TY  - JOUR
AU  - Vukomanović, Marija
AU  - Škapin, Srečo Davor
AU  - Jančar, Boštjan
AU  - Maksin, Tatjana
AU  - Ignjatović, Nenad
AU  - Uskoković, Vuk
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/2749
AB  - Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery
SP  - 404
EP  - 413
VL  - 82
IS  - 2
DO  - 10.1016/j.colsurfb.2010.09.011
UR  - https://hdl.handle.net/21.15107/rcub_dais_2749
ER  - 

@article{
author = "Vukomanović, Marija and Škapin, Srečo Davor and Jančar, Boštjan and Maksin, Tatjana and Ignjatović, Nenad and Uskoković, Vuk and Uskoković, Dragan",
year = "2011",
abstract = "Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery",
pages = "404-413",
volume = "82",
number = "2",
doi = "10.1016/j.colsurfb.2010.09.011",
url = "https://hdl.handle.net/21.15107/rcub_dais_2749"
}

Vukomanović, M., Škapin, S. D., Jančar, B., Maksin, T., Ignjatović, N., Uskoković, V.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces B: Biointerfaces, 82(2), 404-413.
https://doi.org/10.1016/j.colsurfb.2010.09.011
https://hdl.handle.net/21.15107/rcub_dais_2749

Vukomanović M, Škapin SD, Jančar B, Maksin T, Ignjatović N, Uskoković V, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces B: Biointerfaces. 2011;82(2):404-413.
doi:10.1016/j.colsurfb.2010.09.011
https://hdl.handle.net/21.15107/rcub_dais_2749 .

Vukomanović, Marija, Škapin, Srečo Davor, Jančar, Boštjan, Maksin, Tatjana, Ignjatović, Nenad, Uskoković, Vuk, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery" in Colloids and Surfaces B: Biointerfaces, 82, no. 2 (2011):404-413,
https://doi.org/10.1016/j.colsurfb.2010.09.011 .,
https://hdl.handle.net/21.15107/rcub_dais_2749 .

TY  - JOUR
AU  - Stevanović, Magdalena
AU  - Maksin, Tatjana
AU  - Petković, Jana
AU  - Filipič, Metka
AU  - Uskoković, Dragan
PY  - 2009
UR  - https://dais.sanu.ac.rs/123456789/2740
AB  - Nanoparticles of poly(DL-lactide-co-glycolide) (PLGA) in the size range 90-150 nm were produced using the physicochemical method with solvent/non-solvent systems. The encapsulation of the ascorbic acid in the polymer matrix was performed by homogenization of the water and organic phases. In vitro degradation and release tests of PLGA nanoparticles with and without encapsulated ascorbic acid were studied for more than 60 days in PBS and it has been determined that PLGA completely degrades within this period, fully releasing all encapsulated ascorbic acid. The cytotoxicity of PLGA and PLGA/ascorbic acid 85/15% nanoparticles was examined with human hepatoma cell lines (HepG2 ECACC), in vitro. The obtained results indicate that neither PLGA nanospheres nor PLGA/ascorbic acid 85/15% nanoparticles significantly affected the viability of the HepG2 cells. The investigation of the distribution and pharmacokinetics of PLGA is crucial for the effective prediction of host responses to PLGA in particular applications. Thus we present a method of labeling PLGA nanospheres and PLGA/ascorbic acid 85/15 wt% nanoparticles by (99m)Tc which binds outside, leaving the cage intact. This enables a quick and convenient investigation of the pharmacological behavior and metabolism of PLGA. The biodistribution of (99m)Tc-labeled PLGA particles with and without encapsulated ascorbic acid after different periods of time of their installation into rats was examined. PLGA nanospheres with encapsulated ascorbic acid exhibit prolonged blood circulation accompanied by time-dependent reduction in the lungs, liver and spleen, and addition in the kidney, stomach and intestine. The samples were characterized by x-ray diffraction, scanning electron microscopy, stereological analysis, transmission electron microscopy, ultraviolet spectroscopy and instant thin layer chromatography.
PB  - Bristol : IOP Science
T2  - Nanotechnology
T1  - An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres
VL  - 20
IS  - 33
DO  - 10.1088/0957-4484/20/33/335102
UR  - https://hdl.handle.net/21.15107/rcub_dais_2740
ER  - 

@article{
author = "Stevanović, Magdalena and Maksin, Tatjana and Petković, Jana and Filipič, Metka and Uskoković, Dragan",
year = "2009",
abstract = "Nanoparticles of poly(DL-lactide-co-glycolide) (PLGA) in the size range 90-150 nm were produced using the physicochemical method with solvent/non-solvent systems. The encapsulation of the ascorbic acid in the polymer matrix was performed by homogenization of the water and organic phases. In vitro degradation and release tests of PLGA nanoparticles with and without encapsulated ascorbic acid were studied for more than 60 days in PBS and it has been determined that PLGA completely degrades within this period, fully releasing all encapsulated ascorbic acid. The cytotoxicity of PLGA and PLGA/ascorbic acid 85/15% nanoparticles was examined with human hepatoma cell lines (HepG2 ECACC), in vitro. The obtained results indicate that neither PLGA nanospheres nor PLGA/ascorbic acid 85/15% nanoparticles significantly affected the viability of the HepG2 cells. The investigation of the distribution and pharmacokinetics of PLGA is crucial for the effective prediction of host responses to PLGA in particular applications. Thus we present a method of labeling PLGA nanospheres and PLGA/ascorbic acid 85/15 wt% nanoparticles by (99m)Tc which binds outside, leaving the cage intact. This enables a quick and convenient investigation of the pharmacological behavior and metabolism of PLGA. The biodistribution of (99m)Tc-labeled PLGA particles with and without encapsulated ascorbic acid after different periods of time of their installation into rats was examined. PLGA nanospheres with encapsulated ascorbic acid exhibit prolonged blood circulation accompanied by time-dependent reduction in the lungs, liver and spleen, and addition in the kidney, stomach and intestine. The samples were characterized by x-ray diffraction, scanning electron microscopy, stereological analysis, transmission electron microscopy, ultraviolet spectroscopy and instant thin layer chromatography.",
publisher = "Bristol : IOP Science",
journal = "Nanotechnology",
title = "An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres",
volume = "20",
number = "33",
doi = "10.1088/0957-4484/20/33/335102",
url = "https://hdl.handle.net/21.15107/rcub_dais_2740"
}

Stevanović, M., Maksin, T., Petković, J., Filipič, M.,& Uskoković, D.. (2009). An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres. in Nanotechnology
Bristol : IOP Science., 20(33).
https://doi.org/10.1088/0957-4484/20/33/335102
https://hdl.handle.net/21.15107/rcub_dais_2740

Stevanović M, Maksin T, Petković J, Filipič M, Uskoković D. An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres. in Nanotechnology. 2009;20(33).
doi:10.1088/0957-4484/20/33/335102
https://hdl.handle.net/21.15107/rcub_dais_2740 .

Stevanović, Magdalena, Maksin, Tatjana, Petković, Jana, Filipič, Metka, Uskoković, Dragan, "An innovative, quick and convenient labeling method for the investigation of pharmacological behavior and the metabolism of poly(DL-lactide-co-glycolide) nanospheres" in Nanotechnology, 20, no. 33 (2009),
https://doi.org/10.1088/0957-4484/20/33/335102 .,
https://hdl.handle.net/21.15107/rcub_dais_2740 .

TY  - CONF
AU  - Stevanović, Magdalena
AU  - Maksin, Tatjana
AU  - Kandić, Ljiljana
AU  - Uskoković, Dragan
PY  - 2008
UR  - https://dais.sanu.ac.rs/123456789/303
AB  - Poster presented at the 10th Conference of the Materials Research Society of Serbia - YUCOMAT 2008, Herceg Novi, Montenegro, September 8-12, 2008.
T1  - Preparation of 99mTc PLGA and its Distribution Studies
UR  - https://hdl.handle.net/21.15107/rcub_dais_303
ER  - 

@conference{
author = "Stevanović, Magdalena and Maksin, Tatjana and Kandić, Ljiljana and Uskoković, Dragan",
year = "2008",
abstract = "Poster presented at the 10th Conference of the Materials Research Society of Serbia - YUCOMAT 2008, Herceg Novi, Montenegro, September 8-12, 2008.",
title = "Preparation of 99mTc PLGA and its Distribution Studies",
url = "https://hdl.handle.net/21.15107/rcub_dais_303"
}

Stevanović, M., Maksin, T., Kandić, L.,& Uskoković, D.. (2008). Preparation of 99mTc PLGA and its Distribution Studies. .
https://hdl.handle.net/21.15107/rcub_dais_303

Stevanović M, Maksin T, Kandić L, Uskoković D. Preparation of 99mTc PLGA and its Distribution Studies. 2008;.
https://hdl.handle.net/21.15107/rcub_dais_303 .

Stevanović, Magdalena, Maksin, Tatjana, Kandić, Ljiljana, Uskoković, Dragan, "Preparation of 99mTc PLGA and its Distribution Studies" (2008),
https://hdl.handle.net/21.15107/rcub_dais_303 .