TY  - JOUR
AU  - Janićijević, Željko
AU  - Ninkov, Marina
AU  - Kataranovski, Milena
AU  - Radovanović, Filip
PY  - 2019
UR  - https://dais.sanu.ac.rs/123456789/5253
AB  - Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PB  - Wiley
T2  - Macromolecular Bioscience
T1  - Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs
SP  - 1800322
VL  - 19
DO  - 10.1002/mabi.201800322
UR  - https://hdl.handle.net/21.15107/rcub_dais_5253
ER  - 

@article{
author = "Janićijević, Željko and Ninkov, Marina and Kataranovski, Milena and Radovanović, Filip",
year = "2019",
abstract = "Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
publisher = "Wiley",
journal = "Macromolecular Bioscience",
title = "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs",
pages = "1800322",
volume = "19",
doi = "10.1002/mabi.201800322",
url = "https://hdl.handle.net/21.15107/rcub_dais_5253"
}

Janićijević, Ž., Ninkov, M., Kataranovski, M.,& Radovanović, F.. (2019). Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. in Macromolecular Bioscience
Wiley., 19, 1800322.
https://doi.org/10.1002/mabi.201800322
https://hdl.handle.net/21.15107/rcub_dais_5253

Janićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. in Macromolecular Bioscience. 2019;19:1800322.
doi:10.1002/mabi.201800322
https://hdl.handle.net/21.15107/rcub_dais_5253 .

Janićijević, Željko, Ninkov, Marina, Kataranovski, Milena, Radovanović, Filip, "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs" in Macromolecular Bioscience, 19 (2019):1800322,
https://doi.org/10.1002/mabi.201800322 .,
https://hdl.handle.net/21.15107/rcub_dais_5253 .

TY  - JOUR
AU  - Janićijević, Željko
AU  - Ninkov, Marina
AU  - Kataranovski, Milena
AU  - Radovanović, Filip
PY  - 2019
UR  - https://dais.sanu.ac.rs/123456789/4714
AB  - Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PB  - Wiley
T2  - Macromolecular Bioscience
T1  - Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs
SP  - 1800322
VL  - 19
DO  - 10.1002/mabi.201800322
UR  - https://hdl.handle.net/21.15107/rcub_dais_4714
ER  - 

@article{
author = "Janićijević, Željko and Ninkov, Marina and Kataranovski, Milena and Radovanović, Filip",
year = "2019",
abstract = "Poly(DL-lactide-co-ε-caprolactone)/poly(acrylic acid) implantable composite reservoirs for cationic drugs are synthesized by sequentially applying photoirradiation and liquid phase inversion. The chemical composition and microstructure of reservoirs are characterized with Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) and scanning electron microscopy (SEM), respectively. Drug loading and release properties are investigated using methylene blue as the drug model. Biocompatibility of reservoirs is examined through a series of in vitro tests and an in vivo experiment of subcutaneous implantation in Dark Agouti rats. Reservoirs show good ion-exchange capacity, high water content, and fast reversible swelling with retained geometry. Results of drug loading and release reveal excellent loading efficiency and diffusion-controlled release during 2 weeks. Biocompatibility tests in vitro demonstrate the lack of implant proinflammatory potential and hindered adhesion of L929 cells on the implant surface. Implants exhibit low acute toxicity and elicit a normal acute foreign body reaction that reaches the early stages of fibrous capsule formation after 7 days. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
publisher = "Wiley",
journal = "Macromolecular Bioscience",
title = "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs",
pages = "1800322",
volume = "19",
doi = "10.1002/mabi.201800322",
url = "https://hdl.handle.net/21.15107/rcub_dais_4714"
}

Janićijević, Ž., Ninkov, M., Kataranovski, M.,& Radovanović, F.. (2019). Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. in Macromolecular Bioscience
Wiley., 19, 1800322.
https://doi.org/10.1002/mabi.201800322
https://hdl.handle.net/21.15107/rcub_dais_4714

Janićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs. in Macromolecular Bioscience. 2019;19:1800322.
doi:10.1002/mabi.201800322
https://hdl.handle.net/21.15107/rcub_dais_4714 .

Janićijević, Željko, Ninkov, Marina, Kataranovski, Milena, Radovanović, Filip, "Poly(DL-Lactide-co-ε-Caprolactone)/Poly(Acrylic Acid) Composite Implant for Controlled Delivery of Cationic Drugs" in Macromolecular Bioscience, 19 (2019):1800322,
https://doi.org/10.1002/mabi.201800322 .,
https://hdl.handle.net/21.15107/rcub_dais_4714 .

TY  - CONF
AU  - Janićijević, Željko
AU  - Ninkov, Marina
AU  - Kataranovski, Marina
AU  - Radovanović, Filip
PY  - 2017
UR  - https://dais.sanu.ac.rs/123456789/15452
AB  - Composites of biodegradable polymers and hydrogels are promising materials for controlled delivery systems with prolonged drug release. In this contribution, we present an innovative implant design comprising poly(DL-lactide-co-ε-caprolactone) copolymer base and a crosslinked poly(acrylic acid) hydrogel. Implants were prepared in the form of disks using the modified traditional liquid phase inversion process. Solutions containing all implant precursors were dispensed into transparent non-stick molds and cured by UV irradiation. UV curing was followed by immersion into the phosphate buffer solution bath to achieve phase separation and solidification. Structure and composition of the implant were characterized using SEM and FTIR. Obtained implants exhibited high loading capacity for cationic formulations and a moderate degree of swelling. Studies of implant loading and subsequent release of methylene blue into the phosphate-buffered saline demonstrated diffusioncontrolled delivery kinetics over a period of several weeks. To assess biocompatibility of implants as possible materials for drug delivery systems in mammals, we evaluated their effects on viability (Trypan blue exclusion assay), metabolic activity, proliferation (MTT assay) and priming (nitric oxide/NO production) of freshly isolated rat splenocytes during 24 h and 48 h of cultivation. The viability was unaltered, metabolic activity/proliferation was increased after 48 h and the decrease of NO production, as well as drop in responsiveness to cell mitogen concanavalin A (ConA) in cells on implants were observed. These results suggest that implants could be used as a suitable material for drug delivery systems, but their capacity to stimulate cell proliferation and their immunosuppressive potential deserve further investigations.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia
T1  - Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations
SP  - 9
EP  - 9
UR  - https://hdl.handle.net/21.15107/rcub_dais_15452
ER  - 

@conference{
author = "Janićijević, Željko and Ninkov, Marina and Kataranovski, Marina and Radovanović, Filip",
year = "2017",
abstract = "Composites of biodegradable polymers and hydrogels are promising materials for controlled delivery systems with prolonged drug release. In this contribution, we present an innovative implant design comprising poly(DL-lactide-co-ε-caprolactone) copolymer base and a crosslinked poly(acrylic acid) hydrogel. Implants were prepared in the form of disks using the modified traditional liquid phase inversion process. Solutions containing all implant precursors were dispensed into transparent non-stick molds and cured by UV irradiation. UV curing was followed by immersion into the phosphate buffer solution bath to achieve phase separation and solidification. Structure and composition of the implant were characterized using SEM and FTIR. Obtained implants exhibited high loading capacity for cationic formulations and a moderate degree of swelling. Studies of implant loading and subsequent release of methylene blue into the phosphate-buffered saline demonstrated diffusioncontrolled delivery kinetics over a period of several weeks. To assess biocompatibility of implants as possible materials for drug delivery systems in mammals, we evaluated their effects on viability (Trypan blue exclusion assay), metabolic activity, proliferation (MTT assay) and priming (nitric oxide/NO production) of freshly isolated rat splenocytes during 24 h and 48 h of cultivation. The viability was unaltered, metabolic activity/proliferation was increased after 48 h and the decrease of NO production, as well as drop in responsiveness to cell mitogen concanavalin A (ConA) in cells on implants were observed. These results suggest that implants could be used as a suitable material for drug delivery systems, but their capacity to stimulate cell proliferation and their immunosuppressive potential deserve further investigations.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia",
title = "Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations",
pages = "9-9",
url = "https://hdl.handle.net/21.15107/rcub_dais_15452"
}

Janićijević, Ž., Ninkov, M., Kataranovski, M.,& Radovanović, F.. (2017). Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations. in Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 9-9.
https://hdl.handle.net/21.15107/rcub_dais_15452

Janićijević Ž, Ninkov M, Kataranovski M, Radovanović F. Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations. in Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia. 2017;:9-9.
https://hdl.handle.net/21.15107/rcub_dais_15452 .

Janićijević, Željko, Ninkov, Marina, Kataranovski, Marina, Radovanović, Filip, "Biodegradable polymer/hydrogel composite for controlled delivery of cationic formulations" in Program and the Book of Abstracts / Sixteenth Young Researchers' Conference Materials Sciences and Engineering, December 6-8, 2017, Belgrade, Serbia (2017):9-9,
https://hdl.handle.net/21.15107/rcub_dais_15452 .