TY  - CONF
AU  - Guševac Stojanović, Ivana
AU  - Martinović, J.
AU  - Zarić Kontić, M.
AU  - Mitrović, N.
AU  - Stojanović, Zoran
AU  - Grković, I.
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://dais.sanu.ac.rs/123456789/13624
AB  - In the brain, three isoforms of nitric oxide synthase (NOS) regulate production of nitric oxide (NO), a signalling molecule with a role in cerebral blood flow regulation. Depending on the stimulus, NO exerts dual nature, from neuroprotective to neurodestructive. Given the scarcity of literature data on the involvement of nitrosative stress indicators in the rat hippocampal response to 7-day lasting progesterone (P4) treatment following permanent occlusion of both common carotid arteries, we assessed NO level and protein expressions of endothelial nitric oxide synthase (eNOS, including its total (t-eNOS) and phosphorylated at Ser1177 isoform (p-eNOS Ser1177)). According to obtained results, elevated NO levels occurred due to activity of other NOS forms since eNOS expressions were similar between experimental groups. Although NO level was downscaled it was still elevated in occluded animals treated with P4, showing modest anti-nitrosative effect of this potent steroid in the hippocampus.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022
T1  - Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion
SP  - 79
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_dais_13624
ER  - 

@conference{
author = "Guševac Stojanović, Ivana and Martinović, J. and Zarić Kontić, M. and Mitrović, N. and Stojanović, Zoran and Grković, I. and Drakulić, Dunja",
year = "2022",
abstract = "In the brain, three isoforms of nitric oxide synthase (NOS) regulate production of nitric oxide (NO), a signalling molecule with a role in cerebral blood flow regulation. Depending on the stimulus, NO exerts dual nature, from neuroprotective to neurodestructive. Given the scarcity of literature data on the involvement of nitrosative stress indicators in the rat hippocampal response to 7-day lasting progesterone (P4) treatment following permanent occlusion of both common carotid arteries, we assessed NO level and protein expressions of endothelial nitric oxide synthase (eNOS, including its total (t-eNOS) and phosphorylated at Ser1177 isoform (p-eNOS Ser1177)). According to obtained results, elevated NO levels occurred due to activity of other NOS forms since eNOS expressions were similar between experimental groups. Although NO level was downscaled it was still elevated in occluded animals treated with P4, showing modest anti-nitrosative effect of this potent steroid in the hippocampus.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022",
title = "Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion",
pages = "79-79",
url = "https://hdl.handle.net/21.15107/rcub_dais_13624"
}

Guševac Stojanović, I., Martinović, J., Zarić Kontić, M., Mitrović, N., Stojanović, Z., Grković, I.,& Drakulić, D.. (2022). Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion. in Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022
Belgrade : Society of Physical Chemists of Serbia., 79-79.
https://hdl.handle.net/21.15107/rcub_dais_13624

Guševac Stojanović I, Martinović J, Zarić Kontić M, Mitrović N, Stojanović Z, Grković I, Drakulić D. Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion. in Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022. 2022;:79-79.
https://hdl.handle.net/21.15107/rcub_dais_13624 .

Guševac Stojanović, Ivana, Martinović, J., Zarić Kontić, M., Mitrović, N., Stojanović, Zoran, Grković, I., Drakulić, Dunja, "Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion" in Book of abstracts / 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Physical Chemistry 2022 (2022):79-79,
https://hdl.handle.net/21.15107/rcub_dais_13624 .

TY  - CONF
AU  - Martinović, J.
AU  - Guševac Stojanović, I.
AU  - Zarić, M
AU  - Todorović, A.
AU  - Veljković, F.
AU  - Pejić, S.
AU  - Stojanović, Zoran
AU  - Mitrović, N.
AU  - Grković, I.
AU  - Drakulić, Dunja
PY  - 2021
UR  - https://dais.sanu.ac.rs/123456789/12378
AB  - D-galactose (d-gal) is an important physiological nutrient. According to the
widely accepted aging metabolic theory d-gal at high levels can be converted
into aldose and hydroperoxide, resulting in the overproduction of reactive
oxygen species (ROS). Increased ROS levels may subsequently cause oxidative stress, inflammation, mitochondrial dysfunction, and apoptosis which are hallmarks of natural senescence as well as various pathological conditions. We investigated the effects of chronic oral d-gal intake (200 mg/kg and 500 mg/kg for 6 weeks) on physiological, neurological and toxicity parameters in 3 months old male Wistar rats. The obtained results indicate that body weight, food intake, serum glucose, neurological and toxicity status remained unaffected while urine proteins were significantly increased in d-gal treated rats. Although there was no effect on the general health status of the animals, our findings suggest that chronic oral d-gal administration may lead to renal dysfunction.
PB  - Belgrade : Vinča Institute of Nuclear Sciences
C3  - Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021
T1  - Effects of chronic oral D-galactose treatment on general health status in male Wistar rats
SP  - 115
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_dais_12378
ER  - 

@conference{
author = "Martinović, J. and Guševac Stojanović, I. and Zarić, M and Todorović, A. and Veljković, F. and Pejić, S. and Stojanović, Zoran and Mitrović, N. and Grković, I. and Drakulić, Dunja",
year = "2021",
abstract = "D-galactose (d-gal) is an important physiological nutrient. According to the
widely accepted aging metabolic theory d-gal at high levels can be converted
into aldose and hydroperoxide, resulting in the overproduction of reactive
oxygen species (ROS). Increased ROS levels may subsequently cause oxidative stress, inflammation, mitochondrial dysfunction, and apoptosis which are hallmarks of natural senescence as well as various pathological conditions. We investigated the effects of chronic oral d-gal intake (200 mg/kg and 500 mg/kg for 6 weeks) on physiological, neurological and toxicity parameters in 3 months old male Wistar rats. The obtained results indicate that body weight, food intake, serum glucose, neurological and toxicity status remained unaffected while urine proteins were significantly increased in d-gal treated rats. Although there was no effect on the general health status of the animals, our findings suggest that chronic oral d-gal administration may lead to renal dysfunction.",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences",
journal = "Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021",
title = "Effects of chronic oral D-galactose treatment on general health status in male Wistar rats",
pages = "115-118",
url = "https://hdl.handle.net/21.15107/rcub_dais_12378"
}

Martinović, J., Guševac Stojanović, I., Zarić, M., Todorović, A., Veljković, F., Pejić, S., Stojanović, Z., Mitrović, N., Grković, I.,& Drakulić, D.. (2021). Effects of chronic oral D-galactose treatment on general health status in male Wistar rats. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021
Belgrade : Vinča Institute of Nuclear Sciences., 115-118.
https://hdl.handle.net/21.15107/rcub_dais_12378

Martinović J, Guševac Stojanović I, Zarić M, Todorović A, Veljković F, Pejić S, Stojanović Z, Mitrović N, Grković I, Drakulić D. Effects of chronic oral D-galactose treatment on general health status in male Wistar rats. in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021. 2021;:115-118.
https://hdl.handle.net/21.15107/rcub_dais_12378 .

Martinović, J., Guševac Stojanović, I., Zarić, M, Todorović, A., Veljković, F., Pejić, S., Stojanović, Zoran, Mitrović, N., Grković, I., Drakulić, Dunja, "Effects of chronic oral D-galactose treatment on general health status in male Wistar rats" in Proceedings / 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 (2021):115-118,
https://hdl.handle.net/21.15107/rcub_dais_12378 .