TY  - JOUR
AU  - Ajduković, Zorica
AU  - Mihajilov Krstev, Tatjana
AU  - Ignjatović, Nenad
AU  - Stojanović, Zoran S.
AU  - Mladenović Antić, Snežana
AU  - Kocić, Branislava
AU  - Najman, Stevo
AU  - Petrović, Nenad D.
AU  - Uskoković, Dragan
PY  - 2016
UR  - https://dais.sanu.ac.rs/123456789/2385
AB  - In the field of oral implantology the loss of bone tissue prevents adequate patient care, and calls for the use of synthetic biomaterials with properties that resemble natural bone. Special attention is paid to the risk of infection after the implantation of these materials. Studies have suggested that some nanocontructs containing metal ions have antimicrobial properties. The aim of this study was to examine the antimicrobial and hemolytic activity of cobalt-substituted hydroxyapatite nanoparticles, compared to hydroxyapatite and hydroxyapatite/poly-lactide-co-glycolide. The antibacterial effects of these powders were tested against two pathogenic bacterial strains: Escherichia coi (ATCC 25922) and Staphylococcus aureus (ATCC 25923), using the disc diffusion method and the quantitative antimicrobial test in a liquid medium. The quantitative antimicrobial test showed that all of the tested biomaterials have some antibacterial properties. The effects of both tests were more prominent in case of S. aureus than in E coli. A higher percentage of cobalt in the crystal structure of cobalt-substituted hydroxyapatite nanoparticles led to an increased antimicrobial activity. All of the presented biomaterial samples were found to be non-hemolytic. Having in mind that the tested of cobalt-substituted hydroxyapatite (Ca/Co-HAp) material in given concentrations shows good hemocompatibility and antimicrobial effects, along with its previously studied biological properties, the conclusion can be reached that it is a potential candidate that could substitute calcium hydroxyapatite as the material of choice for use in bone tissue engineering and clinical practices in orthopedic, oral and maxillofacial surgery.
PB  - American Scientific Publishers
T2  - Journal of Nanoscience and Nanotechnology
T1  - In Vitro Evaluation of Nanoscale Hydroxyapatite-Based Bone Reconstructive Materials with Antimicrobial Properties
SP  - 1420
EP  - 1428
VL  - 16
IS  - 2
DO  - 10.1166/jnn.2016.10699
UR  - https://hdl.handle.net/21.15107/rcub_dais_2385
ER  - 

@article{
author = "Ajduković, Zorica and Mihajilov Krstev, Tatjana and Ignjatović, Nenad and Stojanović, Zoran S. and Mladenović Antić, Snežana and Kocić, Branislava and Najman, Stevo and Petrović, Nenad D. and Uskoković, Dragan",
year = "2016",
abstract = "In the field of oral implantology the loss of bone tissue prevents adequate patient care, and calls for the use of synthetic biomaterials with properties that resemble natural bone. Special attention is paid to the risk of infection after the implantation of these materials. Studies have suggested that some nanocontructs containing metal ions have antimicrobial properties. The aim of this study was to examine the antimicrobial and hemolytic activity of cobalt-substituted hydroxyapatite nanoparticles, compared to hydroxyapatite and hydroxyapatite/poly-lactide-co-glycolide. The antibacterial effects of these powders were tested against two pathogenic bacterial strains: Escherichia coi (ATCC 25922) and Staphylococcus aureus (ATCC 25923), using the disc diffusion method and the quantitative antimicrobial test in a liquid medium. The quantitative antimicrobial test showed that all of the tested biomaterials have some antibacterial properties. The effects of both tests were more prominent in case of S. aureus than in E coli. A higher percentage of cobalt in the crystal structure of cobalt-substituted hydroxyapatite nanoparticles led to an increased antimicrobial activity. All of the presented biomaterial samples were found to be non-hemolytic. Having in mind that the tested of cobalt-substituted hydroxyapatite (Ca/Co-HAp) material in given concentrations shows good hemocompatibility and antimicrobial effects, along with its previously studied biological properties, the conclusion can be reached that it is a potential candidate that could substitute calcium hydroxyapatite as the material of choice for use in bone tissue engineering and clinical practices in orthopedic, oral and maxillofacial surgery.",
publisher = "American Scientific Publishers",
journal = "Journal of Nanoscience and Nanotechnology",
title = "In Vitro Evaluation of Nanoscale Hydroxyapatite-Based Bone Reconstructive Materials with Antimicrobial Properties",
pages = "1420-1428",
volume = "16",
number = "2",
doi = "10.1166/jnn.2016.10699",
url = "https://hdl.handle.net/21.15107/rcub_dais_2385"
}

Ajduković, Z., Mihajilov Krstev, T., Ignjatović, N., Stojanović, Z. S., Mladenović Antić, S., Kocić, B., Najman, S., Petrović, N. D.,& Uskoković, D.. (2016). In Vitro Evaluation of Nanoscale Hydroxyapatite-Based Bone Reconstructive Materials with Antimicrobial Properties. in Journal of Nanoscience and Nanotechnology
American Scientific Publishers., 16(2), 1420-1428.
https://doi.org/10.1166/jnn.2016.10699
https://hdl.handle.net/21.15107/rcub_dais_2385

Ajduković Z, Mihajilov Krstev T, Ignjatović N, Stojanović ZS, Mladenović Antić S, Kocić B, Najman S, Petrović ND, Uskoković D. In Vitro Evaluation of Nanoscale Hydroxyapatite-Based Bone Reconstructive Materials with Antimicrobial Properties. in Journal of Nanoscience and Nanotechnology. 2016;16(2):1420-1428.
doi:10.1166/jnn.2016.10699
https://hdl.handle.net/21.15107/rcub_dais_2385 .

Ajduković, Zorica, Mihajilov Krstev, Tatjana, Ignjatović, Nenad, Stojanović, Zoran S., Mladenović Antić, Snežana, Kocić, Branislava, Najman, Stevo, Petrović, Nenad D., Uskoković, Dragan, "In Vitro Evaluation of Nanoscale Hydroxyapatite-Based Bone Reconstructive Materials with Antimicrobial Properties" in Journal of Nanoscience and Nanotechnology, 16, no. 2 (2016):1420-1428,
https://doi.org/10.1166/jnn.2016.10699 .,
https://hdl.handle.net/21.15107/rcub_dais_2385 .