TY  - JOUR
AU  - Obradović, Radmila
AU  - Kesić, Ljiljana
AU  - Mihailović, Dragan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2007
UR  - http://www.quintpub.com/journals/jola/abstract.php?iss2_id=800&article_id=9259
UR  - https://dais.sanu.ac.rs/123456789/13689
AB  - Purpose: The efficacy of soft laser application in the treatment of experimentally created bone defects in rat mandibles filled with biocomposite BCP/PLGA (bicalcium phosphate/polylactide–co-glycolide) was analyzed. Materials and Methods: BCP/PLGA biomaterial was implanted in artificially made defects of rat mandibles. Sixty animals were divided into three separate groups. Group A served as the control. In group B1, the implantation site was submitted to GaAlAs laser irradiation, and in group B2 to HeNe laser irradiation for 5 consecutive days. Two, 6 and 8 weeks after completed laser therapy, the animals were killed, specimens taken and routinely processed, and analyzed histologically and morphometrically. Morphometrical analysis consisted of measuring area, area fraction, integral density, mean density, and density variation of bone tissue. Results: After 2 and 6 weeks, significantly higher values of these parameters were obtained in groups submitted to laser irradiation. Conclusions: The results of this study showed a biostimulative effect of soft laser therapy on BCP/PLGA biomaterial osseointegration and increased bone repair with early bone healing.
T2  - The Journal of Oral Laser Applications
T1  - Comparative Efficacy Analysis of Biomaterials and Soft Lasers in Repair of Bone Defects
SP  - 161
EP  - 166
VL  - 7
IS  - 3
UR  - https://hdl.handle.net/21.15107/rcub_dais_13689
ER  - 

@article{
author = "Obradović, Radmila and Kesić, Ljiljana and Mihailović, Dragan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2007",
abstract = "Purpose: The efficacy of soft laser application in the treatment of experimentally created bone defects in rat mandibles filled with biocomposite BCP/PLGA (bicalcium phosphate/polylactide–co-glycolide) was analyzed. Materials and Methods: BCP/PLGA biomaterial was implanted in artificially made defects of rat mandibles. Sixty animals were divided into three separate groups. Group A served as the control. In group B1, the implantation site was submitted to GaAlAs laser irradiation, and in group B2 to HeNe laser irradiation for 5 consecutive days. Two, 6 and 8 weeks after completed laser therapy, the animals were killed, specimens taken and routinely processed, and analyzed histologically and morphometrically. Morphometrical analysis consisted of measuring area, area fraction, integral density, mean density, and density variation of bone tissue. Results: After 2 and 6 weeks, significantly higher values of these parameters were obtained in groups submitted to laser irradiation. Conclusions: The results of this study showed a biostimulative effect of soft laser therapy on BCP/PLGA biomaterial osseointegration and increased bone repair with early bone healing.",
journal = "The Journal of Oral Laser Applications",
title = "Comparative Efficacy Analysis of Biomaterials and Soft Lasers in Repair of Bone Defects",
pages = "161-166",
volume = "7",
number = "3",
url = "https://hdl.handle.net/21.15107/rcub_dais_13689"
}

Obradović, R., Kesić, L., Mihailović, D., Ignjatović, N.,& Uskoković, D.. (2007). Comparative Efficacy Analysis of Biomaterials and Soft Lasers in Repair of Bone Defects. in The Journal of Oral Laser Applications, 7(3), 161-166.
https://hdl.handle.net/21.15107/rcub_dais_13689

Obradović R, Kesić L, Mihailović D, Ignjatović N, Uskoković D. Comparative Efficacy Analysis of Biomaterials and Soft Lasers in Repair of Bone Defects. in The Journal of Oral Laser Applications. 2007;7(3):161-166.
https://hdl.handle.net/21.15107/rcub_dais_13689 .

Obradović, Radmila, Kesić, Ljiljana, Mihailović, Dragan, Ignjatović, Nenad, Uskoković, Dragan, "Comparative Efficacy Analysis of Biomaterials and Soft Lasers in Repair of Bone Defects" in The Journal of Oral Laser Applications, 7, no. 3 (2007):161-166,
https://hdl.handle.net/21.15107/rcub_dais_13689 .

TY  - JOUR
AU  - Živković, Radmila
AU  - Kesić, Ljiljana
AU  - Mihailović, Dragan
AU  - Ignjatović, Nenad
AU  - Uskoković, Dragan
PY  - 2006
UR  - http://www.ncbi.nlm.nih.gov/pubmed/0354-21170602109Z
UR  - https://dais.sanu.ac.rs/123456789/3364
AB  - The efficiency of HeNe laser application in treatment of artificially caused bone defects in mandible of rats filled with biocomposite BCP/PLGA (bicalcium phosphate/polylactide-co-glycolide) was analyzed. Animals were divided in two separate groups. The first group (A) was the control one. In the second group (B) the implantation site was submitted to HeNe laser irradiation. Animals were sacrificed two, six, eight and twelve weeks after laser therapy. Histological samples were decalcified and submerged in paraffin blocks. Samples were colored with HE. Morphometrical analysis consisted of measuring area fraction, area, integral optical density, mean density and density variation. Results showed beneficial effect of laser treatment in reparation of alveolar bone after two and six weeks. After eight and twelve weeks no beneficial laser effect on biocomposite osseointegration could be noticed.
PB  - Niš : University of Niš
T2  - Facta universitatis - Series: Medicine and Biology
T1  - Investigation of HeNe laser therapy influence on BCP/PLGA osseointegration: Experimental study
SP  - 109
EP  - 113
VL  - 13
IS  - 2
UR  - https://hdl.handle.net/21.15107/rcub_dais_3364
ER  - 

@article{
author = "Živković, Radmila and Kesić, Ljiljana and Mihailović, Dragan and Ignjatović, Nenad and Uskoković, Dragan",
year = "2006",
abstract = "The efficiency of HeNe laser application in treatment of artificially caused bone defects in mandible of rats filled with biocomposite BCP/PLGA (bicalcium phosphate/polylactide-co-glycolide) was analyzed. Animals were divided in two separate groups. The first group (A) was the control one. In the second group (B) the implantation site was submitted to HeNe laser irradiation. Animals were sacrificed two, six, eight and twelve weeks after laser therapy. Histological samples were decalcified and submerged in paraffin blocks. Samples were colored with HE. Morphometrical analysis consisted of measuring area fraction, area, integral optical density, mean density and density variation. Results showed beneficial effect of laser treatment in reparation of alveolar bone after two and six weeks. After eight and twelve weeks no beneficial laser effect on biocomposite osseointegration could be noticed.",
publisher = "Niš : University of Niš",
journal = "Facta universitatis - Series: Medicine and Biology",
title = "Investigation of HeNe laser therapy influence on BCP/PLGA osseointegration: Experimental study",
pages = "109-113",
volume = "13",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_dais_3364"
}

Živković, R., Kesić, L., Mihailović, D., Ignjatović, N.,& Uskoković, D.. (2006). Investigation of HeNe laser therapy influence on BCP/PLGA osseointegration: Experimental study. in Facta universitatis - Series: Medicine and Biology
Niš : University of Niš., 13(2), 109-113.
https://hdl.handle.net/21.15107/rcub_dais_3364

Živković R, Kesić L, Mihailović D, Ignjatović N, Uskoković D. Investigation of HeNe laser therapy influence on BCP/PLGA osseointegration: Experimental study. in Facta universitatis - Series: Medicine and Biology. 2006;13(2):109-113.
https://hdl.handle.net/21.15107/rcub_dais_3364 .

Živković, Radmila, Kesić, Ljiljana, Mihailović, Dragan, Ignjatović, Nenad, Uskoković, Dragan, "Investigation of HeNe laser therapy influence on BCP/PLGA osseointegration: Experimental study" in Facta universitatis - Series: Medicine and Biology, 13, no. 2 (2006):109-113,
https://hdl.handle.net/21.15107/rcub_dais_3364 .