Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells
Апстракт
The aim of this study was to compare the effects of two types of nanomaterials, cobalt-exchanged hydroxyapatite (CoHAp) and calcium phosphate/poly-(DL-lactide-co-glycolide) (CP/PLGA), on the viability of Saos-2 osteoblast-like cells, using MTT test. We have examined the suspension of this materials in the following concentrations: 1.6, 8, 40, 200, 1000 and 2500 μg/ml, as well as extracts in concentration range from 2,5% to 100%. Both materials showed cytotoxic effect at higher concentrations of suspension and extract, respectively, but they were not cytotoxic at lower concentrations. CP/PLGA acted stronger cytotoxic compared to CoHAp, regardless of whether it is examined suspension or extract. CoHAp in small concentrations of suspension and extract acted slightly stimulatory on cells. This suggests that CoHAp may have advantage for use in the in vivo systems.
Кључне речи:
nanomaterials / cobalt-exchanged hydroxyapatite / poly-(DL-lactide-co-glycolide)Извор:
The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts, 2012, 126-126Издавач:
- Belgrade : Materials Research Society of Serbia
Финансирање / пројекти:
- Молекуларно дизајнирање наночестица контролисаних морфолошких и физичко-хемијских карактеристика и функционалних материјала на њиховој основи (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45004)
- Виртуелни коштано зглобни систем човека и његова примена у претклиничкој и клиничкој пракси (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41017)
Институција/група
Институт техничких наука САНУ / Institute of Technical Sciences of SASATY - CONF AU - Stojanović, S. AU - Najman, Stevo AU - Ajduković, Zorica AU - Ignjatović, Nenad AU - Uskoković, Dragan PY - 2012 UR - https://dais.sanu.ac.rs/123456789/458 AB - The aim of this study was to compare the effects of two types of nanomaterials, cobalt-exchanged hydroxyapatite (CoHAp) and calcium phosphate/poly-(DL-lactide-co-glycolide) (CP/PLGA), on the viability of Saos-2 osteoblast-like cells, using MTT test. We have examined the suspension of this materials in the following concentrations: 1.6, 8, 40, 200, 1000 and 2500 μg/ml, as well as extracts in concentration range from 2,5% to 100%. Both materials showed cytotoxic effect at higher concentrations of suspension and extract, respectively, but they were not cytotoxic at lower concentrations. CP/PLGA acted stronger cytotoxic compared to CoHAp, regardless of whether it is examined suspension or extract. CoHAp in small concentrations of suspension and extract acted slightly stimulatory on cells. This suggests that CoHAp may have advantage for use in the in vivo systems. PB - Belgrade : Materials Research Society of Serbia C3 - The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts T1 - Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells SP - 126 EP - 126 UR - https://hdl.handle.net/21.15107/rcub_dais_458 ER -
@conference{ author = "Stojanović, S. and Najman, Stevo and Ajduković, Zorica and Ignjatović, Nenad and Uskoković, Dragan", year = "2012", abstract = "The aim of this study was to compare the effects of two types of nanomaterials, cobalt-exchanged hydroxyapatite (CoHAp) and calcium phosphate/poly-(DL-lactide-co-glycolide) (CP/PLGA), on the viability of Saos-2 osteoblast-like cells, using MTT test. We have examined the suspension of this materials in the following concentrations: 1.6, 8, 40, 200, 1000 and 2500 μg/ml, as well as extracts in concentration range from 2,5% to 100%. Both materials showed cytotoxic effect at higher concentrations of suspension and extract, respectively, but they were not cytotoxic at lower concentrations. CP/PLGA acted stronger cytotoxic compared to CoHAp, regardless of whether it is examined suspension or extract. CoHAp in small concentrations of suspension and extract acted slightly stimulatory on cells. This suggests that CoHAp may have advantage for use in the in vivo systems.", publisher = "Belgrade : Materials Research Society of Serbia", journal = "The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts", title = "Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells", pages = "126-126", url = "https://hdl.handle.net/21.15107/rcub_dais_458" }
Stojanović, S., Najman, S., Ajduković, Z., Ignjatović, N.,& Uskoković, D.. (2012). Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts Belgrade : Materials Research Society of Serbia., 126-126. https://hdl.handle.net/21.15107/rcub_dais_458
Stojanović S, Najman S, Ajduković Z, Ignjatović N, Uskoković D. Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells. in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts. 2012;:126-126. https://hdl.handle.net/21.15107/rcub_dais_458 .
Stojanović, S., Najman, Stevo, Ajduković, Zorica, Ignjatović, Nenad, Uskoković, Dragan, "Comparative study of the effects of different nanomaterials on the viability of human osteoblast-like cells" in The Fourteenth Annual Conference YUCOMAT 2012: Programme and the Book of Abstracts (2012):126-126, https://hdl.handle.net/21.15107/rcub_dais_458 .