539-544.
https://doi.org/10.1016/j.powtec.2013.06.021
https://hdl.handle.net/21.15107/rcub_dais_753

Jugović D, Mitrić M, Milović M, Jokić B, Vukomanović M, Suvorov D, Uskoković D. Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method. in Powder Technology. 2013;246:539-544.
doi:10.1016/j.powtec.2013.06.021
https://hdl.handle.net/21.15107/rcub_dais_753 .

Jugović, Dragana, Mitrić, Miodrag, Milović, Miloš, Jokić, Bojan, Vukomanović, Marija, Suvorov, Danilo, Uskoković, Dragan, "Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method" in Powder Technology, 246 (2013):539-544,
https://doi.org/10.1016/j.powtec.2013.06.021 .,
https://hdl.handle.net/21.15107/rcub_dais_753 .

TY  - JOUR
AU  - Jugović, Dragana
AU  - Mitrić, Miodrag
AU  - Milović, Miloš
AU  - Jokić, Bojan
AU  - Vukomanović, Marija
AU  - Suvorov, Danilo
AU  - Uskoković, Dragan
PY  - 2013
UR  - https://dais.sanu.ac.rs/123456789/356
AB  - In this study, nanocrystalline LiFePO4/C composite powder has been synthesized via a cellulose matrix-assisted method. In an experiment conducted under extreme conditions involving rapid heating, short high-temperature delay, and subsequent quenching, well-ordered 35-nm crystallites have been obtained within 5 min. A quantitative filter paper has served both as a template and carbon source. It degrades pyrolytically through fragmentation reactions and formation of volatiles when exposed to rapid heating, which further has an impact on powder morphology, as revealed by electron microscopy studies. The electrochemical measurements in terms of galvanostatic cycling have shown that the approach presented in this study may enable to reach good rate capability and excellent cycling stability.
PB  - Elsevier
T2  - Powder Technology
T1  - Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method
SP  - 539
EP  - 544
VL  - 246
DO  - 10.1016/j.powtec.2013.06.021
UR  - https://hdl.handle.net/21.15107/rcub_dais_356
ER  - 

@article{
author = "Jugović, Dragana and Mitrić, Miodrag and Milović, Miloš and Jokić, Bojan and Vukomanović, Marija and Suvorov, Danilo and Uskoković, Dragan",
year = "2013",
abstract = "In this study, nanocrystalline LiFePO4/C composite powder has been synthesized via a cellulose matrix-assisted method. In an experiment conducted under extreme conditions involving rapid heating, short high-temperature delay, and subsequent quenching, well-ordered 35-nm crystallites have been obtained within 5 min. A quantitative filter paper has served both as a template and carbon source. It degrades pyrolytically through fragmentation reactions and formation of volatiles when exposed to rapid heating, which further has an impact on powder morphology, as revealed by electron microscopy studies. The electrochemical measurements in terms of galvanostatic cycling have shown that the approach presented in this study may enable to reach good rate capability and excellent cycling stability.",
publisher = "Elsevier",
journal = "Powder Technology",
title = "Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method",
pages = "539-544",
volume = "246",
doi = "10.1016/j.powtec.2013.06.021",
url = "https://hdl.handle.net/21.15107/rcub_dais_356"
}

Jugović, D., Mitrić, M., Milović, M., Jokić, B., Vukomanović, M., Suvorov, D.,& Uskoković, D.. (2013). Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method. in Powder Technology
Elsevier., 246, 539-544.
https://doi.org/10.1016/j.powtec.2013.06.021
https://hdl.handle.net/21.15107/rcub_dais_356

Jugović D, Mitrić M, Milović M, Jokić B, Vukomanović M, Suvorov D, Uskoković D. Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method. in Powder Technology. 2013;246:539-544.
doi:10.1016/j.powtec.2013.06.021
https://hdl.handle.net/21.15107/rcub_dais_356 .

Jugović, Dragana, Mitrić, Miodrag, Milović, Miloš, Jokić, Bojan, Vukomanović, Marija, Suvorov, Danilo, Uskoković, Dragan, "Properties of quenched LiFePO4/C powder obtained via cellulose matrix-assisted method" in Powder Technology, 246 (2013):539-544,
https://doi.org/10.1016/j.powtec.2013.06.021 .,
https://hdl.handle.net/21.15107/rcub_dais_356 .

TY  - JOUR
AU  - Uskoković, Vuk
AU  - Hoover, Charles
AU  - Vukomanović, Marija
AU  - Uskoković, Dragan
AU  - Desai, Tejal A.
PY  - 2013
UR  - https://dais.sanu.ac.rs/123456789/382
AB  - Development of a material for simultaneous sustained and localized delivery of antibiotics and induction of spontaneous regeneration of hard tissues affected by osteomyelitis stands for an important clinical need. In this work, a comparative analysis of the bacterial and osteoblastic cell response to two different nanoparticulate carriers of clindamycin, an antibiotic commonly prescribed in the treatment of bone infection, one composed of calcium phosphate and the other comprising poly-(D,L-lactide-co-glycolide)-coated calcium phosphate, was carried out. Three different non-cytotoxic phases of calcium phosphate, exhibiting dissolution and drug release profiles in the range of one week to two months to one year, respectively, were included in the analysis: monetite, amorphous calcium phosphate and hydroxyapatite. Spherical morphologies and narrow size distribution of both types of nanopowders were confirmed in transmission and scanning electron microscopic analyses. The antibiotic-containing powders exhibited sustained drug release contingent upon the degradation rate of the carrier. Assessment of the antibacterial performance of the antibiotic-encapsulated powders against Staphylococcus aureus, the most common pathogen isolated from infected bone, yielded satisfactory results both in broths and on blood agar plates for all the analyzed powders. In contrast, no cytotoxic behavior was detected upon the incubation of the antibiotic powders with the osteoblastic MC3T3-E1 cell line for up to three weeks. The cells were shown to engage in a close contact with the antibiotic-containing particles, irrespective of their internal or surface phase composition, polymeric or mineral. At the same time, both types of particles upregulated the expression of osteogenic markers osteocalcin, osteopontin, Runx2 and protocollagen type I, suggesting their ability to promote osteogenesis and enhance remineralization of the infected site in addition to eliminating the bacterial source of infection.
PB  - Elsevier
T2  - Materials Science and Engineering: C
T1  - Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis
SP  - 3362
EP  - 3373
VL  - 33
IS  - 6
DO  - 10.1016/j.msec.2013.04.023
UR  - https://hdl.handle.net/21.15107/rcub_dais_382
ER  - 

@article{
author = "Uskoković, Vuk and Hoover, Charles and Vukomanović, Marija and Uskoković, Dragan and Desai, Tejal A.",
year = "2013",
abstract = "Development of a material for simultaneous sustained and localized delivery of antibiotics and induction of spontaneous regeneration of hard tissues affected by osteomyelitis stands for an important clinical need. In this work, a comparative analysis of the bacterial and osteoblastic cell response to two different nanoparticulate carriers of clindamycin, an antibiotic commonly prescribed in the treatment of bone infection, one composed of calcium phosphate and the other comprising poly-(D,L-lactide-co-glycolide)-coated calcium phosphate, was carried out. Three different non-cytotoxic phases of calcium phosphate, exhibiting dissolution and drug release profiles in the range of one week to two months to one year, respectively, were included in the analysis: monetite, amorphous calcium phosphate and hydroxyapatite. Spherical morphologies and narrow size distribution of both types of nanopowders were confirmed in transmission and scanning electron microscopic analyses. The antibiotic-containing powders exhibited sustained drug release contingent upon the degradation rate of the carrier. Assessment of the antibacterial performance of the antibiotic-encapsulated powders against Staphylococcus aureus, the most common pathogen isolated from infected bone, yielded satisfactory results both in broths and on blood agar plates for all the analyzed powders. In contrast, no cytotoxic behavior was detected upon the incubation of the antibiotic powders with the osteoblastic MC3T3-E1 cell line for up to three weeks. The cells were shown to engage in a close contact with the antibiotic-containing particles, irrespective of their internal or surface phase composition, polymeric or mineral. At the same time, both types of particles upregulated the expression of osteogenic markers osteocalcin, osteopontin, Runx2 and protocollagen type I, suggesting their ability to promote osteogenesis and enhance remineralization of the infected site in addition to eliminating the bacterial source of infection.",
publisher = "Elsevier",
journal = "Materials Science and Engineering: C",
title = "Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis",
pages = "3362-3373",
volume = "33",
number = "6",
doi = "10.1016/j.msec.2013.04.023",
url = "https://hdl.handle.net/21.15107/rcub_dais_382"
}

Uskoković, V., Hoover, C., Vukomanović, M., Uskoković, D.,& Desai, T. A.. (2013). Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis. in Materials Science and Engineering: C
Elsevier., 33(6), 3362-3373.
https://doi.org/10.1016/j.msec.2013.04.023
https://hdl.handle.net/21.15107/rcub_dais_382

Uskoković V, Hoover C, Vukomanović M, Uskoković D, Desai TA. Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis. in Materials Science and Engineering: C. 2013;33(6):3362-3373.
doi:10.1016/j.msec.2013.04.023
https://hdl.handle.net/21.15107/rcub_dais_382 .

Uskoković, Vuk, Hoover, Charles, Vukomanović, Marija, Uskoković, Dragan, Desai, Tejal A., "Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis" in Materials Science and Engineering: C, 33, no. 6 (2013):3362-3373,
https://doi.org/10.1016/j.msec.2013.04.023 .,
https://hdl.handle.net/21.15107/rcub_dais_382 .

TY  - JOUR
AU  - Uskoković, Vuk
AU  - Hoover, Charles
AU  - Vukomanović, Marija
AU  - Uskoković, Dragan
AU  - Desai, Tejal A.
PY  - 2013
UR  - https://dais.sanu.ac.rs/123456789/15989
AB  - Development of a material for simultaneous sustained and localized delivery of antibiotics and induction of spontaneous regeneration of hard tissues affected by osteomyelitis stands for an important clinical need. In this work, a comparative analysis of the bacterial and osteoblastic cell response to two different nanoparticulate carriers of clindamycin, an antibiotic commonly prescribed in the treatment of bone infection, one composed of calcium phosphate and the other comprising poly-(D,L-lactide-co-glycolide)-coated calcium phosphate, was carried out. Three different non-cytotoxic phases of calcium phosphate, exhibiting dissolution and drug release profiles in the range of one week to two months to one year, respectively, were included in the analysis: monetite, amorphous calcium phosphate and hydroxyapatite. Spherical morphologies and narrow size distribution of both types of nanopowders were confirmed in transmission and scanning electron microscopic analyses. The antibiotic-containing powders exhibited sustained drug release contingent upon the degradation rate of the carrier. Assessment of the antibacterial performance of the antibiotic-encapsulated powders against Staphylococcus aureus, the most common pathogen isolated from infected bone, yielded satisfactory results both in broths and on blood agar plates for all the analyzed powders. In contrast, no cytotoxic behavior was detected upon the incubation of the antibiotic powders with the osteoblastic MC3T3-E1 cell line for up to three weeks. The cells were shown to engage in a close contact with the antibiotic-containing particles, irrespective of their internal or surface phase composition, polymeric or mineral. At the same time, both types of particles upregulated the expression of osteogenic markers osteocalcin, osteopontin, Runx2 and protocollagen type I, suggesting their ability to promote osteogenesis and enhance remineralization of the infected site in addition to eliminating the bacterial source of infection.
T2  - Materials Science and Engineering: C
T1  - Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis
SP  - 3362
EP  - 3373
VL  - 33
IS  - 6
DO  - 10.1016/j.msec.2013.04.023
UR  - https://hdl.handle.net/21.15107/rcub_dais_15989
ER  - 

@article{
author = "Uskoković, Vuk and Hoover, Charles and Vukomanović, Marija and Uskoković, Dragan and Desai, Tejal A.",
year = "2013",
abstract = "Development of a material for simultaneous sustained and localized delivery of antibiotics and induction of spontaneous regeneration of hard tissues affected by osteomyelitis stands for an important clinical need. In this work, a comparative analysis of the bacterial and osteoblastic cell response to two different nanoparticulate carriers of clindamycin, an antibiotic commonly prescribed in the treatment of bone infection, one composed of calcium phosphate and the other comprising poly-(D,L-lactide-co-glycolide)-coated calcium phosphate, was carried out. Three different non-cytotoxic phases of calcium phosphate, exhibiting dissolution and drug release profiles in the range of one week to two months to one year, respectively, were included in the analysis: monetite, amorphous calcium phosphate and hydroxyapatite. Spherical morphologies and narrow size distribution of both types of nanopowders were confirmed in transmission and scanning electron microscopic analyses. The antibiotic-containing powders exhibited sustained drug release contingent upon the degradation rate of the carrier. Assessment of the antibacterial performance of the antibiotic-encapsulated powders against Staphylococcus aureus, the most common pathogen isolated from infected bone, yielded satisfactory results both in broths and on blood agar plates for all the analyzed powders. In contrast, no cytotoxic behavior was detected upon the incubation of the antibiotic powders with the osteoblastic MC3T3-E1 cell line for up to three weeks. The cells were shown to engage in a close contact with the antibiotic-containing particles, irrespective of their internal or surface phase composition, polymeric or mineral. At the same time, both types of particles upregulated the expression of osteogenic markers osteocalcin, osteopontin, Runx2 and protocollagen type I, suggesting their ability to promote osteogenesis and enhance remineralization of the infected site in addition to eliminating the bacterial source of infection.",
journal = "Materials Science and Engineering: C",
title = "Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis",
pages = "3362-3373",
volume = "33",
number = "6",
doi = "10.1016/j.msec.2013.04.023",
url = "https://hdl.handle.net/21.15107/rcub_dais_15989"
}

Uskoković, V., Hoover, C., Vukomanović, M., Uskoković, D.,& Desai, T. A.. (2013). Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis. in Materials Science and Engineering: C, 33(6), 3362-3373.
https://doi.org/10.1016/j.msec.2013.04.023
https://hdl.handle.net/21.15107/rcub_dais_15989

Uskoković V, Hoover C, Vukomanović M, Uskoković D, Desai TA. Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis. in Materials Science and Engineering: C. 2013;33(6):3362-3373.
doi:10.1016/j.msec.2013.04.023
https://hdl.handle.net/21.15107/rcub_dais_15989 .

Uskoković, Vuk, Hoover, Charles, Vukomanović, Marija, Uskoković, Dragan, Desai, Tejal A., "Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis" in Materials Science and Engineering: C, 33, no. 6 (2013):3362-3373,
https://doi.org/10.1016/j.msec.2013.04.023 .,
https://hdl.handle.net/21.15107/rcub_dais_15989 .

TY  - JOUR
AU  - Vukomanović, Marija
AU  - Šarčev, Igor
AU  - Petronijević, B.
AU  - Škapin, Srečo Davor
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2012
UR  - https://dais.sanu.ac.rs/123456789/490
AB  - The surface properties of PLGA/HAp core–shell nanoparticles loaded with clindamycin obtained by an ultrasonic processing method and their changes under the simulated physiological conditions during the degradation process (when the morphology is changed starting from the nanospheres, over micrometer-sized plate-like films to a porous network) were investigated. The dynamic change of the surface properties of this material obtained in a water environment showed an increase of the surface area (up to 70 m2/g) and an improved wettability (estimated water contact angle was in the range between 40° and 60°) suggesting the possibility for its good interaction with cells. The in vitro tests are in a good correlation with this hypothesis, showing a high level of cytocompatibility of the material with the mouse L929 and human lung MRC-5 fibroblasts. The fibroblasts were able to achieve the contact with the material's surface and to attach onto it. The significance of HAp, as the bioceramic phase within the PLGA/HAp core–shell nanoparticles, may be brought into relationship with its role in improving the surface properties of PLGA/HAp obtained during the degradation process. These properties are closely related to the bioactivity and biocompatibility of this material, which are highly relevant for its biomedical application.
PB  - Elsevier
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 4: A change of the surface properties during degradation process and the corresponding in vitro cellular response
SP  - 144
EP  - 153
DO  - 10.1016/j.colsurfb.2011.10.049
UR  - https://hdl.handle.net/21.15107/rcub_dais_490
ER  - 

@article{
author = "Vukomanović, Marija and Šarčev, Igor and Petronijević, B. and Škapin, Srečo Davor and Ignjatović, Nenad and Uskoković, Dragan",
year = "2012",
abstract = "The surface properties of PLGA/HAp core–shell nanoparticles loaded with clindamycin obtained by an ultrasonic processing method and their changes under the simulated physiological conditions during the degradation process (when the morphology is changed starting from the nanospheres, over micrometer-sized plate-like films to a porous network) were investigated. The dynamic change of the surface properties of this material obtained in a water environment showed an increase of the surface area (up to 70 m2/g) and an improved wettability (estimated water contact angle was in the range between 40° and 60°) suggesting the possibility for its good interaction with cells. The in vitro tests are in a good correlation with this hypothesis, showing a high level of cytocompatibility of the material with the mouse L929 and human lung MRC-5 fibroblasts. The fibroblasts were able to achieve the contact with the material's surface and to attach onto it. The significance of HAp, as the bioceramic phase within the PLGA/HAp core–shell nanoparticles, may be brought into relationship with its role in improving the surface properties of PLGA/HAp obtained during the degradation process. These properties are closely related to the bioactivity and biocompatibility of this material, which are highly relevant for its biomedical application.",
publisher = "Elsevier",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 4: A change of the surface properties during degradation process and the corresponding in vitro cellular response",
pages = "144-153",
doi = "10.1016/j.colsurfb.2011.10.049",
url = "https://hdl.handle.net/21.15107/rcub_dais_490"
}

Vukomanović, M., Šarčev, I., Petronijević, B., Škapin, S. D., Ignjatović, N.,& Uskoković, D.. (2012). Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 4: A change of the surface properties during degradation process and the corresponding in vitro cellular response. in Colloids and Surfaces B: Biointerfaces
Elsevier., 144-153.
https://doi.org/10.1016/j.colsurfb.2011.10.049
https://hdl.handle.net/21.15107/rcub_dais_490

Vukomanović M, Šarčev I, Petronijević B, Škapin SD, Ignjatović N, Uskoković D. Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 4: A change of the surface properties during degradation process and the corresponding in vitro cellular response. in Colloids and Surfaces B: Biointerfaces. 2012;:144-153.
doi:10.1016/j.colsurfb.2011.10.049
https://hdl.handle.net/21.15107/rcub_dais_490 .

Vukomanović, Marija, Šarčev, Igor, Petronijević, B., Škapin, Srečo Davor, Ignjatović, Nenad, Uskoković, Dragan, "Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 4: A change of the surface properties during degradation process and the corresponding in vitro cellular response" in Colloids and Surfaces B: Biointerfaces (2012):144-153,
https://doi.org/10.1016/j.colsurfb.2011.10.049 .,
https://hdl.handle.net/21.15107/rcub_dais_490 .

TY  - THES
AU  - Vukomanović, Marija
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/75
AB  - U ovoj doktorskoj disertaciji primenjen je novi koncept inkapsulacije aktivne i proaktivne forme leka u okviru nosača koji bi bio u mogućnosti da kontroliše proces njihovog lokalnog otpuštanja u toku dužeg vremenskog perioda. Cilj formiranja ovakvog sistema su produžetak perioda lokalnog otpuštanja antibiotika i veći stepen kontrole nad njegovom koncentracijom. To su uslovi koji su neophodni za unapređenje tretmana hroničnih infekcija koštanog tkiva. Poli(D,L-laktid-ko-glikolid)/hidroksiapatit (PLGA/HAp) kompozitni materijal, izgrađen iz „jezgro-omotač“ nanostruktura, primenjen je kao nosač klindamicin-baze kao modela aktivne i klindamicin-2-fosfata kao modela proaktivne forme leka. Polimerni omotač, izgrađen iz nanosfernih primarnih čestica dijametra do 20 nm, ima ulogu matrice u okviru koje je dispergovan jedan deo leka. Biokeramičko jezgro je izgrađeno iz štapićastih čestica HAp-a na čijoj je površini, na granici između polimera i keramike, adsorbovan preostali deo leka. Optimizacijom uslova za procesiranje PLGA/HAp materijala i inkapsulaciju leka utvrđeno je da koncentracija leka i priroda izabranog sistema rastvarač/nerastvarač polimera, značajno utiču kako na morfološke karakteristike (oblik i veličinu) čestica PLGA/HAp-a tako i na efikasnost procesa inkapsulacije. Sa povećenjem koncentracije leka i sa povećenjem njegove
rastvorljivosti u sistemu rastvarač/nerastvarač polimera postižu se veća pravilnost
morfologije čestica i veći stepen inkapsulacije.
Tokom procesa degradacije kompozita postiže se kontrolisano otpuštanje proaktivne (fosfatne) forme leka, koju odlikuje bolja rastvorljivost u vodi, i odloženo otpuštanje aktivne (bazne) forme leka, čija je rastvorljivost u vodi slabija. Rezultat toga je visoka koncentracija ukupno otpuštenog leka u toku perioda od 30 dana u in vitro uslovima. U toku ovog procesa dešavaju se promene morfoloških, strukturnih, makromolekulskih i površinskih karakteristika nosača leka. Njihova promena zavisi od prirode inkapsuliranog leka čija interakcija sa nosačem utiče na kinetiku njegove degradacije.
Važnost prisustva HAp-a, kao biokeramičke faze u okviru PLGA/HAp-a, pripisana je kako usporavanju procesa degradacije polimera tako i unapređenju površinskih karakteristika kompozita. Porast specifične površine i unapređena kvašljivost materijala ukazuju na mogućnost njegove dobre interakcije sa ćelijama. Ove osobine su blisko povezane sa bioaktivnošću i biokompatibilnošću ovog materijala za koji je u toku in vitro testova utvrđen visok stepen citokompatibilnosti i netoksičnosti.
Na osnovu postignute kinetike otpuštanja leka kao i izuzetno dobre citokompatibilnosti može se zaključiti da formirani materijal pokazuje dobar potencijal za primenu u biomedicine kao nosač koji, nakon lokalne primene, lek dostavlja direktno na mesto infekcije uz minimalizaciju ili eliminaciju efekata koje uzrokuje tip dostave kod koga se lek distribuira u celom organizmu. To je pristup od koga se očekuje efikasnije lečenje infekcija koštanog tkiva i eliminacija neželjenih efekata.
AB  - In this doctoral dissertation a new concept of encapsulation of active and proactive drug forms within a carrier which will be able to provide a control over the process of their local release during extended period of time is applied. The goal of formation of such a system is prolongation of the period of local release of antibiotic and higher control over its concentration. These are conditions which are required for improvement of the treatment of chronic bone tissue infections.
Poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite material, built of core-shell nanostructures, was applied as a carrier of clindamycin-base, as a model of active drug form, and clindamycin-phosphate, as a model of proactive drug form. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. Ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another p art o f t he d rug is adsorbed- into the interface between polymer and ceramics.
During the optimization of the conditions for processing of PLGA/HAp material and
encapsulation of the drug it was observed that concentration of the drug as well as the nature of selected polymer solvent/nonsolvent system, significantly influence morphological properties of PLGA/HAp particles and efficacy of encapsulation process. With increase of the concentration of the drug and increase of the solubility of the drug within solvent/nonsolvent system, more regular morphology and higher encapsulation degree are obtained.
During the process of degradation of the composite controlled release of the more soluble proactive (phosphate) form and the sustained release of the less-soluble active (base) form of clindamycin are achieved, resulting in a high overall concentration of released drug during a period of 30 days in vitro. During this process morphological, structural, macromolecular and surface changes occurred. Their change depends on the nature of encapsulated drug that interacts with the drug carrier influencing the kinetics of composite degradation.
PB  - Belgrade : University of Belgrade, Faculty of Physical Chemistry
T1  - Kontrolisano oslobađanje antibiotika iz nanosfera poli(D,L-laktid-koglikolid)/hidroksiapatita sintetisanih u ultrazvučnom polju
DO  - 10.2298/BG20110311VUKOMANOVIC
UR  - https://hdl.handle.net/21.15107/rcub_dais_75
ER  - 

@phdthesis{
author = "Vukomanović, Marija",
year = "2011",
abstract = "U ovoj doktorskoj disertaciji primenjen je novi koncept inkapsulacije aktivne i proaktivne forme leka u okviru nosača koji bi bio u mogućnosti da kontroliše proces njihovog lokalnog otpuštanja u toku dužeg vremenskog perioda. Cilj formiranja ovakvog sistema su produžetak perioda lokalnog otpuštanja antibiotika i veći stepen kontrole nad njegovom koncentracijom. To su uslovi koji su neophodni za unapređenje tretmana hroničnih infekcija koštanog tkiva. Poli(D,L-laktid-ko-glikolid)/hidroksiapatit (PLGA/HAp) kompozitni materijal, izgrađen iz „jezgro-omotač“ nanostruktura, primenjen je kao nosač klindamicin-baze kao modela aktivne i klindamicin-2-fosfata kao modela proaktivne forme leka. Polimerni omotač, izgrađen iz nanosfernih primarnih čestica dijametra do 20 nm, ima ulogu matrice u okviru koje je dispergovan jedan deo leka. Biokeramičko jezgro je izgrađeno iz štapićastih čestica HAp-a na čijoj je površini, na granici između polimera i keramike, adsorbovan preostali deo leka. Optimizacijom uslova za procesiranje PLGA/HAp materijala i inkapsulaciju leka utvrđeno je da koncentracija leka i priroda izabranog sistema rastvarač/nerastvarač polimera, značajno utiču kako na morfološke karakteristike (oblik i veličinu) čestica PLGA/HAp-a tako i na efikasnost procesa inkapsulacije. Sa povećenjem koncentracije leka i sa povećenjem njegove
rastvorljivosti u sistemu rastvarač/nerastvarač polimera postižu se veća pravilnost
morfologije čestica i veći stepen inkapsulacije.
Tokom procesa degradacije kompozita postiže se kontrolisano otpuštanje proaktivne (fosfatne) forme leka, koju odlikuje bolja rastvorljivost u vodi, i odloženo otpuštanje aktivne (bazne) forme leka, čija je rastvorljivost u vodi slabija. Rezultat toga je visoka koncentracija ukupno otpuštenog leka u toku perioda od 30 dana u in vitro uslovima. U toku ovog procesa dešavaju se promene morfoloških, strukturnih, makromolekulskih i površinskih karakteristika nosača leka. Njihova promena zavisi od prirode inkapsuliranog leka čija interakcija sa nosačem utiče na kinetiku njegove degradacije.
Važnost prisustva HAp-a, kao biokeramičke faze u okviru PLGA/HAp-a, pripisana je kako usporavanju procesa degradacije polimera tako i unapređenju površinskih karakteristika kompozita. Porast specifične površine i unapređena kvašljivost materijala ukazuju na mogućnost njegove dobre interakcije sa ćelijama. Ove osobine su blisko povezane sa bioaktivnošću i biokompatibilnošću ovog materijala za koji je u toku in vitro testova utvrđen visok stepen citokompatibilnosti i netoksičnosti.
Na osnovu postignute kinetike otpuštanja leka kao i izuzetno dobre citokompatibilnosti može se zaključiti da formirani materijal pokazuje dobar potencijal za primenu u biomedicine kao nosač koji, nakon lokalne primene, lek dostavlja direktno na mesto infekcije uz minimalizaciju ili eliminaciju efekata koje uzrokuje tip dostave kod koga se lek distribuira u celom organizmu. To je pristup od koga se očekuje efikasnije lečenje infekcija koštanog tkiva i eliminacija neželjenih efekata., In this doctoral dissertation a new concept of encapsulation of active and proactive drug forms within a carrier which will be able to provide a control over the process of their local release during extended period of time is applied. The goal of formation of such a system is prolongation of the period of local release of antibiotic and higher control over its concentration. These are conditions which are required for improvement of the treatment of chronic bone tissue infections.
Poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite material, built of core-shell nanostructures, was applied as a carrier of clindamycin-base, as a model of active drug form, and clindamycin-phosphate, as a model of proactive drug form. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. Ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another p art o f t he d rug is adsorbed- into the interface between polymer and ceramics.
During the optimization of the conditions for processing of PLGA/HAp material and
encapsulation of the drug it was observed that concentration of the drug as well as the nature of selected polymer solvent/nonsolvent system, significantly influence morphological properties of PLGA/HAp particles and efficacy of encapsulation process. With increase of the concentration of the drug and increase of the solubility of the drug within solvent/nonsolvent system, more regular morphology and higher encapsulation degree are obtained.
During the process of degradation of the composite controlled release of the more soluble proactive (phosphate) form and the sustained release of the less-soluble active (base) form of clindamycin are achieved, resulting in a high overall concentration of released drug during a period of 30 days in vitro. During this process morphological, structural, macromolecular and surface changes occurred. Their change depends on the nature of encapsulated drug that interacts with the drug carrier influencing the kinetics of composite degradation.",
publisher = "Belgrade : University of Belgrade, Faculty of Physical Chemistry",
title = "Kontrolisano oslobađanje antibiotika iz nanosfera poli(D,L-laktid-koglikolid)/hidroksiapatita sintetisanih u ultrazvučnom polju",
doi = "10.2298/BG20110311VUKOMANOVIC",
url = "https://hdl.handle.net/21.15107/rcub_dais_75"
}

Vukomanović, M.. (2011). Kontrolisano oslobađanje antibiotika iz nanosfera poli(D,L-laktid-koglikolid)/hidroksiapatita sintetisanih u ultrazvučnom polju. 
Belgrade : University of Belgrade, Faculty of Physical Chemistry..
https://doi.org/10.2298/BG20110311VUKOMANOVIC
https://hdl.handle.net/21.15107/rcub_dais_75

Vukomanović M. Kontrolisano oslobađanje antibiotika iz nanosfera poli(D,L-laktid-koglikolid)/hidroksiapatita sintetisanih u ultrazvučnom polju. 2011;.
doi:10.2298/BG20110311VUKOMANOVIC
https://hdl.handle.net/21.15107/rcub_dais_75 .

Vukomanović, Marija, "Kontrolisano oslobađanje antibiotika iz nanosfera poli(D,L-laktid-koglikolid)/hidroksiapatita sintetisanih u ultrazvučnom polju" (2011),
https://doi.org/10.2298/BG20110311VUKOMANOVIC .,
https://hdl.handle.net/21.15107/rcub_dais_75 .

TY  - JOUR
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Poljanšek, Ida
AU  - Žagar, Ema
AU  - Kralj, Bogdan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/14363
AB  - The novel concept of a simultaneous, controlled release of a drug and a prodrug with different physico-chemical properties was applied in order to prolong the release period of antibiotics and estimate their high local concentrations, which are the necessary preconditions for the treatment of some chronic infection diseases. For this purpose poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) core–shell nanostructures were used as the carrier of clindamycin-base, as a drug, and clindamycin-2-phosphate, as a prodrug model. As a result, a two-step release was observed: the controlled release of the more soluble phosphate form and the sustained release of the less-soluble base form of clindamycin, resulting in a high overall concentration of the released drug during the period of 30 days in vitro. The HAp phase within the PLGA core–shells, applied as a drug carrier, delayed the process of the degradation of the polymer; however, the presence of the drug affected the process of degradation and this influence was the dominant factor in the control over the degradation of the polymer phase of PLGA/HAp and the consequent kinetics of the drug release.
PB  - Elsevier BV
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)
SP  - 414
EP  - 421
VL  - 82
IS  - 2
DO  - 10.1016/j.colsurfb.2010.09.012
UR  - https://hdl.handle.net/21.15107/rcub_dais_14363
ER  - 

@article{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Poljanšek, Ida and Žagar, Ema and Kralj, Bogdan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2011",
abstract = "The novel concept of a simultaneous, controlled release of a drug and a prodrug with different physico-chemical properties was applied in order to prolong the release period of antibiotics and estimate their high local concentrations, which are the necessary preconditions for the treatment of some chronic infection diseases. For this purpose poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) core–shell nanostructures were used as the carrier of clindamycin-base, as a drug, and clindamycin-2-phosphate, as a prodrug model. As a result, a two-step release was observed: the controlled release of the more soluble phosphate form and the sustained release of the less-soluble base form of clindamycin, resulting in a high overall concentration of the released drug during the period of 30 days in vitro. The HAp phase within the PLGA core–shells, applied as a drug carrier, delayed the process of the degradation of the polymer; however, the presence of the drug affected the process of degradation and this influence was the dominant factor in the control over the degradation of the polymer phase of PLGA/HAp and the consequent kinetics of the drug release.",
publisher = "Elsevier BV",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)",
pages = "414-421",
volume = "82",
number = "2",
doi = "10.1016/j.colsurfb.2010.09.012",
url = "https://hdl.handle.net/21.15107/rcub_dais_14363"
}

Vukomanović, M., Škapin, S. D., Poljanšek, I., Žagar, E., Kralj, B., Ignjatović, N.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate). in Colloids and Surfaces B: Biointerfaces
Elsevier BV., 82(2), 414-421.
https://doi.org/10.1016/j.colsurfb.2010.09.012
https://hdl.handle.net/21.15107/rcub_dais_14363

Vukomanović M, Škapin SD, Poljanšek I, Žagar E, Kralj B, Ignjatović N, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate). in Colloids and Surfaces B: Biointerfaces. 2011;82(2):414-421.
doi:10.1016/j.colsurfb.2010.09.012
https://hdl.handle.net/21.15107/rcub_dais_14363 .

Vukomanović, Marija, Škapin, Srečo Davor, Poljanšek, Ida, Žagar, Ema, Kralj, Bogdan, Ignjatović, Nenad, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)" in Colloids and Surfaces B: Biointerfaces, 82, no. 2 (2011):414-421,
https://doi.org/10.1016/j.colsurfb.2010.09.012 .,
https://hdl.handle.net/21.15107/rcub_dais_14363 .

TY  - JOUR
AU  - Vukomanović, Marija
AU  - Zavašnik-Bergant, Tina
AU  - Bračko, Ines
AU  - Škapin, Srečo Davor
AU  - Ignjatović, Nenad
AU  - Radmilović, Velimir
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/14364
AB  - A step-by-step analysis of the formation and the drug loading of the poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite was carried out in a perspective of the following parameters: the structure, the morphology and the adsorption/desorption properties of the composite's bioceramic part. The authors demonstrated the importance of the material's capacity to form a fine dispersion of solid HAp particles, as an initial step, for the further loading of the drug and for the formation of the core–shell structures. The nanometer-sized rods of HAp have the capacity of ensuring a rapid adsorption and a controlled desorption of the drug from their surface, and they can act as a nucleating site for the formation of polymeric cores. Each component of this material was labeled with fluorescence dye, which enabled an insight into the distribution of the components in the core–shells that were obtained as the final outcome. Such an analysis showed a high level of uniformity among the cores enclosed within polymeric shells. From a practical perspective, the labeling of each component of the composite can be regarded as an additional functionality of the material: labeling can enable us to monitor its action during the healing process. This ability to be easily detected is expected to enhance the procedure for the controlled delivery of antibiotics after their local implantation of carriers loaded with the antibiotic and to provide more careful control over this process.
PB  - Elsevier BV
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite
SP  - 226
EP  - 235
VL  - 87
IS  - 2
DO  - 10.1016/j.colsurfb.2011.05.023
UR  - https://hdl.handle.net/21.15107/rcub_dais_14364
ER  - 

@article{
author = "Vukomanović, Marija and Zavašnik-Bergant, Tina and Bračko, Ines and Škapin, Srečo Davor and Ignjatović, Nenad and Radmilović, Velimir and Uskoković, Dragan",
year = "2011",
abstract = "A step-by-step analysis of the formation and the drug loading of the poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite was carried out in a perspective of the following parameters: the structure, the morphology and the adsorption/desorption properties of the composite's bioceramic part. The authors demonstrated the importance of the material's capacity to form a fine dispersion of solid HAp particles, as an initial step, for the further loading of the drug and for the formation of the core–shell structures. The nanometer-sized rods of HAp have the capacity of ensuring a rapid adsorption and a controlled desorption of the drug from their surface, and they can act as a nucleating site for the formation of polymeric cores. Each component of this material was labeled with fluorescence dye, which enabled an insight into the distribution of the components in the core–shells that were obtained as the final outcome. Such an analysis showed a high level of uniformity among the cores enclosed within polymeric shells. From a practical perspective, the labeling of each component of the composite can be regarded as an additional functionality of the material: labeling can enable us to monitor its action during the healing process. This ability to be easily detected is expected to enhance the procedure for the controlled delivery of antibiotics after their local implantation of carriers loaded with the antibiotic and to provide more careful control over this process.",
publisher = "Elsevier BV",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite",
pages = "226-235",
volume = "87",
number = "2",
doi = "10.1016/j.colsurfb.2011.05.023",
url = "https://hdl.handle.net/21.15107/rcub_dais_14364"
}

Vukomanović, M., Zavašnik-Bergant, T., Bračko, I., Škapin, S. D., Ignjatović, N., Radmilović, V.,& Uskoković, D.. (2011). Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite. in Colloids and Surfaces B: Biointerfaces
Elsevier BV., 87(2), 226-235.
https://doi.org/10.1016/j.colsurfb.2011.05.023
https://hdl.handle.net/21.15107/rcub_dais_14364

Vukomanović M, Zavašnik-Bergant T, Bračko I, Škapin SD, Ignjatović N, Radmilović V, Uskoković D. Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite. in Colloids and Surfaces B: Biointerfaces. 2011;87(2):226-235.
doi:10.1016/j.colsurfb.2011.05.023
https://hdl.handle.net/21.15107/rcub_dais_14364 .

Vukomanović, Marija, Zavašnik-Bergant, Tina, Bračko, Ines, Škapin, Srečo Davor, Ignjatović, Nenad, Radmilović, Velimir, Uskoković, Dragan, "Poly(d,l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres. Part 3: Properties of hydroxyapatite nano-rods and investigation of a distribution of the drug within the composite" in Colloids and Surfaces B: Biointerfaces, 87, no. 2 (2011):226-235,
https://doi.org/10.1016/j.colsurfb.2011.05.023 .,
https://hdl.handle.net/21.15107/rcub_dais_14364 .

TY  - CONF
AU  - Veselinović, Ljiljana
AU  - Mitrić, Miodrag
AU  - Vukomanović, Marija
AU  - Marković, Smilja
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/161
AB  - Poster presented at the 13th Annual Conference of the Materials Research Society of Serbia - YUCOMAT 2011, Herceg Novi, Crna Gora, 5–9. septembar 2011.
T1  - Rietveld refinement of barium titanate stannate crystal structure
UR  - https://hdl.handle.net/21.15107/rcub_dais_161
ER  - 

@conference{
author = "Veselinović, Ljiljana and Mitrić, Miodrag and Vukomanović, Marija and Marković, Smilja and Uskoković, Dragan",
year = "2011",
abstract = "Poster presented at the 13th Annual Conference of the Materials Research Society of Serbia - YUCOMAT 2011, Herceg Novi, Crna Gora, 5–9. septembar 2011.",
title = "Rietveld refinement of barium titanate stannate crystal structure",
url = "https://hdl.handle.net/21.15107/rcub_dais_161"
}

Veselinović, L., Mitrić, M., Vukomanović, M., Marković, S.,& Uskoković, D.. (2011). Rietveld refinement of barium titanate stannate crystal structure. .
https://hdl.handle.net/21.15107/rcub_dais_161

Veselinović L, Mitrić M, Vukomanović M, Marković S, Uskoković D. Rietveld refinement of barium titanate stannate crystal structure. 2011;.
https://hdl.handle.net/21.15107/rcub_dais_161 .

Veselinović, Ljiljana, Mitrić, Miodrag, Vukomanović, Marija, Marković, Smilja, Uskoković, Dragan, "Rietveld refinement of barium titanate stannate crystal structure" (2011),
https://hdl.handle.net/21.15107/rcub_dais_161 .

TY  - JOUR
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Jančar, Boštjan
AU  - Maksin, Tatjana
AU  - Ignjatović, Nenad
AU  - Uskoković, Vuk
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/2749
AB  - Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery
SP  - 404
EP  - 413
VL  - 82
IS  - 2
DO  - 10.1016/j.colsurfb.2010.09.011
UR  - https://hdl.handle.net/21.15107/rcub_dais_2749
ER  - 

@article{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Jančar, Boštjan and Maksin, Tatjana and Ignjatović, Nenad and Uskoković, Vuk and Uskoković, Dragan",
year = "2011",
abstract = "Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery",
pages = "404-413",
volume = "82",
number = "2",
doi = "10.1016/j.colsurfb.2010.09.011",
url = "https://hdl.handle.net/21.15107/rcub_dais_2749"
}

Vukomanović, M., Škapin, S. D., Jančar, B., Maksin, T., Ignjatović, N., Uskoković, V.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces B: Biointerfaces, 82(2), 404-413.
https://doi.org/10.1016/j.colsurfb.2010.09.011
https://hdl.handle.net/21.15107/rcub_dais_2749

Vukomanović M, Škapin SD, Jančar B, Maksin T, Ignjatović N, Uskoković V, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces B: Biointerfaces. 2011;82(2):404-413.
doi:10.1016/j.colsurfb.2010.09.011
https://hdl.handle.net/21.15107/rcub_dais_2749 .

Vukomanović, Marija, Škapin, Srečo Davor, Jančar, Boštjan, Maksin, Tatjana, Ignjatović, Nenad, Uskoković, Vuk, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery" in Colloids and Surfaces B: Biointerfaces, 82, no. 2 (2011):404-413,
https://doi.org/10.1016/j.colsurfb.2010.09.011 .,
https://hdl.handle.net/21.15107/rcub_dais_2749 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Uskoković, Dragan
AU  - Škapin, Srečo Davor
AU  - Suvorov, Danilo
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/700
AB  - Sonochemical method has a significant role in structural and morphological properties especially for the synthesis of noble metal nanoparticles. Ln the case of these materials reactive radicals formed during sonification are involved in reduction process. Depends on the rate of formation of these particles the rate of their growth is affected resulting in different structure and morphology. Homogeneous sonochemically-assisted precipitation was applied for the synthesis of platinum (Pt) nanoparticles and their composite with hydroxyapatite (HAp/Pt). In this method urea was used for complexation of Pt and/or precipitation of HAp while chloroplatinic acid (H2PtCI6, Tm=60oC) and platinum(ll)2,4 pentanedionat (CIOH140,J>t, Tm=250oC) were applied as Pt-precursors with different thermal and reduction potential properties. In the case of H2PtCI6, pre-fonned platinum-complex formed submicrometer spheres with smooth surfaces. After reduction these spheres kept their size and turned into nanostructures. A similar transformation was noticed when C lOH l40 4Pt was applied. However, in this case pre-formed platinum-complex particles had polyhedral shapes and further reduction resulted in the same shape of formed Pt nanostructures. Morphological and structural properties of Pt obtained during formation of their composites with HAp changed further on. Application of both precursors resulted in formation of plate- and rod- like shape of Hap. However, composites obtained from H2PtCl6 resulted in formation of nanosized while CloHI404Pt resulted in formation of micrometer sized HAp particles. Pt particles attached on the surface of Hap particles were nanosized and non-agglomerated spheres. Obtained results show that sonochemical method can be Llsed for tailoring the properties of Pt nanoparticles by selection of the type of precursor.
PB  - Ljubljana : Institut "Jožef Stefan"
C3  - 5. dan mladih raziskovalcev, Ljubljana, Februar 2011: [Program in povzetki]
T1  - Sonochemical synthesis of platinum nanoparticles and their composite with hydroxyapatite
SP  - 70
EP  - 70
UR  - https://hdl.handle.net/21.15107/rcub_dais_700
ER  - 

@conference{
author = "Vukomanović, Marija and Uskoković, Dragan and Škapin, Srečo Davor and Suvorov, Danilo",
year = "2011",
abstract = "Sonochemical method has a significant role in structural and morphological properties especially for the synthesis of noble metal nanoparticles. Ln the case of these materials reactive radicals formed during sonification are involved in reduction process. Depends on the rate of formation of these particles the rate of their growth is affected resulting in different structure and morphology. Homogeneous sonochemically-assisted precipitation was applied for the synthesis of platinum (Pt) nanoparticles and their composite with hydroxyapatite (HAp/Pt). In this method urea was used for complexation of Pt and/or precipitation of HAp while chloroplatinic acid (H2PtCI6, Tm=60oC) and platinum(ll)2,4 pentanedionat (CIOH140,J>t, Tm=250oC) were applied as Pt-precursors with different thermal and reduction potential properties. In the case of H2PtCI6, pre-fonned platinum-complex formed submicrometer spheres with smooth surfaces. After reduction these spheres kept their size and turned into nanostructures. A similar transformation was noticed when C lOH l40 4Pt was applied. However, in this case pre-formed platinum-complex particles had polyhedral shapes and further reduction resulted in the same shape of formed Pt nanostructures. Morphological and structural properties of Pt obtained during formation of their composites with HAp changed further on. Application of both precursors resulted in formation of plate- and rod- like shape of Hap. However, composites obtained from H2PtCl6 resulted in formation of nanosized while CloHI404Pt resulted in formation of micrometer sized HAp particles. Pt particles attached on the surface of Hap particles were nanosized and non-agglomerated spheres. Obtained results show that sonochemical method can be Llsed for tailoring the properties of Pt nanoparticles by selection of the type of precursor.",
publisher = "Ljubljana : Institut "Jožef Stefan"",
journal = "5. dan mladih raziskovalcev, Ljubljana, Februar 2011: [Program in povzetki]",
title = "Sonochemical synthesis of platinum nanoparticles and their composite with hydroxyapatite",
pages = "70-70",
url = "https://hdl.handle.net/21.15107/rcub_dais_700"
}

Vukomanović, M., Uskoković, D., Škapin, S. D.,& Suvorov, D.. (2011). Sonochemical synthesis of platinum nanoparticles and their composite with hydroxyapatite. in 5. dan mladih raziskovalcev, Ljubljana, Februar 2011: [Program in povzetki]
Ljubljana : Institut "Jožef Stefan"., 70-70.
https://hdl.handle.net/21.15107/rcub_dais_700

Vukomanović M, Uskoković D, Škapin SD, Suvorov D. Sonochemical synthesis of platinum nanoparticles and their composite with hydroxyapatite. in 5. dan mladih raziskovalcev, Ljubljana, Februar 2011: [Program in povzetki]. 2011;:70-70.
https://hdl.handle.net/21.15107/rcub_dais_700 .

Vukomanović, Marija, Uskoković, Dragan, Škapin, Srečo Davor, Suvorov, Danilo, "Sonochemical synthesis of platinum nanoparticles and their composite with hydroxyapatite" in 5. dan mladih raziskovalcev, Ljubljana, Februar 2011: [Program in povzetki] (2011):70-70,
https://hdl.handle.net/21.15107/rcub_dais_700 .

TY  - CONF
AU  - Veselinović, Ljiljana
AU  - Mitrić, Miodrag
AU  - Vukomanović, Marija
AU  - Marković, Smilja
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/688
AB  - The barium titanates have wide application in electronic industry as a dielectric and ferroelectric materials.The BaTiO3 doped with Sn is important for practical application in ceramic capacitors as well as in functionally graded materials. It is known that BaTiO3 materials have the typical perovsikite crystal structural. Their ideal crystal structure is a centrosimetric cubic structure with space group. However, the changes in temperature, pressure, and composition lead to phase transitions and crystal structure transformations. Pm 3m in this study using by Rietveld refinement, we resolved crystal structure of barium titanate stannate (BTS) BaTi1−xSnxO3 (x = 0, 0.025, 0.05, 0.07, 0.10, 0.12, 0.15 and 0.20) solid solutions. The powders were prepared by simple solid state reaction at 1420 oC, in air for 2 hours. The structural investigations of the BTS samples were done at room temperature using an X-ray diffraction, Raman spectroscopy and TEM micrograph. The Rietveld refinement of the X-ray diffraction data was used to analyze the structural changes depending on amount of the Sn4+ ions in the BTS. Obtained data show that increasing of Sn amount in the structure provokes the transformation of crystal structure from tetragonal to cubic one. We suppose that the absence of orthorhombic and rhombohedral phases is probably a consequence of phase (0.025≤x<0.20) stabilization caused by method of sample preparation (high temperature solid state reaction).
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
T1  - Rietveld refinement of barium titanate stannate crystal structure
SP  - 136
EP  - 136
UR  - https://hdl.handle.net/21.15107/rcub_dais_688
ER  - 

@conference{
author = "Veselinović, Ljiljana and Mitrić, Miodrag and Vukomanović, Marija and Marković, Smilja and Uskoković, Dragan",
year = "2011",
abstract = "The barium titanates have wide application in electronic industry as a dielectric and ferroelectric materials.The BaTiO3 doped with Sn is important for practical application in ceramic capacitors as well as in functionally graded materials. It is known that BaTiO3 materials have the typical perovsikite crystal structural. Their ideal crystal structure is a centrosimetric cubic structure with space group. However, the changes in temperature, pressure, and composition lead to phase transitions and crystal structure transformations. Pm 3m in this study using by Rietveld refinement, we resolved crystal structure of barium titanate stannate (BTS) BaTi1−xSnxO3 (x = 0, 0.025, 0.05, 0.07, 0.10, 0.12, 0.15 and 0.20) solid solutions. The powders were prepared by simple solid state reaction at 1420 oC, in air for 2 hours. The structural investigations of the BTS samples were done at room temperature using an X-ray diffraction, Raman spectroscopy and TEM micrograph. The Rietveld refinement of the X-ray diffraction data was used to analyze the structural changes depending on amount of the Sn4+ ions in the BTS. Obtained data show that increasing of Sn amount in the structure provokes the transformation of crystal structure from tetragonal to cubic one. We suppose that the absence of orthorhombic and rhombohedral phases is probably a consequence of phase (0.025≤x<0.20) stabilization caused by method of sample preparation (high temperature solid state reaction).",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts",
title = "Rietveld refinement of barium titanate stannate crystal structure",
pages = "136-136",
url = "https://hdl.handle.net/21.15107/rcub_dais_688"
}

Veselinović, L., Mitrić, M., Vukomanović, M., Marković, S.,& Uskoković, D.. (2011). Rietveld refinement of barium titanate stannate crystal structure. in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 136-136.
https://hdl.handle.net/21.15107/rcub_dais_688

Veselinović L, Mitrić M, Vukomanović M, Marković S, Uskoković D. Rietveld refinement of barium titanate stannate crystal structure. in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts. 2011;:136-136.
https://hdl.handle.net/21.15107/rcub_dais_688 .

Veselinović, Ljiljana, Mitrić, Miodrag, Vukomanović, Marija, Marković, Smilja, Uskoković, Dragan, "Rietveld refinement of barium titanate stannate crystal structure" in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts (2011):136-136,
https://hdl.handle.net/21.15107/rcub_dais_688 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Repnik, U.
AU  - Škapin, Srečo Davor
AU  - Uskoković, Dragan
AU  - Suvorov, Danilo
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/689
AB  - Hydroxyapatite, as a major constituent of the inorganic part of natural human bones, is a natural choice and one of the most frequently applied materials for the reparation and regeneration of bone tissue. The formation of composites based on HAp, the incorporation of foreign ions within its structure and/or the functionalization of their surfaces allow improvements to the morphological, structural and surface properties. Such improvements can be utilized to increase the material quality for applications in dentistry and orthopedics as well to extend the potential applicability in other fields of biomedicine. Hydroxyapatite/silver (HAp/Ag) nanocomposite particles were formed using the sonochemical method. Particles were formed from HAp rods with silver (present in the form of ions) incorporated within the apatite structure and/or metallic particles, embedded into apatite rods and metallic particles attached to the surfaces of these rods. The so obtained materials were tested for antibacterial activity. The p presence of the bacterial growth-inhibition zone around the discs made of composite material and the fluorescence dye detection on the surface of the HAp/Ag composite (corresponding to the labeled live and dead bacteria) proved that the composite was active against both Gram-positive and Gram-negative bacteria. In addition, it was determined that the minimal inhibition concentration (MIC), i.e., the minimal concentration of HAp/Ag composite, which is able to inhibit the growth of bacteria, was higher for Grampositive (MIC = 0.7-0.8 mg/ml) when compared to Gram-negative (MIC = 0.6-0.7 mg/ml) bacteria. The same effect was determined during the investigation of the minimal bactericidal concentration (MBC) of the HAp/Ag composite against the same representatives of Grampositive and Gram-negative bacteria. The obtained concentrations of the HAp/Ag composite which were able to manifest the bactericidal effect were used for an investigation of the toxicity against the representatives of healthy and cancer-modified cell lines. The toxicity of a composite was investigated in vitro and for that purpose the IMR-90 human lung embryonic fibroblast and U-2 OS human osteosarcoma cell lines were applied. In the presentation the antibacterial activity of the HAp/Ag composite and its toxicity against human cells will be discussed.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
T1  - Antibacterial activity and cytotoxicity of hydroxyapatite/silver nanocomposites synthesized by a sonochemical approach
SP  - 69
EP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_dais_689
ER  - 

@conference{
author = "Vukomanović, Marija and Repnik, U. and Škapin, Srečo Davor and Uskoković, Dragan and Suvorov, Danilo",
year = "2011",
abstract = "Hydroxyapatite, as a major constituent of the inorganic part of natural human bones, is a natural choice and one of the most frequently applied materials for the reparation and regeneration of bone tissue. The formation of composites based on HAp, the incorporation of foreign ions within its structure and/or the functionalization of their surfaces allow improvements to the morphological, structural and surface properties. Such improvements can be utilized to increase the material quality for applications in dentistry and orthopedics as well to extend the potential applicability in other fields of biomedicine. Hydroxyapatite/silver (HAp/Ag) nanocomposite particles were formed using the sonochemical method. Particles were formed from HAp rods with silver (present in the form of ions) incorporated within the apatite structure and/or metallic particles, embedded into apatite rods and metallic particles attached to the surfaces of these rods. The so obtained materials were tested for antibacterial activity. The p presence of the bacterial growth-inhibition zone around the discs made of composite material and the fluorescence dye detection on the surface of the HAp/Ag composite (corresponding to the labeled live and dead bacteria) proved that the composite was active against both Gram-positive and Gram-negative bacteria. In addition, it was determined that the minimal inhibition concentration (MIC), i.e., the minimal concentration of HAp/Ag composite, which is able to inhibit the growth of bacteria, was higher for Grampositive (MIC = 0.7-0.8 mg/ml) when compared to Gram-negative (MIC = 0.6-0.7 mg/ml) bacteria. The same effect was determined during the investigation of the minimal bactericidal concentration (MBC) of the HAp/Ag composite against the same representatives of Grampositive and Gram-negative bacteria. The obtained concentrations of the HAp/Ag composite which were able to manifest the bactericidal effect were used for an investigation of the toxicity against the representatives of healthy and cancer-modified cell lines. The toxicity of a composite was investigated in vitro and for that purpose the IMR-90 human lung embryonic fibroblast and U-2 OS human osteosarcoma cell lines were applied. In the presentation the antibacterial activity of the HAp/Ag composite and its toxicity against human cells will be discussed.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts",
title = "Antibacterial activity and cytotoxicity of hydroxyapatite/silver nanocomposites synthesized by a sonochemical approach",
pages = "69-69",
url = "https://hdl.handle.net/21.15107/rcub_dais_689"
}

Vukomanović, M., Repnik, U., Škapin, S. D., Uskoković, D.,& Suvorov, D.. (2011). Antibacterial activity and cytotoxicity of hydroxyapatite/silver nanocomposites synthesized by a sonochemical approach. in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 69-69.
https://hdl.handle.net/21.15107/rcub_dais_689

Vukomanović M, Repnik U, Škapin SD, Uskoković D, Suvorov D. Antibacterial activity and cytotoxicity of hydroxyapatite/silver nanocomposites synthesized by a sonochemical approach. in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts. 2011;:69-69.
https://hdl.handle.net/21.15107/rcub_dais_689 .

Vukomanović, Marija, Repnik, U., Škapin, Srečo Davor, Uskoković, Dragan, Suvorov, Danilo, "Antibacterial activity and cytotoxicity of hydroxyapatite/silver nanocomposites synthesized by a sonochemical approach" in The Thirteenth Annual Conference YUCOMAT 2011: Programme and the Book of Abstracts (2011):69-69,
https://hdl.handle.net/21.15107/rcub_dais_689 .

TY  - CONF
AU  - Stojanović, Zoran S.
AU  - Veselinović, Ljiljana
AU  - Jović, Maja
AU  - Stanković, Ana
AU  - Jevtić, Marija
AU  - Marković, Smilja
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/249
AB  - Poster presented at the conference JUNIOR EUROMAT, Lausanne, Switzerland, 26–30. jul 2010.
T1  - Laser Diffraction Particle Size Analysis of Non Spherical Particles Synthesized by Hydrothermal Method
UR  - https://hdl.handle.net/21.15107/rcub_dais_249
ER  - 

@conference{
author = "Stojanović, Zoran S. and Veselinović, Ljiljana and Jović, Maja and Stanković, Ana and Jevtić, Marija and Marković, Smilja and Uskoković, Dragan",
year = "2010",
abstract = "Poster presented at the conference JUNIOR EUROMAT, Lausanne, Switzerland, 26–30. jul 2010.",
title = "Laser Diffraction Particle Size Analysis of Non Spherical Particles Synthesized by Hydrothermal Method",
url = "https://hdl.handle.net/21.15107/rcub_dais_249"
}

Stojanović, Z. S., Veselinović, L., Jović, M., Stanković, A., Jevtić, M., Marković, S.,& Uskoković, D.. (2010). Laser Diffraction Particle Size Analysis of Non Spherical Particles Synthesized by Hydrothermal Method. .
https://hdl.handle.net/21.15107/rcub_dais_249

Stojanović ZS, Veselinović L, Jović M, Stanković A, Jevtić M, Marković S, Uskoković D. Laser Diffraction Particle Size Analysis of Non Spherical Particles Synthesized by Hydrothermal Method. 2010;.
https://hdl.handle.net/21.15107/rcub_dais_249 .

Stojanović, Zoran S., Veselinović, Ljiljana, Jović, Maja, Stanković, Ana, Jevtić, Marija, Marković, Smilja, Uskoković, Dragan, "Laser Diffraction Particle Size Analysis of Non Spherical Particles Synthesized by Hydrothermal Method" (2010),
https://hdl.handle.net/21.15107/rcub_dais_249 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Šarčev, Ivan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/252
AB  - Poster presented at the Third International “NanoBio – Zurich 2010” Conference, August 2010, Zurich, Switzerland
T1  - Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics
UR  - https://hdl.handle.net/21.15107/rcub_dais_252
ER  - 

@conference{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Šarčev, Ivan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
abstract = "Poster presented at the Third International “NanoBio – Zurich 2010” Conference, August 2010, Zurich, Switzerland",
title = "Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics",
url = "https://hdl.handle.net/21.15107/rcub_dais_252"
}

Vukomanović, M., Škapin, S. D., Šarčev, I., Ignjatović, N.,& Uskoković, D.. (2010). Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. .
https://hdl.handle.net/21.15107/rcub_dais_252

Vukomanović M, Škapin SD, Šarčev I, Ignjatović N, Uskoković D. Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. 2010;.
https://hdl.handle.net/21.15107/rcub_dais_252 .

Vukomanović, Marija, Škapin, Srečo Davor, Šarčev, Ivan, Ignjatović, Nenad, Uskoković, Dragan, "Perspectives of novel poly(d,l-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics" (2010),
https://hdl.handle.net/21.15107/rcub_dais_252 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/219
AB  - Poster presented at 2nd Jožef Stefan International Postgraduate School Students’ Conference-IPSSC, May 27, 2010, Ljubljana, Slovenia
T1  - Application of sonochemistry for formation of nanosized silver and silver/hydroxyapatite composite particles
UR  - https://hdl.handle.net/21.15107/rcub_dais_219
ER  - 

@conference{
author = "Vukomanović, Marija and Škapin, Srečo Davor",
year = "2010",
abstract = "Poster presented at 2nd Jožef Stefan International Postgraduate School Students’ Conference-IPSSC, May 27, 2010, Ljubljana, Slovenia",
title = "Application of sonochemistry for formation of nanosized silver and silver/hydroxyapatite composite particles",
url = "https://hdl.handle.net/21.15107/rcub_dais_219"
}

Vukomanović, M.,& Škapin, S. D.. (2010). Application of sonochemistry for formation of nanosized silver and silver/hydroxyapatite composite particles. .
https://hdl.handle.net/21.15107/rcub_dais_219

Vukomanović M, Škapin SD. Application of sonochemistry for formation of nanosized silver and silver/hydroxyapatite composite particles. 2010;.
https://hdl.handle.net/21.15107/rcub_dais_219 .

Vukomanović, Marija, Škapin, Srečo Davor, "Application of sonochemistry for formation of nanosized silver and silver/hydroxyapatite composite particles" (2010),
https://hdl.handle.net/21.15107/rcub_dais_219 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Otoničar, Mojca
AU  - Uskoković, Dragan
AU  - Škapin, Srečo Davor
AU  - Suvorov, Danilo
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/217
AB  - Poster presented at Adriatic School of Nanoscience – ASON-1, Dubrovnik, Croatia, September 19–23, 2010
T1  - Silver nanoparticels obtained by sonochemical route
UR  - https://hdl.handle.net/21.15107/rcub_dais_217
ER  - 

@conference{
author = "Vukomanović, Marija and Otoničar, Mojca and Uskoković, Dragan and Škapin, Srečo Davor and Suvorov, Danilo",
year = "2010",
abstract = "Poster presented at Adriatic School of Nanoscience – ASON-1, Dubrovnik, Croatia, September 19–23, 2010",
title = "Silver nanoparticels obtained by sonochemical route",
url = "https://hdl.handle.net/21.15107/rcub_dais_217"
}

Vukomanović, M., Otoničar, M., Uskoković, D., Škapin, S. D.,& Suvorov, D.. (2010). Silver nanoparticels obtained by sonochemical route. .
https://hdl.handle.net/21.15107/rcub_dais_217

Vukomanović M, Otoničar M, Uskoković D, Škapin SD, Suvorov D. Silver nanoparticels obtained by sonochemical route. 2010;.
https://hdl.handle.net/21.15107/rcub_dais_217 .

Vukomanović, Marija, Otoničar, Mojca, Uskoković, Dragan, Škapin, Srečo Davor, Suvorov, Danilo, "Silver nanoparticels obtained by sonochemical route" (2010),
https://hdl.handle.net/21.15107/rcub_dais_217 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/216
AB  - Poster presented at 4. Dan Mladih Raziskovalcev KMBO, Institut "Jožef Stefan", Ljubljana, Slovenia, 11. Februar, 2010.
T1  - Morphological changes of poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) particles with loaded clindamycine during degradation process
UR  - https://hdl.handle.net/21.15107/rcub_dais_216
ER  - 

@conference{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Uskoković, Dragan",
year = "2010",
abstract = "Poster presented at 4. Dan Mladih Raziskovalcev KMBO, Institut "Jožef Stefan", Ljubljana, Slovenia, 11. Februar, 2010.",
title = "Morphological changes of poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) particles with loaded clindamycine during degradation process",
url = "https://hdl.handle.net/21.15107/rcub_dais_216"
}

Vukomanović, M., Škapin, S. D.,& Uskoković, D.. (2010). Morphological changes of poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) particles with loaded clindamycine during degradation process. .
https://hdl.handle.net/21.15107/rcub_dais_216

Vukomanović M, Škapin SD, Uskoković D. Morphological changes of poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) particles with loaded clindamycine during degradation process. 2010;.
https://hdl.handle.net/21.15107/rcub_dais_216 .

Vukomanović, Marija, Škapin, Srečo Davor, Uskoković, Dragan, "Morphological changes of poly(d,l-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) particles with loaded clindamycine during degradation process" (2010),
https://hdl.handle.net/21.15107/rcub_dais_216 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Šarčev, Ivan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/3436
AB  - Local drug delivery for the treatment of infectious bone tissue diseases is a high importance topic in the field of biomedicine for a last two decades. [1] In general, some of the main problems related to controlled drug delivery of antibiotics are: (i) high initial burst effect with toxic outcome and (ii) low concentration of released drug during extended period of time with possibility for development of resistant spaces.[2] There are some examples suggesting that core-shell particles applied as carriers of drug are able to provide high control over the process of drug release and to prevent burst effect.[3,4] Therefore, the main goal of our work is to design material which will be able to provide these characteristics.
PB  - Davos: AO Research Institute Davos
C3  - European Cells and Materials
C3  - European Cells and Materials
T1  - Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics
SP  - 266
EP  - 266
VL  - 20
IS  - SUPPL. 3
UR  - https://hdl.handle.net/21.15107/rcub_dais_3436
ER  - 

@conference{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Šarčev, Ivan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
abstract = "Local drug delivery for the treatment of infectious bone tissue diseases is a high importance topic in the field of biomedicine for a last two decades. [1] In general, some of the main problems related to controlled drug delivery of antibiotics are: (i) high initial burst effect with toxic outcome and (ii) low concentration of released drug during extended period of time with possibility for development of resistant spaces.[2] There are some examples suggesting that core-shell particles applied as carriers of drug are able to provide high control over the process of drug release and to prevent burst effect.[3,4] Therefore, the main goal of our work is to design material which will be able to provide these characteristics.",
publisher = "Davos: AO Research Institute Davos",
journal = "European Cells and Materials, European Cells and Materials",
title = "Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics",
pages = "266-266",
volume = "20",
number = "SUPPL. 3",
url = "https://hdl.handle.net/21.15107/rcub_dais_3436"
}

Vukomanović, M., Škapin, S. D., Šarčev, I., Ignjatović, N.,& Uskoković, D.. (2010). Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. in European Cells and Materials
Davos: AO Research Institute Davos., 20(SUPPL. 3), 266-266.
https://hdl.handle.net/21.15107/rcub_dais_3436

Vukomanović M, Škapin SD, Šarčev I, Ignjatović N, Uskoković D. Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics. in European Cells and Materials. 2010;20(SUPPL. 3):266-266.
https://hdl.handle.net/21.15107/rcub_dais_3436 .

Vukomanović, Marija, Škapin, Srečo Davor, Šarčev, Ivan, Ignjatović, Nenad, Uskoković, Dragan, "Perspectives of Novel Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanoparticles as carriers of antibiotics" in European Cells and Materials, 20, no. SUPPL. 3 (2010):266-266,
https://hdl.handle.net/21.15107/rcub_dais_3436 .

TY  - JOUR
AU  - Vukomanović, Marija
AU  - Mitrić, Miodrag
AU  - Škapin, Srečo Davor
AU  - Žagar, Ema
AU  - Plavec, Janez
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/2747
AB  - In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Ultrasonics Sonochemistry
T1  - Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite
SP  - 902
EP  - 908
VL  - 17
IS  - 5
DO  - 10.1016/j.ultsonch.2010.01.007
UR  - https://hdl.handle.net/21.15107/rcub_dais_2747
ER  - 

@article{
author = "Vukomanović, Marija and Mitrić, Miodrag and Škapin, Srečo Davor and Žagar, Ema and Plavec, Janez and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
abstract = "In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Ultrasonics Sonochemistry",
title = "Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite",
pages = "902-908",
volume = "17",
number = "5",
doi = "10.1016/j.ultsonch.2010.01.007",
url = "https://hdl.handle.net/21.15107/rcub_dais_2747"
}

Vukomanović, M., Mitrić, M., Škapin, S. D., Žagar, E., Plavec, J., Ignjatović, N.,& Uskoković, D.. (2010). Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite. in Ultrasonics Sonochemistry, 17(5), 902-908.
https://doi.org/10.1016/j.ultsonch.2010.01.007
https://hdl.handle.net/21.15107/rcub_dais_2747

Vukomanović M, Mitrić M, Škapin SD, Žagar E, Plavec J, Ignjatović N, Uskoković D. Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite. in Ultrasonics Sonochemistry. 2010;17(5):902-908.
doi:10.1016/j.ultsonch.2010.01.007
https://hdl.handle.net/21.15107/rcub_dais_2747 .

Vukomanović, Marija, Mitrić, Miodrag, Škapin, Srečo Davor, Žagar, Ema, Plavec, Janez, Ignjatović, Nenad, Uskoković, Dragan, "Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite" in Ultrasonics Sonochemistry, 17, no. 5 (2010):902-908,
https://doi.org/10.1016/j.ultsonch.2010.01.007 .,
https://hdl.handle.net/21.15107/rcub_dais_2747 .

TY  - CONF
AU  - Vuković, Gorica
AU  - Lazić, Sanja
AU  - Šunjka, Dragana
AU  - Bursić, Vojislava
AU  - Šarčev, Ivan
AU  - Vukomanović, Marija
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/3453
AB  - Clindamycin was determined in pig plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The multiple reaction monitoring (MRM) mode of precursor-product ion transitions for clindamycin (m/z=421.1/126.1) and the internal standard, caffeine (m/z=192/125) was used. The samples were prepared by two methods: 0.1% formic acid in methanol and 1.5% trichloacetic acid. The recovery for the two preparation methods at 0.05mg/ml (n=6) was found to be for the first 104.3% and for the second method 106.5%, with repeatability RSD 1.1% and RSD 4.34%, respectively. The results of the comparison of the two different preparation methods of samples demonstrated that both methods were satisfactory.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia
T1  - Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry
SP  - 19
EP  - 19
UR  - https://hdl.handle.net/21.15107/rcub_dais_3453
ER  - 

@conference{
author = "Vuković, Gorica and Lazić, Sanja and Šunjka, Dragana and Bursić, Vojislava and Šarčev, Ivan and Vukomanović, Marija and Ignjatović, Nenad and Uskoković, Dragan",
year = "2010",
abstract = "Clindamycin was determined in pig plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The multiple reaction monitoring (MRM) mode of precursor-product ion transitions for clindamycin (m/z=421.1/126.1) and the internal standard, caffeine (m/z=192/125) was used. The samples were prepared by two methods: 0.1% formic acid in methanol and 1.5% trichloacetic acid. The recovery for the two preparation methods at 0.05mg/ml (n=6) was found to be for the first 104.3% and for the second method 106.5%, with repeatability RSD 1.1% and RSD 4.34%, respectively. The results of the comparison of the two different preparation methods of samples demonstrated that both methods were satisfactory.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia",
title = "Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry",
pages = "19-19",
url = "https://hdl.handle.net/21.15107/rcub_dais_3453"
}

Vuković, G., Lazić, S., Šunjka, D., Bursić, V., Šarčev, I., Vukomanović, M., Ignjatović, N.,& Uskoković, D.. (2010). Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry. in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 19-19.
https://hdl.handle.net/21.15107/rcub_dais_3453

Vuković G, Lazić S, Šunjka D, Bursić V, Šarčev I, Vukomanović M, Ignjatović N, Uskoković D. Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry. in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia. 2010;:19-19.
https://hdl.handle.net/21.15107/rcub_dais_3453 .

Vuković, Gorica, Lazić, Sanja, Šunjka, Dragana, Bursić, Vojislava, Šarčev, Ivan, Vukomanović, Marija, Ignjatović, Nenad, Uskoković, Dragan, "Determination of clindamycin in pig plasma after implantation of poly(D,Llactide-co-glycolide)/hydroxyapatite/clindamycin core–shell nanosphere by liquid chromatography-tandem mass spectrometry" in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia (2010):19-19,
https://hdl.handle.net/21.15107/rcub_dais_3453 .

TY  - CONF
AU  - Vukomanović, Marija
AU  - Repnik, U.
AU  - Zavašnik, T.
AU  - Škapin, Srečo Davor
AU  - Uskoković, Dragan
AU  - Suvorov, Danilo
PY  - 2010
UR  - https://dais.sanu.ac.rs/123456789/3452
AB  - Hydroxyapatite containing silver nanoparticles (HAp/Ag) was synthesized by homogeneous sonochemical metod. Morphology of obtained particles was formed of micrometer-sized rod-like HAp with nanosized silver sphere-like particles attached to their surface. So obtained material was tested for interaction with bacteria. For that purpose composites with three different contents of silver were prepared and their interactions with two different types of bacteria were studied. Escherichia coli was used as a representative of Gram negative while Staphylococcus aureus was applied as a representative of Gram positive bacteria. In the case of E. coli wider inhibition zone without presence of bacteria and with a layer of inactive bacteria near the surface of material was obtained. In this case obtained antibacterial effect was not concentration dependant. In the case of S. aureus, inhibition zone was narrower with the presence of modified bacteria in inhibition zone. Obtained antibacterial response pronounced dependence on concentration of silver within composite. According to results achieved with this investigation we concluded that HAp/Ag composite is effective against both, Gram positive and Gram negative bacteria and shows stronger activity against E. coli.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia
T1  - Antibacterial activity of hydroxyapatite/silver nanocomposite
SP  - 15
EP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_dais_3452
ER  - 

@conference{
author = "Vukomanović, Marija and Repnik, U. and Zavašnik, T. and Škapin, Srečo Davor and Uskoković, Dragan and Suvorov, Danilo",
year = "2010",
abstract = "Hydroxyapatite containing silver nanoparticles (HAp/Ag) was synthesized by homogeneous sonochemical metod. Morphology of obtained particles was formed of micrometer-sized rod-like HAp with nanosized silver sphere-like particles attached to their surface. So obtained material was tested for interaction with bacteria. For that purpose composites with three different contents of silver were prepared and their interactions with two different types of bacteria were studied. Escherichia coli was used as a representative of Gram negative while Staphylococcus aureus was applied as a representative of Gram positive bacteria. In the case of E. coli wider inhibition zone without presence of bacteria and with a layer of inactive bacteria near the surface of material was obtained. In this case obtained antibacterial effect was not concentration dependant. In the case of S. aureus, inhibition zone was narrower with the presence of modified bacteria in inhibition zone. Obtained antibacterial response pronounced dependence on concentration of silver within composite. According to results achieved with this investigation we concluded that HAp/Ag composite is effective against both, Gram positive and Gram negative bacteria and shows stronger activity against E. coli.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia",
title = "Antibacterial activity of hydroxyapatite/silver nanocomposite",
pages = "15-15",
url = "https://hdl.handle.net/21.15107/rcub_dais_3452"
}

Vukomanović, M., Repnik, U., Zavašnik, T., Škapin, S. D., Uskoković, D.,& Suvorov, D.. (2010). Antibacterial activity of hydroxyapatite/silver nanocomposite. in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 15-15.
https://hdl.handle.net/21.15107/rcub_dais_3452

Vukomanović M, Repnik U, Zavašnik T, Škapin SD, Uskoković D, Suvorov D. Antibacterial activity of hydroxyapatite/silver nanocomposite. in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia. 2010;:15-15.
https://hdl.handle.net/21.15107/rcub_dais_3452 .

Vukomanović, Marija, Repnik, U., Zavašnik, T., Škapin, Srečo Davor, Uskoković, Dragan, Suvorov, Danilo, "Antibacterial activity of hydroxyapatite/silver nanocomposite" in Program and the Book of Abstracts / Ninth Young Researchers Conference Materials Sciences and Engineering, December 20–22, 2010, Belgrade, Serbia (2010):15-15,
https://hdl.handle.net/21.15107/rcub_dais_3452 .