TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad
AU  - Petrović, Nenad
AU  - Rajković, Jelena
AU  - Kenić Marinković, Dragana
AU  - Najman, Stevo
AU  - Mihailović, Dragan
AU  - Uskoković, Dragan
PY  - 2014
UR  - https://dais.sanu.ac.rs/123456789/558
AB  - Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.
PB  - Belgrade : Materials Research Society of Serbia
C3  - The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
T1  - Interaction of nanoparticles and biological fluids
SP  - 113
EP  - 113
UR  - https://hdl.handle.net/21.15107/rcub_dais_558
ER  - 

@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad and Petrović, Nenad and Rajković, Jelena and Kenić Marinković, Dragana and Najman, Stevo and Mihailović, Dragan and Uskoković, Dragan",
year = "2014",
abstract = "Recent studies have shown that the behavior of nanoparticles in in vivo conditions is not solely dependant on their physical properties, such are size and shape. The surface of nanoparticles in biological fluids interacts with biomolecules such are proteins, adsorbs these molecules, and leads to formation of nanoparticle-biomoelcular complex known as “protein corona”. This protein corona changes the properties of nanoparticles and their behavior in vivo. In this work three types of nanomaterial based on Hap and polymers were incubated in rats plasma, and the identification and quantification of proteins in protein corona that had formed around these nanoparticles, was done by means of electrophoresis and mass spectrophotometery.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts",
title = "Interaction of nanoparticles and biological fluids",
pages = "113-113",
url = "https://hdl.handle.net/21.15107/rcub_dais_558"
}

Ajduković, Z., Ignjatović, N., Petrović, N., Rajković, J., Kenić Marinković, D., Najman, S., Mihailović, D.,& Uskoković, D.. (2014). Interaction of nanoparticles and biological fluids. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts
Belgrade : Materials Research Society of Serbia., 113-113.
https://hdl.handle.net/21.15107/rcub_dais_558

Ajduković Z, Ignjatović N, Petrović N, Rajković J, Kenić Marinković D, Najman S, Mihailović D, Uskoković D. Interaction of nanoparticles and biological fluids. in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts. 2014;:113-113.
https://hdl.handle.net/21.15107/rcub_dais_558 .

Ajduković, Zorica, Ignjatović, Nenad, Petrović, Nenad, Rajković, Jelena, Kenić Marinković, Dragana, Najman, Stevo, Mihailović, Dragan, Uskoković, Dragan, "Interaction of nanoparticles and biological fluids" in The Sixteenth Annual Conference YUCOMAT 2014: Programme and the Book of Abstracts (2014):113-113,
https://hdl.handle.net/21.15107/rcub_dais_558 .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Đorđević, Nadica
AU  - Petrović, Nenad
AU  - Ignjatović, Nenad
AU  - Kenić Marinković, Dragana
AU  - Uskoković, Dragan
PY  - 2013
UR  - https://dais.sanu.ac.rs/123456789/432
AB  - The loss of teeth and damage to the jaw bone occur under different circumstances. The deficit may be the result of wearing inadequate dentures, residual ridge resorption, osteoporosis, periodontal disease, trauma, tumors, radiation, etc. The deficit of bone tissue can be a substantial problem because it prevents adequate prosthetic patient care and restoration of disturbed functions of stomatognathic system. With such patients, there is often a need for preprosthetic surgical procedure through the application of various techniques and materials in order to resolve aftermentioned bone shortcomings. The most appropriate biological materials for the reconstruction are autogenous bone graft and artificial bone. With the development of technology and specific
biomaterials it is tried to avoid situations that require autogenous bone grafting, since it involvs long surgical procedure with the possibility of postoperative complications. The application of synthetic biomaterials, whose properties are similar to natural hydroxyapatite, promotes the biological potential for bone tissue repair. Synthetic biomaterials have great biocompatibility and sterility and do not act antigenicaly. The disadvantages of this material are overcome by the addition of organic polymers. Thanks to the stability and flexibility of hydroxyapatite structure, a large number of ionic changes are possible, both cationic and anionic, which improve the characteristics of synthetic hydroxyapatite. Biomaterials that include different drugs, such as antibiotics, vitamins and other preparations, could be used for the treatment of complications after surgical procedures and infection of bone tissue. Our experimental studies indicate that biomaterials based on hydroxyapatite are valuable materials that can be used for preprosthetic surgical preparation.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia
T1  - Biomaterials and their application in preprosthetic surgical procedure
SP  - 5
EP  - 5
UR  - https://hdl.handle.net/21.15107/rcub_dais_432
ER  - 

@conference{
author = "Ajduković, Zorica and Đorđević, Nadica and Petrović, Nenad and Ignjatović, Nenad and Kenić Marinković, Dragana and Uskoković, Dragan",
year = "2013",
abstract = "The loss of teeth and damage to the jaw bone occur under different circumstances. The deficit may be the result of wearing inadequate dentures, residual ridge resorption, osteoporosis, periodontal disease, trauma, tumors, radiation, etc. The deficit of bone tissue can be a substantial problem because it prevents adequate prosthetic patient care and restoration of disturbed functions of stomatognathic system. With such patients, there is often a need for preprosthetic surgical procedure through the application of various techniques and materials in order to resolve aftermentioned bone shortcomings. The most appropriate biological materials for the reconstruction are autogenous bone graft and artificial bone. With the development of technology and specific
biomaterials it is tried to avoid situations that require autogenous bone grafting, since it involvs long surgical procedure with the possibility of postoperative complications. The application of synthetic biomaterials, whose properties are similar to natural hydroxyapatite, promotes the biological potential for bone tissue repair. Synthetic biomaterials have great biocompatibility and sterility and do not act antigenicaly. The disadvantages of this material are overcome by the addition of organic polymers. Thanks to the stability and flexibility of hydroxyapatite structure, a large number of ionic changes are possible, both cationic and anionic, which improve the characteristics of synthetic hydroxyapatite. Biomaterials that include different drugs, such as antibiotics, vitamins and other preparations, could be used for the treatment of complications after surgical procedures and infection of bone tissue. Our experimental studies indicate that biomaterials based on hydroxyapatite are valuable materials that can be used for preprosthetic surgical preparation.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia",
title = "Biomaterials and their application in preprosthetic surgical procedure",
pages = "5-5",
url = "https://hdl.handle.net/21.15107/rcub_dais_432"
}

Ajduković, Z., Đorđević, N., Petrović, N., Ignjatović, N., Kenić Marinković, D.,& Uskoković, D.. (2013). Biomaterials and their application in preprosthetic surgical procedure. in Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 5-5.
https://hdl.handle.net/21.15107/rcub_dais_432

Ajduković Z, Đorđević N, Petrović N, Ignjatović N, Kenić Marinković D, Uskoković D. Biomaterials and their application in preprosthetic surgical procedure. in Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia. 2013;:5-5.
https://hdl.handle.net/21.15107/rcub_dais_432 .

Ajduković, Zorica, Đorđević, Nadica, Petrović, Nenad, Ignjatović, Nenad, Kenić Marinković, Dragana, Uskoković, Dragan, "Biomaterials and their application in preprosthetic surgical procedure" in Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia (2013):5-5,
https://hdl.handle.net/21.15107/rcub_dais_432 .

TY  - CONF
AU  - Ajduković, Zorica
AU  - Ignjatović, Nenad
AU  - Petrović, Nenad
AU  - Savić, Vojin
AU  - Mihailović, Dragan
AU  - Uskoković, Dragan
PY  - 2011
UR  - https://dais.sanu.ac.rs/123456789/690
AB  - Systems for targeted delivery of drugs with high affinity for specific organs, tissues, and cells were introduced at the beginning of the twentieth century. Recently, this concept is attracting much attention. These systems have shown most effective in reducing adverse effects of drugs. In recent years, scientists have created a system of nanoparticles for delivery of vitamin D. Special attention is paid to the role of vitamin D in the division and differentiation of osteoblasts and thus, in its role in osteogenesis. In this regard it was interesting to observe the local effects of the active form of vitamin D3 in osteogenesis, as a part of the system for local delivery. These effects were observed on an experimental model. Three types of nanobiomaterial were implanted in the artificially made defects in rats’ mandibular bone. Six weeks after implantation of hydroxyapatite, hydroxyapatite-coated vitamin D3 and hydroxyapatite nanoparticles coated with vitamin D3 mixed with the polymer, the animals were sacrificed, and the samples of mandibular alveolar bone were taken. The samples were adequately prepared and subjected to histopathological analysis. The best results in regeneration of osteoporotic jaw bone were obtained in the experimental group of animals where the implant was hydroxyapatite-coated vitamin D3 mixed with the polymer. The results show that nanobiomaterials with local delivery of active form of vitamin D3, used in this study, may be materials of the future in the area of weakened jaw bone tissue regeneration.
PB  - Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts
C3  - Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia
T1  - Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration
SP  - 9
EP  - 9
UR  - https://hdl.handle.net/21.15107/rcub_dais_690
ER  - 

@conference{
author = "Ajduković, Zorica and Ignjatović, Nenad and Petrović, Nenad and Savić, Vojin and Mihailović, Dragan and Uskoković, Dragan",
year = "2011",
abstract = "Systems for targeted delivery of drugs with high affinity for specific organs, tissues, and cells were introduced at the beginning of the twentieth century. Recently, this concept is attracting much attention. These systems have shown most effective in reducing adverse effects of drugs. In recent years, scientists have created a system of nanoparticles for delivery of vitamin D. Special attention is paid to the role of vitamin D in the division and differentiation of osteoblasts and thus, in its role in osteogenesis. In this regard it was interesting to observe the local effects of the active form of vitamin D3 in osteogenesis, as a part of the system for local delivery. These effects were observed on an experimental model. Three types of nanobiomaterial were implanted in the artificially made defects in rats’ mandibular bone. Six weeks after implantation of hydroxyapatite, hydroxyapatite-coated vitamin D3 and hydroxyapatite nanoparticles coated with vitamin D3 mixed with the polymer, the animals were sacrificed, and the samples of mandibular alveolar bone were taken. The samples were adequately prepared and subjected to histopathological analysis. The best results in regeneration of osteoporotic jaw bone were obtained in the experimental group of animals where the implant was hydroxyapatite-coated vitamin D3 mixed with the polymer. The results show that nanobiomaterials with local delivery of active form of vitamin D3, used in this study, may be materials of the future in the area of weakened jaw bone tissue regeneration.",
publisher = "Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts",
journal = "Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia",
title = "Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration",
pages = "9-9",
url = "https://hdl.handle.net/21.15107/rcub_dais_690"
}

Ajduković, Z., Ignjatović, N., Petrović, N., Savić, V., Mihailović, D.,& Uskoković, D.. (2011). Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts., 9-9.
https://hdl.handle.net/21.15107/rcub_dais_690

Ajduković Z, Ignjatović N, Petrović N, Savić V, Mihailović D, Uskoković D. Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia. 2011;:9-9.
https://hdl.handle.net/21.15107/rcub_dais_690 .

Ajduković, Zorica, Ignjatović, Nenad, Petrović, Nenad, Savić, Vojin, Mihailović, Dragan, Uskoković, Dragan, "Joint effects of vitamin D and nanobiomaterial in the jaw bone regeneration" in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia (2011):9-9,
https://hdl.handle.net/21.15107/rcub_dais_690 .